DE3572978D1 - Piperazine compound as paf-antagonist - Google Patents

Piperazine compound as paf-antagonist

Info

Publication number
DE3572978D1
DE3572978D1 DE8585307869T DE3572978T DE3572978D1 DE 3572978 D1 DE3572978 D1 DE 3572978D1 DE 8585307869 T DE8585307869 T DE 8585307869T DE 3572978 T DE3572978 T DE 3572978T DE 3572978 D1 DE3572978 D1 DE 3572978D1
Authority
DE
Germany
Prior art keywords
alkyl
paf
heterocyclic
protected
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585307869T
Other languages
English (en)
Inventor
Norihiko Shimazaki
Keiji Hemmi
Osamu Nakaguti
Yoshio Miyazaki
Masashi Hashimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE3572978D1 publication Critical patent/DE3572978D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE8585307869T 1984-11-02 1985-10-30 Piperazine compound as paf-antagonist Expired DE3572978D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848427735A GB8427735D0 (en) 1984-11-02 1984-11-02 Piperazine compound

Publications (1)

Publication Number Publication Date
DE3572978D1 true DE3572978D1 (en) 1989-10-19

Family

ID=10569141

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585307869T Expired DE3572978D1 (en) 1984-11-02 1985-10-30 Piperazine compound as paf-antagonist

Country Status (8)

Country Link
EP (1) EP0181152B1 (de)
KR (1) KR860004032A (de)
AT (1) ATE46335T1 (de)
CA (1) CA1257265A (de)
DE (1) DE3572978D1 (de)
DK (1) DK499385A (de)
ES (1) ES8702903A1 (de)
GB (1) GB8427735D0 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806538A (en) * 1984-11-02 1989-02-21 Fujisawa Pharmaceutical Co., Ltd. Piperazine compound as PAF-antagonist
US4694081A (en) * 1985-09-23 1987-09-15 Monsanto Company Process to prepare 2,5-diketopiperazines
DK181687A (da) * 1986-04-23 1987-10-24 Fujisawa Pharmaceutical Co Piperazinderivater og fremgangsmaade til fremstiling deraf
ES2054748T3 (es) * 1987-08-11 1994-08-16 Otsuka Pharma Co Ltd Un procedimiento para proporcionar un compuesto de pirazinoxido.
DE3830096A1 (de) * 1988-09-03 1990-03-15 Hoechst Ag Piperazindione mit psychotroper wirkung
GB8823776D0 (en) * 1988-10-11 1988-11-16 Scras New 2-methoxycarbonyl sustituted n n'-di-(trimethoxybenzoyl)piperazines
GB8823775D0 (en) * 1988-10-11 1988-11-16 Scras New 2-carbonyl substituted n n'-di-(trimethoxybenzoyl)piperazines
US5238938A (en) * 1989-02-10 1993-08-24 Otsuka Pharmaceutical Co., Ltd. Indole derivatives
EP0411150B1 (de) * 1989-02-10 1996-11-27 Otsuka Pharmaceutical Co., Ltd. Indolderivate, ihre herstellung und diese enthaltendes arzneimittel zum verhindern und behandeln von nephritis
DE3909379A1 (de) * 1989-03-22 1990-09-27 Cassella Ag Thienylpiperazine, verfahren zu ihrer herstellung, ihre verwendung sowie diese enthaltende arzneimittel und deren herstellung
MX9202022A (es) * 1991-05-01 1992-11-01 Otsuka Pharma Co Ltd Derivados de pirazina y proceso para su preparacion.
US5990112A (en) * 1996-06-18 1999-11-23 Affymax Technologies N.V. Inhibitors of metalloproteases pharmaceutical compositions comprising same and methods of their use
FR2722787B1 (fr) * 1994-07-21 1996-10-11 Univ Claude Bernard Lyon Composes a activite anthelminthique: dicetopiperazines, precurseurs et analogues
US5932579A (en) * 1996-06-18 1999-08-03 Affymax Technologies N.V. Collagenase-1 and stromelysin-1 inhibitors, pharmaceutical compositions comprising same and methods of their use
US6555543B2 (en) 2000-08-04 2003-04-29 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
AR058408A1 (es) 2006-01-02 2008-01-30 Basf Ag Compuestos de piperazina con accion herbicida
CA2659875C (en) 2006-08-04 2015-01-27 Manus Pharmaceuticals (Canada) Ltd. Multifunctional bioactive compounds
CN108947979B (zh) * 2017-05-22 2020-10-16 首都医科大学 3r-吲哚甲基-6r-极性氨基酸修饰的哌嗪-2,5-二酮，其合成，活性和应用
CN108947978B (zh) * 2017-05-22 2020-12-01 首都医科大学 3R-吲哚甲基-6R-Tyr修饰的哌嗪-2,5-二酮，其合成，活性和应用
CN108976203B (zh) * 2017-05-31 2020-10-16 首都医科大学 3S-吲哚甲基-6R-Lys修饰的哌嗪-2,5-二酮，其合成，活性和应用
CN108976206B (zh) * 2017-06-01 2020-07-28 首都医科大学 3S-吲哚甲基-6R-Glu修饰的哌嗪-2,5-二酮，其合成，活性和应用
CN108976209B (zh) * 2017-06-01 2020-07-28 首都医科大学 3s-吲哚甲基-6r-含n杂环氨基酸修饰的哌嗪-2,5-二酮，其合成，活性和应用
CN108976205B (zh) * 2017-06-01 2020-07-28 首都医科大学 3s-吲哚甲基-6r-极性氨基酸修饰的哌嗪-2,5-二酮，其合成，活性和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1600127A (en) * 1977-03-23 1981-10-14 Wellcome Found Piperazine-dione derivatives
EP0008186A1 (de) * 1978-08-08 1980-02-20 Beecham Group Plc Zyklische Diamide, ein Verfahren zu ihrer Herstellung und ihre pharmazeutischen Zusammensetzungen

Also Published As

Publication number Publication date
ES8702903A1 (es) 1987-01-16
EP0181152B1 (de) 1989-09-13
DK499385D0 (da) 1985-10-30
GB8427735D0 (en) 1984-12-12
CA1257265A (en) 1989-07-11
EP0181152A1 (de) 1986-05-14
ES548418A0 (es) 1987-01-16
DK499385A (da) 1986-05-03
KR860004032A (ko) 1986-06-16
ATE46335T1 (de) 1989-09-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee