DK170771B1 - N-(2'-aminophenyl)-benzamid-derivater, deres fremstilling og anvendelse til fremstilling af et farmaceutisk præparat samt sådant præparat - Google Patents

N-(2'-aminophenyl)-benzamid-derivater, deres fremstilling og anvendelse til fremstilling af et farmaceutisk præparat samt sådant præparat Download PDF

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Publication number
DK170771B1
DK170771B1 DK198487A DK198487A DK170771B1 DK 170771 B1 DK170771 B1 DK 170771B1 DK 198487 A DK198487 A DK 198487A DK 198487 A DK198487 A DK 198487A DK 170771 B1 DK170771 B1 DK 170771B1
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DK
Denmark
Prior art keywords
aminophenyl
benzamide
preparation
compounds
group
Prior art date
Application number
DK198487A
Other languages
Danish (da)
English (en)
Other versions
DK198487D0 (da
DK198487A (da
Inventor
Ute Weiershausen
Gerhard Satzinger
Karl-Otto Vollmer
Wolfgang Herrmann
Original Assignee
Goedecke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19863613571 external-priority patent/DE3613571A1/de
Priority claimed from DE19863625359 external-priority patent/DE3625359A1/de
Application filed by Goedecke Ag filed Critical Goedecke Ag
Publication of DK198487D0 publication Critical patent/DK198487D0/da
Publication of DK198487A publication Critical patent/DK198487A/da
Application granted granted Critical
Publication of DK170771B1 publication Critical patent/DK170771B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK198487A 1986-04-22 1987-04-15 N-(2'-aminophenyl)-benzamid-derivater, deres fremstilling og anvendelse til fremstilling af et farmaceutisk præparat samt sådant præparat DK170771B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3613571 1986-04-22
DE19863613571 DE3613571A1 (de) 1986-04-22 1986-04-22 N-(2'-aminophenyl)-benzamid-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung neoplastischer erkrankungen
DE19863625359 DE3625359A1 (de) 1986-07-26 1986-07-26 N-(2'-aminophenyl)-benzamid-derivat, verfahren zu dessen herstellung und dessen verwendung bei der bekaempfung neoplastischer erkrankungen
DE3625359 1986-07-26

Publications (3)

Publication Number Publication Date
DK198487D0 DK198487D0 (da) 1987-04-15
DK198487A DK198487A (da) 1987-10-23
DK170771B1 true DK170771B1 (da) 1996-01-15

Family

ID=25843119

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198487A DK170771B1 (da) 1986-04-22 1987-04-15 N-(2'-aminophenyl)-benzamid-derivater, deres fremstilling og anvendelse til fremstilling af et farmaceutisk præparat samt sådant præparat

Country Status (19)

Country Link
US (1) US5137918A (no)
EP (1) EP0242851B1 (no)
JP (1) JPH0825977B2 (no)
CN (1) CN1012498B (no)
AT (1) AT388913B (no)
CA (1) CA1334760C (no)
CS (1) CS262448B2 (no)
DE (1) DE3763191D1 (no)
DK (1) DK170771B1 (no)
ES (1) ES2095824T3 (no)
FI (1) FI87766C (no)
GR (1) GR3000562T3 (no)
HU (1) HU197295B (no)
IE (1) IE60332B1 (no)
IL (1) IL82265A (no)
NO (1) NO168353C (no)
NZ (1) NZ219974A (no)
PH (1) PH23928A (no)
PT (1) PT84737B (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602277A (en) * 1995-03-30 1997-02-11 Biocryst Pharmaceuticals, Inc. Substituted benzene derivatives useful as neuraminidase inhibitors
AU6878198A (en) * 1997-04-24 1998-11-13 Warner-Lambert Company Use of acetyldinaline for the manufacture of a medicament for the treatment of renal cell carcinoma
AP2001002109A0 (en) * 1998-09-25 2001-03-31 Warner Lambert Co Chemotherapy of cancer with acetyldinaline in combination with gemcitabine, capecitabine or cisplatin.
KR20020060226A (ko) * 1999-11-10 2002-07-16 로즈 암스트롱, 크리스틴 에이. 트러트웨인 배합 화학요법
CZ20022216A3 (cs) * 2001-07-02 2003-05-14 Warner-Lambert Company Kombinační chemoterapie
AR034897A1 (es) * 2001-08-07 2004-03-24 Hoffmann La Roche Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos
AU2002327627B2 (en) * 2001-09-14 2006-09-14 Methylgene Inc. Inhibitors of histone deacetylase
US7868204B2 (en) * 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
US6897220B2 (en) * 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
GB0202873D0 (en) * 2002-02-07 2002-03-27 Novartis Ag Organic compounds
TW200426138A (en) 2002-12-10 2004-12-01 Hoffmann La Roche Novel arylene-carboxylic acid (2-amino-phenyl)-amide derivatives, their manufacture and use as pharmaceutical agents
TW200424174A (en) 2003-02-06 2004-11-16 Hoffmann La Roche New TP diamide
US7208491B2 (en) 2003-02-07 2007-04-24 Hoffmann-La Roche Inc. N-monoacylated o-phenylenediamines
TW200424187A (en) 2003-04-04 2004-11-16 Hoffmann La Roche New oxime derivatives and their use as pharmaceutically active agents
AU2004276337B2 (en) * 2003-09-24 2009-11-12 Methylgene Inc. Inhibitors of histone deacetylase
US9115090B2 (en) * 2003-12-02 2015-08-25 The Ohio State University Research Foundation Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors
US7253204B2 (en) * 2004-03-26 2007-08-07 Methylgene Inc. Inhibitors of histone deacetylase
CA2648804C (en) * 2006-04-07 2014-05-27 Methylgene Inc. Benzamide derivatives as inhibitors of histone deacetylase
WO2007136858A2 (en) 2006-05-19 2007-11-29 H. Lee Moffitt Cancer Center & Research Institute Small molecule inhibitors of stat3 with anti-tumor activity
WO2009076234A2 (en) * 2007-12-07 2009-06-18 University Of Maryland, Baltimore Synthesis methods of histone deacetylase inhibitors (hdacis)
WO2010036404A2 (en) * 2008-05-09 2010-04-01 University Of Maryland, Baltimore Novel retinamide retinoic acid metabolism blocking agents
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
AR074897A1 (es) 2008-12-23 2011-02-23 Pharmasset Inc Fosforamidatos de nucleosidos
PA8855801A1 (es) 2008-12-23 2010-07-27 Sintesis de nucleosidos de purina
EP2376514A2 (en) 2008-12-23 2011-10-19 Pharmasset, Inc. Nucleoside analogs
US8859756B2 (en) 2010-03-31 2014-10-14 Gilead Pharmasset Llc Stereoselective synthesis of phosphorus containing actives
WO2012149540A1 (en) 2011-04-28 2012-11-01 The Broad Institute Inc Inhibitors of histone deacetylase
US8691875B2 (en) 2011-07-01 2014-04-08 Broad Institute, Inc. Solid forms of tacedinaline
JP6337255B2 (ja) * 2012-07-27 2018-06-06 ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. ヒストンデアセチラーゼの阻害剤
WO2014100438A1 (en) 2012-12-20 2014-06-26 The Broad Institute, Inc. Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
US9636298B2 (en) 2014-01-17 2017-05-02 Methylgene Inc. Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs
CN104058983B (zh) * 2014-07-02 2016-01-13 郑攀锋 一种医药原料酰胺类化合物的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1493783A1 (de) * 1965-07-12 1969-01-30 Goedecke Ag Verfahren zur Herstellung von 2-Amino-4'-(diaethylamino)-2'-methyl-benzanilid
DE1643264A1 (de) * 1967-12-20 1971-06-09 Basf Ag Verfahren zur Herstellung von Aminoaniliden
US4004029A (en) * 1974-05-13 1977-01-18 The Upjohn Company Compositions and method for treating epilepsy and convulsions
DE3305755A1 (de) * 1983-02-19 1984-08-23 Gödecke AG, 1000 Berlin N-phenyl-benzamid-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von erkranungen des immunsystems
CH653670A5 (de) * 1983-03-03 1986-01-15 Hoffmann La Roche Benzamid-derivate.
US4642379A (en) * 1985-08-30 1987-02-10 Eli Lilly And Company Intermediates for anticonvulsant agents

Also Published As

Publication number Publication date
ES2095824T3 (es) 1997-03-01
HUT43808A (en) 1987-12-28
JPS63115852A (ja) 1988-05-20
IL82265A0 (en) 1987-10-30
PT84737B (pt) 1989-12-29
IE60332B1 (en) 1994-06-29
FI87766C (fi) 1993-02-25
NZ219974A (en) 1989-08-29
FI871733A (fi) 1987-10-23
DK198487D0 (da) 1987-04-15
EP0242851B1 (de) 1990-06-13
FI871733A0 (fi) 1987-04-21
US5137918A (en) 1992-08-11
HU197295B (en) 1989-03-28
IE871046L (en) 1987-10-22
ATA265187A (de) 1989-02-15
FI87766B (fi) 1992-11-13
CA1334760C (en) 1995-03-14
JPH0825977B2 (ja) 1996-03-13
IL82265A (en) 1991-01-31
PT84737A (en) 1987-05-01
NO871640L (no) 1987-10-23
DK198487A (da) 1987-10-23
CN1012498B (zh) 1991-05-01
NO168353C (no) 1992-02-12
PH23928A (en) 1990-01-23
GR3000562T3 (en) 1991-07-31
CN87103096A (zh) 1987-11-18
CS273687A2 (en) 1988-07-15
AT388913B (de) 1989-09-25
CS262448B2 (en) 1989-03-14
NO168353B (no) 1991-11-04
EP0242851A1 (de) 1987-10-28
NO871640D0 (no) 1987-04-21
DE3763191D1 (de) 1990-07-19

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