DK172539B1 - Fremgangsmåde til fremstilling af 1-desoxynojirimyciner - Google Patents

Fremgangsmåde til fremstilling af 1-desoxynojirimyciner Download PDF

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Publication number
DK172539B1
DK172539B1 DK198701793A DK179387A DK172539B1 DK 172539 B1 DK172539 B1 DK 172539B1 DK 198701793 A DK198701793 A DK 198701793A DK 179387 A DK179387 A DK 179387A DK 172539 B1 DK172539 B1 DK 172539B1
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DK
Denmark
Prior art keywords
formula
amino
preparation
compounds
formyl
Prior art date
Application number
DK198701793A
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Danish (da)
English (en)
Other versions
DK179387D0 (da
DK179387A (da
Inventor
Theo Schroeder
Mathias Stubbe
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of DK179387D0 publication Critical patent/DK179387D0/da
Publication of DK179387A publication Critical patent/DK179387A/da
Application granted granted Critical
Publication of DK172539B1 publication Critical patent/DK172539B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK198701793A 1986-04-09 1987-04-08 Fremgangsmåde til fremstilling af 1-desoxynojirimyciner DK172539B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3611841 1986-04-09
DE19863611841 DE3611841A1 (de) 1986-04-09 1986-04-09 Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten

Publications (3)

Publication Number Publication Date
DK179387D0 DK179387D0 (da) 1987-04-08
DK179387A DK179387A (da) 1987-10-10
DK172539B1 true DK172539B1 (da) 1998-12-07

Family

ID=6298252

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198701793A DK172539B1 (da) 1986-04-09 1987-04-08 Fremgangsmåde til fremstilling af 1-desoxynojirimyciner

Country Status (11)

Country Link
US (1) US4806650A (fr)
EP (1) EP0240868B1 (fr)
JP (1) JPH085858B2 (fr)
KR (1) KR950005196B1 (fr)
AT (1) ATE104962T1 (fr)
CA (1) CA1277624C (fr)
DE (2) DE3611841A1 (fr)
DK (1) DK172539B1 (fr)
ES (1) ES2051701T3 (fr)
HU (1) HU196819B (fr)
IL (1) IL82120A (fr)

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US5256788A (en) * 1989-02-13 1993-10-26 Nippon Shinyaku Co. Ltd. Moranoline derivatives and their production and the use of moranoline and its derivatives as a stabilizing agent for enzymes
DK0410953T3 (da) * 1989-07-27 1996-01-22 Monsanto Co Piperidinforbindelser
DE3936295A1 (de) * 1989-11-01 1991-05-02 Bayer Ag Verfahren zur herstellung von zwischenprodukten und zur synthese von n-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine
US5151519A (en) * 1990-05-07 1992-09-29 G. D. Searle & Co. Process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof
CA2086413A1 (fr) * 1990-06-29 1991-12-30 Yohji Ezure Derives piperidine
ATE137266T1 (de) * 1990-09-20 1996-05-15 Monsanto Co Verfahren zur herstellung von n-substituiertem 1- deoxynojirimycin
DE4030040A1 (de) * 1990-09-22 1992-03-26 Bayer Ag Enzymatische de-acylierung von acyl-aminosorbosen und dessen verwendung bei der herstellung von 1-desoxynojirimicin
US5401645A (en) * 1992-03-16 1995-03-28 Monsanto Company Process for producing n-substituted polyhydroxy nitrogen-containing heterocycles utilizing acetobacteraceae and corynebacterium
US5258518A (en) * 1992-04-01 1993-11-02 G. D. Searle & Co. 2-substituted tertiary carbinol derivatives of deoxynojirimycin
WO1995022975A1 (fr) * 1994-02-25 1995-08-31 G.D. Searle & Co. Utilisation de 1-desoxynojirimycine et de ses derives pour traiter des mammiferes infectes par le virus syncytial respiratoire
US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
CA2309321A1 (fr) 1997-11-10 1999-05-20 G.D. Searle & Co. Emploi d'iminosucres alkyles pour traiter la resistance multiple aux anticancereux
US6465488B1 (en) 1997-12-11 2002-10-15 Chancellor, Masters & Scholars Of The University Of Oxford Inhibition of glycolipid biosynthesis
CA2312423A1 (fr) 1997-12-11 1999-06-17 The Chancellor, Masters And Scholars Of The University Of Oxford Inhibition de la replication virale associee a une membrane cellulaire
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
AU762125B2 (en) 1998-02-12 2003-06-19 G.D. Searle & Co. Use of (N)-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
AU3595500A (en) 1999-02-12 2000-08-29 G.D. Searle & Co. Use of substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
WO2001008672A2 (fr) 1999-02-12 2001-02-08 G.D. Searle & Co. Composes glucamine destines au traitement d'infections dues au virus de l'hepatite
ATE382351T1 (de) 1999-08-10 2008-01-15 Univ Oxford Langkettige n-alkyl verbindungen und deren oxa- derivate zur verwendung als anitvirale mittel
US7256005B2 (en) 1999-08-10 2007-08-14 The Chancellor, Masters And Scholars Of The University Of Oxford Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
EP1261339A1 (fr) * 2000-02-14 2002-12-04 Pharmacia Corporation UTILISATION DE COMPOSES 1,5-DIDESOXY-1,5-IMINO-D-GLUCITOL i N /i -SUBSTITUES POUR LE TRAITEMENT DES INFECTIONS PAR UN VIRUS D'HEPATITE
US6462197B2 (en) 2000-03-31 2002-10-08 Board Of Trustees Of Michigan State University Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines
US20030236489A1 (en) * 2002-06-21 2003-12-25 Baxter International, Inc. Method and apparatus for closed-loop flow control system
KR100520007B1 (ko) 2003-05-19 2005-10-11 건 식 조 혈압 강하 기능을 가지는 키토산 함유 소금의 제조방법
KR20080025373A (ko) 2005-05-17 2008-03-20 아미쿠스 세라퓨틱스, 인코포레이티드 1-데옥시노지리마이신 및 유도체를 이용한 폼페병의 치료방법
GB0614947D0 (en) * 2006-07-27 2006-09-06 Isis Innovation Epitope reduction therapy
JP2009545621A (ja) 2006-08-02 2009-12-24 ユナイテッド セラピューティクス コーポレーション ウィルス感染症のリポソーム処置
JP2010510171A (ja) * 2006-08-21 2010-04-02 ユナイテッド セラピューティクス コーポレーション ウイルス感染症の治療のための併用療法
US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
CN102046151A (zh) * 2008-03-26 2011-05-04 牛津大学 靶向内质网的脂质体
CN102655746B (zh) 2009-02-23 2016-08-03 联合治疗公司 亚氨基糖以及治疗病毒性疾病的方法
KR101787434B1 (ko) * 2009-02-24 2017-11-15 유나이티드 세러퓨틱스 코오포레이션 이미노슈가 및 아레나바이러스성 감염을 치료하는 방법
KR20120059447A (ko) * 2009-03-27 2012-06-08 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 콜레스테롤 수준 저하 리포좀
EP2440205B1 (fr) * 2009-06-12 2014-08-27 United Therapeutics Corporation Immunosucres pour leur utilisation dans le traitement des maladies bunyavirales et togavirales
KR101459530B1 (ko) * 2009-09-04 2014-11-07 유나이티드 세러퓨틱스 코오포레이션 폭스바이러스 감염의 치료 방법
CN102625796B (zh) * 2009-09-04 2015-03-11 联合治疗公司 治疗正粘病毒感染的方法
CA2772813A1 (fr) * 2009-09-04 2011-03-10 The Chancellor, Masters And Scholars Of The University Of Oxford Iminosucres et procedes de traitement de maladies filovirales
CA2783405A1 (fr) * 2009-12-07 2011-06-16 The Chancellor, Masters And Scholars Of The University Of Oxford Composes de desoxynojirimycine n-substituee destines a l'inhibition de l'osteoclastogenese et/ou de l'activation des osteoclastes
WO2014017915A2 (fr) 2012-07-27 2014-01-30 Universiteit Utrecht Holding B.V. Dérivés d'urée et de guanidinium d'iminosucres
RU2702133C2 (ru) 2013-09-16 2019-10-04 ЭМЕРГЕНТ ВИРОЛОДЖИ ЭлЭлСи Производные дезоксинойиримицина и способы их применения
BR112017008898B1 (pt) 2014-11-05 2022-11-29 Emergent Virology Llc Compostos de iminoaçúcares, suas composições farmacêuticas e usos dos mesmos para tratar doenças virais
EP3318277A1 (fr) 2016-11-04 2018-05-09 Institut du Cerveau et de la Moelle Epiniere-ICM Inhibiteurs de la synthase de glucosylcéramide pour le traitement de maladies du motoneurone
JP2021514200A (ja) 2018-01-26 2021-06-10 浙江工▲業▼大学 グルコノバクターオキシダンスのソルビトールデヒドロゲナーゼおよびコエンザイムピロロキノリンキニーネの合成を促進する方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
GB2009152B (en) * 1977-11-10 1982-01-06 Nippon Shinyaku Co Ltd Method for producing moranoline and n-methylmoranoline
DE2834122A1 (de) * 1978-08-03 1980-02-14 Bayer Ag Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose
DE2853573A1 (de) * 1978-12-12 1980-07-03 Bayer Ag Herstellung von n-substituierten derivaten des l-desoxynojirimycins
DE2936240A1 (de) * 1979-09-07 1981-03-26 Bayer Ag, 51373 Leverkusen Verfahren zur herstellung bekannter und neuer 6-amino-6-desoxy-2,3-0-isopropyliden-(alpha)-l-sorbofuranose-derivate sowie neue zwischenprodukte des verfahrens
DE2942365A1 (de) * 1979-10-19 1981-05-14 Bayer Ag, 5090 Leverkusen 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3038901A1 (de) * 1980-10-15 1982-05-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins
DE3049446A1 (de) * 1980-12-30 1982-07-29 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 1,5-didesoxy-1,5-imino-d-glucitol und dessen n-derivaten

Also Published As

Publication number Publication date
ATE104962T1 (de) 1994-05-15
HU196819B (en) 1989-01-30
HUT43865A (en) 1987-12-28
KR950005196B1 (ko) 1995-05-19
DK179387D0 (da) 1987-04-08
EP0240868B1 (fr) 1994-04-27
CA1277624C (fr) 1990-12-11
EP0240868A3 (en) 1988-09-21
DE3611841A1 (de) 1987-10-15
JPH085858B2 (ja) 1996-01-24
ES2051701T3 (es) 1994-07-01
IL82120A (en) 1990-12-23
IL82120A0 (en) 1987-10-30
DK179387A (da) 1987-10-10
US4806650A (en) 1989-02-21
KR870010071A (ko) 1987-11-30
DE3789682D1 (de) 1994-06-01
JPS62242663A (ja) 1987-10-23
EP0240868A2 (fr) 1987-10-14

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)