ATE88481T1 - Crf-analoga. - Google Patents
Crf-analoga.Info
- Publication number
- ATE88481T1 ATE88481T1 AT85301093T AT85301093T ATE88481T1 AT E88481 T1 ATE88481 T1 AT E88481T1 AT 85301093 T AT85301093 T AT 85301093T AT 85301093 T AT85301093 T AT 85301093T AT E88481 T1 ATE88481 T1 AT E88481T1
- Authority
- AT
- Austria
- Prior art keywords
- leu
- glu
- ala
- gln
- agonists
- Prior art date
Links
- 239000000556 agonist Substances 0.000 abstract 4
- 102100027467 Pro-opiomelanocortin Human genes 0.000 abstract 3
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 2
- 125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 101800005049 Beta-endorphin Proteins 0.000 abstract 1
- OMFXVFTZEKFJBZ-UHFFFAOYSA-N Corticosterone Natural products O=C1CCC2(C)C3C(O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 OMFXVFTZEKFJBZ-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 108010069820 Pro-Opiomelanocortin Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 108010042362 beta-Lipotropin Proteins 0.000 abstract 1
- WOPZMFQRCBYPJU-NTXHZHDSSA-N beta-endorphin Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CC=CC=C1 WOPZMFQRCBYPJU-NTXHZHDSSA-N 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 abstract 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 1
- 229960000258 corticotropin Drugs 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 230000036651 mood Effects 0.000 abstract 1
- AOCUKGFDRUSDQH-PIKKTMSISA-N ocrf Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)C(C)CC)[C@@H](C)O)C(C)C)C(C)O)C1=CNC=N1 AOCUKGFDRUSDQH-PIKKTMSISA-N 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000021 stimulant Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Train Traffic Observation, Control, And Security (AREA)
- Developing Agents For Electrophotography (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Details Of Television Scanning (AREA)
- Amplifiers (AREA)
- Polyesters Or Polycarbonates (AREA)
- Steroid Compounds (AREA)
- Control Of Eletrric Generators (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Vehicle Body Suspensions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/583,092 US4605642A (en) | 1984-02-23 | 1984-02-23 | CRF antagonists |
| US06/610,110 US4594329A (en) | 1984-05-14 | 1984-05-14 | CRF analogs |
| EP85301093A EP0153845B1 (en) | 1984-02-23 | 1985-02-19 | Crf analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE88481T1 true ATE88481T1 (de) | 1993-05-15 |
Family
ID=27078728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85301093T ATE88481T1 (de) | 1984-02-23 | 1985-02-19 | Crf-analoga. |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP0153845B1 (enExample) |
| JP (1) | JPH0742318B2 (enExample) |
| KR (1) | KR870000812B1 (enExample) |
| AT (1) | ATE88481T1 (enExample) |
| AU (1) | AU585500B2 (enExample) |
| DE (1) | DE3587276T2 (enExample) |
| DK (1) | DK172518B1 (enExample) |
| ES (1) | ES8606403A1 (enExample) |
| FI (1) | FI91413C (enExample) |
| GR (1) | GR850454B (enExample) |
| IE (2) | IE63601B1 (enExample) |
| NO (1) | NO171729C (enExample) |
| WO (1) | WO1985003705A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3703340A1 (de) * | 1987-02-04 | 1988-08-18 | Dirck Dr Med Oppermann | Pharmazeutische zubereitung zur behandlung der herzinsuffizienz |
| IE64788B1 (en) * | 1988-06-21 | 1995-09-06 | Salk Inst For Biological Studi | CRF analogs |
| CA1341051C (en) * | 1988-09-23 | 2000-07-11 | Jean Edouard Frederic Rivier | Crf antagonists |
| CA1340964C (en) * | 1988-09-30 | 2000-04-18 | Jean E. F. Rivier | Crf analogs |
| CA2002004A1 (en) * | 1988-11-14 | 1990-05-14 | Karl P. Lederis | Fish crf |
| CA2075718C (en) * | 1990-03-23 | 2001-08-07 | Jean E. F. Rivier | Crf analogs |
| US5235036A (en) * | 1991-05-31 | 1993-08-10 | The Salk Institute For Biological Studies | Crf analogs |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4244946A (en) * | 1979-06-11 | 1981-01-13 | The Salk Institute For Biological Studies | Water-soluble peptides affecting gonadal function |
| US4415558A (en) * | 1981-06-08 | 1983-11-15 | The Salk Institute For Biological Studies | CRF And analogs |
| GR75679B (enExample) * | 1981-06-08 | 1984-08-02 | Salk Inst For Biological Studi | |
| US4385050A (en) * | 1981-06-26 | 1983-05-24 | Armour Pharmaceutical Company | Antihypertensive polypeptides |
| WO1984001378A1 (en) * | 1982-09-29 | 1984-04-12 | Karl P Lederis | Urotensin peptides |
| US4489163A (en) * | 1983-04-14 | 1984-12-18 | The Salk Institute For Biological Studies | rCRF and analogs |
-
1985
- 1985-02-19 DE DE8585301093T patent/DE3587276T2/de not_active Expired - Lifetime
- 1985-02-19 EP EP85301093A patent/EP0153845B1/en not_active Expired - Lifetime
- 1985-02-19 EP EP92115541A patent/EP0518391A1/en not_active Ceased
- 1985-02-19 AT AT85301093T patent/ATE88481T1/de not_active IP Right Cessation
- 1985-02-21 KR KR1019850700252A patent/KR870000812B1/ko not_active Expired
- 1985-02-21 JP JP60501132A patent/JPH0742318B2/ja not_active Expired - Lifetime
- 1985-02-21 WO PCT/US1985/000297 patent/WO1985003705A1/en not_active Ceased
- 1985-02-21 GR GR850454A patent/GR850454B/el unknown
- 1985-02-21 AU AU40693/85A patent/AU585500B2/en not_active Expired
- 1985-02-22 ES ES540632A patent/ES8606403A1/es not_active Expired
- 1985-02-22 IE IE45285A patent/IE63601B1/en not_active IP Right Cessation
- 1985-02-22 IE IE940016A patent/IE64241B1/en not_active IP Right Cessation
- 1985-10-22 NO NO85854208A patent/NO171729C/no not_active IP Right Cessation
- 1985-10-22 FI FI854122A patent/FI91413C/fi not_active IP Right Cessation
- 1985-10-23 DK DK198504866A patent/DK172518B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0153845A3 (en) | 1988-09-07 |
| FI854122A0 (fi) | 1985-10-22 |
| AU585500B2 (en) | 1989-06-22 |
| DK172518B1 (da) | 1998-11-09 |
| FI91413C (fi) | 1994-06-27 |
| NO171729C (no) | 1993-04-28 |
| KR870000812B1 (ko) | 1987-04-20 |
| IE63601B1 (en) | 1995-05-17 |
| DE3587276T2 (de) | 1993-07-29 |
| IE64241B1 (en) | 1995-07-26 |
| IE850452L (en) | 1985-08-23 |
| JPS61502396A (ja) | 1986-10-23 |
| ES8606403A1 (es) | 1986-04-16 |
| EP0153845B1 (en) | 1993-04-21 |
| EP0518391A1 (en) | 1992-12-16 |
| DK486685A (da) | 1985-10-23 |
| NO854208L (no) | 1985-12-20 |
| AU4069385A (en) | 1985-09-10 |
| NO171729B (no) | 1993-01-18 |
| ES540632A0 (es) | 1986-04-16 |
| KR850700246A (ko) | 1985-12-26 |
| FI854122L (fi) | 1985-10-22 |
| GR850454B (enExample) | 1985-06-19 |
| IE940016L (en) | 1985-08-23 |
| FI91413B (fi) | 1994-03-15 |
| JPH0742318B2 (ja) | 1995-05-10 |
| WO1985003705A1 (en) | 1985-08-29 |
| DK486685D0 (da) | 1985-10-23 |
| EP0153845A2 (en) | 1985-09-04 |
| DE3587276D1 (de) | 1993-05-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE96807T1 (de) | Rcrf und aehnliche verbindungen. | |
| ATE88481T1 (de) | Crf-analoga. | |
| EP0361954A3 (en) | Crf analogs | |
| DE68918271D1 (de) | Crf-analoge. | |
| DE69129985D1 (de) | Crf-analoge | |
| ES2057147T3 (es) | Crf de pescado. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EELA | Cancelled due to lapse of time |