DK171788B1 - 1-Acyl-3-[4-(2-pyrimidinyl)-1-piperazinyl]propan-forbindelser, og deres anvendelse til fremstilling af angstdæmpende lægemidler og farmaceutiske præparater indeholdende disse forbindelser - Google Patents

1-Acyl-3-[4-(2-pyrimidinyl)-1-piperazinyl]propan-forbindelser, og deres anvendelse til fremstilling af angstdæmpende lægemidler og farmaceutiske præparater indeholdende disse forbindelser Download PDF

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Publication number
DK171788B1
DK171788B1 DK591488A DK591488A DK171788B1 DK 171788 B1 DK171788 B1 DK 171788B1 DK 591488 A DK591488 A DK 591488A DK 591488 A DK591488 A DK 591488A DK 171788 B1 DK171788 B1 DK 171788B1
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DK
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Prior art keywords
compounds
pyrimidinyl
piperazinyl
preparation
acyl
Prior art date
Application number
DK591488A
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Danish (da)
English (en)
Other versions
DK591488D0 (da
DK591488A (da
Inventor
Jr Willard Mckowan Welch
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK591488D0 publication Critical patent/DK591488D0/da
Publication of DK591488A publication Critical patent/DK591488A/da
Application granted granted Critical
Publication of DK171788B1 publication Critical patent/DK171788B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Graft Or Block Polymers (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK591488A 1987-10-26 1988-10-25 1-Acyl-3-[4-(2-pyrimidinyl)-1-piperazinyl]propan-forbindelser, og deres anvendelse til fremstilling af angstdæmpende lægemidler og farmaceutiske præparater indeholdende disse forbindelser DK171788B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8702855 1987-10-26
PCT/US1987/002855 WO1989003831A1 (fr) 1987-10-26 1987-10-26 Agents anxiolytiques

Publications (3)

Publication Number Publication Date
DK591488D0 DK591488D0 (da) 1988-10-25
DK591488A DK591488A (da) 1989-04-27
DK171788B1 true DK171788B1 (da) 1997-05-26

Family

ID=22202642

Family Applications (1)

Application Number Title Priority Date Filing Date
DK591488A DK171788B1 (da) 1987-10-26 1988-10-25 1-Acyl-3-[4-(2-pyrimidinyl)-1-piperazinyl]propan-forbindelser, og deres anvendelse til fremstilling af angstdæmpende lægemidler og farmaceutiske præparater indeholdende disse forbindelser

Country Status (28)

Country Link
US (1) US4994455A (fr)
EP (1) EP0314363B1 (fr)
JP (1) JPH0643406B2 (fr)
KR (1) KR900006722B1 (fr)
CN (1) CN1022246C (fr)
AT (1) ATE87919T1 (fr)
AU (1) AU598161B2 (fr)
CA (1) CA1314881C (fr)
CS (2) CS274441B2 (fr)
DD (2) DD283388A5 (fr)
DE (1) DE3880077T2 (fr)
DK (1) DK171788B1 (fr)
ES (1) ES2054823T3 (fr)
FI (1) FI94638C (fr)
HU (2) HU208690B (fr)
IE (1) IE63285B1 (fr)
IL (1) IL88085A (fr)
MX (1) MX173180B (fr)
MY (1) MY103435A (fr)
NO (2) NO901652L (fr)
NZ (1) NZ226691A (fr)
PH (1) PH25106A (fr)
PL (2) PL153184B1 (fr)
PT (1) PT88835B (fr)
RU (1) RU2029768C1 (fr)
WO (1) WO1989003831A1 (fr)
YU (1) YU46592B (fr)
ZA (1) ZA887925B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR242678A1 (es) * 1986-03-05 1993-04-30 Gonzalez Jorge Alberto Mejoras en instrumentos musicales de cuerda de arco.
US4797488A (en) * 1987-04-03 1989-01-10 American Home Products Corporation Psychotropic polycyclic imides
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
DE68918832T2 (de) * 1988-12-28 1995-02-09 Suntory Ltd Benzoxazepinderivate.
US5114936A (en) * 1990-08-23 1992-05-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use
UA77526C2 (en) * 2002-06-07 2006-12-15 Sanofi Aventis Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy
FR2862967B1 (fr) * 2003-12-01 2006-08-04 Sanofi Synthelabo Derives de (4-phenylpiperazin-1-yl)acylpiperidine, leur preparation et leur application en therapeutique
FR2862968B1 (fr) * 2003-12-01 2006-08-04 Sanofi Synthelabo Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique
US20110166124A1 (en) * 2008-07-23 2011-07-07 Mccormick Kevin D Tricyclic spirocycle derivatives and methods of use
US8617801B2 (en) * 2009-06-03 2013-12-31 Carestream Health, Inc. Film with blue dye

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US466691A (en) * 1892-01-05 Egg-crate
US2672460A (en) * 1952-06-24 1954-03-16 American Cyanamid Co Disubstituted piperazines and methods of preparing the same
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US4666911A (en) * 1981-07-14 1987-05-19 Taiho Pharmaceutical Company Limited Allophanoylpiperazine compound and analgesic composition containing same as active ingredient
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4605655A (en) * 1984-03-06 1986-08-12 Bristol-Myers Company Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
JPS6175A (ja) * 1984-03-06 1986-01-06 ブリストル−マイア−ズ　コムパニ− 神経弛緩剤、１‐フルオロフェニルブチル‐４‐（５‐ハロ‐２‐ピリミジニル）ピペラジン誘導体
US4562255A (en) * 1984-03-30 1985-12-31 American Home Products Corporation Substituted bi-alicyclic imides
US4668687A (en) * 1984-07-23 1987-05-26 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
AR242678A1 (es) * 1986-03-05 1993-04-30 Gonzalez Jorge Alberto Mejoras en instrumentos musicales de cuerda de arco.
US4797488A (en) * 1987-04-03 1989-01-10 American Home Products Corporation Psychotropic polycyclic imides

Also Published As

Publication number Publication date
CS135189A2 (en) 1990-08-14
FI902070A0 (fi) 1990-04-25
ZA887925B (en) 1990-06-27
MY103435A (en) 1993-06-30
PH25106A (en) 1991-02-19
PL153184B1 (en) 1991-03-29
NO901652D0 (no) 1990-04-11
IE883218L (en) 1989-04-26
HUT59393A (en) 1992-05-28
WO1989003831A1 (fr) 1989-05-05
CA1314881C (fr) 1993-03-23
HU913849D0 (en) 1992-03-30
CS274446B2 (en) 1991-04-11
AU598161B2 (en) 1990-06-14
PT88835B (pt) 1993-01-29
FI94638B (fi) 1995-06-30
MX13562A (es) 1993-04-01
CN1042148A (zh) 1990-05-16
CS274441B2 (en) 1991-04-11
US4994455A (en) 1991-02-19
CN1022246C (zh) 1993-09-29
HUT58724A (en) 1992-03-30
FI94638C (fi) 1995-10-10
HU208690B (en) 1993-12-28
ES2054823T3 (es) 1994-08-16
DK591488D0 (da) 1988-10-25
KR900006722B1 (ko) 1990-09-20
KR890006621A (ko) 1989-06-14
CS708088A2 (en) 1990-08-14
JPH0643406B2 (ja) 1994-06-08
IE63285B1 (en) 1995-04-05
EP0314363B1 (fr) 1993-04-07
DK591488A (da) 1989-04-27
DE3880077T2 (de) 1993-07-22
HU206109B (en) 1992-08-28
PL279558A1 (en) 1990-01-08
DE3880077D1 (de) 1993-05-13
PL275476A1 (en) 1989-09-18
IL88085A (en) 1993-02-21
YU46592B (sh) 1993-11-16
MX173180B (es) 1994-02-07
PL152117B1 (en) 1990-11-30
EP0314363A2 (fr) 1989-05-03
ATE87919T1 (de) 1993-04-15
YU198988A (en) 1990-06-30
EP0314363A3 (en) 1990-07-11
NZ226691A (en) 1990-04-26
NO901652L (no) 1990-04-11
JPH01157979A (ja) 1989-06-21
DD283388A5 (de) 1990-10-10
DD298397A5 (de) 1992-02-20
AU2432788A (en) 1989-04-27
NO901826D0 (no) 1990-04-25
RU2029768C1 (ru) 1995-02-27

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