DK499385A - Piperazinforbindelser - Google Patents

Piperazinforbindelser Download PDF

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Publication number
DK499385A
DK499385A DK499385A DK499385A DK499385A DK 499385 A DK499385 A DK 499385A DK 499385 A DK499385 A DK 499385A DK 499385 A DK499385 A DK 499385A DK 499385 A DK499385 A DK 499385A
Authority
DK
Denmark
Prior art keywords
alkyl
heterocyclic
protected
paf
aryl
Prior art date
Application number
DK499385A
Other languages
English (en)
Other versions
DK499385D0 (da
Inventor
Norihiko Shimazaki
Keiji Hemmi
Osamu Nakaguti
Yoshio Miyazaki
Masashi Hashimoto
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of DK499385D0 publication Critical patent/DK499385D0/da
Publication of DK499385A publication Critical patent/DK499385A/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK499385A 1984-11-02 1985-10-30 Piperazinforbindelser DK499385A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848427735A GB8427735D0 (en) 1984-11-02 1984-11-02 Piperazine compound

Publications (2)

Publication Number Publication Date
DK499385D0 DK499385D0 (da) 1985-10-30
DK499385A true DK499385A (da) 1986-05-03

Family

ID=10569141

Family Applications (1)

Application Number Title Priority Date Filing Date
DK499385A DK499385A (da) 1984-11-02 1985-10-30 Piperazinforbindelser

Country Status (8)

Country Link
EP (1) EP0181152B1 (da)
KR (1) KR860004032A (da)
AT (1) ATE46335T1 (da)
CA (1) CA1257265A (da)
DE (1) DE3572978D1 (da)
DK (1) DK499385A (da)
ES (1) ES8702903A1 (da)
GB (1) GB8427735D0 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806538A (en) * 1984-11-02 1989-02-21 Fujisawa Pharmaceutical Co., Ltd. Piperazine compound as PAF-antagonist
US4694081A (en) * 1985-09-23 1987-09-15 Monsanto Company Process to prepare 2,5-diketopiperazines
DK181687A (da) * 1986-04-23 1987-10-24 Fujisawa Pharmaceutical Co Piperazinderivater og fremgangsmaade til fremstiling deraf
ES2054748T3 (es) * 1987-08-11 1994-08-16 Otsuka Pharma Co Ltd Un procedimiento para proporcionar un compuesto de pirazinoxido.
DE3830096A1 (de) * 1988-09-03 1990-03-15 Hoechst Ag Piperazindione mit psychotroper wirkung
GB8823776D0 (en) * 1988-10-11 1988-11-16 Scras New 2-methoxycarbonyl sustituted n n'-di-(trimethoxybenzoyl)piperazines
GB8823775D0 (en) * 1988-10-11 1988-11-16 Scras New 2-carbonyl substituted n n'-di-(trimethoxybenzoyl)piperazines
US5238938A (en) * 1989-02-10 1993-08-24 Otsuka Pharmaceutical Co., Ltd. Indole derivatives
EP0411150B1 (en) * 1989-02-10 1996-11-27 Otsuka Pharmaceutical Co., Ltd. Indole derivatives, preparation thereof, and drug for preventing and treating nephritis containing same
DE3909379A1 (de) * 1989-03-22 1990-09-27 Cassella Ag Thienylpiperazine, verfahren zu ihrer herstellung, ihre verwendung sowie diese enthaltende arzneimittel und deren herstellung
MX9202022A (es) * 1991-05-01 1992-11-01 Otsuka Pharma Co Ltd Derivados de pirazina y proceso para su preparacion.
US5990112A (en) * 1996-06-18 1999-11-23 Affymax Technologies N.V. Inhibitors of metalloproteases pharmaceutical compositions comprising same and methods of their use
FR2722787B1 (fr) * 1994-07-21 1996-10-11 Univ Claude Bernard Lyon Composes a activite anthelminthique: dicetopiperazines, precurseurs et analogues
US5932579A (en) * 1996-06-18 1999-08-03 Affymax Technologies N.V. Collagenase-1 and stromelysin-1 inhibitors, pharmaceutical compositions comprising same and methods of their use
US6555543B2 (en) 2000-08-04 2003-04-29 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
AR058408A1 (es) 2006-01-02 2008-01-30 Basf Ag Compuestos de piperazina con accion herbicida
CA2659875C (en) 2006-08-04 2015-01-27 Manus Pharmaceuticals (Canada) Ltd. Multifunctional bioactive compounds
CN108947979B (zh) * 2017-05-22 2020-10-16 首都医科大学 3r-吲哚甲基-6r-极性氨基酸修饰的哌嗪-2,5-二酮,其合成,活性和应用
CN108947978B (zh) * 2017-05-22 2020-12-01 首都医科大学 3R-吲哚甲基-6R-Tyr修饰的哌嗪-2,5-二酮,其合成,活性和应用
CN108976203B (zh) * 2017-05-31 2020-10-16 首都医科大学 3S-吲哚甲基-6R-Lys修饰的哌嗪-2,5-二酮,其合成,活性和应用
CN108976206B (zh) * 2017-06-01 2020-07-28 首都医科大学 3S-吲哚甲基-6R-Glu修饰的哌嗪-2,5-二酮,其合成,活性和应用
CN108976209B (zh) * 2017-06-01 2020-07-28 首都医科大学 3s-吲哚甲基-6r-含n杂环氨基酸修饰的哌嗪-2,5-二酮,其合成,活性和应用
CN108976205B (zh) * 2017-06-01 2020-07-28 首都医科大学 3s-吲哚甲基-6r-极性氨基酸修饰的哌嗪-2,5-二酮,其合成,活性和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1600127A (en) * 1977-03-23 1981-10-14 Wellcome Found Piperazine-dione derivatives
EP0008186A1 (en) * 1978-08-08 1980-02-20 Beecham Group Plc Cyclic diamides, a process for their preparation and their pharmaceutical compositions

Also Published As

Publication number Publication date
ES8702903A1 (es) 1987-01-16
EP0181152B1 (en) 1989-09-13
DK499385D0 (da) 1985-10-30
GB8427735D0 (en) 1984-12-12
DE3572978D1 (en) 1989-10-19
CA1257265A (en) 1989-07-11
EP0181152A1 (en) 1986-05-14
ES548418A0 (es) 1987-01-16
KR860004032A (ko) 1986-06-16
ATE46335T1 (de) 1989-09-15

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment