ATE411994T1 - Herstellung eines substituierten chinoxalins von hoher reinheit - Google Patents
Herstellung eines substituierten chinoxalins von hoher reinheitInfo
- Publication number
- ATE411994T1 ATE411994T1 AT06710423T AT06710423T ATE411994T1 AT E411994 T1 ATE411994 T1 AT E411994T1 AT 06710423 T AT06710423 T AT 06710423T AT 06710423 T AT06710423 T AT 06710423T AT E411994 T1 ATE411994 T1 AT E411994T1
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- high purity
- substituted quinoxaline
- purity substituted
- quinoxaline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65629605P | 2005-02-24 | 2005-02-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE411994T1 true ATE411994T1 (de) | 2008-11-15 |
Family
ID=36405938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06710423T ATE411994T1 (de) | 2005-02-24 | 2006-02-21 | Herstellung eines substituierten chinoxalins von hoher reinheit |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20080275051A1 (de) |
| EP (1) | EP1866308B1 (de) |
| JP (1) | JP2008531540A (de) |
| KR (1) | KR20070098942A (de) |
| CN (1) | CN101128462A (de) |
| AT (1) | ATE411994T1 (de) |
| AU (1) | AU2006217616A1 (de) |
| BR (1) | BRPI0607838A2 (de) |
| CA (1) | CA2598533A1 (de) |
| DE (1) | DE602006003320D1 (de) |
| ES (1) | ES2313625T3 (de) |
| IL (1) | IL185013A0 (de) |
| MX (1) | MX2007010375A (de) |
| RU (1) | RU2007131535A (de) |
| WO (1) | WO2006090236A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2009116260A (ru) | 2006-11-09 | 2010-11-10 | Пфайзер Продактс Инк. (Us) | Полиморфные модификации никотиновых промежуточных продуктов |
| WO2009065872A2 (en) * | 2007-11-20 | 2009-05-28 | Medichem, S.A. | Improved processes for the synthesis of varenicline l-tartrate |
| EP2268639A2 (de) | 2008-05-22 | 2011-01-05 | Teva Pharmaceutical Industries Ltd. | Vareniclin-tosylat, ein zwischenprodukt bei der herstellung von vareniclin-l-tartrat |
| US20090318695A1 (en) * | 2008-06-19 | 2009-12-24 | Vinod Kumar Kansal | Processes for the preparation of varenicline and intermediates thereof |
| WO2010005643A1 (en) * | 2008-07-10 | 2010-01-14 | Teva Pharmaceutical Industries Ltd. | Processes for purifying varenicline l-tartrate salt and preparing crystalline forms of varenicline l-tartrate salt |
| US8178537B2 (en) | 2009-06-22 | 2012-05-15 | Teva Pharmaceutical Industries Ltd. | Solid state forms of varenicline salts and processes for preparation thereof |
| US20120277433A1 (en) * | 2009-12-29 | 2012-11-01 | Mahendranath Rao Narasimha Rao | Process for the preparation of substituted quinoxalines |
| CA2791460A1 (en) * | 2010-03-09 | 2011-09-15 | Actavis Group Ptc Ehf | Highly pure varenicline or a pharmaceutically acceptable salt thereof substantially free of methylvarenicline impurity |
| US20120004239A1 (en) * | 2010-06-11 | 2012-01-05 | Medichem, S.A. | Process for Preparing Quinoxaline Derivatives |
| CN113956255A (zh) * | 2020-07-20 | 2022-01-21 | 威智医药有限公司 | 一种伐尼克兰中间体、伐尼克兰及其盐的制备方法 |
| WO2022035434A1 (en) | 2020-08-14 | 2022-02-17 | Almatica Pharma Llc | Cocrystal of varenicline and oxalic acid, pharmaceutical composition thereof, and methods of use thereof |
| WO2022222019A1 (en) * | 2021-04-20 | 2022-10-27 | Suzhou Fude Zhaofeng Biochemical Technology Co., Ltd | Total synthesis of varenicline |
| CN114349701B (zh) * | 2022-01-07 | 2024-04-05 | 江苏豪森药业集团有限公司 | 一种酒石酸伐尼克兰中间体的制备方法 |
| US11602537B2 (en) | 2022-03-11 | 2023-03-14 | Par Pharmaceutical, Inc. | Varenicline compound and process of manufacture thereof |
| EP4241775A1 (de) | 2022-03-11 | 2023-09-13 | Par Pharmaceutical, Inc. | Tablette mit vareniclin und verfahren zur herstellung davon |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6605610B1 (en) * | 1997-12-31 | 2003-08-12 | Pfizer Inc | Aryl fused azapolycyclic compounds |
| SK286886B6 (sk) * | 1997-12-31 | 2009-07-06 | Pfizer Products Inc. | Azapolycyklické zlúčeniny s anelovanou arylskupinou, ich použitie, farmaceutické kompozície na ich báze a medziprodukty |
| EP1392307B1 (de) * | 2001-05-14 | 2005-08-24 | Pfizer Products Inc. | Tartrate des 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaens |
| DE602004015986D1 (de) * | 2003-06-04 | 2008-10-02 | Pfizer Prod Inc | Herstellung von substituierten chinoxalinen aus den dianilinen mit 2,3-dihydroxy-1,4-dioxan |
-
2006
- 2006-02-21 CA CA002598533A patent/CA2598533A1/en not_active Abandoned
- 2006-02-21 BR BRPI0607838-9A patent/BRPI0607838A2/pt not_active IP Right Cessation
- 2006-02-21 US US11/722,817 patent/US20080275051A1/en not_active Abandoned
- 2006-02-21 ES ES06710423T patent/ES2313625T3/es active Active
- 2006-02-21 WO PCT/IB2006/000351 patent/WO2006090236A1/en active Application Filing
- 2006-02-21 AT AT06710423T patent/ATE411994T1/de not_active IP Right Cessation
- 2006-02-21 JP JP2007556673A patent/JP2008531540A/ja active Pending
- 2006-02-21 KR KR1020077019287A patent/KR20070098942A/ko not_active Application Discontinuation
- 2006-02-21 CN CNA2006800060133A patent/CN101128462A/zh active Pending
- 2006-02-21 EP EP06710423A patent/EP1866308B1/de not_active Not-in-force
- 2006-02-21 AU AU2006217616A patent/AU2006217616A1/en not_active Abandoned
- 2006-02-21 MX MX2007010375A patent/MX2007010375A/es not_active Application Discontinuation
- 2006-02-21 DE DE602006003320T patent/DE602006003320D1/de not_active Expired - Fee Related
- 2006-02-21 RU RU2007131535/04A patent/RU2007131535A/ru not_active Application Discontinuation
-
2007
- 2007-08-02 IL IL185013A patent/IL185013A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1866308B1 (de) | 2008-10-22 |
| MX2007010375A (es) | 2007-09-25 |
| ES2313625T3 (es) | 2009-03-01 |
| EP1866308A1 (de) | 2007-12-19 |
| RU2007131535A (ru) | 2009-03-27 |
| CA2598533A1 (en) | 2006-08-31 |
| CN101128462A (zh) | 2008-02-20 |
| JP2008531540A (ja) | 2008-08-14 |
| DE602006003320D1 (de) | 2008-12-04 |
| KR20070098942A (ko) | 2007-10-05 |
| IL185013A0 (en) | 2007-12-03 |
| AU2006217616A1 (en) | 2006-08-31 |
| US20080275051A1 (en) | 2008-11-06 |
| WO2006090236A1 (en) | 2006-08-31 |
| BRPI0607838A2 (pt) | 2009-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |