DK174053B1 - Stjerneesksplosionskonjugater, fremgangsmåder til fremstilling deraf, fremgangsmåde til fremstilling af en stjerneeksplosionspolyethylenimin og fremgangsmåde til rensning af en stjerneeksplosionsdendrimer - Google Patents

Stjerneesksplosionskonjugater, fremgangsmåder til fremstilling deraf, fremgangsmåde til fremstilling af en stjerneeksplosionspolyethylenimin og fremgangsmåde til rensning af en stjerneeksplosionsdendrimer Download PDF

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DK174053B1
DK174053B1 DK198802053A DK205388A DK174053B1 DK 174053 B1 DK174053 B1 DK 174053B1 DK 198802053 A DK198802053 A DK 198802053A DK 205388 A DK205388 A DK 205388A DK 174053 B1 DK174053 B1 DK 174053B1
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Prior art keywords
star
explosion
dendrimer
star explosion
conjugate
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DK198802053A
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Danish (da)
English (en)
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DK205388D0 (da
DK205388A (da
Inventor
Michael J Fazio
David M Hedstrand
Donald A Tomalia
Roberta C Cheng
Donald A Kaplan
Ian A Tomlinson
William J Kruper
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Dow Chemical Co
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Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of DK205388D0 publication Critical patent/DK205388D0/da
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A61K47/6885—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy the conjugate or the polymer being a starburst, a dendrimer, a cascade
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/005—Dendritic macromolecules

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Nanotechnology (AREA)
  • Medical Informatics (AREA)
  • Toxicology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Luminescent Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK198802053A 1986-08-18 1988-04-14 Stjerneesksplosionskonjugater, fremgangsmåder til fremstilling deraf, fremgangsmåde til fremstilling af en stjerneeksplosionspolyethylenimin og fremgangsmåde til rensning af en stjerneeksplosionsdendrimer DK174053B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US89745586A 1986-08-18 1986-08-18
US89745586 1986-08-18
PCT/US1987/002074 WO1988001178A1 (fr) 1986-08-18 1987-08-18 Conjugues du type a eclatement etoile
US8702074 1987-08-18

Publications (3)

Publication Number Publication Date
DK205388D0 DK205388D0 (da) 1988-04-14
DK205388A DK205388A (da) 1988-06-14
DK174053B1 true DK174053B1 (da) 2002-05-13

Family

ID=25407923

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198802053A DK174053B1 (da) 1986-08-18 1988-04-14 Stjerneesksplosionskonjugater, fremgangsmåder til fremstilling deraf, fremgangsmåde til fremstilling af en stjerneeksplosionspolyethylenimin og fremgangsmåde til rensning af en stjerneeksplosionsdendrimer

Country Status (21)

Country Link
EP (1) EP0271180B2 (fr)
JP (6) JPH072840B2 (fr)
KR (1) KR970011151B1 (fr)
AT (1) ATE89743T1 (fr)
AU (2) AU609051B2 (fr)
BR (3) BR8707433A (fr)
DE (1) DE3786000T3 (fr)
DK (1) DK174053B1 (fr)
ES (1) ES2054678T5 (fr)
FI (2) FI103410B1 (fr)
GR (1) GR3024215T3 (fr)
HK (1) HK54396A (fr)
HU (2) HU209252B (fr)
IE (1) IE61356B1 (fr)
IL (1) IL83567A (fr)
MX (1) MX169992B (fr)
MY (1) MY102878A (fr)
NO (1) NO176306C (fr)
NZ (1) NZ221484A (fr)
WO (3) WO1988001178A1 (fr)
ZA (1) ZA876114B (fr)

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DE3786000T3 (de) 1997-08-21
WO1988001179A1 (fr) 1988-02-25
DK205388D0 (da) 1988-04-14
IE872210L (en) 1988-02-18
WO1988001178A1 (fr) 1988-02-25
FI881768A0 (fi) 1988-04-15
JPH0757736B2 (ja) 1995-06-21
JPS63501878A (ja) 1988-07-28
AU638153B2 (en) 1993-06-17
NO881639L (no) 1988-06-15
FI881768A (fi) 1988-04-15
NO176306C (no) 1995-03-15
WO1988001180A1 (fr) 1988-02-25
DE3786000D1 (de) 1993-07-01
ZA876114B (en) 1989-04-26
KR880701564A (ko) 1988-11-03
NO176306B (no) 1994-12-05
DK205388A (da) 1988-06-14
HU9303379D0 (en) 1994-03-28
JPH06220190A (ja) 1994-08-09
JPH069778A (ja) 1994-01-18
JPS63501876A (ja) 1988-07-28
EP0271180B1 (fr) 1993-05-26
MY102878A (en) 1993-03-31
BR8707433A (pt) 1988-11-01
MX169992B (es) 1993-08-04
NZ221484A (en) 1991-01-29
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JPS63502350A (ja) 1988-09-08
HU220205B (hu) 2001-11-28
GR3024215T3 (en) 1997-10-31
IE61356B1 (en) 1994-11-02
ES2054678T5 (es) 1997-09-16
DE3786000T2 (de) 1993-09-02
EP0271180A1 (fr) 1988-06-15
KR970011151B1 (ko) 1997-07-07
IL83567A (en) 1992-02-16
HK54396A (en) 1996-04-03
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JPH06219966A (ja) 1994-08-09
FI105693B (fi) 2000-09-29
BR8707431A (pt) 1988-11-01
IL83567A0 (en) 1988-01-31
NO881639D0 (no) 1988-04-15
BR8707432A (pt) 1988-11-01
AU7715987A (en) 1988-03-03
JP2848218B2 (ja) 1999-01-20
AU8139191A (en) 1991-10-03
ES2054678T3 (es) 1994-08-16
ATE89743T1 (de) 1993-06-15
FI103410B (fi) 1999-06-30
JPH0757735B2 (ja) 1995-06-21
HU209252B (en) 1994-04-28
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