DK390989D0 - Octanforbindelser - Google Patents
OctanforbindelserInfo
- Publication number
- DK390989D0 DK390989D0 DK390989A DK390989A DK390989D0 DK 390989 D0 DK390989 D0 DK 390989D0 DK 390989 A DK390989 A DK 390989A DK 390989 A DK390989 A DK 390989A DK 390989 D0 DK390989 D0 DK 390989D0
- Authority
- DK
- Denmark
- Prior art keywords
- alkylcarbamoyl
- alkyl
- hydroxy
- alkenoyl
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Furan Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Photoreceptors In Electrophotography (AREA)
- Dental Preparations (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cereal-Derived Products (AREA)
- Seasonings (AREA)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888819258A GB8819258D0 (en) | 1988-08-12 | 1988-08-12 | Oxaspiro(2 5)octane compound |
GB8819258 | 1988-08-12 | ||
GB888819256A GB8819256D0 (en) | 1988-08-12 | 1988-08-12 | Oxaspiro(2 5)octane derivative |
GB8819256 | 1988-08-12 | ||
GB8908029 | 1989-04-10 | ||
GB898908029A GB8908029D0 (en) | 1989-04-10 | 1989-04-10 | Oxaspriro(2,5)octane derivative |
GB8909794 | 1989-04-28 | ||
GB898909794A GB8909794D0 (en) | 1989-04-28 | 1989-04-28 | Cyclohexane derivative |
Publications (3)
Publication Number | Publication Date |
---|---|
DK390989D0 true DK390989D0 (da) | 1989-08-09 |
DK390989A DK390989A (da) | 1990-02-13 |
DK171987B1 DK171987B1 (da) | 1997-09-08 |
Family
ID=27450157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK390989A DK171987B1 (da) | 1988-08-12 | 1989-08-09 | Oxaspiro(2,5)octanderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne |
Country Status (18)
Country | Link |
---|---|
US (2) | US5789405A (da) |
EP (1) | EP0354787B1 (da) |
JP (2) | JP2773275B2 (da) |
KR (1) | KR0130765B1 (da) |
CN (1) | CN1051703C (da) |
AT (1) | ATE118490T1 (da) |
AU (1) | AU632056B2 (da) |
CA (1) | CA1340291C (da) |
DE (1) | DE68921114T2 (da) |
DK (1) | DK171987B1 (da) |
ES (1) | ES2067546T3 (da) |
FI (1) | FI97805C (da) |
GR (1) | GR3015382T3 (da) |
HU (1) | HU211569A9 (da) |
IE (1) | IE66923B1 (da) |
IL (1) | IL91250A (da) |
NO (1) | NO173236C (da) |
PH (1) | PH26256A (da) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH26256A (en) * | 1988-08-12 | 1992-04-01 | Fujisawa Pharmaceutical Co | Oxaspiro [2,5] octane derivative |
JPH0660168B2 (ja) * | 1988-09-01 | 1994-08-10 | 武田薬品工業株式会社 | 0―置換フマギロール誘導体 |
EP0682020A1 (en) * | 1988-09-01 | 1995-11-15 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives useful as angiogenesis inhibitors |
JPH0660095B2 (ja) * | 1988-09-01 | 1994-08-10 | 武田薬品工業株式会社 | 血管新生阻害剤 |
DE69001187T2 (de) * | 1989-03-06 | 1993-07-08 | Takeda Chemical Industries Ltd | 6-epifumagillole, ihre herstellung und ihre verwendung. |
US6017954A (en) * | 1989-08-10 | 2000-01-25 | Children's Medical Center Corp. | Method of treating tumors using O-substituted fumagillol derivatives |
US5290807A (en) * | 1989-08-10 | 1994-03-01 | Children's Medical Center Corporation | Method for regressing angiogenesis using o-substituted fumagillol derivatives |
EP0415294A3 (en) * | 1989-08-31 | 1991-06-12 | Takeda Chemical Industries, Ltd. | Cyclohexanol derivatives, production and use thereof |
TW282399B (da) * | 1990-05-25 | 1996-08-01 | Takeda Pharm Industry Co Ltd | |
EP0519428B1 (en) * | 1991-06-21 | 2000-09-20 | Takeda Chemical Industries, Ltd. | Cyclodextrin compositions with fumagillol derivates |
EP0608419A4 (en) * | 1991-09-18 | 1995-01-11 | Fujisawa Pharmaceutical Co | TRANSOCULAR PREPARATION. |
DE69311278T2 (de) * | 1992-12-16 | 1997-10-30 | Takeda Chemical Industries Ltd | Stabile pharmazeutische Zubereitung mit Fumagillolderivaten |
US5710148A (en) * | 1995-03-06 | 1998-01-20 | Senju Pharmaceuticals Co., Ltd. | Corneal opacification inhibitory composition |
FR2733498B1 (fr) * | 1995-04-27 | 1997-05-30 | Adir | Nouveaux composes cyclohexaniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2733499B1 (fr) * | 1995-04-27 | 1997-05-30 | Adir | Nouvelles tetrahydropyrano(3,2-d)oxazolones substituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5798356A (en) * | 1995-08-07 | 1998-08-25 | Alcon Laboratories, Inc. | Angiostatic compounds |
US5719167A (en) * | 1995-08-07 | 1998-02-17 | Alcon Laboratories, Inc. | Angiostatic compounds |
US6180626B1 (en) | 1995-10-11 | 2001-01-30 | Fujisawa Pharmaceutical Co., Ltd. | Vascular-permeability suppressants |
WO1998056372A1 (en) | 1997-06-09 | 1998-12-17 | Massachusetts Institute Of Technology | TYPE 2 METHIONINE AMINOPEPTIDASE (MetAP2) INHIBITORS AND USES THEROF |
WO1999061432A1 (en) * | 1998-05-12 | 1999-12-02 | Biochem Pharma Inc. | Fumagillin analogs and their use as angiogenesis inhibitors |
KR100357542B1 (ko) * | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 푸마질롤 유도체 및 그 제조방법 |
KR100357541B1 (ko) * | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 5-데메톡시 푸마질롤 유도체 및 그 제조방법 |
US6919307B2 (en) * | 2000-11-01 | 2005-07-19 | Praecis Pharmaceuticals, Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
US6548477B1 (en) * | 2000-11-01 | 2003-04-15 | Praecis Pharmaceuticals Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
US7105482B2 (en) | 2000-11-01 | 2006-09-12 | Praecis Pharmaceuticals, Inc. | Methionine aminopeptidase-2 inhibitors and methods of use thereof |
PL366216A1 (en) * | 2000-11-01 | 2005-01-24 | Praecis Pharmaceuticals Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
AU2004312512A1 (en) * | 2003-12-29 | 2005-07-21 | Praecis Pharmaceuticals, Inc. | Inhibitors of methionine aminopeptidase-2 and uses thereof |
EP1976785A4 (en) * | 2006-01-24 | 2012-02-01 | Goss Int Americas Inc | SIGNATURE STORE WITH TOWER ADJUSTMENT DEVICE |
MX2010005857A (es) | 2007-11-28 | 2010-11-22 | Mersana Therapeutics Inc | Conjugados de analogos de fumagillina biodegradables biocompatibles. |
CN102123586A (zh) * | 2008-07-18 | 2011-07-13 | 法弗根股份有限公司 | 治疗超重或肥胖受试者的方法 |
WO2010065883A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Method of treating an overweight or obese subject |
WO2010065877A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Methods of treating an overweight or obese subject |
WO2010138719A1 (en) | 2009-05-28 | 2010-12-02 | Mersana Therapeutics, Inc. | Polyal drug conjugates comprising variable rate-releasing linkers |
EP2486004B1 (en) | 2009-10-09 | 2017-05-03 | Zafgen, Inc. | Sulphone compounds for use in the treatment of obesity |
BR112012016793A2 (pt) | 2010-01-08 | 2018-07-31 | Zafgen Corp | compostos tipo fumagilol e métodos de fazer e usar os mesmos |
WO2011085198A1 (en) | 2010-01-08 | 2011-07-14 | Zafgen Corporation | Metap-2 inhibitor for use in treating benign prostatic hypertrophy (bph) |
WO2011127304A2 (en) | 2010-04-07 | 2011-10-13 | Zafgen Corporation | Methods of treating an overweight subject |
WO2012012642A1 (en) | 2010-07-22 | 2012-01-26 | Zafgen Corporation | Tricyclic compounds and methds of making and using same |
CA2817199C (en) | 2010-11-09 | 2019-01-15 | Zafgen, Inc. | Crystalline solids of a metap-2 inhibitor and methods of making and using same |
MX2013005989A (es) | 2010-11-29 | 2013-08-21 | Zafgen Inc | Tratamiento de obesidad utilizando administracion no diaria de 6-o-(4-dimetilaminoetoxi)cinamoil fumagilol. |
US9321740B2 (en) | 2011-01-26 | 2016-04-26 | Zafgen, Inc. | Tetrazole compounds and methods of making and using same |
BR112013023056A2 (pt) | 2011-03-08 | 2018-10-09 | Zafgen Inc | derivados de oxaespiro [2,5] octano e análogos |
EP2705030B1 (en) | 2011-05-06 | 2016-07-27 | Zafgen, Inc. | Partially saturated tricyclic compounds and methods of making and using same |
AU2012253759B2 (en) | 2011-05-06 | 2016-01-21 | Zafgen Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
EP2705035B1 (en) | 2011-05-06 | 2016-12-14 | Zafgen, Inc. | Tricyclic pyrazole sulfonamide compounds and methods of making and using same |
EP3228325A1 (en) | 2011-06-10 | 2017-10-11 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
EP2763671A2 (en) | 2011-10-03 | 2014-08-13 | Zafgen, Inc. | Methods of treating age related disorders |
AU2013209723B2 (en) | 2012-01-18 | 2016-11-24 | Zafgen, Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
WO2013109735A1 (en) | 2012-01-18 | 2013-07-25 | Zafgen, Inc. | Tricyclic sulfone compounds and methods of making and using same |
KR20150016303A (ko) | 2012-05-07 | 2015-02-11 | 자프겐 인크. | 6-o-(4-디메틸아미노에톡시) 신나모일 푸마지롤의 옥살레이트 염의 다형체 염 및 이의 제조 및 사용 방법 |
CA2872876A1 (en) | 2012-05-08 | 2013-11-14 | Zafgen, Inc. | Treating hypothalamic obesity with metap2 inhibitors |
CN104364251B (zh) * | 2012-05-09 | 2017-02-22 | 扎夫根股份有限公司 | 烟曲霉醇型化合物及其制备和使用方法 |
CN104870433A (zh) | 2012-11-05 | 2015-08-26 | 扎夫根股份有限公司 | 三环化合物及其制备方法和用途 |
MX2015005734A (es) | 2012-11-05 | 2016-02-10 | Zafgen Inc | Metodos de tratamiento de enfermedades hepaticas. |
CN104918928A (zh) | 2012-11-05 | 2015-09-16 | 扎夫根股份有限公司 | 三环化合物及其制备方法和用途 |
CA2892863C (en) | 2012-12-10 | 2022-03-15 | Mersana Therapeutics, Inc. | Polymeric scaffold based on phf for targeted drug delivery |
WO2014093640A1 (en) | 2012-12-12 | 2014-06-19 | Mersana Therapeutics,Inc. | Hydroxy-polmer-drug-protein conjugates |
MX362391B (es) | 2013-03-14 | 2019-01-15 | Zafgen Inc | Métodos de tratamiento de enfermedad renal y otros trastornos. |
JP6427564B2 (ja) | 2013-10-11 | 2018-11-21 | アサナ・バイオサイエンシズ,リミテッド・ライアビリティ・カンパニー | タンパク質−ポリマー−薬物共役体 |
EP3054991B1 (en) | 2013-10-11 | 2019-04-03 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
TW201636342A (zh) | 2014-12-19 | 2016-10-16 | 武田藥品工業有限公司 | 煙黴醇衍生物 |
AR105671A1 (es) | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
CN106432255A (zh) | 2015-08-11 | 2017-02-22 | 扎夫根公司 | 烟曲霉素醇螺环化合物和制备和使用其的方法 |
US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
CN111315414A (zh) | 2017-06-22 | 2020-06-19 | 梅尔莎纳医疗公司 | 产生载药聚合物支架和蛋白-聚合物-药物缀合物的方法 |
CN108530375B (zh) * | 2018-05-29 | 2020-04-21 | 南京药石科技股份有限公司 | 4-氧杂-7-氮杂螺[2.5]辛烷或其盐的中间体及制备方法 |
JP2022513400A (ja) | 2018-10-29 | 2022-02-07 | メルサナ セラピューティクス インコーポレイテッド | ペプチド含有リンカーを有するシステイン操作抗体-薬物コンジュゲート |
WO2023156996A1 (en) * | 2022-02-16 | 2023-08-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Metap2 inhibitors and uses thereof |
WO2024013723A1 (en) | 2022-07-15 | 2024-01-18 | Pheon Therapeutics Ltd | Antibody drug conjugates that bind cdcp1 and uses thereof |
WO2024040009A2 (en) * | 2022-08-17 | 2024-02-22 | Primetime Life Sciences, Llc | Inhibitors of methionine aminopeptidase-2 and methods of preparation and uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0629278B2 (ja) * | 1985-06-26 | 1994-04-20 | 藤沢薬品工業株式会社 | オキサスピロオクタン化合物 |
PH26256A (en) * | 1988-08-12 | 1992-04-01 | Fujisawa Pharmaceutical Co | Oxaspiro [2,5] octane derivative |
KR0141692B1 (ko) * | 1988-09-01 | 1998-06-01 | 우메모또 요시마사 | 맥관 형성 억제제 |
JPH0660168B2 (ja) * | 1988-09-01 | 1994-08-10 | 武田薬品工業株式会社 | 0―置換フマギロール誘導体 |
EP0682020A1 (en) * | 1988-09-01 | 1995-11-15 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives useful as angiogenesis inhibitors |
DE69001187T2 (de) * | 1989-03-06 | 1993-07-08 | Takeda Chemical Industries Ltd | 6-epifumagillole, ihre herstellung und ihre verwendung. |
-
1989
- 1989-08-01 PH PH39029A patent/PH26256A/en unknown
- 1989-08-02 IE IE250589A patent/IE66923B1/en not_active IP Right Cessation
- 1989-08-07 JP JP1204257A patent/JP2773275B2/ja not_active Expired - Lifetime
- 1989-08-08 IL IL9125089A patent/IL91250A/en not_active IP Right Cessation
- 1989-08-09 AU AU39453/89A patent/AU632056B2/en not_active Ceased
- 1989-08-09 DE DE68921114T patent/DE68921114T2/de not_active Expired - Fee Related
- 1989-08-09 DK DK390989A patent/DK171987B1/da not_active IP Right Cessation
- 1989-08-09 AT AT89308113T patent/ATE118490T1/de not_active IP Right Cessation
- 1989-08-09 ES ES89308113T patent/ES2067546T3/es not_active Expired - Lifetime
- 1989-08-09 EP EP89308113A patent/EP0354787B1/en not_active Expired - Lifetime
- 1989-08-10 CA CA000607998A patent/CA1340291C/en not_active Expired - Fee Related
- 1989-08-11 CN CN93104924A patent/CN1051703C/zh not_active Expired - Fee Related
- 1989-08-11 NO NO893235A patent/NO173236C/no unknown
- 1989-08-11 KR KR1019890011591A patent/KR0130765B1/ko not_active IP Right Cessation
- 1989-08-11 FI FI893794A patent/FI97805C/fi not_active IP Right Cessation
-
1991
- 1991-06-05 US US07/711,420 patent/US5789405A/en not_active Expired - Fee Related
-
1994
- 1994-08-05 US US08/287,589 patent/US5767293A/en not_active Expired - Fee Related
-
1995
- 1995-03-13 GR GR950400533T patent/GR3015382T3/el unknown
- 1995-06-22 HU HU95P/P00365P patent/HU211569A9/hu unknown
-
1996
- 1996-03-25 JP JP8067849A patent/JP2970524B2/ja not_active Expired - Fee Related
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Legal Events
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