DK173842B1 - Genmodificeret E. coli-celle til fremstilling af biotin, samt fremgangsmåde til omdannelse af desthiobiotin til biotin - Google Patents

Genmodificeret E. coli-celle til fremstilling af biotin, samt fremgangsmåde til omdannelse af desthiobiotin til biotin Download PDF

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Publication number
DK173842B1
DK173842B1 DK198701974A DK197487A DK173842B1 DK 173842 B1 DK173842 B1 DK 173842B1 DK 198701974 A DK198701974 A DK 198701974A DK 197487 A DK197487 A DK 197487A DK 173842 B1 DK173842 B1 DK 173842B1
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Prior art keywords
biotin
genotype
cell
coli cell
coli
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DK198701974A
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Danish (da)
English (en)
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DK197487A (da
DK197487D0 (da
Inventor
Eric F Fisher
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Archer Daniels Midland Co
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Publication of DK197487D0 publication Critical patent/DK197487D0/da
Publication of DK197487A publication Critical patent/DK197487A/da
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Publication of DK173842B1 publication Critical patent/DK173842B1/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
    • C12P17/186—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system containing a 2-oxo-thieno[3,4-d]imidazol nucleus, e.g. Biotin

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  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK198701974A 1985-08-26 1987-04-15 Genmodificeret E. coli-celle til fremstilling af biotin, samt fremgangsmåde til omdannelse af desthiobiotin til biotin DK173842B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US76984985A 1985-08-26 1985-08-26
US76984985 1985-08-26
US89304286A 1986-08-12 1986-08-12
US89304286 1986-08-12
PCT/US1986/001759 WO1987001391A1 (en) 1985-08-26 1986-08-26 System for biotin synthesis
US8601759 1986-08-26

Publications (3)

Publication Number Publication Date
DK197487D0 DK197487D0 (da) 1987-04-15
DK197487A DK197487A (da) 1987-06-24
DK173842B1 true DK173842B1 (da) 2001-12-10

Family

ID=27118229

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198701974A DK173842B1 (da) 1985-08-26 1987-04-15 Genmodificeret E. coli-celle til fremstilling af biotin, samt fremgangsmåde til omdannelse af desthiobiotin til biotin

Country Status (15)

Country Link
EP (1) EP0236429B1 (no)
KR (1) KR880700072A (no)
AT (1) ATE87975T1 (no)
AU (1) AU599046B2 (no)
CA (1) CA1317245C (no)
DE (1) DE3688248T2 (no)
DK (1) DK173842B1 (no)
ES (1) ES2001398A6 (no)
FI (1) FI93657C (no)
GR (1) GR862197B (no)
IL (1) IL79834A (no)
NO (1) NO177756C (no)
NZ (1) NZ217336A (no)
PT (1) PT83256B (no)
WO (1) WO1987001391A1 (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3786578T2 (de) * 1986-03-25 1994-02-03 Nippon Zeon Co Biotin-Synthetase kodierendes Gen und dessen Verwendung.
AU616380B2 (en) * 1986-09-30 1991-10-31 Transgene S.A. Cloning of the bioA, bioD, bioF, bioC, and bioH genes of Bacillus sphaericus, vectors and transformed cells and method for preparing biotin
FR2615514B2 (fr) * 1987-05-18 1991-01-11 Transgene Sa Clonage des genes bioc et bioh de bacillus sphaericus, vecteurs et cellules transformees et procede de preparation de la biotine
FR2604436B1 (fr) * 1986-09-30 1989-07-21 Transgene Sa Clonage des genes bioa, biod, biof de bacillus sphaericus, vecteurs et cellules transformes et procede de preparation de la biotine
GB2216530B (en) * 1988-03-22 1992-07-08 Mini Agriculture & Fisheries Genetic material for expression of biotin synthetase enzymes
US5252466A (en) * 1989-05-19 1993-10-12 Biotechnology Research And Development Corporation Fusion proteins having a site for in vivo post-translation modification and methods of making and purifying them
FR2657622B1 (fr) 1990-01-31 1994-11-25 Rhone Poulenc Sante Polypeptides impliques dans la biosynthese des cobalamines et/ou des cobamides, sequences d'adn codant pour ces polypeptides, procede de preparation, et leur utilisation.
DE4013522A1 (de) * 1990-04-27 1991-10-31 Bayer Ag Verwendung von alkylcarbonsaeure-dimethylamiden als kristallisationsinhibitoren
KR100250692B1 (ko) * 1991-09-13 2000-04-01 후쿠하라 요시하루 바이오틴 오페론
JP2658716B2 (ja) * 1992-01-24 1997-09-30 田辺製薬株式会社 新規微生物及びそれを用いるｄ−ビオチンの製法
JP3566287B2 (ja) * 1992-10-02 2004-09-15 ロンザ ア−ゲ− ビオチンの生物工学的製造方法
EP0635572A3 (en) * 1993-06-25 1995-03-08 Hoffmann La Roche Biosynthesis of biotin in bacillus subtilis.
DK0806479T3 (da) 1996-05-06 2003-10-06 Hoffmann La Roche Produktion af biotin ved fermentering
DK0853127T3 (da) 1996-09-27 2005-03-07 Dsm Ip Assets Bv Biotin-biosyntese-gener II
DE19731274A1 (de) 1997-07-22 1999-01-28 Basf Ag Verfahren zur Herstellung von Biotin
US6432686B1 (en) 1998-05-12 2002-08-13 E. I. Du Pont De Nemours And Company Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport
US7074608B1 (en) 1998-05-12 2006-07-11 E. I. Du Pont De Nemours And Company Method for the production of 1,3-propanediol by recombinant organisms comprising genes for coenzyme B12 synthesis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56160998A (en) * 1980-05-15 1981-12-11 Nippon Zeon Co Ltd Production of biotin active substance biotin vitamer
JPS60996A (ja) * 1983-06-18 1985-01-07 山田機械工業株式会社 折丁供給装置

Also Published As

Publication number Publication date
AU599046B2 (en) 1990-07-12
GR862197B (en) 1986-12-31
DK197487A (da) 1987-06-24
IL79834A (en) 1992-08-18
FI93657B (fi) 1995-01-31
KR880700072A (ko) 1988-02-15
NO871723D0 (no) 1987-04-24
FI93657C (fi) 1995-05-10
DE3688248D1 (de) 1993-05-13
NO871723L (no) 1987-04-24
NO177756C (no) 1995-11-15
IL79834A0 (en) 1986-11-30
ATE87975T1 (de) 1993-04-15
DK197487D0 (da) 1987-04-15
ES2001398A6 (es) 1988-05-16
EP0236429A1 (en) 1987-09-16
DE3688248T2 (de) 1993-07-15
WO1987001391A1 (en) 1987-03-12
EP0236429B1 (en) 1993-04-07
PT83256B (pt) 1988-07-01
FI871689A (fi) 1987-04-16
NZ217336A (en) 1988-06-30
FI871689A0 (fi) 1987-04-16
CA1317245C (en) 1993-05-04
AU6229786A (en) 1987-03-24
NO177756B (no) 1995-08-07
PT83256A (en) 1986-09-01
EP0236429A4 (en) 1988-02-03

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B1 Patent granted (law 1993)
PUP Patent expired