DK175154B1 - Fremgangsmåde til fremstilling af en farmaceutisk ionbytterharpikssammensætning - Google Patents
Fremgangsmåde til fremstilling af en farmaceutisk ionbytterharpikssammensætning Download PDFInfo
- Publication number
- DK175154B1 DK175154B1 DK198905645A DK564589A DK175154B1 DK 175154 B1 DK175154 B1 DK 175154B1 DK 198905645 A DK198905645 A DK 198905645A DK 564589 A DK564589 A DK 564589A DK 175154 B1 DK175154 B1 DK 175154B1
- Authority
- DK
- Denmark
- Prior art keywords
- sugar
- alcohol
- water
- weight
- ion exchange
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8826407 | 1988-11-11 | ||
GB888826407A GB8826407D0 (en) | 1988-11-11 | 1988-11-11 | Pharmaceutical ion exchange resin composition |
GB888828592A GB8828592D0 (en) | 1988-12-07 | 1988-12-07 | Pharmaceutical ion exchange resin composition |
GB8828592 | 1988-12-07 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK564589D0 DK564589D0 (da) | 1989-11-10 |
DK564589A DK564589A (da) | 1990-05-12 |
DK175154B1 true DK175154B1 (da) | 2004-06-21 |
Family
ID=26294609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK198905645A DK175154B1 (da) | 1988-11-11 | 1989-11-10 | Fremgangsmåde til fremstilling af en farmaceutisk ionbytterharpikssammensætning |
Country Status (11)
Country | Link |
---|---|
US (1) | US5071646A (es) |
EP (1) | EP0368682B1 (es) |
JP (1) | JP2825202B2 (es) |
AT (1) | ATE123218T1 (es) |
AU (1) | AU621949B2 (es) |
CA (1) | CA2002492A1 (es) |
DE (1) | DE68922894T2 (es) |
DK (1) | DK175154B1 (es) |
ES (1) | ES2075061T3 (es) |
GB (1) | GB2225941B (es) |
IE (1) | IE893625L (es) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9003903D0 (sv) * | 1990-12-07 | 1990-12-07 | Astra Ab | New pharmaceutical formulations |
SE9003904D0 (sv) * | 1990-12-07 | 1990-12-07 | Astra Ab | Method for the manufacture of a pharmaceutical dosage form |
US5275820A (en) * | 1990-12-27 | 1994-01-04 | Allergan, Inc. | Stable suspension formulations of bioerodible polymer matrix microparticles incorporating drug loaded ion exchange resin particles |
US5840339A (en) * | 1991-07-30 | 1998-11-24 | Kunin; Robert | Blood cholesterol reducing pharmaceutical composition |
SE9103110D0 (sv) * | 1991-10-24 | 1991-10-24 | Kabi Pharmacia Ab | New drug formulation |
US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
US5296228A (en) * | 1992-03-13 | 1994-03-22 | Allergan, Inc. | Compositions for controlled delivery of pharmaceutical compounds |
US5350584A (en) * | 1992-06-26 | 1994-09-27 | Merck & Co., Inc. | Spheronization process using charged resins |
USRE39300E1 (en) | 1993-01-28 | 2006-09-19 | Virginia Commonwealth University Medical College Of Virginia | Inhibiting the development of tolerance to and/or dependence on an addictive substance |
US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
IL119660A (en) * | 1993-05-10 | 2002-09-12 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
US7740881B1 (en) | 1993-07-01 | 2010-06-22 | Purdue Pharma Lp | Method of treating humans with opioid formulations having extended controlled release |
IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
US5879705A (en) * | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
US5843480A (en) * | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
GB9422154D0 (en) * | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
US5931809A (en) | 1995-07-14 | 1999-08-03 | Depotech Corporation | Epidural administration of therapeutic compounds with sustained rate of release |
GB9517883D0 (en) * | 1995-09-01 | 1995-11-01 | Euro Celtique Sa | Improved pharmaceutical ion exchange resin composition |
GB9519363D0 (en) | 1995-09-22 | 1995-11-22 | Euro Celtique Sa | Pharmaceutical formulation |
JPH11506473A (ja) * | 1997-02-25 | 1999-06-08 | ザ、プロクター、エンド、ギャンブル、カンパニー | 湿式粒状化方法 |
US5980882A (en) * | 1997-04-16 | 1999-11-09 | Medeva Pharmaceuticals Manufacturing | Drug-resin complexes stabilized by chelating agents |
SI1685839T1 (sl) | 1997-12-22 | 2013-08-30 | Euro-Celtique S.A. | Farmacevtska oralna dozirna oblika, ki vsebuje kombinacijo opioidnega agonista in opioidnega antagonista |
US6806294B2 (en) | 1998-10-15 | 2004-10-19 | Euro-Celtique S.A. | Opioid analgesic |
US8545880B2 (en) * | 1999-02-26 | 2013-10-01 | Andrx Pharmaceuticals, Llc | Controlled release oral dosage form |
US6210716B1 (en) | 1999-02-26 | 2001-04-03 | Andrx Pharmaceuticals, Inc. | Controlled release bupropion formulation |
ES2374717T3 (es) | 1999-10-29 | 2012-02-21 | Euro-Celtique S.A. | Formulaciones de hidrocodona de liberación controlada. |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
NZ520554A (en) | 2000-02-08 | 2005-08-26 | Euro Celtique S | Tamper-resistant oral opioid agonist formulations |
CN1396829A (zh) * | 2000-02-24 | 2003-02-12 | 法玛西雅厄普约翰美国公司 | 新的药物联合形式 |
US6855721B1 (en) | 2000-07-28 | 2005-02-15 | Indevus Pharmaceuticals, Inc. | Methods and compositions for alleviating stuttering |
JP2004512354A (ja) | 2000-10-30 | 2004-04-22 | ユーロ−セルティーク,エス.エイ. | ヒドロコドン放出制御製剤 |
US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
UA81224C2 (uk) | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
CN1525851A (zh) | 2001-05-11 | 2004-09-01 | ������ҩ������˾ | 抗滥用阿片样物质控释剂型 |
DK1416842T3 (da) | 2001-07-18 | 2009-03-16 | Euro Celtique Sa | Farmaceutiske kombinationer af oxycodon og naloxon |
US20030157168A1 (en) | 2001-08-06 | 2003-08-21 | Christopher Breder | Sequestered antagonist formulations |
DE60232417D1 (de) | 2001-08-06 | 2009-07-02 | Euro Celtique Sa | Opioid-agonist-formulierungen mit freisetzbarem und sequestriertem antagonist |
US20030044458A1 (en) | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
US20030099711A1 (en) * | 2001-08-29 | 2003-05-29 | David Meadows | Sustained release preparations |
US20030180249A1 (en) * | 2002-03-18 | 2003-09-25 | Khanna Satish Chandra | Dosage forms for hygroscopic active ingredients |
KR20040098050A (ko) | 2002-04-05 | 2004-11-18 | 유로-셀띠끄 소시에떼 아노님 | 옥시코돈 및 날록손을 포함하는 약제학적 제제 |
PT1551372T (pt) | 2002-09-20 | 2018-07-23 | Alpharma Pharmaceuticals Llc | Subunidade de sequestração e composições e métodos relacionados |
US6893660B2 (en) * | 2002-11-21 | 2005-05-17 | Andrx Pharmaceuticals, Inc. | Stable pharmaceutical compositions without a stabilizer |
US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
TWI347201B (en) | 2003-04-21 | 2011-08-21 | Euro Celtique Sa | Pharmaceutical products,uses thereof and methods for preparing the same |
US20050036977A1 (en) * | 2003-08-11 | 2005-02-17 | Dilip Gole | Taste-masked resinate and preparation thereof |
EP1667658A2 (en) * | 2003-09-03 | 2006-06-14 | Mallinckrodt Inc. | Granular sustained release preparation and production thereof |
US20050181050A1 (en) * | 2004-01-28 | 2005-08-18 | Collegium Pharmaceutical, Inc. | Dosage forms using drug-loaded ion exchange resins |
AU2005237607B2 (en) | 2004-04-27 | 2010-12-16 | Medicinova, Inc. | Phenoxyalkycarboxylic acid derivatives in the treatment of inflammatory diseases |
EP1750710B1 (en) * | 2004-05-14 | 2014-04-16 | KNU-Industry Cooperation Foundation | Neuroprotective properties of dextrorotatory morphinans |
EP1604666A1 (en) | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD) |
US20080095842A1 (en) * | 2004-12-06 | 2008-04-24 | Antarkar Amit K | Rapidly Disintegrating Taste Masked Compositions and a Process for Its Preparations |
EP1846040A2 (en) * | 2005-01-28 | 2007-10-24 | Collegium Pharmaceutical, Inc. | Non-ionic non-aqueous vehicles for topical and oral administration of carrier-complexed active agents |
EP1702558A1 (en) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Method and device for the assessment of bowel function |
US8343546B2 (en) * | 2005-09-13 | 2013-01-01 | Coating Place, Inc. | Ion exchange resin treated to control swelling |
US7811604B1 (en) | 2005-11-14 | 2010-10-12 | Barr Laboratories, Inc. | Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same |
CA2645855C (en) | 2006-03-16 | 2015-02-03 | Tris Pharma, Inc. | Modified release formulations containing drug-ion exchange resin complexes |
US8158156B2 (en) | 2006-06-19 | 2012-04-17 | Alpharma Pharmaceuticals, Llc | Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist |
US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
WO2009088385A1 (en) * | 2008-01-04 | 2009-07-16 | Capricorn Pharma Inc. | Resin-complex granulation for water-soluble drugs and associated methods |
EP2405915B1 (en) | 2009-03-10 | 2018-10-24 | Euro-Celtique S.A. | Immediate release pharmaceutical compositions comprising oxycodone and naloxone |
WO2010132662A1 (en) * | 2009-05-13 | 2010-11-18 | Relypsa, Inc. | Powder formulations of potassium-binding active agents |
US8962687B2 (en) | 2012-12-05 | 2015-02-24 | Medicinova, Inc. | Method of treating liver disorders |
US8835499B2 (en) | 2011-12-08 | 2014-09-16 | Medicinova, Inc. | Method of treating non-alcoholic fatty liver disease and steatohepatitis |
WO2014167440A1 (en) * | 2013-03-26 | 2014-10-16 | Wockhardt Limited | Modified release pharmaceutical compositions of cyclobenzaprine or salts thereof |
NZ716267A (en) | 2013-07-23 | 2017-05-26 | Euro Celtique Sa | A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
WO2015013395A1 (en) | 2013-07-25 | 2015-01-29 | Medicinova, Inc. | Methods for reducing triglyceride, total cholesterol and low density lipoprotein blood levels |
US9346754B2 (en) | 2014-05-08 | 2016-05-24 | Medicinova, Inc. | Method of treating advanced non-alcoholic steatohepatitis |
US20150321989A1 (en) | 2014-05-08 | 2015-11-12 | Medicinova, Inc. | Method of treating idiopathic pulmonary fibrosis |
JP6469727B2 (ja) | 2014-06-02 | 2019-02-13 | メディシノバ・インコーポレイテッドMediciNova, Inc. | 線維症の抑制又は治療方法 |
ES2891306T3 (es) | 2014-11-26 | 2022-01-27 | Medicinova Inc | Combinación de ibudilast y riluzol y métodos de utilización de los mismos |
US11590228B1 (en) | 2015-09-08 | 2023-02-28 | Tris Pharma, Inc | Extended release amphetamine compositions |
CA3034895A1 (en) | 2016-08-26 | 2018-03-01 | Exciva Ug (Haftungsbeschrankt) | Compositions and methods thereof |
US11590081B1 (en) | 2017-09-24 | 2023-02-28 | Tris Pharma, Inc | Extended release amphetamine tablets |
CA3217719A1 (en) | 2021-05-28 | 2022-12-01 | Kazuko Matsuda | Phenoxyalkylcarboxylic acid derivatives and their use in lowering triglyceride levels |
Family Cites Families (21)
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GB791281A (en) * | 1955-01-13 | 1958-02-26 | Genatosan Ltd | Pharmaceutical products |
GB822728A (en) * | 1955-07-14 | 1959-10-28 | Pfizer & Co C | Vitamin products and process of preparing same |
GB835932A (en) * | 1956-03-27 | 1960-05-25 | Ciba Ltd | Process for the manufacture of therapeutic tablet granulations |
FR792M (es) * | 1959-11-13 | 1961-09-11 | ||
US3138525A (en) * | 1961-06-16 | 1964-06-23 | Hoffmann La Roche | Castor wax-amprotropine-resin compositions |
GB982150A (en) * | 1961-09-29 | 1965-02-03 | Glaxo Group Ltd | Therapeutic resin complexes |
NL129666C (es) * | 1962-08-06 | |||
DE2706660A1 (de) * | 1977-02-17 | 1978-08-24 | Merck Patent Gmbh | Ascorbinsaeure enthaltende granulate und verfahren zu ihrer herstellung |
GB1566609A (en) * | 1977-03-10 | 1980-05-08 | Reckitt & Colmann Prod Ltd | Pharmaceutical compositions containing cholestyramine and alginic acid |
US4221778A (en) * | 1979-01-08 | 1980-09-09 | Pennwalt Corporation | Prolonged release pharmaceutical preparations |
DE2929456A1 (de) * | 1979-07-20 | 1981-02-05 | Lentia Gmbh | Zusammensetzung mit verlaengerter broncholytischer und tokolytischer wirksamkeit, ein verfahren zu deren herstellung und broncholytisch und tokolytisch wirkendes mittel |
US4404346A (en) * | 1980-08-05 | 1983-09-13 | Rohm And Haas Company | Production of powdered resin and the powdered resin so produced |
US4369175A (en) * | 1981-07-27 | 1983-01-18 | Ciba-Geigy Corporation | Process for the manufacture of prolonged action vincamine preparations, the vincamine preparations so obtained, and medicaments containing them |
CH655507B (es) * | 1983-01-12 | 1986-04-30 | ||
US4847362A (en) * | 1985-02-01 | 1989-07-11 | New York University | Method for purifying antihemophilic factor |
EP0199855A1 (en) * | 1985-05-02 | 1986-11-05 | Gist-Brocades N.V. | Tablets comprising tromethoprim and a sulfonamide |
EP0200252B1 (en) * | 1985-05-02 | 1999-03-10 | Yamanouchi Europe B.V. | Tablets comprising trimethoprim and a sulfonamide |
CA1273981A (en) * | 1985-12-05 | 1990-09-11 | Mitsubishi Materials Corporation | Electric motor having rotor and stator provided with conical portions loosely fitted with each other |
US4788055A (en) * | 1985-12-09 | 1988-11-29 | Ciba-Geigy Corporation | Resinate sustained release dextromethorphan composition |
DD249634B1 (de) * | 1986-06-04 | 1988-09-21 | Bitterfeld Chemie | Cholesterolsenkendes mittel und verfahren zu seiner herstellung |
IL90245A (en) * | 1988-05-11 | 1994-04-12 | Glaxo Group Ltd | Resin adsorption containing ranitidine together with synthetic resin replaces cations, its preparation and pharmaceutical preparations containing it |
-
1989
- 1989-11-08 CA CA002002492A patent/CA2002492A1/en not_active Abandoned
- 1989-11-09 JP JP1290147A patent/JP2825202B2/ja not_active Expired - Lifetime
- 1989-11-09 US US07/434,416 patent/US5071646A/en not_active Expired - Lifetime
- 1989-11-09 AU AU44530/89A patent/AU621949B2/en not_active Expired
- 1989-11-10 ES ES89311701T patent/ES2075061T3/es not_active Expired - Lifetime
- 1989-11-10 DK DK198905645A patent/DK175154B1/da not_active IP Right Cessation
- 1989-11-10 GB GB8925492A patent/GB2225941B/en not_active Revoked
- 1989-11-10 DE DE68922894T patent/DE68922894T2/de not_active Expired - Lifetime
- 1989-11-10 AT AT89311701T patent/ATE123218T1/de not_active IP Right Cessation
- 1989-11-10 IE IE893625A patent/IE893625L/xx not_active IP Right Cessation
- 1989-11-10 EP EP89311701A patent/EP0368682B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2002492A1 (en) | 1990-05-11 |
DK564589A (da) | 1990-05-12 |
GB8925492D0 (en) | 1989-12-28 |
AU621949B2 (en) | 1992-03-26 |
ATE123218T1 (de) | 1995-06-15 |
GB2225941B (en) | 1992-12-09 |
US5071646A (en) | 1991-12-10 |
EP0368682B1 (en) | 1995-05-31 |
AU4453089A (en) | 1990-05-17 |
ES2075061T3 (es) | 1995-10-01 |
DK564589D0 (da) | 1989-11-10 |
JP2825202B2 (ja) | 1998-11-18 |
EP0368682A1 (en) | 1990-05-16 |
DE68922894T2 (de) | 1996-01-11 |
JPH02243618A (ja) | 1990-09-27 |
GB2225941A (en) | 1990-06-20 |
DE68922894D1 (de) | 1995-07-06 |
IE893625L (en) | 1990-05-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUP | Patent expired |