HUP9801128A2 - Fukopeptidek, eljárás azok előállítására és alkalmazására, valamint ilyen vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Fukopeptidek, eljárás azok előállítására és alkalmazására, valamint ilyen vegyületeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9801128A2
HUP9801128A2 HU9801128A HUP9801128A HUP9801128A2 HU P9801128 A2 HUP9801128 A2 HU P9801128A2 HU 9801128 A HU9801128 A HU 9801128A HU P9801128 A HUP9801128 A HU P9801128A HU P9801128 A2 HUP9801128 A2 HU P9801128A2
Authority
HU
Hungary
Prior art keywords
general formula
pipe powder
peptides
compounds
powder
Prior art date
Application number
HU9801128A
Other languages
English (en)
Inventor
Tetsuya Kajimoto
Chi-Huey Wong
Original Assignee
Novartis Ag.
The Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/407,912 external-priority patent/US5599915A/en
Application filed by Novartis Ag., The Scripps Research Institute filed Critical Novartis Ag.
Publication of HUP9801128A2 publication Critical patent/HUP9801128A2/hu
Publication of HUP9801128A3 publication Critical patent/HUP9801128A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A találmány fűkőpeptidekre, azők előállítására és alkalmazásáraszőlgáló eljárásőkra, valamint fűkőpeptideket tartalmazógyógyszerkészítményekre vőnatkőzik. A találmány tárgya képező vegyületek (I) általánős képletében (i) R jelentése metilcsőpőrt, R1 jelentése pedig (a1), (a2), (b) vagy(c) csőpőrt, vagy (ii) R1 jelentése hidrőxilcsőpőrt, R jelentése pedig (d) általánősképletű csőpőrt. A találmány szerinti (I) általánős képletű vegyületeket szelektinekmegkötődésével kapcsőlatős rendellenességek kezelésére alkalmasgyógyszerként alkalmazzák. A találmány szerinti gyógyszerkészítmények valamilyen farmakőlógiaiszempőntból hígítóanyag vagy hőrdőzóanyag mellett hatóanyagként (I)általánős képletű vegyületet tartalmaznak. ŕ
HU9801128A 1995-03-21 1996-03-21 Fucopeptides HUP9801128A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/407,912 US5599915A (en) 1995-03-21 1995-03-21 Sialyl Lewis X mimetics
US08/519,203 US5614615A (en) 1995-03-21 1995-08-25 Sialyl Lewis X mimetics incorporating fucopeptides

Publications (2)

Publication Number Publication Date
HUP9801128A2 true HUP9801128A2 (hu) 1998-09-28
HUP9801128A3 HUP9801128A3 (en) 1999-06-28

Family

ID=27020064

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801128A HUP9801128A3 (en) 1995-03-21 1996-03-21 Fucopeptides

Country Status (17)

Country Link
US (3) US5614615A (hu)
EP (1) EP0815127A1 (hu)
JP (1) JPH11502216A (hu)
KR (1) KR19980703171A (hu)
CN (1) CN1184483A (hu)
AU (1) AU5147496A (hu)
BR (1) BR9607795A (hu)
CA (1) CA2214107A1 (hu)
CZ (1) CZ294597A3 (hu)
FI (1) FI973503A (hu)
HU (1) HUP9801128A3 (hu)
NO (1) NO974320L (hu)
NZ (1) NZ304317A (hu)
PL (1) PL322361A1 (hu)
SK (1) SK127797A3 (hu)
TR (1) TR199700974T1 (hu)
WO (1) WO1996029339A1 (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277975B1 (en) * 1992-10-23 2001-08-21 Genetics Institute, Inc. Fusions of P-selectin ligand protein and polynucleotides encoding same
WO1995013094A1 (en) * 1993-11-10 1995-05-18 Bristol-Myers Squibb Company Treatment of bacterially-induced inflammatory diseases
US5614615A (en) * 1995-03-21 1997-03-25 The Scripps Research Institute Sialyl Lewis X mimetics incorporating fucopeptides
AU1144799A (en) * 1997-08-26 1999-03-16 Novartis Ag Organic compounds
AU774419C (en) * 1998-10-30 2005-03-03 Genetics Institute, Llc Inhibition of differentiation of cytotoxic T-cells by P-selectin ligand (PSGL) antagonists
US6960566B1 (en) * 1998-11-06 2005-11-01 The Wister Institute of Anatomy and Biology Compositions and methods for treatment of cancer
UA75083C2 (uk) * 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
DE10056136A1 (de) * 2000-11-07 2002-05-16 Nemod New Modalities Verwendung von Schwangerschaftsproteinen, Liposomen, nativen Muzin-Fragmenten und Mimikry-Verbindungen zur Behandlung und Prophylaxe von entzündlichen Erkrankungen, zur Verhinderung der Metastasierung und zur Prophylaxe von Tumorerkrankungen
FR2861729B1 (fr) * 2003-10-31 2006-09-08 Fabre Pierre Dermo Cosmetique Monomere d'alkyl-rhamnose ou d'alkyl-fucose, medicament comprenant un monomere d'alkyl-sucre reducteur
GB0426661D0 (en) * 2004-12-06 2005-01-05 Isis Innovation Pyrrolidine compounds
FR2899464B1 (fr) * 2006-04-07 2008-06-06 Oreal Compose c-glycoside et utilisation comme agent activateur et regulateur de l'immunite cutanee
FR2899463B1 (fr) * 2006-04-07 2008-05-30 Oreal Utilisation dej compose c-glycoside comme agent activateur et regulateur de l'immunite cutanee
ES2325567B2 (es) * 2007-11-14 2010-02-12 Universidad De Sevilla Tiofucosidos conteniendo polihidroxialquil-furanos. sintesis y usos delos mismos.
ES2324137B2 (es) * 2007-11-14 2010-02-12 Universidad De Sevilla Tiofucosidos conteniendo prolinas hidroxiladas. sintesis y usos de los mismos.
FR2951377B1 (fr) 2009-10-21 2012-06-22 Oreal Association d'un lysat de probiotique et d'un derive c-glycoside
JP6605201B2 (ja) * 2014-12-31 2019-11-13 公益財団法人野口研究所 糖アミノ酸誘導体または糖ペプチド誘導体の製造方法
CN107011203B (zh) * 2017-04-28 2019-03-29 江苏阿尔法药业有限公司 一种lcz696中间体ahu-377的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3871958A (en) * 1972-03-04 1975-03-18 Ajinomoto Kk Biological method of producing serine and serinol derivatives
US5079353A (en) * 1987-12-02 1992-01-07 Chembiomed, Ltd. Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation
AU8007791A (en) * 1990-06-15 1992-01-07 Cytel Corporation Intercellular adhesion mediators
US5143712A (en) * 1990-07-30 1992-09-01 Glycomed Incorporated Method of determining a site of inflammation utilizing elam-1 ligands
US5508387A (en) * 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
US5614615A (en) * 1995-03-21 1997-03-25 The Scripps Research Institute Sialyl Lewis X mimetics incorporating fucopeptides
US5599915A (en) * 1995-03-21 1997-02-04 The Scripps Research Institute Sialyl Lewis X mimetics

Also Published As

Publication number Publication date
FI973503A (fi) 1997-11-21
NO974320D0 (no) 1997-09-19
NZ304317A (en) 1999-01-28
US6111084A (en) 2000-08-29
SK127797A3 (en) 1998-02-04
TR199700974T1 (en) 1998-02-21
MX9707158A (es) 1998-07-31
AU5147496A (en) 1996-10-08
JPH11502216A (ja) 1999-02-23
EP0815127A1 (en) 1998-01-07
WO1996029339A1 (en) 1996-09-26
KR19980703171A (ko) 1998-10-15
NO974320L (no) 1997-10-27
BR9607795A (pt) 1998-07-07
CZ294597A3 (en) 1997-12-17
CA2214107A1 (en) 1996-09-26
US5962660A (en) 1999-10-05
HUP9801128A3 (en) 1999-06-28
FI973503A0 (fi) 1997-08-26
US5614615A (en) 1997-03-25
PL322361A1 (en) 1998-01-19
CN1184483A (zh) 1998-06-10

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