DK1812581T3 - Fremgangsmåde til fremstilling af optisk aktive N-carbamat-beskyttede beta-lactamer ved optisk oplösning under anvendelse af en candida antarctica lipase - Google Patents
Fremgangsmåde til fremstilling af optisk aktive N-carbamat-beskyttede beta-lactamer ved optisk oplösning under anvendelse af en candida antarctica lipaseInfo
- Publication number
- DK1812581T3 DK1812581T3 DK05826088T DK05826088T DK1812581T3 DK 1812581 T3 DK1812581 T3 DK 1812581T3 DK 05826088 T DK05826088 T DK 05826088T DK 05826088 T DK05826088 T DK 05826088T DK 1812581 T3 DK1812581 T3 DK 1812581T3
- Authority
- DK
- Denmark
- Prior art keywords
- lactams
- carbamate
- candida antarctica
- preparation
- optically active
- Prior art date
Links
- 150000003952 β-lactams Chemical class 0.000 title abstract 3
- 102000004882 Lipase Human genes 0.000 title abstract 2
- 108090001060 Lipase Proteins 0.000 title abstract 2
- 239000004367 Lipase Substances 0.000 title abstract 2
- 241001661345 Moesziomyces antarcticus Species 0.000 title abstract 2
- 235000019421 lipase Nutrition 0.000 title abstract 2
- 230000003287 optical effect Effects 0.000 title 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical group NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 238000006555 catalytic reaction Methods 0.000 abstract 1
- 238000006911 enzymatic reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62840104P | 2004-11-15 | 2004-11-15 | |
| PCT/US2005/041276 WO2006055528A2 (en) | 2004-11-15 | 2005-11-15 | Process for the preparation of an optically acitive n-carbamate protected beta-lactam by optical resolution employing a candida antarctica lipase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1812581T3 true DK1812581T3 (da) | 2009-05-11 |
Family
ID=36190809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05826088T DK1812581T3 (da) | 2004-11-15 | 2005-11-15 | Fremgangsmåde til fremstilling af optisk aktive N-carbamat-beskyttede beta-lactamer ved optisk oplösning under anvendelse af en candida antarctica lipase |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7459301B2 (https=) |
| EP (1) | EP1812581B1 (https=) |
| JP (1) | JP4738416B2 (https=) |
| AT (1) | ATE421996T1 (https=) |
| CA (1) | CA2580151C (https=) |
| DE (1) | DE602005012597D1 (https=) |
| DK (1) | DK1812581T3 (https=) |
| ES (1) | ES2320364T3 (https=) |
| PT (1) | PT1812581E (https=) |
| WO (1) | WO2006055528A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7754714B2 (en) * | 2004-05-18 | 2010-07-13 | Rigel Pharmaceuticals, Inc. | Cycloalkyl substituted pyrimidinediamine compounds and their uses |
| GB2420559B (en) * | 2004-11-15 | 2008-08-06 | Rigel Pharmaceuticals Inc | Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses |
| WO2007070872A1 (en) | 2005-12-15 | 2007-06-21 | Rigel Pharmaceuticals, Inc. | Kinase inhibitors and their uses |
| HU227663B1 (en) * | 2007-07-09 | 2011-10-28 | Univ Szegedi | Resolution process |
| RU2535032C2 (ru) | 2008-12-22 | 2014-12-10 | Милленниум Фармасьютикалз, Инк. | Сочетание ингибиторов аврора киназы и анти-cd 20 антител |
| EP2489663A1 (en) | 2011-02-16 | 2012-08-22 | Almirall, S.A. | Compounds as syk kinase inhibitors |
| EP3076963A4 (en) | 2013-12-06 | 2017-09-13 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-cd30 antibodies |
| WO2017015316A1 (en) | 2015-07-21 | 2017-01-26 | Millennium Pharmaceuticals, Inc. | Administration of aurora kinase inhibitor and chemotherapeutic agents |
| WO2019195658A1 (en) | 2018-04-05 | 2019-10-10 | Dana-Farber Cancer Institute, Inc. | Sting levels as a biomarker for cancer immunotherapy |
| CN111194304B (zh) * | 2018-04-18 | 2022-09-27 | 宜昌东阳光长江药业股份有限公司 | 一种桥环化合物的制备方法 |
| US20220305048A1 (en) | 2019-08-26 | 2022-09-29 | Dana-Farber Cancer Institute, Inc. | Use of heparin to promote type 1 interferon signaling |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE258605T1 (de) | 1998-07-09 | 2004-02-15 | Lonza Ag | Verfahren zur herstellung von (1r,4s)-2- azabicyclo 2.2.1 hept-5-en-3-on-derivaten |
-
2005
- 2005-11-15 AT AT05826088T patent/ATE421996T1/de active
- 2005-11-15 EP EP05826088A patent/EP1812581B1/en not_active Expired - Lifetime
- 2005-11-15 DE DE602005012597T patent/DE602005012597D1/de not_active Expired - Lifetime
- 2005-11-15 ES ES05826088T patent/ES2320364T3/es not_active Expired - Lifetime
- 2005-11-15 DK DK05826088T patent/DK1812581T3/da active
- 2005-11-15 JP JP2007541425A patent/JP4738416B2/ja not_active Expired - Fee Related
- 2005-11-15 US US11/281,186 patent/US7459301B2/en active Active
- 2005-11-15 WO PCT/US2005/041276 patent/WO2006055528A2/en not_active Ceased
- 2005-11-15 PT PT05826088T patent/PT1812581E/pt unknown
- 2005-11-15 CA CA2580151A patent/CA2580151C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005012597D1 (de) | 2009-03-19 |
| EP1812581A2 (en) | 2007-08-01 |
| WO2006055528A3 (en) | 2006-08-31 |
| WO2006055528A2 (en) | 2006-05-26 |
| JP4738416B2 (ja) | 2011-08-03 |
| EP1812581B1 (en) | 2009-01-28 |
| CA2580151A1 (en) | 2006-05-26 |
| ES2320364T3 (es) | 2009-05-21 |
| US7459301B2 (en) | 2008-12-02 |
| PT1812581E (pt) | 2009-04-22 |
| CA2580151C (en) | 2014-02-04 |
| JP2008520206A (ja) | 2008-06-19 |
| ATE421996T1 (de) | 2009-02-15 |
| US20060166308A1 (en) | 2006-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Busto et al. | Hydrolases in the stereoselective synthesis of N-heterocyclic amines and amino acid derivatives | |
| Gotor | Biocatalysis applied to the preparation of pharmaceuticals | |
| Margolin | Enzymes in the synthesis of chiral drugs | |
| Patel | Biocatalytic synthesis of intermediates for the synthesis of chiral drug substances | |
| Milner et al. | Biocatalytic approaches to the Henry (nitroaldol) reaction | |
| DK1812581T3 (da) | Fremgangsmåde til fremstilling af optisk aktive N-carbamat-beskyttede beta-lactamer ved optisk oplösning under anvendelse af en candida antarctica lipase | |
| Gotor | Non-conventional hydrolase chemistry: amide and carbamate bond formation catalyzed by lipases | |
| Miyazawa | Enzymatic resolution of amino acids via ester hydrolysis | |
| Maugeri et al. | Reductive amination of ketones catalyzed by whole cell biocatalysts containing imine reductases (IREDs) | |
| DE69914458D1 (de) | Verfahren zur enzymatischen auflösung von laktamen | |
| Sergeeva et al. | Lipase-catalyzed transamidation of non-activated amides in organic solvent | |
| Gill et al. | Biocatalytic ammonolysis of (5S)-4, 5-dihydro-1H-pyrrole-1, 5-dicarboxylic acid, 1-(1, 1-dimethylethyl)-5-ethyl ester: Preparation of an intermediate to the dipeptidyl peptidase IV inhibitor Saxagliptin | |
| Assaf et al. | Scope, limitations and classification of lactamases | |
| DK0649907T3 (da) | Enzymatisk hydroxyleringsproces til fremstilling af HMG-CoA-reduktaseinhibitorer og mellemprodukter derfor | |
| ATE484575T1 (de) | Mikroorganismus des genus corynebacterium der eine erhöhte l-lysinproduktivität hat und verfahren zur herstellung von l-lysin durch besagten mikroorganismus | |
| NO20071602L (no) | Fremgangsmate for fremstilling av mycofenolatmofetil ved enzymatisk transsesterifisering | |
| Matsuda et al. | A new cyclase family catalyzing head-to-tail macrolactamization of non-ribosomal peptides | |
| Liu et al. | Synthesis of methyl (R)-3-(4-fluorophenyl) glutarate via enzymatic desymmetrization of a prochiral diester | |
| DK0904348T3 (da) | Fremgangsmåde til fremstilling af aminoalkoholer og derivater deraf | |
| ATE134610T1 (de) | Verfahren zur herstellung von optisch aktiven 4- amino-3-hydroxycarbonsäuren | |
| DK0602740T3 (da) | Fremgangsmåde til enzymatisk fremstilling af optisk aktive transglycidsyreestere | |
| Lundell et al. | Enantiomers of adrenaline-type amino alcohols by Burkholderia cepacia lipase-catalyzed asymmetric acylation | |
| WO2005085462A1 (en) | Enzymatic preparation of an enantiomerically enriched beta-2-amino acids | |
| Takabe et al. | Convenient route to both enantiomers of chiral 5-hydroxypyrrolidin-2-one and 5-hydroxy-1, 5-dihydropyrrol-2-one: reverse enantioselectivity in lipase-catalyzed kinetic resolution | |
| Martelli et al. | Chiral β-lactam-based integrin ligands through Lipase-catalysed kinetic resolution and their enantioselective receptor response |