DK172350B1 - Hirudin-derivat, DNA, der koder derfor, vektorer, der indeholder en sådan DNA, fremstilling af hirudin-derivatet samt lægemiddel indeholdende dette - Google Patents

Hirudin-derivat, DNA, der koder derfor, vektorer, der indeholder en sådan DNA, fremstilling af hirudin-derivatet samt lægemiddel indeholdende dette Download PDF

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Publication number
DK172350B1
DK172350B1 DK013189A DK13189A DK172350B1 DK 172350 B1 DK172350 B1 DK 172350B1 DK 013189 A DK013189 A DK 013189A DK 13189 A DK13189 A DK 13189A DK 172350 B1 DK172350 B1 DK 172350B1
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DK
Denmark
Prior art keywords
gly
glu
dna
thr
cys
Prior art date
Application number
DK013189A
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Danish (da)
English (en)
Other versions
DK13189D0 (da
DK13189A (da
Inventor
Peter Crause
Paul Habermann
Dominique Tripier
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25865106&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK172350(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from HU851341A external-priority patent/HU198085B/hu
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK13189D0 publication Critical patent/DK13189D0/da
Publication of DK13189A publication Critical patent/DK13189A/da
Application granted granted Critical
Publication of DK172350B1 publication Critical patent/DK172350B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK013189A 1985-04-11 1989-01-12 Hirudin-derivat, DNA, der koder derfor, vektorer, der indeholder en sådan DNA, fremstilling af hirudin-derivatet samt lægemiddel indeholdende dette DK172350B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU851341A HU198085B (en) 1984-04-18 1985-04-11 Process for producing new hirudine derivatives with anticoagulant effect and pharmaceutical compositions comprising same as active ingredient
HU134185 1985-04-11
DE3805540 1988-02-23
DE3805540 1988-02-23

Publications (3)

Publication Number Publication Date
DK13189D0 DK13189D0 (da) 1989-01-12
DK13189A DK13189A (da) 1989-07-14
DK172350B1 true DK172350B1 (da) 1998-04-06

Family

ID=25865106

Family Applications (1)

Application Number Title Priority Date Filing Date
DK013189A DK172350B1 (da) 1985-04-11 1989-01-12 Hirudin-derivat, DNA, der koder derfor, vektorer, der indeholder en sådan DNA, fremstilling af hirudin-derivatet samt lægemiddel indeholdende dette

Country Status (9)

Country Link
EP (1) EP0324712B1 (fi)
AT (1) ATE87938T1 (fi)
DE (2) DE19775033I2 (fi)
DK (1) DK172350B1 (fi)
ES (1) ES2055149T3 (fi)
FI (1) FI96956C (fi)
IL (1) IL88925A (fi)
LU (1) LU90127I2 (fi)
NL (1) NL970027I2 (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3835815A1 (de) * 1988-10-21 1990-04-26 Hoechst Ag Neue isohirudine
JP3187044B2 (ja) * 1989-12-01 2001-07-11 ビーエーエスエフ アクチェンゲゼルシャフト ヒルジン突然変異蛋白質及びヒルジンポリアルキレングリコール複合体
DE4140381A1 (de) * 1991-12-07 1993-06-09 Hoechst Ag, 6230 Frankfurt, De Neue synthetische isohirudine mit verbesserter stabilitaet
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
DE19529997C1 (de) 1995-08-16 1997-04-10 Hoechst Ag Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen
DE19543737A1 (de) 1995-11-24 1997-05-28 Hoechst Ag Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices
DE19544233A1 (de) 1995-11-28 1997-06-05 Hoechst Ag Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten
DE69625623T2 (de) 1996-01-31 2003-11-06 Sumitomo Bakelite Co Verfahren zur Herstellung von in Epoxyharz eingekapselter Halbleitervorrichtung
DE19607239A1 (de) 1996-02-27 1997-08-28 Behringwerke Ag Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung
DE19944870A1 (de) * 1999-09-18 2001-03-29 Aventis Pharma Gmbh Signalsequenzen zur Herstellung von Leu-Hirudin über Sekretion durch E. coli in das Kulturmedium
DE10033195A1 (de) * 2000-07-07 2002-03-21 Aventis Pharma Gmbh Bifunktionale Fusionsproteine aus Hirudin und TAP
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
JP2006096668A (ja) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.

Also Published As

Publication number Publication date
FI890127A (fi) 1989-07-14
DK13189D0 (da) 1989-01-12
NL970027I1 (nl) 1997-10-01
LU90127I2 (fr) 1997-10-06
IL88925A (en) 1995-11-27
DK13189A (da) 1989-07-14
ES2055149T3 (es) 1994-08-16
FI890127A0 (fi) 1989-01-11
EP0324712A3 (en) 1990-07-04
EP0324712B1 (de) 1993-04-07
FI96956B (fi) 1996-06-14
ATE87938T1 (de) 1993-04-15
EP0324712A2 (de) 1989-07-19
DE58903988D1 (de) 1993-05-13
DE19775033I2 (de) 2011-01-20
FI96956C (fi) 1996-09-25
NL970027I2 (nl) 1998-04-01

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1998 00017, 19980520, EXPIRES: 20120313

CTFG Supplementary protection certificate (spc) issued

Spc suppl protection certif: CA 1998 00017

PUP Patent expired