DK174811B1 - Stabiliserede humanproteinpræparater samt fremgangsmåde til fremstilling deraf - Google Patents

Stabiliserede humanproteinpræparater samt fremgangsmåde til fremstilling deraf Download PDF

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Publication number
DK174811B1
DK174811B1 DK198804831A DK483188A DK174811B1 DK 174811 B1 DK174811 B1 DK 174811B1 DK 198804831 A DK198804831 A DK 198804831A DK 483188 A DK483188 A DK 483188A DK 174811 B1 DK174811 B1 DK 174811B1
Authority
DK
Denmark
Prior art keywords
human protein
erythropoietin
composition according
preparation
epo
Prior art date
Application number
DK198804831A
Other languages
Danish (da)
English (en)
Other versions
DK483188A (da
DK483188D0 (da
Inventor
Fritz Demmer
Werner Gruber
Heinrich Woog
Hans-Joerg Markl
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of DK483188D0 publication Critical patent/DK483188D0/da
Publication of DK483188A publication Critical patent/DK483188A/da
Application granted granted Critical
Publication of DK174811B1 publication Critical patent/DK174811B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK198804831A 1987-09-05 1988-08-30 Stabiliserede humanproteinpræparater samt fremgangsmåde til fremstilling deraf DK174811B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3729863 1987-09-05
DE19873729863 DE3729863A1 (de) 1987-09-05 1987-09-05 Stabilisierte erythropoietin-lyophilisate

Publications (3)

Publication Number Publication Date
DK483188D0 DK483188D0 (da) 1988-08-30
DK483188A DK483188A (da) 1989-03-06
DK174811B1 true DK174811B1 (da) 2003-12-01

Family

ID=6335375

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198804831A DK174811B1 (da) 1987-09-05 1988-08-30 Stabiliserede humanproteinpræparater samt fremgangsmåde til fremstilling deraf

Country Status (29)

Country Link
US (1) US4992419A (lv)
EP (1) EP0306824B1 (lv)
JP (1) JPH0780782B2 (lv)
KR (1) KR960009929B1 (lv)
CN (1) CN1027224C (lv)
AT (1) ATE77556T1 (lv)
AU (1) AU610636B2 (lv)
CA (1) CA1330301C (lv)
CS (1) CS274681B2 (lv)
DD (1) DD273004A5 (lv)
DE (2) DE3729863A1 (lv)
DK (1) DK174811B1 (lv)
ES (1) ES2051806T3 (lv)
FI (1) FI93517C (lv)
GR (1) GR3005454T3 (lv)
HK (1) HK89495A (lv)
HU (1) HU202761B (lv)
IE (1) IE60310B1 (lv)
IL (1) IL87628A (lv)
LV (1) LV10178B (lv)
MX (1) MX12880A (lv)
NO (1) NO178687C (lv)
NZ (1) NZ225975A (lv)
PH (1) PH25618A (lv)
PL (1) PL157944B1 (lv)
PT (1) PT88417B (lv)
RU (2) RU2043118C1 (lv)
UA (2) UA26855C2 (lv)
ZA (1) ZA886528B (lv)

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JPH0341033A (ja) * 1989-07-07 1991-02-21 Kyowa Hakko Kogyo Co Ltd 安定なモチリン類含有製剤
DE3939346A1 (de) * 1989-11-29 1991-06-06 Behringwerke Ag Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide
DE4014654A1 (de) * 1990-05-08 1991-11-14 Behringwerke Ag Galenische waessrige formulierungen von erythropoietin und ihre verwendung
DE4126983A1 (de) * 1991-08-15 1993-02-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke
DE4126984A1 (de) * 1991-08-15 1993-02-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von humanprotein-enthaltenden, gut vertraeglichen arzneimitteln fuer infusions- oder injektionszwecke
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US20030035845A1 (en) * 1992-06-11 2003-02-20 Zale Stephen E. Composition for sustained release of non-aggregated erythropoietin
US5674534A (en) * 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5716644A (en) * 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5661125A (en) * 1992-08-06 1997-08-26 Amgen, Inc. Stable and preserved erythropoietin compositions
EP0582933A1 (de) * 1992-08-11 1994-02-16 F. Hoffmann-La Roche Ag Therapeutisches System zur parenteralen Verabreichung von hämatopoetischen Wachstumsfaktoren
DE4242919A1 (de) * 1992-12-18 1994-06-23 Boehringer Mannheim Gmbh Verfahren zur Herstellung von lagerstabilen wässrigen pharmazeutischen Zubereitungen von G-CSF
US5358708A (en) * 1993-01-29 1994-10-25 Schering Corporation Stabilization of protein formulations
US6372716B1 (en) * 1994-04-26 2002-04-16 Genetics Institute, Inc. Formulations for factor IX
JP2747979B2 (ja) * 1994-08-19 1998-05-06 雪印乳業株式会社 ヒト由来の糖蛋白質からなる生理活性因子を有効成分とする医薬
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US20030138402A1 (en) * 1995-12-25 2003-07-24 Otsuka Pharmaceutical Co., Ltd. Dry compositions
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US20030190307A1 (en) * 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
CN1733296B (zh) * 1996-12-24 2010-05-26 拜奥根Idec马萨诸塞公司 稳定的液体干扰素制剂
DE19716154A1 (de) * 1997-04-18 1998-10-22 Boehringer Mannheim Gmbh Stabile pharmazeutische Darreichungsform für Peptide, Proteine und Nukleinsäuren
US6391633B1 (en) * 1997-07-23 2002-05-21 Roche Diagnostics Gmbh Production of erythropoietin by endogenous gene activation
US6548296B1 (en) * 1997-07-23 2003-04-15 Roche Diagnostics Gmbh Methods for identifying human cell lines useful for endogenous gene activation, isolated human lines identified thereby, and uses thereof
EP0965349A1 (de) * 1998-06-18 1999-12-22 Roche Diagnostics GmbH Verwendung von Erythropoietin zur Behandlung von Hämochromatosen
AR019025A1 (es) * 1998-04-09 2001-12-26 Roche Diagnostics Gmbh Uso de eritropoyetina en bajas dosis para producir un preparado farmaceutico para el tratamiento de hemocromatosis, preparado farmaceutico combinadoutilizado segun dicho uso y envase farmaceutico unitario que contiene al referido preparado farmaceutico combinado
JP2000247903A (ja) 1999-03-01 2000-09-12 Chugai Pharmaceut Co Ltd 長期安定化製剤
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US7345019B1 (en) * 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
EP1232753B1 (en) * 1999-09-08 2008-03-19 Chugai Seiyaku Kabushiki Kaisha Stable protein solution filled in a container made from a hydrophobic resin and method of stabilizing the same
KR20070032815A (ko) 2000-05-15 2007-03-22 에프. 호프만-라 로슈 아게 신규한 약학 조성물
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DE10234192B4 (de) * 2002-07-26 2009-11-26 Epoplus Gmbh Co.Kg Verwendung von Erythropoetin
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JPS6197229A (ja) * 1984-10-18 1986-05-15 Chugai Pharmaceut Co Ltd 安定なエリトロポエチン製剤
DE3686684T2 (de) * 1985-03-06 1993-01-28 Survival Technology Mittel zur absorptionsverbesserung von proteinen.

Also Published As

Publication number Publication date
HK89495A (en) 1995-06-16
CS274681B2 (en) 1991-09-15
RU2100032C1 (ru) 1997-12-27
ES2051806T3 (es) 1994-07-01
CN1027224C (zh) 1995-01-04
DD273004A5 (de) 1989-11-01
NO883926L (no) 1989-03-06
DK483188A (da) 1989-03-06
UA26123A (uk) 1999-06-07
FI884051A (fi) 1989-03-06
ATE77556T1 (de) 1992-07-15
IL87628A (en) 1993-07-08
EP0306824A2 (de) 1989-03-15
CA1330301C (en) 1994-06-21
UA26855C2 (uk) 1999-12-29
AU2173988A (en) 1989-04-27
KR960009929B1 (ko) 1996-07-25
EP0306824A3 (en) 1990-01-31
MX12880A (es) 1993-12-01
FI93517B (fi) 1995-01-13
PL157944B1 (en) 1992-07-31
IE60310B1 (en) 1994-06-29
FI884051A0 (fi) 1988-09-02
NO178687C (no) 1996-05-15
JPH0780782B2 (ja) 1995-08-30
GR3005454T3 (lv) 1993-05-24
KR890004718A (ko) 1989-05-09
IE882671L (en) 1989-03-05
US4992419A (en) 1991-02-12
ZA886528B (en) 1989-05-30
LV10178A (lv) 1994-10-20
PT88417A (pt) 1989-07-31
CS590188A2 (en) 1990-12-13
NO178687B (no) 1996-02-05
PH25618A (en) 1991-08-08
PL274485A1 (en) 1989-04-17
NO883926D0 (no) 1988-09-02
NZ225975A (en) 1991-07-26
EP0306824B1 (de) 1992-06-24
IL87628A0 (en) 1989-01-31
AU610636B2 (en) 1991-05-23
HU202761B (en) 1991-04-29
DK483188D0 (da) 1988-08-30
RU2043118C1 (ru) 1995-09-10
PT88417B (pt) 1992-10-30
LV10178B (en) 1995-04-20
HUT47863A (en) 1989-04-28
DE3872334D1 (de) 1992-07-30
FI93517C (fi) 1995-04-25
CN1031801A (zh) 1989-03-22
DE3729863A1 (de) 1989-03-16
JPS6471818A (en) 1989-03-16

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