DK173854B1 - 7alfa-Acylthio-9alfa,11alfa-epoxy-20-spirox-4-en-3,21-dioner, fremgangsmåde til deres fremstilling, farmaceutiske præparater med indhold deraf samt deres anvendelse til fremstilling af farmaceutiske præparater - Google Patents
7alfa-Acylthio-9alfa,11alfa-epoxy-20-spirox-4-en-3,21-dioner, fremgangsmåde til deres fremstilling, farmaceutiske præparater med indhold deraf samt deres anvendelse til fremstilling af farmaceutiske præparater Download PDFInfo
- Publication number
- DK173854B1 DK173854B1 DK198502800A DK280085A DK173854B1 DK 173854 B1 DK173854 B1 DK 173854B1 DK 198502800 A DK198502800 A DK 198502800A DK 280085 A DK280085 A DK 280085A DK 173854 B1 DK173854 B1 DK 173854B1
- Authority
- DK
- Denmark
- Prior art keywords
- mixture
- epoxy
- solution
- dione
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH300984 | 1984-06-21 | ||
| CH300984 | 1984-06-21 | ||
| CH464684 | 1984-09-28 | ||
| CH464684 | 1984-09-28 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK280085D0 DK280085D0 (da) | 1985-06-20 |
| DK280085A DK280085A (da) | 1985-12-22 |
| DK173854B1 true DK173854B1 (da) | 2001-12-27 |
Family
ID=25691934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198502800A DK173854B1 (da) | 1984-06-21 | 1985-06-20 | 7alfa-Acylthio-9alfa,11alfa-epoxy-20-spirox-4-en-3,21-dioner, fremgangsmåde til deres fremstilling, farmaceutiske præparater med indhold deraf samt deres anvendelse til fremstilling af farmaceutiske præparater |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4670551A (hu) |
| EP (1) | EP0165902B1 (hu) |
| AR (2) | AR242036A1 (hu) |
| AU (1) | AU582754B2 (hu) |
| CA (1) | CA1239388A (hu) |
| DE (1) | DE3569540D1 (hu) |
| DK (1) | DK173854B1 (hu) |
| ES (2) | ES8704967A1 (hu) |
| FI (1) | FI83225C (hu) |
| GR (1) | GR851499B (hu) |
| HU (1) | HU192232B (hu) |
| IE (1) | IE58050B1 (hu) |
| IL (1) | IL75569A (hu) |
| NO (1) | NO165496C (hu) |
| NZ (1) | NZ212492A (hu) |
| PT (1) | PT80663B (hu) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100384866C (zh) | 1995-12-11 | 2008-04-30 | G·D·瑟尔公司 | 制备7α-羧基9,11-环氧甾族化合物的方法和其中使用的中间体以及烯双键环氧化作用的一般方法 |
| EP1223174A3 (en) * | 1996-12-11 | 2005-03-16 | G.D. Searle & Co. | Processes for preparation of 3-keto-7alpha-alkoxycarbonyl-delta-4,5- steroids and intermediates useful therein |
| US6887991B1 (en) | 1996-12-11 | 2005-05-03 | G. D. Searle & Company | Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein |
| DK0944644T3 (da) * | 1996-12-11 | 2003-02-03 | Searle & Co | Fremgangsmåde til fremstilling af 3-keto-7-alfa-alkoxycarbonyl-delta-4,5-steroider og mellemprodukter, som er nyttite derfor |
| WO1999061055A1 (en) | 1998-05-22 | 1999-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
| AU2002346721A1 (en) | 2001-12-12 | 2003-06-23 | Pharmacia Corporation | Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists |
| US7235655B2 (en) | 2002-03-22 | 2007-06-26 | Pharmacia & Upjohn Company | Processes to prepare eplerenone |
| DK1889198T3 (da) | 2005-04-28 | 2015-02-09 | Proteus Digital Health Inc | Farma-informatiksystem |
| WO2007025780A2 (en) * | 2005-09-02 | 2007-03-08 | Recordati Ireland Limited | Aldosterone receptor antagonists |
| JP2009508494A (ja) | 2005-09-16 | 2009-03-05 | ラプトール ファーマシューティカル インコーポレイテッド | Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用 |
| CA2969926C (en) | 2009-02-20 | 2018-05-15 | 2-Bbb Medicines B.V. | Glutathione-based drug delivery system |
| IL295075A (en) | 2009-05-06 | 2022-09-01 | Laboratory Skin Care Inc | Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3013012A (en) * | 1960-12-22 | 1961-12-12 | Searle & Co | Alkanoylthio-17alpha-carboxyethyl-17beta-hydroxyandrosten-3-one lactones |
| US3095412A (en) * | 1961-12-19 | 1963-06-25 | Searle & Co | 9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs |
| GB1041534A (en) * | 1963-04-24 | 1966-09-07 | Merck & Co Inc | 20-spiroxane compounds |
| DE2652761C2 (de) * | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| FI77669C (fi) * | 1983-04-13 | 1989-04-10 | Ciba Geigy Ag | 20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat. |
| DE3481707D1 (de) * | 1983-08-17 | 1990-04-26 | Schering Ag | 7-alpha-substituierte 3-oxo-17alpha-pregn-4-en-21.17-carbolactone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate. |
-
1985
- 1985-06-13 US US06/744,444 patent/US4670551A/en not_active Expired - Fee Related
- 1985-06-17 EP EP85810277A patent/EP0165902B1/de not_active Expired
- 1985-06-17 DE DE8585810277T patent/DE3569540D1/de not_active Expired
- 1985-06-19 IL IL75569A patent/IL75569A/xx not_active IP Right Cessation
- 1985-06-19 CA CA000484418A patent/CA1239388A/en not_active Expired
- 1985-06-19 PT PT80663A patent/PT80663B/pt not_active IP Right Cessation
- 1985-06-19 GR GR851499A patent/GR851499B/el unknown
- 1985-06-19 FI FI852430A patent/FI83225C/fi not_active IP Right Cessation
- 1985-06-20 NO NO852501A patent/NO165496C/no unknown
- 1985-06-20 IE IE153585A patent/IE58050B1/en not_active IP Right Cessation
- 1985-06-20 ES ES544387A patent/ES8704967A1/es not_active Expired
- 1985-06-20 NZ NZ212492A patent/NZ212492A/xx unknown
- 1985-06-20 DK DK198502800A patent/DK173854B1/da not_active IP Right Cessation
- 1985-06-20 HU HU852433A patent/HU192232B/hu not_active IP Right Cessation
- 1985-06-21 AR AR85300773A patent/AR242036A1/es active
- 1985-06-21 AU AU43971/85A patent/AU582754B2/en not_active Ceased
-
1986
- 1986-10-01 ES ES557112A patent/ES8707737A1/es not_active Expired
-
1989
- 1989-07-31 AR AR89314546A patent/AR245731A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0165902B1 (de) | 1989-04-19 |
| CA1239388A (en) | 1988-07-19 |
| NO852501L (no) | 1985-12-23 |
| ES8707737A1 (es) | 1987-08-16 |
| EP0165902A2 (de) | 1985-12-27 |
| AU582754B2 (en) | 1989-04-13 |
| HUT38367A (en) | 1986-05-28 |
| AR245731A1 (es) | 1994-02-28 |
| HU192232B (en) | 1987-05-28 |
| AU4397185A (en) | 1986-01-02 |
| DE3569540D1 (en) | 1989-05-24 |
| GR851499B (hu) | 1985-11-25 |
| FI852430A0 (fi) | 1985-06-19 |
| PT80663A (en) | 1985-07-01 |
| NO165496B (no) | 1990-11-12 |
| IE851535L (en) | 1985-12-21 |
| FI852430L (fi) | 1985-12-22 |
| US4670551A (en) | 1987-06-02 |
| ES544387A0 (es) | 1987-04-16 |
| FI83225B (fi) | 1991-02-28 |
| NZ212492A (en) | 1989-02-24 |
| IE58050B1 (en) | 1993-06-16 |
| ES557112A0 (es) | 1987-08-16 |
| NO165496C (no) | 1991-02-20 |
| IL75569A (en) | 1989-03-31 |
| DK280085A (da) | 1985-12-22 |
| AR242036A1 (es) | 1993-02-26 |
| IL75569A0 (en) | 1985-10-31 |
| PT80663B (en) | 1987-05-08 |
| ES8704967A1 (es) | 1987-04-16 |
| FI83225C (fi) | 1991-06-10 |
| DK280085D0 (da) | 1985-06-20 |
| EP0165902A3 (en) | 1986-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |
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