DK175514B1 - Fremgangsmåde til oprensning af K-vitaminafhængige blodkoagulationsfaktorer - Google Patents

Fremgangsmåde til oprensning af K-vitaminafhængige blodkoagulationsfaktorer Download PDF

Info

Publication number
DK175514B1
DK175514B1 DK199001534A DK153490A DK175514B1 DK 175514 B1 DK175514 B1 DK 175514B1 DK 199001534 A DK199001534 A DK 199001534A DK 153490 A DK153490 A DK 153490A DK 175514 B1 DK175514 B1 DK 175514B1
Authority
DK
Denmark
Prior art keywords
factor
protein
factors
elution
nacl
Prior art date
Application number
DK199001534A
Other languages
Danish (da)
English (en)
Other versions
DK153490D0 (da
DK153490A (da
Inventor
Peter Anthony Feldman
Original Assignee
Nat Blood Authority
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Blood Authority filed Critical Nat Blood Authority
Publication of DK153490D0 publication Critical patent/DK153490D0/da
Publication of DK153490A publication Critical patent/DK153490A/da
Application granted granted Critical
Publication of DK175514B1 publication Critical patent/DK175514B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • External Artificial Organs (AREA)
  • Steroid Compounds (AREA)
DK199001534A 1987-12-22 1990-06-22 Fremgangsmåde til oprensning af K-vitaminafhængige blodkoagulationsfaktorer DK175514B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB878729822A GB8729822D0 (en) 1987-12-22 1987-12-22 Chemical process
GB8729822 1987-12-22
GB8801150 1988-12-22
PCT/GB1988/001150 WO1989005650A2 (en) 1987-12-22 1988-12-22 Chemical process

Publications (3)

Publication Number Publication Date
DK153490D0 DK153490D0 (da) 1990-06-22
DK153490A DK153490A (da) 1990-06-22
DK175514B1 true DK175514B1 (da) 2004-11-15

Family

ID=10628844

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199001534A DK175514B1 (da) 1987-12-22 1990-06-22 Fremgangsmåde til oprensning af K-vitaminafhængige blodkoagulationsfaktorer

Country Status (9)

Country Link
EP (1) EP0391974B1 (ja)
JP (1) JPH0664B2 (ja)
AT (1) ATE90567T1 (ja)
AU (1) AU627446B2 (ja)
DE (1) DE3881895T2 (ja)
DK (1) DK175514B1 (ja)
GB (1) GB8729822D0 (ja)
NO (1) NO178882C (ja)
WO (1) WO1989005650A2 (ja)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT402262B (de) * 1991-06-20 1997-03-25 Immuno Ag Arzneimittel enthaltend aktiviertes protein c
IT1262899B (it) * 1992-03-27 1996-07-22 Sclavo Spa Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano
DE4430204A1 (de) * 1994-08-26 1996-02-29 Behringwerke Ag Arzneimittel, welches als Gegenmittel für Blut-Antikoagulanzien geeignet ist und seine Verwendung
US5589571A (en) * 1994-10-28 1996-12-31 Cor Therapeutics, Inc. Process for production of inhibited forms of activated blood factors
US5714583A (en) 1995-06-07 1998-02-03 Genetics Institute, Inc. Factor IX purification methods
AT409334B (de) * 1997-09-19 2002-07-25 Immuno Ag Pharmazeutisches präparat enthaltend vitamin k-abhängige einzelfaktoren
SE0203551D0 (sv) * 2002-12-02 2002-12-02 Biovitrum Ab Prothrombin purification
US20060068454A1 (en) * 2004-09-27 2006-03-30 Sysmex Corporation Method of inactivating blood coagulation factor and blood coagulation factor-inactivated sample
GB0710321D0 (en) 2007-05-30 2007-07-11 Nhs Blood & Transplant Method
US9956272B2 (en) 2007-05-30 2018-05-01 Bio Products Laboratory Limited Methods for preparing factor X, activated factor X, inactivated factor X and inactivated factor Xa, and pharmaceutical compositions comprising same
US20140206844A1 (en) 2013-01-18 2014-07-24 Prothera Biologics Methods for isolating blood products from an inter-alpha inhibitor protein-depleted blood product material
CN104328036B (zh) * 2014-10-28 2016-08-24 成都英德生物医药装备技术有限公司 一种人凝血酶原复合物吸附分离装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2303466C2 (de) * 1973-01-25 1975-03-20 Stanislaus Dipl.-Ing. 7340 Geislingen Malik Verfahren zur Herstellung eines Wabenträgers
JPS5263835A (en) * 1975-11-21 1977-05-26 Hokusan Kk Method of fabricating light shaped steel material
US4473553A (en) * 1983-12-02 1984-09-25 Miles Laboratories, Inc. Process for producing a lipoprotein-poor concentrate of coagulation factors VII and VIIa
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
US4981952A (en) * 1988-10-04 1991-01-01 Eli Lilly And Company Method for the purification of vitamin K-dependent proteins

Also Published As

Publication number Publication date
WO1989005650A3 (en) 1989-07-27
EP0391974B1 (en) 1993-06-16
AU627446B2 (en) 1992-08-27
ATE90567T1 (de) 1993-07-15
AU3032989A (en) 1989-07-19
JPH03501085A (ja) 1991-03-14
DE3881895D1 (de) 1993-07-22
DK153490D0 (da) 1990-06-22
JPH0664B2 (ja) 1994-01-05
WO1989005650A2 (en) 1989-06-29
NO178882B (no) 1996-03-18
DK153490A (da) 1990-06-22
NO902757L (no) 1990-06-21
GB8729822D0 (en) 1988-02-03
DE3881895T2 (de) 1993-12-02
NO902757D0 (no) 1990-06-21
EP0391974A1 (en) 1990-10-17
NO178882C (no) 1996-06-26

Similar Documents

Publication Publication Date Title
EP0317376B2 (fr) Préparation de concentré de facteur IX humain de haute pureté et d'autres protéines plasmatiques
EP0528701B1 (fr) Procédé de préparation d'un concentré de thrombine humaine destiné à un usage thérapeutique
JP3094167B2 (ja) 免疫血清グロブリンの精製方法
JP4218980B2 (ja) 治療用の免疫グロブリンｇ濃厚液および該濃厚液の製造方法
DK175514B1 (da) Fremgangsmåde til oprensning af K-vitaminafhængige blodkoagulationsfaktorer
JPS61275210A (ja) ウイルス及び発熱原不活性化剤を用いる固相に吸着させた生物医学的生成物及び製薬生成物の処理法
US5679776A (en) Process for preparing a concentrate of blood coagulation factor VIII-von willebrand factor complex from total plasma
US4470969A (en) Process for producing a concentrate of coagulation factors VII and VIIa
JPH0480886B2 (ja)
JP3976351B2 (ja) 免疫寛容プロトロンビン複合体の調製
US4749783A (en) Viral inactivation and purification of active proteins
JP2579217B2 (ja) 凝固因子▲ｉｉ▼、▲ｖｉｉ▼、▲ｉｘ▼およびｘの１または２以上を濃縮する方法
FR2681867A1 (fr) Procede de purification du facteur viii et preparations obtenues.
US5445958A (en) Process for purifying blood clotting factors
JP2593951B2 (ja) 血液凝固因子▲ｉｘ▼の単離方法
JP3043558B2 (ja) ヒト活性化プロテインｃ調製物及びその製法
EP0650364B1 (en) Purification of factor ix
AU627446C (en) Chemical process
AU665452C (en) Purification of factor IX
JPH03258728A (ja) 蛋白質製剤の製造法
JPH03176500A (ja) リポコルチン類の精製方法
FR2622108A1 (fr) Preparation de concentres de proconvertine (facteur vii), de facteur antihemophilique b (facteur ix) et d'autres proteines plasmatiques, et leur utilisation therapeutique
de Lille Burnouf-Radosevich et a
JPH0819159B2 (ja) 殺菌された抗プラスミン溶液の製造方法

Legal Events

Date Code Title Description
PUP Patent expired
PBP Patent lapsed

Country of ref document: DK