DK175793B1 - Substituerede benzimidazoler, deres fremstilling samt anvendelse til fremstilling af lægemidler mod epitellidelser - Google Patents

Substituerede benzimidazoler, deres fremstilling samt anvendelse til fremstilling af lægemidler mod epitellidelser Download PDF

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Publication number
DK175793B1
DK175793B1 DK198905995A DK599589A DK175793B1 DK 175793 B1 DK175793 B1 DK 175793B1 DK 198905995 A DK198905995 A DK 198905995A DK 599589 A DK599589 A DK 599589A DK 175793 B1 DK175793 B1 DK 175793B1
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Prior art keywords
formula
alkyl
phenyl
substituted
hydrogen
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Application number
DK198905995A
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Danish (da)
English (en)
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DK599589A (da
DK599589D0 (da
Inventor
Alfons Herman Marg Raeymaekers
Jean Pierre Frans Van Wauwe
Original Assignee
Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of DK599589D0 publication Critical patent/DK599589D0/da
Publication of DK599589A publication Critical patent/DK599589A/da
Priority to DK200401449A priority Critical patent/DK175785B1/da
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Publication of DK175793B1 publication Critical patent/DK175793B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/496—Triazoles or their condensed derivatives, e.g. benzotriazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK198905995A 1988-11-29 1989-11-28 Substituerede benzimidazoler, deres fremstilling samt anvendelse til fremstilling af lægemidler mod epitellidelser DK175793B1 (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK200401449A DK175785B1 (da) 1988-11-29 2004-09-23 Topicale formuleringer omfattende benzimidazoler og benzotriazoler

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27715288A 1988-11-29 1988-11-29
US27715288 1988-11-29

Publications (3)

Publication Number Publication Date
DK599589D0 DK599589D0 (da) 1989-11-28
DK599589A DK599589A (da) 1990-05-30
DK175793B1 true DK175793B1 (da) 2005-02-21

Family

ID=23059616

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198905995A DK175793B1 (da) 1988-11-29 1989-11-28 Substituerede benzimidazoler, deres fremstilling samt anvendelse til fremstilling af lægemidler mod epitellidelser

Country Status (16)

Country Link
EP (2) EP0609963B1 (es)
JP (2) JP2752200B2 (es)
AT (2) ATE213941T1 (es)
AU (2) AU623454B2 (es)
CA (1) CA2002859C (es)
CY (1) CY1867A (es)
DE (2) DE68918809T2 (es)
DK (1) DK175793B1 (es)
ES (2) ES2065369T3 (es)
HK (1) HK114895A (es)
IE (1) IE63877B1 (es)
IL (1) IL92487A (es)
NZ (1) NZ231405A (es)
PT (1) PT92449B (es)
SG (1) SG50466A1 (es)
ZA (1) ZA899074B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2002859C (en) * 1988-11-29 1998-12-29 Jean P. F. Van Wauwe Method of treating epithelial disorders
NZ257551A (en) * 1992-11-10 1995-10-26 Janssen Pharmaceutica Nv Preparation of 6-[(4-chlorophenyl)(1h-1,2,4-triazol-1-yl)methyl]-1-methyl-1h-benzotriazole in enantiomerically pure form;intermediates
SG47122A1 (en) * 1994-02-18 1998-03-20 Janssen Pharmaceutica Nv Enantiomerically pure(-)-liarozole
EP0745077A1 (en) * 1994-02-18 1996-12-04 Janssen Pharmaceutica N.V. Enantiomerically pure (+)-liarozole
TW316902B (es) * 1994-12-28 1997-10-01 Janssen Pharmaceutica Nv
EP0800391A1 (en) * 1994-12-28 1997-10-15 Janssen Pharmaceutica N.V. Benzimidazoles as inhibitors of calcitriol metabolism
US5536740A (en) * 1995-06-01 1996-07-16 Elizabeth Arden Company, Division Of Conopco, Inc. Skin care compositions containing dimethyl imidazolidinone and retinol or retinyl ester
AU6821196A (en) * 1995-08-14 1997-03-12 Janssen Pharmaceutica N.V. Transdermal administration of vorozole
TW349948B (en) * 1995-10-31 1999-01-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 2-quinolone derivatives
US5716627A (en) * 1996-04-25 1998-02-10 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing fatty acid amides, azoles, and retinol or retinyl ester
CN1102593C (zh) * 1996-06-27 2003-03-05 詹森药业有限公司 N－[4－(杂芳基甲基)苯基]－杂芳基胺类化合物
JPH10220909A (ja) 1996-12-03 1998-08-21 Komatsu Ltd 流体温度制御装置
TW591030B (en) * 1997-03-10 2004-06-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
CA2312720A1 (en) 1997-12-11 1999-06-17 Janssen-Cilag S.A. Retinoic acid mimetic anilides
US6420555B1 (en) 1998-06-16 2002-07-16 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Imidazolyl derivatives
WO1999065898A1 (en) * 1998-06-16 1999-12-23 Societe De Conseils De Recherches Et D'applications Scientifiques Sas Imidazolyl derivatives
EP1173148A4 (en) * 1999-04-29 2002-07-24 Avon Prod Inc METHOD FOR IMPROVING THE AESTHETIC APPEARANCE OF THE EPITHEL
EP1420015A1 (en) * 1999-06-11 2004-05-19 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Imidazolyl derivatives
FR2815857B1 (fr) * 2000-10-30 2003-02-14 Oreal Composition, notamment cosmetique, renfermant un retinoide et une silicone benzotriazole
US7405235B2 (en) 2001-05-04 2008-07-29 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
CA2504448C (en) * 2002-11-01 2012-06-19 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
CA2562763A1 (en) 2004-04-23 2006-07-20 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
CN102781940B (zh) 2009-12-30 2016-09-07 艾科尔公司 取代的咪唑并吡啶基-氨基吡啶化合物
WO2012177852A1 (en) 2011-06-24 2012-12-27 Arqule, Inc Substituted imidazopyridinyl compounds
CA2837727C (en) 2011-06-24 2019-12-03 Arqule, Inc. Substituted imidazopyridinyl-aminopyridine compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ221729A (en) * 1986-09-15 1989-07-27 Janssen Pharmaceutica Nv Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions
US4859684A (en) * 1986-09-15 1989-08-22 Janssen Pharmaceutica N.V. (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders
NZ224714A (en) * 1987-06-01 1990-03-27 Janssen Pharmaceutica Nv Substituted benzotriazole derivatives and pharmaceutical compositions
CA2002859C (en) * 1988-11-29 1998-12-29 Jean P. F. Van Wauwe Method of treating epithelial disorders

Also Published As

Publication number Publication date
HK114895A (en) 1995-07-21
PT92449B (pt) 1995-07-18
JPH1095782A (ja) 1998-04-14
DE68929377D1 (de) 2002-04-11
IE950033L (en) 1990-05-29
CA2002859A1 (en) 1990-05-29
IL92487A (en) 1994-12-29
IE893781L (en) 1990-05-29
JP2752200B2 (ja) 1998-05-18
IL92487A0 (en) 1990-08-31
EP0371559B1 (en) 1994-10-12
JP2912596B2 (ja) 1999-06-28
EP0371559A3 (en) 1992-04-08
DE68918809D1 (de) 1994-11-17
ATE213941T1 (de) 2002-03-15
ZA899074B (en) 1991-07-31
IE63877B1 (en) 1995-06-14
AU623454B2 (en) 1992-05-14
AU630579B2 (en) 1992-10-29
AU1071692A (en) 1992-03-19
NZ231405A (en) 1991-08-27
ES2173902T3 (es) 2002-11-01
AU4564889A (en) 1990-06-07
DK599589A (da) 1990-05-30
CY1867A (en) 1996-04-05
EP0609963B1 (en) 2002-03-06
DE68929377T2 (de) 2002-10-31
JPH0320273A (ja) 1991-01-29
PT92449A (pt) 1990-05-31
SG50466A1 (en) 1998-07-20
ES2065369T3 (es) 1995-02-16
DK599589D0 (da) 1989-11-28
DE68918809T2 (de) 1995-03-23
EP0609963A1 (en) 1994-08-10
EP0371559A2 (en) 1990-06-06
CA2002859C (en) 1998-12-29
ATE112681T1 (de) 1994-10-15

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