CY1110688T1 - Διεργασια για την παρασκευη καρβεδιλολης και εναντιομερων αυτης - Google Patents

Διεργασια για την παρασκευη καρβεδιλολης και εναντιομερων αυτης

Info

Publication number
CY1110688T1
CY1110688T1 CY20091101281T CY091101281T CY1110688T1 CY 1110688 T1 CY1110688 T1 CY 1110688T1 CY 20091101281 T CY20091101281 T CY 20091101281T CY 091101281 T CY091101281 T CY 091101281T CY 1110688 T1 CY1110688 T1 CY 1110688T1
Authority
CY
Cyprus
Prior art keywords
preparation
carvediolol
antiomometer
procedure
enantiomers
Prior art date
Application number
CY20091101281T
Other languages
English (en)
Inventor
Guixer Elisenda Trepat
Alvarez Anna Munoz
Marco Marta Pomares
Olondriz Francisco Marquillas
Original Assignee
Zach System S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zach System S.P.A. filed Critical Zach System S.P.A.
Publication of CY1110688T1 publication Critical patent/CY1110688T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με διεργασία για την παρασκευή καρβεδιλόλης καθώς και οπτικώς ενεργών εναντιομερών R και S αυτής και μιγμάτων των εναντιομερών αυτών, και, ειδικότερα, σχετίζεται με βελτιωμένη διεργασία για την παρασκευή καρβεδιλόλης και εναντιομερών αυτής που χαρακτηρίζονται από τη χρήση οξικού αιθυλεστέρα ως διαλύτη της αντίδρασης.
CY20091101281T 2004-12-09 2009-12-08 Διεργασια για την παρασκευη καρβεδιλολης και εναντιομερων αυτης CY1110688T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04106438 2004-12-09
EP05815876A EP1838670B1 (en) 2004-12-09 2005-12-05 Process for the preparation of carvedilol and its enantiomers

Publications (1)

Publication Number Publication Date
CY1110688T1 true CY1110688T1 (el) 2015-06-10

Family

ID=35985349

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091101281T CY1110688T1 (el) 2004-12-09 2009-12-08 Διεργασια για την παρασκευη καρβεδιλολης και εναντιομερων αυτης

Country Status (16)

Country Link
US (2) US20090005429A1 (el)
EP (1) EP1838670B1 (el)
JP (1) JP2008523025A (el)
CN (1) CN100591668C (el)
AT (1) ATE445601T1 (el)
CA (1) CA2589699A1 (el)
CY (1) CY1110688T1 (el)
DE (1) DE602005017194D1 (el)
DK (1) DK1838670T3 (el)
ES (1) ES2333537T3 (el)
HR (1) HRP20100023T1 (el)
IL (1) IL183449A0 (el)
PL (1) PL1838670T3 (el)
PT (1) PT1838670E (el)
SI (1) SI1838670T1 (el)
WO (1) WO2006061364A1 (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02012795A (es) 2000-06-28 2004-07-30 Teva Pharma Carvedilol.
PL371409A1 (en) 2002-01-15 2005-06-13 Teva Pharmaceutical Industries Ltd. Crystalline solids of carvedilol and processes for their preparation
KR100746455B1 (ko) * 2006-02-23 2007-08-03 안국약품 주식회사 고광학순도의 키랄 카베딜롤의 제조방법
US8022094B2 (en) 2006-06-28 2011-09-20 Teva Pharmaceutical Industries Ltd. Carvedilol phosphate
CN102190613B (zh) * 2010-03-14 2014-06-25 浙江华海药业股份有限公司 一种卡维地洛的制备方法
DK2549871T3 (en) 2010-03-23 2018-12-10 Siga Tech Inc Polymorphic form ST-246 and processes for its preparation
US12091408B2 (en) * 2013-08-30 2024-09-17 Uti Limited Partnership Store overload-induced calcium release inhibitors and methods for producing and using the same
CN104592096A (zh) * 2014-12-24 2015-05-06 江苏苏南药业实业有限公司 一种s-卡维地洛的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3319027A1 (de) * 1983-05-26 1984-11-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten
EP0893440A1 (en) * 1997-07-22 1999-01-27 Roche Diagnostics GmbH Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it
MXPA02012795A (es) * 2000-06-28 2004-07-30 Teva Pharma Carvedilol.

Also Published As

Publication number Publication date
CN101072753A (zh) 2007-11-14
US20090005429A1 (en) 2009-01-01
JP2008523025A (ja) 2008-07-03
EP1838670A1 (en) 2007-10-03
DE602005017194D1 (de) 2009-11-26
ATE445601T1 (de) 2009-10-15
CA2589699A1 (en) 2006-06-15
HRP20100023T1 (hr) 2010-02-28
ES2333537T3 (es) 2010-02-23
EP1838670B1 (en) 2009-10-14
IL183449A0 (en) 2007-09-20
WO2006061364A1 (en) 2006-06-15
US20120041044A1 (en) 2012-02-16
DK1838670T3 (da) 2010-03-01
CN100591668C (zh) 2010-02-24
SI1838670T1 (sl) 2010-04-30
PT1838670E (pt) 2009-12-18
PL1838670T3 (pl) 2010-03-31

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