DK175251B1 - Renfremstilling af erythropoietin - Google Patents

Renfremstilling af erythropoietin Download PDF

Info

Publication number
DK175251B1
DK175251B1 DK198700813A DK81387A DK175251B1 DK 175251 B1 DK175251 B1 DK 175251B1 DK 198700813 A DK198700813 A DK 198700813A DK 81387 A DK81387 A DK 81387A DK 175251 B1 DK175251 B1 DK 175251B1
Authority
DK
Denmark
Prior art keywords
erythropoietin
resin
recombinant
liquid
process according
Prior art date
Application number
DK198700813A
Other languages
Danish (da)
English (en)
Other versions
DK81387A (da
DK81387D0 (da
Inventor
Thomas Wayne Strickland
Lai Por-Hsiung
Original Assignee
Kirin Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/747,119 external-priority patent/US4667016A/en
Application filed by Kirin Amgen Inc filed Critical Kirin Amgen Inc
Publication of DK81387A publication Critical patent/DK81387A/da
Publication of DK81387D0 publication Critical patent/DK81387D0/da
Application granted granted Critical
Publication of DK175251B1 publication Critical patent/DK175251B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Cephalosporin Compounds (AREA)
DK198700813A 1985-06-20 1987-02-18 Renfremstilling af erythropoietin DK175251B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US06/747,119 US4667016A (en) 1985-06-20 1985-06-20 Erythropoietin purification
US74711985 1985-06-20
US87215286A 1986-06-13 1986-06-13
US87215286 1986-06-13
US8601342 1986-06-20
PCT/US1986/001342 WO1986007594A1 (en) 1985-06-20 1986-06-20 Protein purification

Publications (3)

Publication Number Publication Date
DK81387A DK81387A (da) 1987-02-18
DK81387D0 DK81387D0 (da) 1987-02-18
DK175251B1 true DK175251B1 (da) 2004-07-19

Family

ID=27114696

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198700813A DK175251B1 (da) 1985-06-20 1987-02-18 Renfremstilling af erythropoietin

Country Status (14)

Country Link
EP (1) EP0228452B1 (el)
JP (1) JPH0698019B2 (el)
KR (1) KR930003665B1 (el)
AT (1) ATE120208T1 (el)
AU (1) AU606578B2 (el)
CA (1) CA1297635C (el)
DE (1) DE3650276T2 (el)
DK (1) DK175251B1 (el)
ES (1) ES8801381A1 (el)
GR (1) GR861624B (el)
IE (1) IE69343B1 (el)
IL (1) IL79176A (el)
PT (1) PT82811B (el)
WO (1) WO1986007594A1 (el)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179199A (en) * 1986-10-20 1993-01-12 Genzyme Corporation Protein purification
IL118201A (en) * 1995-05-11 2004-12-15 Roche Diagnostics Gmbh Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof
KR100374308B1 (ko) * 1995-07-27 2003-12-18 주식회사 엘지생명과학 재조합차이니스햄스터오바리세포로부터발현된수두바이러스의지피i당단백질의정제방법
AU752946B2 (en) * 1997-10-16 2002-10-03 Avigenics, Inc. Vectors comprising a magnum-specific promoter for avian transgenesis
US6210924B1 (en) 1998-08-11 2001-04-03 Amgen Inc. Overexpressing cyclin D 1 in a eukaryotic cell line
BR9917606A (pt) * 1998-11-06 2002-12-31 Bio Sidus S A Procedimento para a purificação de eritropoetina humana recombinante a partir de sobrenadantes de cultivo de células e eritropoetina humana recombinante obtida com tal procedimento
PT1428878E (pt) * 2002-12-13 2008-11-18 Bioceuticals Arzneimittel Ag Processo para a produção e purificação de eritropoietina
US7423139B2 (en) 2004-01-20 2008-09-09 Insight Biopharmaceuticals Ltd. High level expression of recombinant human erythropoietin having a modified 5′-UTR
DE102004027816A1 (de) 2004-06-08 2006-01-05 Bioceuticals Arzneimittel Ag Verfahren zur Reinigung von Erythropoietin
IL165484A0 (en) 2004-11-30 2006-01-15 Applied Research Systems Production of proteins
US8921518B2 (en) 2005-12-23 2014-12-30 Novo Nordisk A/S Purification of proteins using preparative reverse phase chromatography (RPC)
KR100900033B1 (ko) * 2007-11-21 2009-06-01 한국생명공학연구원 인간 에리스로포이에틴의 정제방법
DE102008002209A1 (de) 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur Aufreinigung von Erythropoietin
CA2736141C (en) 2008-09-23 2018-03-20 F. Hoffmann-La Roche Ag Purification of erythropoietin
DE102008054716A1 (de) 2008-12-16 2010-06-17 Evonik Degussa Gmbh Inprozesskontrolle in einem Verfahren zur Herstellung von EPO
CA2759276A1 (en) * 2009-04-22 2010-10-28 Bayer Bioscience N.V. Production of multi-antennary n-glycan structures in plants
KR20120117728A (ko) 2009-09-23 2012-10-24 바이오제너릭스 에이지 재조합 인간 에리트로포이에틴(ｅｐｏ)의 정제 방법, 이렇게 정제된 ｅｐｏ 및 이를 포함하는 약학적 조성물
CN103068999A (zh) 2010-08-20 2013-04-24 贝林格尔.英格海姆国际有限公司 通过在获自细胞培养物的液体中改变ph灭活蛋白酶的方法
WO2013002330A1 (ja) * 2011-06-29 2013-01-03 協和発酵キリン株式会社 たん白質の精製方法
EP3153522A1 (en) 2015-10-09 2017-04-12 Hetero Drugs Limited Process for the purification of erythropoietin and darbepoetin alfa

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (el) * 1978-11-24 1982-12-04 Hoffmann La Roche
JPS5616496A (en) * 1979-07-20 1981-02-17 Sumitomo Chem Co Ltd Recovery of erythropoietin
JPS5653696A (en) * 1979-10-09 1981-05-13 Ajinomoto Co Inc Isolation of erythropoietin by adsorption
JPS57149228A (en) * 1981-03-11 1982-09-14 Ajinomoto Co Inc Novel erythropoietin and its preparation
US4558005A (en) * 1982-09-13 1985-12-10 University Patents, Inc. Monoclonal anti-erythropoietin
JPH0686480B2 (ja) * 1983-02-21 1994-11-02 雪印乳業株式会社 エリスロポエチン製造用モノクローナル抗体
NZ210501A (en) * 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
US4568488A (en) * 1984-01-11 1986-02-04 Lee Huang Sylvia Reverse immunoaffinity chromatography purification method
US4677195A (en) * 1985-01-11 1987-06-30 Genetics Institute, Inc. Method for the purification of erythropoietin and erythropoietin compositions

Also Published As

Publication number Publication date
IL79176A0 (en) 1986-09-30
EP0228452B1 (en) 1995-03-22
PT82811B (pt) 1988-04-21
ATE120208T1 (de) 1995-04-15
DE3650276D1 (de) 1995-04-27
KR930003665B1 (ko) 1993-05-08
JPH0698019B2 (ja) 1994-12-07
IL79176A (en) 1992-06-21
IE861628L (en) 1986-12-20
AU6123086A (en) 1987-01-13
AU606578B2 (en) 1991-02-14
GR861624B (en) 1986-10-21
CA1297635C (en) 1992-03-17
WO1986007594A1 (en) 1986-12-31
DK81387A (da) 1987-02-18
PT82811A (en) 1986-07-01
EP0228452A4 (en) 1989-05-16
DK81387D0 (da) 1987-02-18
DE3650276T2 (de) 1995-07-27
ES8801381A1 (es) 1988-01-01
ES556257A0 (es) 1988-01-01
IE69343B1 (en) 1996-09-04
EP0228452A1 (en) 1987-07-15
KR880000464A (ko) 1988-03-26
JPS63503352A (ja) 1988-12-08

Similar Documents

Publication Publication Date Title
DK175251B1 (da) Renfremstilling af erythropoietin
US4667016A (en) Erythropoietin purification
US6399333B1 (en) Process for producing erythropoietin containing no animal proteins
KR100771252B1 (ko) 양이온 교환 크로마토그래피를 통한 약리학적 활성단백질의 정제방법
JP3438735B2 (ja) 上清ｉｖ、特にｉｖ−４またはコーンフラクションｖまたはそれと類似の上清または画分からヒトアルブミンを単離する方法
KR100320394B1 (ko) 멤브레인크로마토그래피시켜비타민-k의존형단백질을정제시키는방법
JPS59231097A (ja) 均質ヒト免疫インターフェロンサブタイプ２１ｋおよびその製造法
CA2548165A1 (en) Process for purifying interferon beta
JPH02115196A (ja) エリスロポエチンの精製法
WO2020234742A1 (en) Granulocyte colony stimulating factor purification
CN105541994B (zh) 一种血小板生成素或其变体或衍生物的纯化方法
JPH01230522A (ja) トランスフォーミンググロウスファクター―βの精製方法
Reifsnyder et al. Purification of insulin-like growth factor-I and related proteins using underivatized silica
EP0396555B1 (en) Purification of monomeric interferon
AU5955294A (en) Process for the purification and refolding of human respiratory syncytial virus fg glycoprotein
JP6647220B2 (ja) Ｈｍｇ−ｕｐ（超高純度グレードのヒト閉経期ゴナドトロピン）を得るための方法及び夾雑物を含まない組成物
JP3476242B2 (ja) インフルエンザｈａ蛋白の精製方法
CA2548160A1 (en) Process for purifying interferon beta
JPH05170799A (ja) ヒトインターロイキン８の精製方法
US5760187A (en) Purification process of a human growth hormone
KR20240128671A (ko) 단백질을 단리하기 위한 조성물 및 방법(compositions and methods for isolating proteins)
JP5948425B2 (ja) 非アセチル化タンパク質からのアセチル化タンパク質の分離
JPH10265499A (ja) ヒト成長ホルモンの精製方法

Legal Events

Date Code Title Description
PUP Patent expired