DK1824887T3 - CYTOTOXIC ANTIBODY DIRECTED AGAINST TYPE B lymphoid HEMATOPOIETIC proliferations - Google Patents
CYTOTOXIC ANTIBODY DIRECTED AGAINST TYPE B lymphoid HEMATOPOIETIC proliferations Download PDFInfo
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- DK1824887T3 DK1824887T3 DK05825974.8T DK05825974T DK1824887T3 DK 1824887 T3 DK1824887 T3 DK 1824887T3 DK 05825974 T DK05825974 T DK 05825974T DK 1824887 T3 DK1824887 T3 DK 1824887T3
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- Prior art keywords
- antibody
- ser
- cells
- lymphoma
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1069—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from blood cells, e.g. the cancer being a myeloma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0413320A FR2879204B1 (fr) | 2004-12-15 | 2004-12-15 | Anticorps cytotoxique dirige contre les proliferations hematopoietiques lymphoides de type b. |
| PCT/FR2005/003123 WO2006064121A2 (fr) | 2004-12-15 | 2005-12-14 | Anticorps cytotoxique dirige contre les proliferations hematopoïetiques lymphoïdes de type b |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1824887T3 true DK1824887T3 (en) | 2016-09-05 |
Family
ID=34953790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05825974.8T DK1824887T3 (en) | 2004-12-15 | 2005-12-14 | CYTOTOXIC ANTIBODY DIRECTED AGAINST TYPE B lymphoid HEMATOPOIETIC proliferations |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9234045B2 (OSRAM) |
| EP (2) | EP2949674A1 (OSRAM) |
| JP (2) | JP4999699B2 (OSRAM) |
| KR (3) | KR20120023177A (OSRAM) |
| CN (1) | CN101115772B (OSRAM) |
| AU (1) | AU2005315534B2 (OSRAM) |
| BE (1) | BE2023C542I2 (OSRAM) |
| BR (1) | BRPI0519044B8 (OSRAM) |
| CA (1) | CA2590303C (OSRAM) |
| DK (1) | DK1824887T3 (OSRAM) |
| ES (1) | ES2588161T3 (OSRAM) |
| FR (2) | FR2879204B1 (OSRAM) |
| IL (1) | IL183947A0 (OSRAM) |
| NL (1) | NL301242I2 (OSRAM) |
| PL (1) | PL1824887T3 (OSRAM) |
| WO (1) | WO2006064121A2 (OSRAM) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| DK2213683T3 (da) | 2004-08-04 | 2013-09-02 | Mentrik Biotech Llc | VARIANT-Fc-REGIONER |
| FR2879204B1 (fr) * | 2004-12-15 | 2007-02-16 | Lab Francais Du Fractionnement | Anticorps cytotoxique dirige contre les proliferations hematopoietiques lymphoides de type b. |
| FR2879605B1 (fr) | 2004-12-16 | 2008-10-17 | Centre Nat Rech Scient Cnrse | Production de formats d'anticorps et applications immunologiques de ces formats |
| NZ599464A (en) | 2005-02-03 | 2014-03-28 | Topotarget Uk Ltd | Combination therapies using hdac inhibitors |
| ATE542527T1 (de) | 2005-05-13 | 2012-02-15 | Topotarget Uk Ltd | Pharmazeutische formulierungen von hdac-hemmern |
| PL2298815T3 (pl) | 2005-07-25 | 2015-08-31 | Emergent Product Dev Seattle | Zmniejszenie ilości komórek B przy użyciu cząsteczek wiążących specyficznych dla CD20 i CD37 |
| JP5377968B2 (ja) | 2005-11-10 | 2013-12-25 | トポターゲット ユーケー リミテッド | 癌治療のために単独で用いるまたは化学療法薬と併用するヒストンデアセチラーゼ（ｈｄａｃ）阻害剤 |
| US9382327B2 (en) | 2006-10-10 | 2016-07-05 | Vaccinex, Inc. | Anti-CD20 antibodies and methods of use |
| FR2910896B1 (fr) * | 2006-12-29 | 2012-11-16 | Lab Francais Du Fractionnement | Anticorps monoclonal dirige contre le recepteur humain des ldl |
| FR2915398B1 (fr) * | 2007-04-25 | 2012-12-28 | Lab Francais Du Fractionnement | "ensemble de moyens pour le traitement d'une pathologie maligne, d'une maladie auto-immune ou d'une maladie infectieuse" |
| EP1985633A1 (en) * | 2007-04-26 | 2008-10-29 | LFB Biotechnologies | Kit of parts for the treatment of cancer or infectious diseases |
| WO2009040517A2 (en) | 2007-09-25 | 2009-04-02 | Topotarget Uk Limited | Methods of synthesis of certain hydroxamic acid compounds |
| ATE513856T1 (de) | 2008-04-11 | 2011-07-15 | Emergent Product Dev Seattle | Cd37-immuntherapeutikum und kombination mit bifunktionellem chemotherapeutikum davon |
| TW201014605A (en) | 2008-09-16 | 2010-04-16 | Genentech Inc | Methods for treating progressive multiple sclerosis |
| WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
| FR2940616A1 (fr) * | 2008-12-30 | 2010-07-02 | Lfb Biotechnologies | Utilisation d'un anticorps anti-cd20 pour le traitement du lymphome primaire intraoculaire. |
| EP2233500A1 (en) | 2009-03-20 | 2010-09-29 | LFB Biotechnologies | Optimized Fc variants |
| JP5841072B2 (ja) | 2010-02-10 | 2016-01-06 | イミュノジェン・インコーポレーテッド | Ｃｄ２０抗体およびその使用 |
| FR2962908A1 (fr) * | 2010-07-20 | 2012-01-27 | Lfb Biotechnologies | Formulation d'anticorps anti-cd20 |
| FR2966043A1 (fr) * | 2010-10-14 | 2012-04-20 | Lfb Biotechnologies | Utilisation d'un anticorps anti-cd20 pour le traitement du lymphome cerebral primitif |
| FR2976811A1 (fr) | 2011-06-22 | 2012-12-28 | Lfb Biotechnologies | Utilisation d'un anticorps anti-cd20 a haute adcc pour le traitement de la maladie de waldenstrom |
| EP2537864B1 (en) | 2011-06-24 | 2019-08-07 | Laboratoire Français du Fractionnement et des Biotechnologies | Fc variants with reduced effector functions |
| FR2980110A1 (fr) * | 2011-09-20 | 2013-03-22 | Lfb Biotechnologies | Combinaison d'anticorps anti-cd20 et de bendamustine |
| AU2013289984B2 (en) * | 2012-07-13 | 2018-03-08 | The Trustees Of The University Of Pennsylvania | Use of CART19 to deplete normal B cells to induce tolerance |
| WO2014071125A1 (en) * | 2012-11-02 | 2014-05-08 | Tg Therapeutics, Inc. | Combination of anti-cd20 antibody and pi3 kinase selective inhibitor |
| WO2017201527A2 (en) * | 2016-05-20 | 2017-11-23 | President And Fellows Of Harvard College | Gene therapy methods for age-related diseases and conditions |
| EP3463318A4 (en) | 2016-05-27 | 2020-01-01 | TG Therapeutics Inc. | COMBINATION OF ANTI-CD20-ANTIBODIES, P13-KINASE-DELTA-SELECTIVE INHIBITOR AND BTK-INHIBITOR FOR THE TREATMENT OF PROLIFERATIVE B-CELL DISORDERS |
| CN110191720A (zh) | 2016-09-09 | 2019-08-30 | Tg治疗有限公司 | 用于治疗血液学癌症的抗-CD20抗体、PI 3激酶-δ抑制剂以及抗-PD-1或抗-PD-L1抗体的组合 |
| US20220143026A1 (en) | 2020-11-12 | 2022-05-12 | Tg Therapeutics, Inc. | Triple combination to treat b-cell malignancies |
| US11807689B1 (en) | 2022-06-01 | 2023-11-07 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11884740B1 (en) | 2022-06-01 | 2024-01-30 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11814439B1 (en) | 2022-06-01 | 2023-11-14 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11965032B1 (en) | 2022-06-01 | 2024-04-23 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0669836T3 (da) * | 1992-11-13 | 1996-10-14 | Idec Pharma Corp | Terapeutisk anvendelse af kimære og radioaktivt mærkede antistoffer og humant B-lymfocytbegrænset differentieringsantigen til behandling af B-cellelymfom |
| DE69830312T2 (de) * | 1997-03-14 | 2006-02-02 | Biogen Idec Inc., San Diego | Methode zur spezifischen integration von genen in säugetierzellen durch homologe rekombination, und vektoren zu deren durchführung |
| US8557244B1 (en) * | 1999-08-11 | 2013-10-15 | Biogen Idec Inc. | Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody |
| US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030133939A1 (en) * | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| EP1383800A4 (en) | 2001-04-02 | 2004-09-22 | Idec Pharma Corp | RECOMBINANT ANTIBODIES CO-EXPRESSED WITH GNTIII |
| US7214660B2 (en) * | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| AU2003236022A1 (en) | 2002-04-09 | 2003-10-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells with modified genome |
| CA2498315C (fr) | 2002-09-13 | 2013-01-29 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Anticorps induisant la production de cytokines |
| FR2844513B1 (fr) | 2002-09-13 | 2007-08-03 | Lab Francais Du Fractionnement | Anticorps pour adcc et induisant la production de cytokines. |
| FR2844455B1 (fr) | 2002-09-13 | 2007-12-14 | Lab Francais Du Fractionnement | Traitement des pathologies echappant a la reponse immune par des anticorps optimises |
| SI1558648T1 (sl) | 2002-10-17 | 2012-05-31 | Genmab As | Človeška monoklonalna protitelesa proti CD |
| SI2289936T1 (sl) | 2002-12-16 | 2017-10-30 | Genentech, Inc. | Imunoglobulinske variante in njihove uporabe |
| CN1542132A (zh) * | 2003-04-30 | 2004-11-03 | 上海新霁生物科技有限公司 | 高效表达治疗肿瘤并含有人恒定区全抗体基因的重组病毒及其用途 |
| WO2005063815A2 (en) | 2003-11-12 | 2005-07-14 | Biogen Idec Ma Inc. | Fcϝ receptor-binding polypeptide variants and methods related thereto |
| FR2879204B1 (fr) * | 2004-12-15 | 2007-02-16 | Lab Francais Du Fractionnement | Anticorps cytotoxique dirige contre les proliferations hematopoietiques lymphoides de type b. |
-
2004
- 2004-12-15 FR FR0413320A patent/FR2879204B1/fr not_active Expired - Lifetime
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2005
- 2005-12-14 KR KR1020127000194A patent/KR20120023177A/ko not_active Ceased
- 2005-12-14 JP JP2007546110A patent/JP4999699B2/ja active Active
- 2005-12-14 ES ES05825974.8T patent/ES2588161T3/es active Active
- 2005-12-14 EP EP15174374.7A patent/EP2949674A1/fr not_active Ceased
- 2005-12-14 DK DK05825974.8T patent/DK1824887T3/en active
- 2005-12-14 AU AU2005315534A patent/AU2005315534B2/en active Active
- 2005-12-14 US US11/793,138 patent/US9234045B2/en active Active
- 2005-12-14 KR KR1020077015908A patent/KR101340192B1/ko active Active
- 2005-12-14 EP EP05825974.8A patent/EP1824887B1/fr active Active
- 2005-12-14 PL PL05825974.8T patent/PL1824887T3/pl unknown
- 2005-12-14 CN CN2005800478101A patent/CN101115772B/zh active Active
- 2005-12-14 WO PCT/FR2005/003123 patent/WO2006064121A2/fr active Application Filing
- 2005-12-14 CA CA2590303A patent/CA2590303C/fr active Active
- 2005-12-14 KR KR1020137033324A patent/KR101418695B1/ko active Active
- 2005-12-14 BR BRPI0519044A patent/BRPI0519044B8/pt active IP Right Grant
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2007
- 2007-06-14 IL IL183947A patent/IL183947A0/en active IP Right Grant
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2011
- 2011-12-16 JP JP2011276347A patent/JP5693440B2/ja active Active
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2015
- 2015-08-17 US US14/828,177 patent/US9873745B2/en active Active
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2023
- 2023-09-14 NL NL301242C patent/NL301242I2/nl unknown
- 2023-10-20 FR FR23C1038C patent/FR23C1038I2/fr active Active
- 2023-11-21 BE BE2023C542C patent/BE2023C542I2/fr unknown
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