DK169974B1 - Anvendelse af midler til påvisning af esterolytiske og/eller proteolytiske enzymer i leukocytter samt midler til en sådan anvendelse - Google Patents

Anvendelse af midler til påvisning af esterolytiske og/eller proteolytiske enzymer i leukocytter samt midler til en sådan anvendelse Download PDF

Info

Publication number
DK169974B1
DK169974B1 DK204881A DK204881A DK169974B1 DK 169974 B1 DK169974 B1 DK 169974B1 DK 204881 A DK204881 A DK 204881A DK 204881 A DK204881 A DK 204881A DK 169974 B1 DK169974 B1 DK 169974B1
Authority
DK
Denmark
Prior art keywords
lower alkyl
group
lower alkoxy
optionally
hydrogen
Prior art date
Application number
DK204881A
Other languages
Danish (da)
English (en)
Other versions
DK204881A (da
Inventor
Dieter Berger
Guenter Frey
Wolfgang-Reinhold Knappe
Manfred Kuhr
Walter Rittersdorf
Wolfgang Werner
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6101946&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK169974(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK204881A publication Critical patent/DK204881A/da
Application granted granted Critical
Publication of DK169974B1 publication Critical patent/DK169974B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/30—Naphthol derivatives, e.g. alpha-naphthyl-esters, i.e. alpha-NE, beta-naphthyl-esters, i.e. beta-NE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/50—Indoles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/70—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases the product, e.g. phenol, naphthol being diazotised in situ, e.g. with Fast Red
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
DK204881A 1980-05-09 1981-05-08 Anvendelse af midler til påvisning af esterolytiske og/eller proteolytiske enzymer i leukocytter samt midler til en sådan anvendelse DK169974B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19803017721 DE3017721A1 (de) 1980-05-09 1980-05-09 Mittel zum nachweis esterolytischer und/oder proteolytischer enzyme und dafuer geeignete substrate
DE3017721 1980-05-09

Publications (2)

Publication Number Publication Date
DK204881A DK204881A (da) 1981-11-10
DK169974B1 true DK169974B1 (da) 1995-04-18

Family

ID=6101946

Family Applications (1)

Application Number Title Priority Date Filing Date
DK204881A DK169974B1 (da) 1980-05-09 1981-05-08 Anvendelse af midler til påvisning af esterolytiske og/eller proteolytiske enzymer i leukocytter samt midler til en sådan anvendelse

Country Status (24)

Country Link
US (2) US4551428A (pl)
EP (1) EP0039880B2 (pl)
JP (2) JPS578798A (pl)
AR (1) AR228452A1 (pl)
AT (1) ATE3993T1 (pl)
AU (1) AU523744B2 (pl)
BR (1) BR8102876A (pl)
CA (1) CA1186201A (pl)
CS (1) CS223999B2 (pl)
DD (1) DD158559A5 (pl)
DE (2) DE3017721A1 (pl)
DK (1) DK169974B1 (pl)
ES (1) ES502034A0 (pl)
FI (1) FI77692C (pl)
HK (1) HK82586A (pl)
HU (1) HU187334B (pl)
MY (1) MY8600605A (pl)
PL (1) PL131123B1 (pl)
PT (1) PT73005B (pl)
SG (1) SG38786G (pl)
SU (1) SU1466663A3 (pl)
UA (1) UA6035A1 (pl)
YU (2) YU117781A (pl)
ZA (1) ZA812961B (pl)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3017721A1 (de) * 1980-05-09 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim Mittel zum nachweis esterolytischer und/oder proteolytischer enzyme und dafuer geeignete substrate
US4499185A (en) * 1982-05-17 1985-02-12 Miles Laboratories, Inc. Test for esterase activity in a liquid sample
DE3309544A1 (de) * 1983-03-17 1984-09-20 Macherey-Nagel & Co Chemikalienhandel, 5160 Düren Teststreifen zum nachweis von leukozyten im harn
DE3329394A1 (de) * 1983-08-13 1985-02-28 Bayer Ag, 5090 Leverkusen Chromogene und fluorogene carbonsaeureester, verfahren zu deren herstellung sowie verfahren und mittel zum nachweis und zur bestimmung von hydrolasen
DE3484867D1 (de) * 1983-12-14 1991-09-05 Upjohn Co Substituierte naphthalene, indole, benzofurane und benzothiophene als lypoxygenase-inhibitoren.
DE3413120A1 (de) * 1984-04-06 1985-10-24 Miles Laboratories, Inc., Elkhart, Ind. Analysenverfahren und mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
DE3413077A1 (de) * 1984-04-06 1985-10-17 Miles Laboratories, Inc., Elkhart, Ind. Chromogene aminosaeure- und peptidester, verfahren zu deren herstellung, verwendung dieser verbindungen in analysenverfahren sowie mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
DE3413078A1 (de) * 1984-04-06 1985-10-24 Miles Laboratories, Inc., Elkhart, Ind. Chromogene aminosaeure- und peptidester, verfahren zu deren herstellung, verwendung dieser verbindungen in analysenverfahren sowie mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
US4637979A (en) * 1984-04-06 1987-01-20 Miles Laboratories, Inc. Composition and test device for determining the presence of leukocytes containing a zwitterion coupling agent
US4657855A (en) * 1984-04-06 1987-04-14 Miles Laboratories, Inc. Composition and test device for determining the presence of leukocytes, esterase and protease in a test sample
DE3413119A1 (de) * 1984-04-06 1985-10-24 Miles Laboratories, Inc., Elkhart, Ind. Analysenverfahren und mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
DE3413118A1 (de) * 1984-04-06 1985-10-24 Miles Laboratories, Inc., Elkhart, Ind. Analysenverfahren und mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
DE3446714A1 (de) * 1984-12-21 1986-06-26 Boehringer Mannheim Gmbh Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens
US4777267A (en) * 1986-02-07 1988-10-11 Kanebo Ltd. 1,3-dioxol-2-one derivatives
US4677075A (en) * 1986-05-05 1987-06-30 Louderback Allan Lee Urobilinogen control
DE3813503A1 (de) * 1988-04-22 1989-11-02 Boehringer Mannheim Gmbh Traegergebundenes mehrkomponentiges nachweissystem zur kolorimetrischen bestimmung esterolytisch oder/und proteolytisch aktiver inhaltsstoffe von koerperfluessigkeiten
US5084324A (en) * 1989-08-25 1992-01-28 W. R. Grace & Co.-Conn. Micro-bubble laminate with perforated substrate
US4950354A (en) * 1989-08-25 1990-08-21 W. R. Grace & Co.-Conn. Method of making a micro-bubble laminate
JPH0465584U (pl) * 1990-10-12 1992-06-08
EP0661280A1 (en) * 1993-12-29 1995-07-05 Kyoto Daiichi Kagaku Co., Ltd. Novel amino acid ester and reagent composition for detecting leucocytes or elastase in body liquid
CA2161574A1 (en) 1994-11-15 1996-05-16 James Noffsinger Methodology for colorimetrically determining the concentration of white blood cells in a biological fluid
US6528652B1 (en) * 1999-01-21 2003-03-04 Chronimed Composition and device for detecting leukocytes in urine
US6348324B1 (en) 1999-01-21 2002-02-19 Hypoguard America Limited Composition and device for detecting leukocytes in urine
US6203496B1 (en) * 1999-08-12 2001-03-20 Michael R. Gael Apparatus with reagents for detection of medical conditions
IL140993A0 (en) 2000-05-15 2002-02-10 Bayer Ag Trypsin substrate and diagnostic device, and method of using same
US6955921B2 (en) 2001-04-30 2005-10-18 Bayer Corporation Trypsin substrate and diagnostic device, and method of using same
US6709868B2 (en) * 2002-05-20 2004-03-23 Portascience Inc. Method and apparatus for measuring white blood cell count
US7727206B2 (en) * 2005-12-27 2010-06-01 Gorres Geoffrey H Device for monitoring a patient for a urinary tract infection
EP3848708A1 (en) * 2020-01-13 2021-07-14 Roche Diagnostics GmbH Reagent formulation for leukocyte test strip

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1128371A (en) * 1965-10-04 1968-09-25 Miles Lab Diagnostic composition
US3585001A (en) * 1969-02-17 1971-06-15 Miles Lab Stabilized test device and process for detecting couplable compounds
US3715325A (en) * 1970-10-02 1973-02-06 Miles Lab Insoluble polymeric diazonium salt chromogen
US3905872A (en) * 1973-12-14 1975-09-16 American Cyanamid Co Alkaline phosphatase test material
DE2531539A1 (de) * 1975-07-15 1977-01-20 Riedel De Haen Ag Indikatorsubstanz zum nachweis von kuppelnden fluessigkeits-inhaltsstoffen, diese enthaltende diagnostische mittel und verfahren zu deren herstellung
DE2836644A1 (de) * 1978-08-22 1980-03-06 Boehringer Mannheim Gmbh Diagnostisches mittel zum nachweis von leukozyten in koerperfluessigkeiten und dafuer geeignete chromogene
DE2854987A1 (de) * 1978-12-20 1980-06-26 Boehringer Mannheim Gmbh Diagnostische mittel zum nachweis proteolytischer enzyme und dafuer geeignete chromogene
DE2905531A1 (de) * 1979-02-14 1981-01-08 Boehringer Mannheim Gmbh Diagnostisches mittel zum nachweis von leukozyten in koerperfluessigkeiten
DE2936543A1 (de) * 1979-09-10 1981-04-09 Behringwerke Ag, 3550 Marburg Chromogene verbindungen
DE3017721A1 (de) * 1980-05-09 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim Mittel zum nachweis esterolytischer und/oder proteolytischer enzyme und dafuer geeignete substrate

Also Published As

Publication number Publication date
HU187334B (en) 1985-12-28
JPS6145982B2 (pl) 1986-10-11
CA1186201A (en) 1985-04-30
PL131123B1 (en) 1984-10-31
AU523744B2 (en) 1982-08-12
JPS61199800A (ja) 1986-09-04
SG38786G (en) 1989-09-01
EP0039880B1 (de) 1983-06-29
US4551428A (en) 1985-11-05
HK82586A (en) 1986-11-07
DE3017721A1 (de) 1981-11-26
CS223999B2 (en) 1983-11-25
PT73005A (de) 1981-06-01
ES8202792A1 (es) 1982-03-01
YU112483A (en) 1989-10-31
DE3160522D1 (en) 1983-08-04
PL231002A1 (pl) 1981-12-23
DK204881A (da) 1981-11-10
SU1466663A3 (ru) 1989-03-15
BR8102876A (pt) 1982-02-02
YU117781A (en) 1983-12-31
FI77692C (fi) 1989-04-10
US4749648A (en) 1988-06-07
FI77692B (fi) 1988-12-30
MY8600605A (en) 1986-12-31
EP0039880B2 (de) 1987-06-03
EP0039880A1 (de) 1981-11-18
DD158559A5 (de) 1983-01-19
PT73005B (de) 1982-07-01
JPS578798A (en) 1982-01-18
JPH0243480B2 (pl) 1990-09-28
AU7023981A (en) 1981-11-12
YU45887B (sh) 1992-09-07
FI811418L (fi) 1981-11-10
ES502034A0 (es) 1982-03-01
ATE3993T1 (de) 1983-07-15
ZA812961B (en) 1982-05-26
UA6035A1 (uk) 1994-12-29
AR228452A1 (es) 1983-03-15

Similar Documents

Publication Publication Date Title
DK169974B1 (da) Anvendelse af midler til påvisning af esterolytiske og/eller proteolytiske enzymer i leukocytter samt midler til en sådan anvendelse
FI77229C (fi) Indoxyl-aminosyraestrar och -peptidestrar, deras framstaellning och anvaendning foer paovisande av proteolytiska enzymer.
JP3558348B2 (ja) 微生物代謝産物の検出
DE3413077A1 (de) Chromogene aminosaeure- und peptidester, verfahren zu deren herstellung, verwendung dieser verbindungen in analysenverfahren sowie mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
CA1272671A (en) Chromogenic amino acid esters and peptide esters, processes for their preparation, the use of these compounds in analytical processes and agents for the detection of esterolytic and/or proteolytic enzymes
FI81359C (fi) Glykosider av resorufin-derivat, foerfarande foer framstaellning daerav samt deras anvaendning foer bestaemning av aktiviteten av glykosidaser.
DE69933855T2 (de) Indolderivate zum nachweis von peptidasen von mikroorganismen
EP0158225B1 (de) Analysenverfahren und Mittel zum Nachweis esterolytischer und/oder proteolytischer Enzyme
US5334505A (en) N- and O-substituted aminophenols, method and use for diagnosis
US4755462A (en) Analytical process and agents for the detection of esterolytic and/or proteolytic enzymes
CA1248697A (en) Phenoxyamino acid esters and peptide esters
US20120122134A1 (en) Novel Peptidase Substrates
DE3413119A1 (de) Analysenverfahren und mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
EP2459733B1 (fr) Nouveaux substrats de peptidase

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired