RU94045839A - Производные 3-(фенилалкиламиноалкилокси)-5-фенилпиразола, а также способ и промежуточные вещества для их получения, лекарственное средство, содержащее эти соединения - Google Patents

Производные 3-(фенилалкиламиноалкилокси)-5-фенилпиразола, а также способ и промежуточные вещества для их получения, лекарственное средство, содержащее эти соединения

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Publication number
RU94045839A
RU94045839A RU94045839/04A RU94045839A RU94045839A RU 94045839 A RU94045839 A RU 94045839A RU 94045839/04 A RU94045839/04 A RU 94045839/04A RU 94045839 A RU94045839 A RU 94045839A RU 94045839 A RU94045839 A RU 94045839A
Authority
RU
Russia
Prior art keywords
compounds
preparation
well
phenulalkylaminoalkyloxy
drug containing
Prior art date
Application number
RU94045839/04A
Other languages
English (en)
Inventor
Кербах Вольфганг
De]
Млинарик Михаэль
Циглер Дитер
Брюкнер Райнхард
Биленберг Вилли
Original Assignee
Кали-Хеми Фарма ГмбХ (DE)
Кали-Хеми Фарма ГмбХ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кали-Хеми Фарма ГмбХ (DE), Кали-Хеми Фарма ГмбХ filed Critical Кали-Хеми Фарма ГмбХ (DE)
Publication of RU94045839A publication Critical patent/RU94045839A/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Описываются производные 3-(фенилалкиламиноалкилокси)-5-фенилпиразола, обладающие эффектен понижения частоты сердечных сокращений, а также способ их получения. Предлагаемые соединения имеют общую формулу 1, представленную в описании, в которой заместители имеют значения, указанные в описании. Предложено также лекарственное средство, содержащее указанные соединения в качестве активного начала.

Claims (1)

  1. Описываются производные 3-(фенилалкиламиноалкилокси)-5-фенилпиразола, обладающие эффектен понижения частоты сердечных сокращений, а также способ их получения. Предлагаемые соединения имеют общую формулу 1, представленную в описании, в которой заместители имеют значения, указанные в описании. Предложено также лекарственное средство, содержащее указанные соединения в качестве активного начала.
RU94045839/04A 1993-12-08 1994-12-08 Производные 3-(фенилалкиламиноалкилокси)-5-фенилпиразола, а также способ и промежуточные вещества для их получения, лекарственное средство, содержащее эти соединения RU94045839A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4341749.3 1993-12-08
DE4341749A DE4341749A1 (de) 1993-12-08 1993-12-08 3-(Phenylalkylaminoalkyloxy)-5-phenylpyrazol- Verbindungen sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
RU94045839A true RU94045839A (ru) 1996-09-27

Family

ID=6504420

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94045839/04A RU94045839A (ru) 1993-12-08 1994-12-08 Производные 3-(фенилалкиламиноалкилокси)-5-фенилпиразола, а также способ и промежуточные вещества для их получения, лекарственное средство, содержащее эти соединения

Country Status (19)

Country Link
EP (1) EP0663395B1 (ru)
JP (1) JP3492433B2 (ru)
KR (1) KR950017965A (ru)
CN (1) CN1109051A (ru)
AT (1) ATE201200T1 (ru)
AU (1) AU7769494A (ru)
CA (1) CA2137446A1 (ru)
CZ (1) CZ303194A3 (ru)
DE (2) DE4341749A1 (ru)
ES (1) ES2156135T3 (ru)
FI (1) FI945750A (ru)
HU (1) HUT68518A (ru)
IL (1) IL111539A0 (ru)
NO (1) NO944722L (ru)
NZ (1) NZ264883A (ru)
PL (1) PL306155A1 (ru)
RU (1) RU94045839A (ru)
SK (1) SK150694A3 (ru)
ZA (1) ZA949537B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9422708D0 (en) * 1994-11-10 1995-01-04 Zeneca Ltd Herbicides
FR2773153A1 (fr) * 1997-12-29 1999-07-02 Rhone Poulenc Agrochimie Nouveaux composes fongicides
EP1829873A1 (en) * 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Pyrrazole derivatives as sigma receptors antagonists
EP1829866A1 (en) * 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1001161A (en) * 1972-05-05 1976-12-07 Burton K. Wasson 5-(3-substituted amino-2-hydroxypropoxy)1,3-disubstituted pyrazoles and method of preparation
DE2828529A1 (de) * 1978-06-29 1980-01-17 Kali Chemie Pharma Gmbh Neue 5-phenylpyrazol-derivate, verfahren zu deren herstellung und arzneimittel
FR2479219A1 (fr) * 1980-04-01 1981-10-02 Nativelle Sa Ets Amino-alcoxy pyrazoles, procede pour leur preparation, et medicaments les contenant
FR2513996A1 (fr) * 1981-10-02 1983-04-08 Nativelle Sa Ets Derives du pyrazole, procede pour leur preparation et application en therapeutique
DE3424586A1 (de) * 1984-07-04 1986-01-09 Kali-Chemie Pharma Gmbh, 3000 Hannover 3-aminocarbonylmethoxy-5-phenyl-pyrazol-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4040632A1 (de) * 1990-12-19 1992-06-25 Kali Chemie Pharma Gmbh Phenylalkylaminoalkyl-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
FI945750A (fi) 1995-06-09
HU9403458D0 (en) 1995-02-28
AU7769494A (en) 1995-06-15
CA2137446A1 (en) 1995-06-09
JPH07196622A (ja) 1995-08-01
EP0663395B1 (de) 2001-05-16
SK150694A3 (en) 1995-07-11
DE59409756D1 (de) 2001-06-21
ATE201200T1 (de) 2001-06-15
PL306155A1 (en) 1995-06-12
CN1109051A (zh) 1995-09-27
IL111539A0 (en) 1995-01-24
KR950017965A (ko) 1995-07-22
DE4341749A1 (de) 1995-06-14
EP0663395A1 (de) 1995-07-19
JP3492433B2 (ja) 2004-02-03
NO944722L (no) 1995-06-09
FI945750A0 (fi) 1994-12-07
CZ303194A3 (en) 1995-08-16
NZ264883A (en) 1995-12-21
NO944722D0 (no) 1994-12-07
ZA949537B (en) 1995-08-11
HUT68518A (en) 1995-06-28
ES2156135T3 (es) 2001-06-16

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