DK171987B1 - Oxaspiro(2,5)octanderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne - Google Patents

Oxaspiro(2,5)octanderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne Download PDF

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Publication number
DK171987B1
DK171987B1 DK390989A DK390989A DK171987B1 DK 171987 B1 DK171987 B1 DK 171987B1 DK 390989 A DK390989 A DK 390989A DK 390989 A DK390989 A DK 390989A DK 171987 B1 DK171987 B1 DK 171987B1
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DK
Denmark
Prior art keywords
alkyl
alkylcarbamoyl
compound
formula
hydroxy
Prior art date
Application number
DK390989A
Other languages
Danish (da)
English (en)
Other versions
DK390989D0 (da
DK390989A (da
Inventor
Teruo Oku
Chiyoshi Kasahara
Takehiko Ohkawa
Masashi Hashimoto
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888819258A external-priority patent/GB8819258D0/en
Priority claimed from GB888819256A external-priority patent/GB8819256D0/en
Priority claimed from GB898908029A external-priority patent/GB8908029D0/en
Priority claimed from GB898909794A external-priority patent/GB8909794D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of DK390989D0 publication Critical patent/DK390989D0/da
Publication of DK390989A publication Critical patent/DK390989A/da
Application granted granted Critical
Publication of DK171987B1 publication Critical patent/DK171987B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Dental Preparations (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Seasonings (AREA)
  • Cereal-Derived Products (AREA)
DK390989A 1988-08-12 1989-08-09 Oxaspiro(2,5)octanderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne DK171987B1 (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB888819258A GB8819258D0 (en) 1988-08-12 1988-08-12 Oxaspiro(2 5)octane compound
GB888819256A GB8819256D0 (en) 1988-08-12 1988-08-12 Oxaspiro(2 5)octane derivative
GB8819258 1988-08-12
GB8819256 1988-08-12
GB8908029 1989-04-10
GB898908029A GB8908029D0 (en) 1989-04-10 1989-04-10 Oxaspriro(2,5)octane derivative
GB898909794A GB8909794D0 (en) 1989-04-28 1989-04-28 Cyclohexane derivative
GB8909794 1989-04-28

Publications (3)

Publication Number Publication Date
DK390989D0 DK390989D0 (da) 1989-08-09
DK390989A DK390989A (da) 1990-02-13
DK171987B1 true DK171987B1 (da) 1997-09-08

Family

ID=27450157

Family Applications (1)

Application Number Title Priority Date Filing Date
DK390989A DK171987B1 (da) 1988-08-12 1989-08-09 Oxaspiro(2,5)octanderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne

Country Status (18)

Country Link
US (2) US5789405A (de)
EP (1) EP0354787B1 (de)
JP (2) JP2773275B2 (de)
KR (1) KR0130765B1 (de)
CN (1) CN1051703C (de)
AT (1) ATE118490T1 (de)
AU (1) AU632056B2 (de)
CA (1) CA1340291C (de)
DE (1) DE68921114T2 (de)
DK (1) DK171987B1 (de)
ES (1) ES2067546T3 (de)
FI (1) FI97805C (de)
GR (1) GR3015382T3 (de)
HU (1) HU211569A9 (de)
IE (1) IE66923B1 (de)
IL (1) IL91250A (de)
NO (1) NO173236C (de)
PH (1) PH26256A (de)

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PH26256A (en) * 1988-08-12 1992-04-01 Fujisawa Pharmaceutical Co Oxaspiro [2,5] octane derivative
JPH0660095B2 (ja) * 1988-09-01 1994-08-10 武田薬品工業株式会社 血管新生阻害剤
EP0359036B1 (de) * 1988-09-01 1997-03-26 Takeda Chemical Industries, Ltd. Fumagillol-Derivate
JPH0660168B2 (ja) * 1988-09-01 1994-08-10 武田薬品工業株式会社 ０―置換フマギロール誘導体
EP0387650B1 (de) * 1989-03-06 1993-03-31 Takeda Chemical Industries, Ltd. 6-Epifumagillole, ihre Herstellung und ihre Verwendung
US5290807A (en) * 1989-08-10 1994-03-01 Children's Medical Center Corporation Method for regressing angiogenesis using o-substituted fumagillol derivatives
US6017954A (en) * 1989-08-10 2000-01-25 Children's Medical Center Corp. Method of treating tumors using O-substituted fumagillol derivatives
EP0415294A3 (en) * 1989-08-31 1991-06-12 Takeda Chemical Industries, Ltd. Cyclohexanol derivatives, production and use thereof
TW282399B (de) * 1990-05-25 1996-08-01 Takeda Pharm Industry Co Ltd
DE69231457T2 (de) * 1991-06-21 2001-05-23 Takeda Chemical Industries Ltd Zyklodextrin-Zusammensetzung enthaltend Fumagillol-Derivate
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US5710148A (en) * 1995-03-06 1998-01-20 Senju Pharmaceuticals Co., Ltd. Corneal opacification inhibitory composition
FR2733498B1 (fr) * 1995-04-27 1997-05-30 Adir Nouveaux composes cyclohexaniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2733499B1 (fr) * 1995-04-27 1997-05-30 Adir Nouvelles tetrahydropyrano(3,2-d)oxazolones substituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5798356A (en) * 1995-08-07 1998-08-25 Alcon Laboratories, Inc. Angiostatic compounds
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WO1997013509A1 (fr) * 1995-10-11 1997-04-17 Fujisawa Pharmaceutical Co., Ltd. Inhibiteur de permeation vasculaire
US6207704B1 (en) 1997-06-09 2001-03-27 Massachusetts Institute Of Technology Type 2 methionine aminopeptidase [MetAP2] inhibitors and uses thereof
WO1999061432A1 (en) * 1998-05-12 1999-12-02 Biochem Pharma Inc. Fumagillin analogs and their use as angiogenesis inhibitors
KR100357541B1 (ko) * 1998-05-15 2002-10-18 주식회사종근당 5-데메톡시 푸마질롤 유도체 및 그 제조방법
KR100357542B1 (ko) * 1998-05-15 2002-10-18 주식회사종근당 푸마질롤 유도체 및 그 제조방법
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WO2012154676A1 (en) 2011-05-06 2012-11-15 Zafgen Corporation Partially saturated tricyclic compounds and methods of making and using same
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Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
JPH0629278B2 (ja) * 1985-06-26 1994-04-20 藤沢薬品工業株式会社 オキサスピロオクタン化合物
PH26256A (en) * 1988-08-12 1992-04-01 Fujisawa Pharmaceutical Co Oxaspiro [2,5] octane derivative
EP0359036B1 (de) * 1988-09-01 1997-03-26 Takeda Chemical Industries, Ltd. Fumagillol-Derivate
KR0141692B1 (ko) * 1988-09-01 1998-06-01 우메모또 요시마사 맥관 형성 억제제
JPH0660168B2 (ja) * 1988-09-01 1994-08-10 武田薬品工業株式会社 ０―置換フマギロール誘導体
EP0387650B1 (de) * 1989-03-06 1993-03-31 Takeda Chemical Industries, Ltd. 6-Epifumagillole, ihre Herstellung und ihre Verwendung

Also Published As

Publication number Publication date
GR3015382T3 (en) 1995-06-30
KR0130765B1 (ko) 1998-04-09
JP2970524B2 (ja) 1999-11-02
FI893794A (fi) 1990-02-13
NO173236C (no) 1993-11-17
IE892505L (en) 1990-02-12
PH26256A (en) 1992-04-01
CN1079898A (zh) 1993-12-29
NO173236B (no) 1993-08-09
AU632056B2 (en) 1992-12-17
DK390989D0 (da) 1989-08-09
DE68921114T2 (de) 1995-06-08
IL91250A (en) 1994-10-21
EP0354787A1 (de) 1990-02-14
FI97805C (fi) 1997-02-25
JP2773275B2 (ja) 1998-07-09
KR900003164A (ko) 1990-03-23
CN1051703C (zh) 2000-04-26
IE66923B1 (en) 1996-02-07
AU3945389A (en) 1990-02-15
US5767293A (en) 1998-06-16
DK390989A (da) 1990-02-13
JPH08319281A (ja) 1996-12-03
DE68921114D1 (de) 1995-03-23
JPH0285272A (ja) 1990-03-26
EP0354787B1 (de) 1995-02-15
FI97805B (fi) 1996-11-15
CA1340291C (en) 1998-12-29
ATE118490T1 (de) 1995-03-15
IL91250A0 (en) 1990-03-19
FI893794A0 (fi) 1989-08-11
HU211569A9 (en) 1995-12-28
NO893235D0 (no) 1989-08-11
NO893235L (no) 1990-02-13
ES2067546T3 (es) 1995-04-01
US5789405A (en) 1998-08-04

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