JP4738416B2 - Ｃａｎｄｉｄａａｎｔａｒｃｔｉｃａリパーゼを使用した光学分割による光学活性Ｎ−カルバメート保護化β−ラクタムを調製するためのプロセス - Google Patents

Ｃａｎｄｉｄａａｎｔａｒｃｔｉｃａリパーゼを使用した光学分割による光学活性Ｎ−カルバメート保護化β−ラクタムを調製するためのプロセス Download PDF

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JP4738416B2
JP4738416B2 JP2007541425A JP2007541425A JP4738416B2 JP 4738416 B2 JP4738416 B2 JP 4738416B2 JP 2007541425 A JP2007541425 A JP 2007541425A JP 2007541425 A JP2007541425 A JP 2007541425A JP 4738416 B2 JP4738416 B2 JP 4738416B2
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lipase
diyl
lactam
protected
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Japanese (ja)
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JP2008520206A5 (https=
JP2008520206A (ja
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アンクシュ アルガーデ，
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ライジェル ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2007541425A 2004-11-15 2005-11-15 Ｃａｎｄｉｄａａｎｔａｒｃｔｉｃａリパーゼを使用した光学分割による光学活性Ｎ−カルバメート保護化β−ラクタムを調製するためのプロセス Expired - Fee Related JP4738416B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62840104P 2004-11-15 2004-11-15
US60/628,401 2004-11-15
PCT/US2005/041276 WO2006055528A2 (en) 2004-11-15 2005-11-15 Process for the preparation of an optically acitive n-carbamate protected beta-lactam by optical resolution employing a candida antarctica lipase

Publications (3)

Publication Number Publication Date
JP2008520206A JP2008520206A (ja) 2008-06-19
JP2008520206A5 JP2008520206A5 (https=) 2009-01-08
JP4738416B2 true JP4738416B2 (ja) 2011-08-03

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JP2007541425A Expired - Fee Related JP4738416B2 (ja) 2004-11-15 2005-11-15 Ｃａｎｄｉｄａａｎｔａｒｃｔｉｃａリパーゼを使用した光学分割による光学活性Ｎ−カルバメート保護化β−ラクタムを調製するためのプロセス

Country Status (10)

Country Link
US (1) US7459301B2 (https=)
EP (1) EP1812581B1 (https=)
JP (1) JP4738416B2 (https=)
AT (1) ATE421996T1 (https=)
CA (1) CA2580151C (https=)
DE (1) DE602005012597D1 (https=)
DK (1) DK1812581T3 (https=)
ES (1) ES2320364T3 (https=)
PT (1) PT1812581E (https=)
WO (1) WO2006055528A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1763514A2 (en) * 2004-05-18 2007-03-21 Rigel Pharmaceuticals, Inc. Cycloalkyl substituted pyrimidinediamine compounds and their uses
GB2420559B (en) * 2004-11-15 2008-08-06 Rigel Pharmaceuticals Inc Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
JP5400388B2 (ja) 2005-12-15 2014-01-29 ライジェル ファーマシューティカルズ， インコーポレイテッド キナーゼインヒビターおよびその利用
HU227663B1 (en) * 2007-07-09 2011-10-28 Univ Szegedi Resolution process
RU2535032C2 (ru) 2008-12-22 2014-12-10 Милленниум Фармасьютикалз, Инк. Сочетание ингибиторов аврора киназы и анти-cd 20 антител
EP2489663A1 (en) 2011-02-16 2012-08-22 Almirall, S.A. Compounds as syk kinase inhibitors
EP3076963A4 (en) 2013-12-06 2017-09-13 Millennium Pharmaceuticals, Inc. Combination of aurora kinase inhibitors and anti-cd30 antibodies
JP2018524292A (ja) 2015-07-21 2018-08-30 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オーロラキナーゼインヒビターと化学療法剤の投与
US11874276B2 (en) 2018-04-05 2024-01-16 Dana-Farber Cancer Institute, Inc. STING levels as a biomarker for cancer immunotherapy
WO2019201279A1 (zh) * 2018-04-18 2019-10-24 广东东阳光药业有限公司 一种桥环化合物的制备方法
US20220305048A1 (en) 2019-08-26 2022-09-29 Dana-Farber Cancer Institute, Inc. Use of heparin to promote type 1 interferon signaling

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002520027A (ja) * 1998-07-09 2002-07-09 ロンザ ア−ゲ− （１ｒ，４ｓ）−２−アザビシクロ［２．２．１］ヘプタ−５−エン−３−オン誘導体の製造方法

Also Published As

Publication number Publication date
PT1812581E (pt) 2009-04-22
EP1812581B1 (en) 2009-01-28
DK1812581T3 (da) 2009-05-11
CA2580151A1 (en) 2006-05-26
JP2008520206A (ja) 2008-06-19
ES2320364T3 (es) 2009-05-21
US20060166308A1 (en) 2006-07-27
WO2006055528A2 (en) 2006-05-26
CA2580151C (en) 2014-02-04
DE602005012597D1 (de) 2009-03-19
EP1812581A2 (en) 2007-08-01
ATE421996T1 (de) 2009-02-15
WO2006055528A3 (en) 2006-08-31
US7459301B2 (en) 2008-12-02

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