DE602005012597D1 - Verfahren zur herstellung optisch aktiver n-carbamat-geschützter beta-lactame durch optische auflösung unter verwendung einer candida antarctica lipase - Google Patents

Verfahren zur herstellung optisch aktiver n-carbamat-geschützter beta-lactame durch optische auflösung unter verwendung einer candida antarctica lipase

Info

Publication number
DE602005012597D1
DE602005012597D1 DE602005012597T DE602005012597T DE602005012597D1 DE 602005012597 D1 DE602005012597 D1 DE 602005012597D1 DE 602005012597 T DE602005012597 T DE 602005012597T DE 602005012597 T DE602005012597 T DE 602005012597T DE 602005012597 D1 DE602005012597 D1 DE 602005012597D1
Authority
DE
Germany
Prior art keywords
carbamate
candida antarctica
lactame
production
optically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602005012597T
Other languages
German (de)
English (en)
Inventor
Ankush Argade
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rigel Pharmaceuticals Inc
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of DE602005012597D1 publication Critical patent/DE602005012597D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE602005012597T 2004-11-15 2005-11-15 Verfahren zur herstellung optisch aktiver n-carbamat-geschützter beta-lactame durch optische auflösung unter verwendung einer candida antarctica lipase Expired - Lifetime DE602005012597D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62840104P 2004-11-15 2004-11-15
PCT/US2005/041276 WO2006055528A2 (en) 2004-11-15 2005-11-15 Process for the preparation of an optically acitive n-carbamate protected beta-lactam by optical resolution employing a candida antarctica lipase

Publications (1)

Publication Number Publication Date
DE602005012597D1 true DE602005012597D1 (de) 2009-03-19

Family

ID=36190809

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005012597T Expired - Lifetime DE602005012597D1 (de) 2004-11-15 2005-11-15 Verfahren zur herstellung optisch aktiver n-carbamat-geschützter beta-lactame durch optische auflösung unter verwendung einer candida antarctica lipase

Country Status (10)

Country Link
US (1) US7459301B2 (https=)
EP (1) EP1812581B1 (https=)
JP (1) JP4738416B2 (https=)
AT (1) ATE421996T1 (https=)
CA (1) CA2580151C (https=)
DE (1) DE602005012597D1 (https=)
DK (1) DK1812581T3 (https=)
ES (1) ES2320364T3 (https=)
PT (1) PT1812581E (https=)
WO (1) WO2006055528A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1763514A2 (en) * 2004-05-18 2007-03-21 Rigel Pharmaceuticals, Inc. Cycloalkyl substituted pyrimidinediamine compounds and their uses
GB2420559B (en) * 2004-11-15 2008-08-06 Rigel Pharmaceuticals Inc Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
JP5400388B2 (ja) 2005-12-15 2014-01-29 ライジェル ファーマシューティカルズ， インコーポレイテッド キナーゼインヒビターおよびその利用
HU227663B1 (en) * 2007-07-09 2011-10-28 Univ Szegedi Resolution process
RU2535032C2 (ru) 2008-12-22 2014-12-10 Милленниум Фармасьютикалз, Инк. Сочетание ингибиторов аврора киназы и анти-cd 20 антител
EP2489663A1 (en) 2011-02-16 2012-08-22 Almirall, S.A. Compounds as syk kinase inhibitors
EP3076963A4 (en) 2013-12-06 2017-09-13 Millennium Pharmaceuticals, Inc. Combination of aurora kinase inhibitors and anti-cd30 antibodies
JP2018524292A (ja) 2015-07-21 2018-08-30 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オーロラキナーゼインヒビターと化学療法剤の投与
US11874276B2 (en) 2018-04-05 2024-01-16 Dana-Farber Cancer Institute, Inc. STING levels as a biomarker for cancer immunotherapy
WO2019201279A1 (zh) * 2018-04-18 2019-10-24 广东东阳光药业有限公司 一种桥环化合物的制备方法
US20220305048A1 (en) 2019-08-26 2022-09-29 Dana-Farber Cancer Institute, Inc. Use of heparin to promote type 1 interferon signaling

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002520027A (ja) * 1998-07-09 2002-07-09 ロンザ ア−ゲ− （１ｒ，４ｓ）−２−アザビシクロ［２．２．１］ヘプタ−５−エン−３−オン誘導体の製造方法

Also Published As

Publication number Publication date
PT1812581E (pt) 2009-04-22
EP1812581B1 (en) 2009-01-28
DK1812581T3 (da) 2009-05-11
CA2580151A1 (en) 2006-05-26
JP2008520206A (ja) 2008-06-19
ES2320364T3 (es) 2009-05-21
JP4738416B2 (ja) 2011-08-03
US20060166308A1 (en) 2006-07-27
WO2006055528A2 (en) 2006-05-26
CA2580151C (en) 2014-02-04
EP1812581A2 (en) 2007-08-01
ATE421996T1 (de) 2009-02-15
WO2006055528A3 (en) 2006-08-31
US7459301B2 (en) 2008-12-02

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