ATE46335T1 - Piperazinverbindungen als paf-antagonisten. - Google Patents
Piperazinverbindungen als paf-antagonisten.Info
- Publication number
- ATE46335T1 ATE46335T1 AT85307869T AT85307869T ATE46335T1 AT E46335 T1 ATE46335 T1 AT E46335T1 AT 85307869 T AT85307869 T AT 85307869T AT 85307869 T AT85307869 T AT 85307869T AT E46335 T1 ATE46335 T1 AT E46335T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- piperazine compounds
- heterocyclic
- paf
- protected
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 18
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- HVAUUPRFYPCOCA-AREMUKBSSA-N 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C HVAUUPRFYPCOCA-AREMUKBSSA-N 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000004885 piperazines Chemical class 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 108010003541 Platelet Activating Factor Proteins 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 125000005108 alkenylthio group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- -1 asthma Chemical compound 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000008383 nephritis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848427735A GB8427735D0 (en) | 1984-11-02 | 1984-11-02 | Piperazine compound |
| EP85307869A EP0181152B1 (de) | 1984-11-02 | 1985-10-30 | Piperazinverbindungen als PAF-Antagonisten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE46335T1 true ATE46335T1 (de) | 1989-09-15 |
Family
ID=10569141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85307869T ATE46335T1 (de) | 1984-11-02 | 1985-10-30 | Piperazinverbindungen als paf-antagonisten. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0181152B1 (de) |
| KR (1) | KR860004032A (de) |
| AT (1) | ATE46335T1 (de) |
| CA (1) | CA1257265A (de) |
| DE (1) | DE3572978D1 (de) |
| DK (1) | DK499385A (de) |
| ES (1) | ES8702903A1 (de) |
| GB (1) | GB8427735D0 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4806538A (en) * | 1984-11-02 | 1989-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine compound as PAF-antagonist |
| US4694081A (en) * | 1985-09-23 | 1987-09-15 | Monsanto Company | Process to prepare 2,5-diketopiperazines |
| DK181687A (da) * | 1986-04-23 | 1987-10-24 | Fujisawa Pharmaceutical Co | Piperazinderivater og fremgangsmaade til fremstiling deraf |
| DK170617B1 (da) * | 1987-08-11 | 1995-11-13 | Otsuka Pharma Co Ltd | Pyrazinoxidforbindelse NF-1616-904, fremgangsmåde til fremstilling heraf og farmaceutiske præparater indeholdende denne |
| DE3830096A1 (de) * | 1988-09-03 | 1990-03-15 | Hoechst Ag | Piperazindione mit psychotroper wirkung |
| GB8823775D0 (en) * | 1988-10-11 | 1988-11-16 | Scras | New 2-carbonyl substituted n n'-di-(trimethoxybenzoyl)piperazines |
| GB8823776D0 (en) * | 1988-10-11 | 1988-11-16 | Scras | New 2-methoxycarbonyl sustituted n n'-di-(trimethoxybenzoyl)piperazines |
| WO1990009380A1 (fr) * | 1989-02-10 | 1990-08-23 | Otsuka Pharmaceutical Co., Ltd. | Derives d'indole, leur preparation et medicament les contenant destine a la prevention et au traitement de la nephrite |
| US5238938A (en) * | 1989-02-10 | 1993-08-24 | Otsuka Pharmaceutical Co., Ltd. | Indole derivatives |
| DE3909379A1 (de) * | 1989-03-22 | 1990-09-27 | Cassella Ag | Thienylpiperazine, verfahren zu ihrer herstellung, ihre verwendung sowie diese enthaltende arzneimittel und deren herstellung |
| MX9202022A (es) * | 1991-05-01 | 1992-11-01 | Otsuka Pharma Co Ltd | Derivados de pirazina y proceso para su preparacion. |
| US5990112A (en) * | 1996-06-18 | 1999-11-23 | Affymax Technologies N.V. | Inhibitors of metalloproteases pharmaceutical compositions comprising same and methods of their use |
| FR2722787B1 (fr) * | 1994-07-21 | 1996-10-11 | Univ Claude Bernard Lyon | Composes a activite anthelminthique: dicetopiperazines, precurseurs et analogues |
| US5932579A (en) * | 1996-06-18 | 1999-08-03 | Affymax Technologies N.V. | Collagenase-1 and stromelysin-1 inhibitors, pharmaceutical compositions comprising same and methods of their use |
| CA2417960C (en) | 2000-08-04 | 2012-07-10 | Dmi Biosciences, Inc. | Method of using diketopiperazines and composition containing them |
| AR058408A1 (es) | 2006-01-02 | 2008-01-30 | Basf Ag | Compuestos de piperazina con accion herbicida |
| WO2008014613A1 (en) * | 2006-08-04 | 2008-02-07 | Manus Pharmaceuticals (Canada) Ltd. | Multifunctional bioactive compounds |
| CN108947979B (zh) * | 2017-05-22 | 2020-10-16 | 首都医科大学 | 3r-吲哚甲基-6r-极性氨基酸修饰的哌嗪-2,5-二酮，其合成，活性和应用 |
| CN108947978B (zh) * | 2017-05-22 | 2020-12-01 | 首都医科大学 | 3R-吲哚甲基-6R-Tyr修饰的哌嗪-2,5-二酮，其合成，活性和应用 |
| CN108976203B (zh) * | 2017-05-31 | 2020-10-16 | 首都医科大学 | 3S-吲哚甲基-6R-Lys修饰的哌嗪-2,5-二酮，其合成，活性和应用 |
| CN108976205B (zh) * | 2017-06-01 | 2020-07-28 | 首都医科大学 | 3s-吲哚甲基-6r-极性氨基酸修饰的哌嗪-2,5-二酮，其合成，活性和应用 |
| CN108976206B (zh) * | 2017-06-01 | 2020-07-28 | 首都医科大学 | 3S-吲哚甲基-6R-Glu修饰的哌嗪-2,5-二酮，其合成，活性和应用 |
| CN108976209B (zh) * | 2017-06-01 | 2020-07-28 | 首都医科大学 | 3s-吲哚甲基-6r-含n杂环氨基酸修饰的哌嗪-2,5-二酮，其合成，活性和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1600127A (en) * | 1977-03-23 | 1981-10-14 | Wellcome Found | Piperazine-dione derivatives |
| EP0008186A1 (de) * | 1978-08-08 | 1980-02-20 | Beecham Group Plc | Zyklische Diamide, ein Verfahren zu ihrer Herstellung und ihre pharmazeutischen Zusammensetzungen |
-
1984
- 1984-11-02 GB GB848427735A patent/GB8427735D0/en active Pending
-
1985
- 1985-10-29 CA CA000494059A patent/CA1257265A/en not_active Expired
- 1985-10-30 EP EP85307869A patent/EP0181152B1/de not_active Expired
- 1985-10-30 AT AT85307869T patent/ATE46335T1/de not_active IP Right Cessation
- 1985-10-30 DK DK499385A patent/DK499385A/da not_active Application Discontinuation
- 1985-10-30 DE DE8585307869T patent/DE3572978D1/de not_active Expired
- 1985-10-31 ES ES548418A patent/ES8702903A1/es not_active Expired
- 1985-11-02 KR KR1019850008160A patent/KR860004032A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE3572978D1 (en) | 1989-10-19 |
| KR860004032A (ko) | 1986-06-16 |
| EP0181152B1 (de) | 1989-09-13 |
| DK499385D0 (da) | 1985-10-30 |
| EP0181152A1 (de) | 1986-05-14 |
| CA1257265A (en) | 1989-07-11 |
| ES548418A0 (es) | 1987-01-16 |
| ES8702903A1 (es) | 1987-01-16 |
| GB8427735D0 (en) | 1984-12-12 |
| DK499385A (da) | 1986-05-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |