DK172235B1 - Azelastinholdigt lægemiddel med kontrolleret frigivelse af det aktive stof - Google Patents

Azelastinholdigt lægemiddel med kontrolleret frigivelse af det aktive stof Download PDF

Info

Publication number
DK172235B1
DK172235B1 DK189189A DK189189A DK172235B1 DK 172235 B1 DK172235 B1 DK 172235B1 DK 189189 A DK189189 A DK 189189A DK 189189 A DK189189 A DK 189189A DK 172235 B1 DK172235 B1 DK 172235B1
Authority
DK
Denmark
Prior art keywords
azelastine
active substance
substances
acid
release
Prior art date
Application number
DK189189A
Other languages
Danish (da)
English (en)
Other versions
DK189189D0 (da
DK189189A (da
Inventor
Helmut Hettche
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of DK189189D0 publication Critical patent/DK189189D0/da
Publication of DK189189A publication Critical patent/DK189189A/da
Application granted granted Critical
Publication of DK172235B1 publication Critical patent/DK172235B1/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585Ion exchange resins, e.g. polystyrene sulfonic acid resin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5026Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Switches With Compound Operations (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Rotary Pumps (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK189189A 1988-04-20 1989-04-19 Azelastinholdigt lægemiddel med kontrolleret frigivelse af det aktive stof DK172235B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3813244 1988-04-20
DE3813244 1988-04-20

Publications (3)

Publication Number Publication Date
DK189189D0 DK189189D0 (da) 1989-04-19
DK189189A DK189189A (da) 1989-10-21
DK172235B1 true DK172235B1 (da) 1998-02-02

Family

ID=6352451

Family Applications (1)

Application Number Title Priority Date Filing Date
DK189189A DK172235B1 (da) 1988-04-20 1989-04-19 Azelastinholdigt lægemiddel med kontrolleret frigivelse af det aktive stof

Country Status (15)

Country Link
EP (1) EP0338444B1 (pt)
JP (1) JP2950845B2 (pt)
AT (1) ATE97572T1 (pt)
AU (1) AU3318389A (pt)
CA (1) CA1325976C (pt)
DE (1) DE58906232D1 (pt)
DK (1) DK172235B1 (pt)
ES (1) ES2060685T3 (pt)
FI (1) FI891865A (pt)
HK (1) HK134494A (pt)
HU (1) HU202403B (pt)
IE (1) IE62778B1 (pt)
MC (1) MC2025A1 (pt)
PT (1) PT90308B (pt)
ZA (1) ZA892877B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9003903D0 (sv) * 1990-12-07 1990-12-07 Astra Ab New pharmaceutical formulations
DE4207234A1 (de) * 1992-03-07 1993-09-09 Asta Medica Ag Neue aminocarbonsaeure-derivate mit antiallergischer/antiasthmatischer wirkung und verfahren zu deren herstellung
JPH0710747A (ja) * 1993-04-28 1995-01-13 Takeda Chem Ind Ltd 固形製剤およびその製造方法
GB9514842D0 (en) * 1995-07-20 1995-09-20 Smithkline Beecham Plc Novel formulation
JP4138910B2 (ja) * 1997-07-02 2008-08-27 帝國製薬株式会社 経皮吸収性が良好で且つ皮膚刺激性の少ない塩酸アゼラスチン含有経皮製剤
UA67802C2 (uk) * 1998-10-23 2004-07-15 Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції
KR20070051953A (ko) 1998-11-02 2007-05-18 엘란 코포레이션, 피엘씨 다입자 변형 방출 조성물
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
HU230828B1 (en) 1999-10-29 2018-08-28 Euro Celtique Sa Controlled release hydrocodone formulations
CN101317825A (zh) 2000-10-30 2008-12-10 欧罗赛铁克股份有限公司 控释氢可酮制剂
EP1396263A1 (en) * 2002-08-09 2004-03-10 Warner-Lambert Company Film coating for tablets and caplets
US20070218139A1 (en) * 2002-12-20 2007-09-20 Smith Thomas J High Pressure Compaction For Pharmaceutical Formulations
DK2486942T3 (en) * 2004-11-24 2019-01-28 Meda Pharmaceuticals Inc COMPOSITIONS CONTAINING AZELASTINE AND PROCEDURES FOR USING IT
WO2014153541A1 (en) 2013-03-21 2014-09-25 Eupraxia Pharmaceuticals USA LLC Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith
EP3206672B1 (en) 2015-10-27 2018-03-14 Eupraxia Pharmaceuticals Inc. Sustained release formulations of local anesthetics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3575135D1 (de) * 1984-09-14 1990-02-08 Asta Pharma Ag Substituierte benzylphthalazinon-derivate.

Also Published As

Publication number Publication date
HU202403B (en) 1991-03-28
DK189189D0 (da) 1989-04-19
DK189189A (da) 1989-10-21
JP2950845B2 (ja) 1999-09-20
FI891865A0 (fi) 1989-04-19
HK134494A (en) 1994-12-09
JPH01311024A (ja) 1989-12-15
PT90308A (pt) 1989-11-10
EP0338444A1 (de) 1989-10-25
ES2060685T3 (es) 1994-12-01
IE62778B1 (en) 1995-02-22
ATE97572T1 (de) 1993-12-15
FI891865A (fi) 1989-10-21
EP0338444B1 (de) 1993-11-24
IE891263L (en) 1989-10-20
HUT49808A (en) 1989-11-28
AU3318389A (en) 1989-10-26
ZA892877B (en) 1989-12-27
PT90308B (pt) 1994-10-31
MC2025A1 (fr) 1990-04-25
CA1325976C (en) 1994-01-11
DE58906232D1 (de) 1994-01-05

Similar Documents

Publication Publication Date Title
US5271946A (en) Controlled release azelastine-containing pharmaceutical compositions
DK172235B1 (da) Azelastinholdigt lægemiddel med kontrolleret frigivelse af det aktive stof
KR101489401B1 (ko) 약 염기성 약물과 유기산을 포함하는 약물 전달 시스템
JP3403203B2 (ja) ダリフェナシン含有製剤
JP5285913B2 (ja) 経口投与できる固体の放出改変型医薬投与形
US7838027B2 (en) Pantoprazole multiparticulate formulations
JP2007070363A (ja) 持続性放出被覆を有する不溶性医薬品の即時放出錠剤コア
JP2005516020A (ja) ゼロ次持続放出剤形およびその製造方法
CN1244119A (zh) 迅速释放和掩蔽味觉的药物剂型
PT655240E (pt) Nucleos comprimidos de libertacao imediata de drogas insoluveis, com um revestimento de libertacao controlada
PT642335E (pt) Preparacao de um sal de morfina de libertacao controlada
SG184388A1 (en) Pharmaceutical formulations for the treatment of overactive bladder
BRPI0615014A2 (pt) composição farmacêutica sólida compreendendo 1-(4-cloroanilino)-4-(4-piridilmetil)ftalazina e um modificador de ph e uso da mesma
US20100047343A1 (en) Multiparticulate formulation having tramadol in immediate and controlled release form
JP2022163681A (ja) 治療方法
EP0615754A1 (de) Feste Flupirtin enthaltende orale Darreichungsformen mit kontrollierter Wirkstoffabgabe
JP2000080028A (ja) 長持続時間を有するシサプリドの経口剤形
KR101436516B1 (ko) 코팅된 펠렛을 함유하는 현탁정 및 이의 제조방법
JP2000053563A (ja) 苦味がマスクされた速放性細粒剤
ES2429436T3 (es) Preparaciones de liberación lenta y procedimiento para la producción de las mismas
CN103860464A (zh) 一种抗过敏药物缓释混悬剂及其制备方法
JP2007332102A (ja) 腸溶性顆粒剤及びその製造方法
JP2000502066A (ja) 徐放性シサプリド
DE3912292A1 (de) Azelastin enthaltende arzneimittel mit kontrollierter wirkstoffabgabe
CN101209245A (zh) 含氨氯地平的粒子及含有其的口腔崩解片

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired