DK1737855T3 - Fremgangsmåde til halvsyntese af deserpidin - Google Patents

Fremgangsmåde til halvsyntese af deserpidin

Info

Publication number
DK1737855T3
DK1737855T3 DK05715662T DK05715662T DK1737855T3 DK 1737855 T3 DK1737855 T3 DK 1737855T3 DK 05715662 T DK05715662 T DK 05715662T DK 05715662 T DK05715662 T DK 05715662T DK 1737855 T3 DK1737855 T3 DK 1737855T3
Authority
DK
Denmark
Prior art keywords
deserpidine
synthesis
semi
acid lactone
reserpic acid
Prior art date
Application number
DK05715662T
Other languages
English (en)
Inventor
Gabriele Fontana
Ezio Bombardelli
Cristian Samori
Eleonora Baldelli
Andrea Guerrini
Arturo Battaglia
Bruno Danieli
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Application granted granted Critical
Publication of DK1737855T3 publication Critical patent/DK1737855T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D459/00Heterocyclic compounds containing benz [g] indolo [2, 3-a] quinolizine ring systems, e.g. yohimbine; 16, 18-lactones thereof, e.g. reserpic acid lactone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
DK05715662T 2004-03-25 2005-03-02 Fremgangsmåde til halvsyntese af deserpidin DK1737855T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000582A ITMI20040582A1 (it) 2004-03-25 2004-03-25 Processo per la semisintesi di deserpidina
PCT/EP2005/002190 WO2005095394A1 (en) 2004-03-25 2005-03-02 A process for the semisynthesis of deserpidine

Publications (1)

Publication Number Publication Date
DK1737855T3 true DK1737855T3 (da) 2008-10-20

Family

ID=34961379

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05715662T DK1737855T3 (da) 2004-03-25 2005-03-02 Fremgangsmåde til halvsyntese af deserpidin

Country Status (20)

Country Link
US (1) US7468438B2 (da)
EP (1) EP1737855B1 (da)
JP (1) JP4841542B2 (da)
KR (1) KR101087461B1 (da)
CN (1) CN100475811C (da)
AT (1) ATE399167T1 (da)
AU (1) AU2005229344B2 (da)
CA (1) CA2560778C (da)
DE (1) DE602005007724D1 (da)
DK (1) DK1737855T3 (da)
ES (1) ES2308452T3 (da)
HK (1) HK1100776A1 (da)
IL (1) IL178228A (da)
IT (1) ITMI20040582A1 (da)
NO (1) NO20064273L (da)
PL (1) PL1737855T3 (da)
PT (1) PT1737855E (da)
RU (1) RU2372351C2 (da)
SI (1) SI1737855T1 (da)
WO (1) WO2005095394A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101042381B (zh) * 2007-04-28 2014-01-08 长春迈灵生物工程有限公司 一种地舍平的检测方法
CN116693524B (zh) * 2023-08-07 2023-11-03 长春迈灵生物工程有限公司 一种地舍平的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB809913A (en) * 1954-11-10 1959-03-04 Ciba Ltd A new acid derived from an alkaloid named "deserpidine," its esters and salts thereof, and process for their manufacture
GB868478A (en) * 1957-05-22 1961-05-17 Chimiotherapie Lab Franc Synthesis of deserpidine

Also Published As

Publication number Publication date
PL1737855T3 (pl) 2008-12-31
KR20060134074A (ko) 2006-12-27
CA2560778A1 (en) 2005-10-13
CN1934110A (zh) 2007-03-21
EP1737855B1 (en) 2008-06-25
ITMI20040582A1 (it) 2004-06-25
US20080242864A1 (en) 2008-10-02
AU2005229344A1 (en) 2005-10-13
NO20064273L (no) 2006-10-24
JP4841542B2 (ja) 2011-12-21
US7468438B2 (en) 2008-12-23
WO2005095394A1 (en) 2005-10-13
IL178228A0 (en) 2006-12-31
SI1737855T1 (sl) 2008-10-31
CN100475811C (zh) 2009-04-08
RU2372351C2 (ru) 2009-11-10
AU2005229344B2 (en) 2011-03-31
DE602005007724D1 (de) 2008-08-07
IL178228A (en) 2010-12-30
KR101087461B1 (ko) 2011-11-25
RU2006133740A (ru) 2008-03-27
ATE399167T1 (de) 2008-07-15
EP1737855A1 (en) 2007-01-03
HK1100776A1 (en) 2007-09-28
CA2560778C (en) 2012-11-06
WO2005095394A8 (en) 2006-09-14
JP2007530467A (ja) 2007-11-01
ES2308452T3 (es) 2008-12-01
PT1737855E (pt) 2008-09-15

Similar Documents

Publication Publication Date Title
DK1633697T3 (da) Fremgangsmåde til fremstilling af substituerede 3-aryl-butyl-aminforbindelser
EA200800549A1 (ru) Региоселективный способ получения бензимидазолтиофенов
EA201201476A1 (ru) Синтез кето-эпоксидов аминокислот
ATE427965T1 (de) Antikírper gegen 25-hydroxyvitamin d
MX2007009282A (es) Nuevos procesos para la preparacion de un 2h-cromeno.
NO20076371L (no) Fremgangsmate for fremstilling av fenoliske 4-bifenylylazetidin-2-oner
ATE411994T1 (de) Herstellung eines substituierten chinoxalins von hoher reinheit
ATE417849T1 (de) Pyrazoloä4,3-düpyrimidine
DK1817326T3 (da) Industriel fremgangsmåde til fremstilling af 17-hydroxy-6-beta, 7-beta, 15-beta, 16-beta-bismethylen-3-oxo-17-alpha-pregn-4-en-21-carboxylsyre-gamma-lacton og nøglemellemprodukter for denne fremgangsmåde
DK1831239T3 (da) Fremgangsmåde til fremstilling af 17-hydroxy-6 beta, 7 beta, 15 beta, 16 beta-bismethylen-17alpha-pregn-4-en-3-on-21-carboxylsyre-lambda-lacton og nøgle-mellemprodukter til denne fremgangsmåde
EA200602169A1 (ru) Способ получения производных 2-оксо-1-пирролидина внутримолекулярным аллилированием
EA200700550A1 (ru) Производные алкилидентетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
DK1838670T3 (da) Fremgangsmåde til fremstilling af carvedilol og dets enantiomere
EA200801549A1 (ru) Новые производные фенантридина в качестве антагонистов брадикинина
NO20081617L (no) Metoder for fremstilling av Glutaminsyrederivater
DK1877370T3 (da) Fremgangsmåde til fremstilling af hydrazon-derivater
DK1926732T3 (da) Fremgangsmåde til fremstillingen af carbapenemforbindelser
EA200702428A1 (ru) Способы получения 4-бифенилилазетидин-2-онов
CL2007003066A1 (es) Metodo de obtencion de derivados de 8-fenil-cromanos por reduccion de la correspondiente amida.
DK1737855T3 (da) Fremgangsmåde til halvsyntese af deserpidin
NO20065157L (no) Biotransformasjon av colchicinoidforbindelser
NO20084839L (no) Metoder for fremstilling av glutaminsyrederivater og melomprodukter
DK2004670T3 (da) Fremgangsmåde til fremstilling af lysobactin-derivater
ATE546451T1 (de) Cyclopropancarbonsäureester von acyclovir
ATE464280T1 (de) Synthese von idarubin-aglycon