DK172518B1 - Derivater af ovin CRF, farmacutiske eller veterinære sammensætninger, der indeholder disse, samt midler til mindskelse af s - Google Patents
Derivater af ovin CRF, farmacutiske eller veterinære sammensætninger, der indeholder disse, samt midler til mindskelse af s Download PDFInfo
- Publication number
- DK172518B1 DK172518B1 DK198504866A DK486685A DK172518B1 DK 172518 B1 DK172518 B1 DK 172518B1 DK 198504866 A DK198504866 A DK 198504866A DK 486685 A DK486685 A DK 486685A DK 172518 B1 DK172518 B1 DK 172518B1
- Authority
- DK
- Denmark
- Prior art keywords
- leu
- glu
- ala
- arg
- gln
- Prior art date
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- 101000895481 Homo sapiens Corticoliberin Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid Chemical compound CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 1
- QUOGESRFPZDMMT-UHFFFAOYSA-N L-Homoarginine Natural products OC(=O)C(N)CCCCNC(N)=N QUOGESRFPZDMMT-UHFFFAOYSA-N 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- QUOGESRFPZDMMT-YFKPBYRVSA-N L-homoarginine Chemical group OC(=O)[C@@H](N)CCCCNC(N)=N QUOGESRFPZDMMT-YFKPBYRVSA-N 0.000 description 1
- 235000019454 L-leucine Nutrition 0.000 description 1
- 125000002842 L-seryl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])O[H] 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- FYYSQDHBALBGHX-YFKPBYRVSA-N N(alpha)-t-butoxycarbonyl-L-asparagine Chemical compound CC(C)(C)OC(=O)N[C@H](C(O)=O)CC(N)=O FYYSQDHBALBGHX-YFKPBYRVSA-N 0.000 description 1
- 102000003797 Neuropeptides Human genes 0.000 description 1
- 108090000189 Neuropeptides Proteins 0.000 description 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
- 239000000683 Pro-Opiomelanocortin Substances 0.000 description 1
- 102000003946 Prolactin Human genes 0.000 description 1
- 108010057464 Prolactin Proteins 0.000 description 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 102400000336 Thyrotropin-releasing hormone Human genes 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 description 1
- 235000008206 alpha-amino acids Nutrition 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 125000006242 amine protecting group Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000003403 autonomic nervous system Anatomy 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000006957 competitive inhibition Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 230000003131 corticotrophic effect Effects 0.000 description 1
- 239000002769 corticotropin releasing factor antagonist Substances 0.000 description 1
- 239000007822 coupling agent Substances 0.000 description 1
- 229930003836 cresol Natural products 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 210000005095 gastrointestinal system Anatomy 0.000 description 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 238000005462 in vivo assay Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000000520 microinjection Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000005897 peptide coupling reaction Methods 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 229940097325 prolactin Drugs 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 108010020432 prolyl-prolylisoleucine Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000011894 semi-preparative HPLC Methods 0.000 description 1
- 229960001153 serine Drugs 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Amplifiers (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Details Of Television Scanning (AREA)
- Steroid Compounds (AREA)
- Train Traffic Observation, Control, And Security (AREA)
- Developing Agents For Electrophotography (AREA)
- Polyesters Or Polycarbonates (AREA)
- Control Of Eletrric Generators (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Vehicle Body Suspensions (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58309284 | 1984-02-23 | ||
| US06/583,092 US4605642A (en) | 1984-02-23 | 1984-02-23 | CRF antagonists |
| US06/610,110 US4594329A (en) | 1984-05-14 | 1984-05-14 | CRF analogs |
| US61011084 | 1984-05-14 | ||
| PCT/US1985/000297 WO1985003705A1 (en) | 1984-02-23 | 1985-02-21 | Crf analogs |
| US8500297 | 1985-02-21 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK486685A DK486685A (da) | 1985-10-23 |
| DK486685D0 DK486685D0 (da) | 1985-10-23 |
| DK172518B1 true DK172518B1 (da) | 1998-11-09 |
Family
ID=27078728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198504866A DK172518B1 (da) | 1984-02-23 | 1985-10-23 | Derivater af ovin CRF, farmacutiske eller veterinære sammensætninger, der indeholder disse, samt midler til mindskelse af s |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP0153845B1 (enExample) |
| JP (1) | JPH0742318B2 (enExample) |
| KR (1) | KR870000812B1 (enExample) |
| AT (1) | ATE88481T1 (enExample) |
| AU (1) | AU585500B2 (enExample) |
| DE (1) | DE3587276T2 (enExample) |
| DK (1) | DK172518B1 (enExample) |
| ES (1) | ES8606403A1 (enExample) |
| FI (1) | FI91413C (enExample) |
| GR (1) | GR850454B (enExample) |
| IE (2) | IE63601B1 (enExample) |
| NO (1) | NO171729C (enExample) |
| WO (1) | WO1985003705A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3703340A1 (de) * | 1987-02-04 | 1988-08-18 | Dirck Dr Med Oppermann | Pharmazeutische zubereitung zur behandlung der herzinsuffizienz |
| IE64788B1 (en) * | 1988-06-21 | 1995-09-06 | Salk Inst For Biological Studi | CRF analogs |
| CA1341051C (en) * | 1988-09-23 | 2000-07-11 | Jean Edouard Frederic Rivier | Crf antagonists |
| CA1340964C (en) * | 1988-09-30 | 2000-04-18 | Jean E. F. Rivier | Crf analogs |
| CA2002004A1 (en) * | 1988-11-14 | 1990-05-14 | Karl P. Lederis | Fish crf |
| JP3243250B2 (ja) * | 1990-03-23 | 2002-01-07 | ザ・ソーク・インスティチュート・フォー・バイオロジカル・スタディーズ | Ｃｒｆ同族体 |
| US5235036A (en) * | 1991-05-31 | 1993-08-10 | The Salk Institute For Biological Studies | Crf analogs |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4244946A (en) * | 1979-06-11 | 1981-01-13 | The Salk Institute For Biological Studies | Water-soluble peptides affecting gonadal function |
| US4415558A (en) * | 1981-06-08 | 1983-11-15 | The Salk Institute For Biological Studies | CRF And analogs |
| GR75679B (enExample) * | 1981-06-08 | 1984-08-02 | Salk Inst For Biological Studi | |
| US4385050A (en) * | 1981-06-26 | 1983-05-24 | Armour Pharmaceutical Company | Antihypertensive polypeptides |
| US4533654A (en) * | 1982-09-29 | 1985-08-06 | The Salk Institute For Biological Studies | Urotensin peptides |
| US4489163A (en) * | 1983-04-14 | 1984-12-18 | The Salk Institute For Biological Studies | rCRF and analogs |
-
1985
- 1985-02-19 AT AT85301093T patent/ATE88481T1/de not_active IP Right Cessation
- 1985-02-19 EP EP85301093A patent/EP0153845B1/en not_active Expired - Lifetime
- 1985-02-19 DE DE8585301093T patent/DE3587276T2/de not_active Expired - Lifetime
- 1985-02-19 EP EP92115541A patent/EP0518391A1/en not_active Ceased
- 1985-02-21 KR KR1019850700252A patent/KR870000812B1/ko not_active Expired
- 1985-02-21 AU AU40693/85A patent/AU585500B2/en not_active Expired
- 1985-02-21 JP JP60501132A patent/JPH0742318B2/ja not_active Expired - Lifetime
- 1985-02-21 WO PCT/US1985/000297 patent/WO1985003705A1/en not_active Ceased
- 1985-02-21 GR GR850454A patent/GR850454B/el unknown
- 1985-02-22 ES ES540632A patent/ES8606403A1/es not_active Expired
- 1985-02-22 IE IE45285A patent/IE63601B1/en not_active IP Right Cessation
- 1985-02-22 IE IE940016A patent/IE64241B1/en not_active IP Right Cessation
- 1985-10-22 FI FI854122A patent/FI91413C/fi not_active IP Right Cessation
- 1985-10-22 NO NO85854208A patent/NO171729C/no not_active IP Right Cessation
- 1985-10-23 DK DK198504866A patent/DK172518B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1985003705A1 (en) | 1985-08-29 |
| NO854208L (no) | 1985-12-20 |
| FI854122L (fi) | 1985-10-22 |
| EP0153845A3 (en) | 1988-09-07 |
| NO171729C (no) | 1993-04-28 |
| ES8606403A1 (es) | 1986-04-16 |
| AU4069385A (en) | 1985-09-10 |
| EP0153845B1 (en) | 1993-04-21 |
| ES540632A0 (es) | 1986-04-16 |
| FI854122A0 (fi) | 1985-10-22 |
| JPH0742318B2 (ja) | 1995-05-10 |
| DE3587276D1 (de) | 1993-05-27 |
| AU585500B2 (en) | 1989-06-22 |
| EP0153845A2 (en) | 1985-09-04 |
| FI91413B (fi) | 1994-03-15 |
| NO171729B (no) | 1993-01-18 |
| ATE88481T1 (de) | 1993-05-15 |
| IE63601B1 (en) | 1995-05-17 |
| IE940016L (en) | 1985-08-23 |
| DE3587276T2 (de) | 1993-07-29 |
| JPS61502396A (ja) | 1986-10-23 |
| IE850452L (en) | 1985-08-23 |
| DK486685A (da) | 1985-10-23 |
| KR850700246A (ko) | 1985-12-26 |
| DK486685D0 (da) | 1985-10-23 |
| IE64241B1 (en) | 1995-07-26 |
| EP0518391A1 (en) | 1992-12-16 |
| GR850454B (enExample) | 1985-06-19 |
| FI91413C (fi) | 1994-06-27 |
| KR870000812B1 (ko) | 1987-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PUP | Patent expired |