DE69228999T2 - Neue jodierte makromolekulare polyaminverbindungen, verfahren zur herstellung und verwendung als kontrastmittel - Google Patents

Neue jodierte makromolekulare polyaminverbindungen, verfahren zur herstellung und verwendung als kontrastmittel

Info

Publication number
DE69228999T2
DE69228999T2 DE69228999T DE69228999T DE69228999T2 DE 69228999 T2 DE69228999 T2 DE 69228999T2 DE 69228999 T DE69228999 T DE 69228999T DE 69228999 T DE69228999 T DE 69228999T DE 69228999 T2 DE69228999 T2 DE 69228999T2
Authority
DE
Germany
Prior art keywords
iodated
new
production
contrast agent
polyamine compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69228999T
Other languages
English (en)
Other versions
DE69228999D1 (de
Inventor
Dominique Meyer
Greneur Soizic Le
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guerbet SA
Original Assignee
Guerbet SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9115037A external-priority patent/FR2684678B1/fr
Priority claimed from FR9203063A external-priority patent/FR2688508A1/fr
Application filed by Guerbet SA filed Critical Guerbet SA
Publication of DE69228999D1 publication Critical patent/DE69228999D1/de
Application granted granted Critical
Publication of DE69228999T2 publication Critical patent/DE69228999T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0233—Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/028—Polyamidoamines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69228999T 1991-12-04 1992-12-03 Neue jodierte makromolekulare polyaminverbindungen, verfahren zur herstellung und verwendung als kontrastmittel Expired - Fee Related DE69228999T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9115037A FR2684678B1 (fr) 1991-12-04 1991-12-04 Nouveau compose macromoleculaire polyamine iode, son procede de preparation et son utilisation comme agent de contraste.
FR9203063A FR2688508A1 (fr) 1992-03-13 1992-03-13 Nouveau produit de contraste iode, son procede de preparation et son utilisation comme agent de contraste.
PCT/FR1992/001135 WO1993010824A1 (fr) 1991-12-04 1992-12-03 Nouveau compose macromoleculaire polyamine iode, son procede de preparation et son utilisation comme agent de contraste

Publications (2)

Publication Number Publication Date
DE69228999D1 DE69228999D1 (de) 1999-05-27
DE69228999T2 true DE69228999T2 (de) 1999-12-02

Family

ID=26229095

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69228999T Expired - Fee Related DE69228999T2 (de) 1991-12-04 1992-12-03 Neue jodierte makromolekulare polyaminverbindungen, verfahren zur herstellung und verwendung als kontrastmittel

Country Status (6)

Country Link
EP (1) EP0616538B1 (de)
JP (1) JPH07506085A (de)
AU (1) AU3354993A (de)
CA (1) CA2125188A1 (de)
DE (1) DE69228999T2 (de)
WO (1) WO1993010824A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005021846A1 (de) * 2005-05-11 2006-11-16 Albupharm Heidelberg Gmbh & Co. Kg Verfahren zur Herstellung von Albumin-Konjugaten mit einem Röntgenkontrastmittel als Wirkstoff

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4344464A1 (de) * 1993-12-22 1995-06-29 Schering Ag Kaskadenpolymere mit Iodaromaten
DE69510460T2 (de) * 1994-09-22 2000-01-13 Guerbet Villepinte Iodo-verbindungen, ihre herstellung und verwendung als kontrastmittel für röntgen-radiologie
CA2174870A1 (fr) * 1994-09-22 1996-03-28 Gael Le Lem Derives iodes, leur preparation et leur application comme agents de contraste en radiologie x
US5622687A (en) * 1994-11-15 1997-04-22 Molecular Biosystems, Inc. Calixarene conjugates useful as MRI and CT diagnostic imaging agents
US5756066A (en) * 1995-06-07 1998-05-26 Schering Aktiengesellschaft Iodine-containing peptides
DE19521940A1 (de) * 1995-06-07 1996-12-12 Schering Ag Iodhaltige lineare Polyamine und Polyamide
DE19521945A1 (de) * 1995-06-12 1996-12-19 Schering Ag Kaskadenpolymere mit Iodaromaten
DE19726340C2 (de) * 1996-08-16 1999-05-06 Schering Ag Zinndendrimere, ihre Verwendung als Röntgenkontrastmittel und Verfahren zu ihrer Herstellung
DE19635419C1 (de) * 1996-08-23 1998-08-20 Schering Ag Wismutdendrimere und ihre Verwendung als Röntgenkontrastmittel
GB9624822D0 (en) * 1996-11-28 1997-01-15 Nycomed Imaging As Method
EP1011736A2 (de) * 1997-01-29 2000-06-28 Nycomed Imaging As Polymere
CA2531894C (en) * 2003-09-25 2014-02-11 Rutgers, The State University Inherently radiopaque polymeric products for embolotherapy
US8507639B2 (en) * 2006-09-11 2013-08-13 Boston Scientific Scimed, Inc. Radiopaque amide polymers and medical devices formed thereof
DE102008027133A1 (de) * 2008-05-30 2009-12-03 Ls Medcap Gmbh Vollsynthetisches Albumin-Analogon
WO2012080279A1 (en) 2010-12-17 2012-06-21 Universite De Strasbourg Radiopaque iodinated products intended for use medical imaging and their methods of preparation
WO2013121284A1 (en) 2012-02-14 2013-08-22 Universite De Strasbourg Iodinated products intended for a use for the medical imaging and their methods of preparation
WO2019177740A1 (en) * 2018-03-12 2019-09-19 Boston Scientific Scimed, Inc. Scavenging methods, and scavenging system for radiocontrast agents
CN109701040B (zh) * 2019-03-08 2021-04-06 昆明医科大学第一附属医院 一种用于诊治mtc的纳米pamam靶向多肽放射性核素制剂及制备方法
US20230127824A1 (en) * 2021-10-25 2023-04-27 Boston Scientific Scimed Inc. Iodine labeled hydrogels and precursors thereof with improved radiopacity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4406878A (en) * 1978-08-02 1983-09-27 Eastman Kodak Company Iodinated contrast agent for radiography
DE3661200D1 (en) * 1985-04-29 1988-12-22 Dow Chemical Co Radiopaque thermoset polymer
DE3786000T3 (de) * 1986-08-18 1997-08-21 Dow Chemical Co Conjugate dichter Sterne.
FR2610935B1 (fr) * 1987-02-13 1989-09-01 Guerbet Sa Polymeres iodes, leurs procedes de preparation et leurs applications comme produits de contraste
FR2635327B1 (fr) * 1988-08-10 1990-11-16 Guerbet Sa Polymeres iodes, a squelette dextrane, leurs procedes de preparation et leurs applications comme produits de contraste
EP0436316A1 (de) * 1989-12-08 1991-07-10 Milos Sovak Röntgenkontrastmittel für verlängerte Opacifikation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005021846A1 (de) * 2005-05-11 2006-11-16 Albupharm Heidelberg Gmbh & Co. Kg Verfahren zur Herstellung von Albumin-Konjugaten mit einem Röntgenkontrastmittel als Wirkstoff
DE102005021846A8 (de) * 2005-05-11 2007-03-08 Hannsjörg Dr. Sinn Verfahren zur Herstellung von Albumin-Konjugaten mit einem Röntgenkontrastmittel als Wirkstoff

Also Published As

Publication number Publication date
EP0616538A1 (de) 1994-09-28
DE69228999D1 (de) 1999-05-27
WO1993010824A1 (fr) 1993-06-10
CA2125188A1 (fr) 1993-06-10
EP0616538B1 (de) 1999-04-21
AU3354993A (en) 1993-06-28
JPH07506085A (ja) 1995-07-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee