NO173236C - Analogifremgangsmaate for fremstilling av terapeutisk aktive oksaspiro(2.5)oktanderivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive oksaspiro(2.5)oktanderivater

Info

Publication number
NO173236C
NO173236C NO893235A NO893235A NO173236C NO 173236 C NO173236 C NO 173236C NO 893235 A NO893235 A NO 893235A NO 893235 A NO893235 A NO 893235A NO 173236 C NO173236 C NO 173236C
Authority
NO
Norway
Prior art keywords
alkylcarbamoyl
alkyl
hydroxy
alkenoyl
oxaspiro
Prior art date
Application number
NO893235A
Other languages
English (en)
Other versions
NO173236B (no
NO893235L (no
NO893235D0 (no
Inventor
Teruo Oku
Chiyoshi Kasahara
Takehiko Ohkawa
Masashi Hashimoto
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888819258A external-priority patent/GB8819258D0/en
Priority claimed from GB888819256A external-priority patent/GB8819256D0/en
Priority claimed from GB898908029A external-priority patent/GB8908029D0/en
Priority claimed from GB898909794A external-priority patent/GB8909794D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of NO893235D0 publication Critical patent/NO893235D0/no
Publication of NO893235L publication Critical patent/NO893235L/no
Priority to NO930648A priority Critical patent/NO174552C/no
Publication of NO173236B publication Critical patent/NO173236B/no
Publication of NO173236C publication Critical patent/NO173236C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
NO893235A 1988-08-12 1989-08-11 Analogifremgangsmaate for fremstilling av terapeutisk aktive oksaspiro(2.5)oktanderivater NO173236C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO930648A NO174552C (no) 1988-08-12 1993-02-24 Analogifremgangsmåte for fremstilling av angiogenese-hemmende oksaspiro(2.5)oktanderivater

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB888819258A GB8819258D0 (en) 1988-08-12 1988-08-12 Oxaspiro(2 5)octane compound
GB888819256A GB8819256D0 (en) 1988-08-12 1988-08-12 Oxaspiro(2 5)octane derivative
GB898908029A GB8908029D0 (en) 1989-04-10 1989-04-10 Oxaspriro(2,5)octane derivative
GB898909794A GB8909794D0 (en) 1989-04-28 1989-04-28 Cyclohexane derivative

Publications (4)

Publication Number Publication Date
NO893235D0 NO893235D0 (no) 1989-08-11
NO893235L NO893235L (no) 1990-02-13
NO173236B NO173236B (no) 1993-08-09
NO173236C true NO173236C (no) 1993-11-17

Family

ID=27450157

Family Applications (1)

Application Number Title Priority Date Filing Date
NO893235A NO173236C (no) 1988-08-12 1989-08-11 Analogifremgangsmaate for fremstilling av terapeutisk aktive oksaspiro(2.5)oktanderivater

Country Status (18)

Country Link
US (2) US5789405A (no)
EP (1) EP0354787B1 (no)
JP (2) JP2773275B2 (no)
KR (1) KR0130765B1 (no)
CN (1) CN1051703C (no)
AT (1) ATE118490T1 (no)
AU (1) AU632056B2 (no)
CA (1) CA1340291C (no)
DE (1) DE68921114T2 (no)
DK (1) DK171987B1 (no)
ES (1) ES2067546T3 (no)
FI (1) FI97805C (no)
GR (1) GR3015382T3 (no)
HU (1) HU211569A9 (no)
IE (1) IE66923B1 (no)
IL (1) IL91250A (no)
NO (1) NO173236C (no)
PH (1) PH26256A (no)

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PH26256A (en) * 1988-08-12 1992-04-01 Fujisawa Pharmaceutical Co Oxaspiro [2,5] octane derivative
JPH0660095B2 (ja) * 1988-09-01 1994-08-10 武田薬品工業株式会社 血管新生阻害剤
JPH0660168B2 (ja) * 1988-09-01 1994-08-10 武田薬品工業株式会社 ０―置換フマギロール誘導体
EP0359036B1 (en) * 1988-09-01 1997-03-26 Takeda Chemical Industries, Ltd. Fumagillol derivatives
DE69001187T2 (de) * 1989-03-06 1993-07-08 Takeda Chemical Industries Ltd 6-epifumagillole, ihre herstellung und ihre verwendung.
US6017954A (en) * 1989-08-10 2000-01-25 Children's Medical Center Corp. Method of treating tumors using O-substituted fumagillol derivatives
US5290807A (en) * 1989-08-10 1994-03-01 Children's Medical Center Corporation Method for regressing angiogenesis using o-substituted fumagillol derivatives
EP0415294A3 (en) * 1989-08-31 1991-06-12 Takeda Chemical Industries, Ltd. Cyclohexanol derivatives, production and use thereof
TW282399B (no) * 1990-05-25 1996-08-01 Takeda Pharm Industry Co Ltd
EP0519428B1 (en) * 1991-06-21 2000-09-20 Takeda Chemical Industries, Ltd. Cyclodextrin compositions with fumagillol derivates
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ATE153854T1 (de) * 1992-12-16 1997-06-15 Takeda Chemical Industries Ltd Stabile pharmazeutische zubereitung mit fumagillolderivaten
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FR2733499B1 (fr) * 1995-04-27 1997-05-30 Adir Nouvelles tetrahydropyrano(3,2-d)oxazolones substituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2733498B1 (fr) * 1995-04-27 1997-05-30 Adir Nouveaux composes cyclohexaniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5798356A (en) * 1995-08-07 1998-08-25 Alcon Laboratories, Inc. Angiostatic compounds
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BR112013028534A2 (pt) 2011-05-06 2016-09-06 Zafgen Inc compostos tricíclicos parcialmente saturados e métodos para produção e utilização dos mesmos
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Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0629278B2 (ja) * 1985-06-26 1994-04-20 藤沢薬品工業株式会社 オキサスピロオクタン化合物
PH26256A (en) * 1988-08-12 1992-04-01 Fujisawa Pharmaceutical Co Oxaspiro [2,5] octane derivative
EP0359036B1 (en) * 1988-09-01 1997-03-26 Takeda Chemical Industries, Ltd. Fumagillol derivatives
JPH0660168B2 (ja) * 1988-09-01 1994-08-10 武田薬品工業株式会社 ０―置換フマギロール誘導体
ES2053890T3 (es) * 1988-09-01 1994-08-01 Takeda Chemical Industries Ltd Agente inhibidor de la angiogenesis.
DE69001187T2 (de) * 1989-03-06 1993-07-08 Takeda Chemical Industries Ltd 6-epifumagillole, ihre herstellung und ihre verwendung.

Also Published As

Publication number Publication date
DE68921114T2 (de) 1995-06-08
EP0354787B1 (en) 1995-02-15
CA1340291C (en) 1998-12-29
AU3945389A (en) 1990-02-15
EP0354787A1 (en) 1990-02-14
IL91250A0 (en) 1990-03-19
PH26256A (en) 1992-04-01
HU211569A9 (en) 1995-12-28
FI893794A (fi) 1990-02-13
IL91250A (en) 1994-10-21
DK171987B1 (da) 1997-09-08
DE68921114D1 (de) 1995-03-23
ATE118490T1 (de) 1995-03-15
CN1079898A (zh) 1993-12-29
GR3015382T3 (en) 1995-06-30
JPH08319281A (ja) 1996-12-03
FI97805B (fi) 1996-11-15
US5767293A (en) 1998-06-16
NO173236B (no) 1993-08-09
US5789405A (en) 1998-08-04
JP2773275B2 (ja) 1998-07-09
DK390989A (da) 1990-02-13
KR0130765B1 (ko) 1998-04-09
FI97805C (fi) 1997-02-25
IE892505L (en) 1990-02-12
KR900003164A (ko) 1990-03-23
FI893794A0 (fi) 1989-08-11
JP2970524B2 (ja) 1999-11-02
AU632056B2 (en) 1992-12-17
DK390989D0 (da) 1989-08-09
IE66923B1 (en) 1996-02-07
CN1051703C (zh) 2000-04-26
ES2067546T3 (es) 1995-04-01
NO893235L (no) 1990-02-13
NO893235D0 (no) 1989-08-11
JPH0285272A (ja) 1990-03-26

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