YU45887B - Sredstvo in postopek za dokaz ekterolitskih in/ali proteolitskih encimov - Google Patents

Sredstvo in postopek za dokaz ekterolitskih in/ali proteolitskih encimov

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Publication number
YU45887B
YU45887B YU112483A YU112483A YU45887B YU 45887 B YU45887 B YU 45887B YU 112483 A YU112483 A YU 112483A YU 112483 A YU112483 A YU 112483A YU 45887 B YU45887 B YU 45887B
Authority
YU
Yugoslavia
Prior art keywords
group
alkoxy
alkyl
naphthyl
phenyl
Prior art date
Application number
YU112483A
Other languages
English (en)
Other versions
YU112483A (en
Inventor
D. Berger
G. Frey
W.R. Knappe
M. Kuhr
W. Rittersdorf
W. Werner
Original Assignee
Boehringer Mannheim Gbmh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6101946&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU45887(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim Gbmh. filed Critical Boehringer Mannheim Gbmh.
Priority to SI8311124A priority Critical patent/SI8311124A8/sl
Publication of YU112483A publication Critical patent/YU112483A/xx
Publication of YU45887B publication Critical patent/YU45887B/sh
Priority to HRP-1124/83A priority patent/HRP940700B1/xx

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/30Naphthol derivatives, e.g. alpha-naphthyl-esters, i.e. alpha-NE, beta-naphthyl-esters, i.e. beta-NE
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/50Indoles
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/70O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases the product, e.g. phenol, naphthol being diazotised in situ, e.g. with Fast Red
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/805Test papers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

SREDSTVO IN POSTOPEK ZA DOKAZ EKTEROLITSKIH IN/ALI PROTEOLITSKIH ENCIMOV, oznacen s tem, da vzorec spravimo v stik z estrom ali vec estri, izbranimi iz skupine spojin s splosno formulo II v kateri pomenijo R1,R2, R3, R4, ki so lahko vsakokrat enaki ali razlicni, vsakokrat atom vodika ali halogena, C1-C5-alkilno, C1-C5-alkoksi, fenilno, naftilno, C1-C5-alkilsubst. fenilnoali-naftilno skupino, oksi-C1-C5-alkilsubst. fenilno ali -naftilno skupino, hidroksi, karboksi, karboksi-C1-C5-alkoksi, oksi-C1-C5-alkilsubstituirano fenil-ali naftil-karbonilno skupino, oksi-C1-C5 alkilsubstituirano fenil-ali naftil-karbonilC1-C5-alkoksi, nitro ali C1-C5- acilamino skupino ali vsakokrat dva sosednja substituenta v danem primeru s halogenom substituiran benzoaneliran ostanek, X atom zvepla ali v danem primeru s C1-C5-alkilnim, fenilnim ali naftilnim, C1-C5-alkilsubst. fenilnim ali -naftilnim ali z acilnim ostankom substituirano imino skupino, A ostanek amino kisline ali peptidni ostanek, B v peptidni kemiji obicajno ali iz nje izvedeno dusikovo zascitno skupino, ali spojin s splosno formulo III v kateri pomenijo R1", R2", R3", R4", ki so lahko enaki ali razlicni, vsakokrat vodik, C1-C5-alkilno, C1-C5-alkoksi, alkilamino ali dialkilamino skupino, pri cemer lahko dva sosednja substituenta predstavljata tudi aneliran benzolov obroc, ter imata A in B zgoraj navedeni pomen, se alkoholi, ki nastanejo s cepitvijo teh estrov zaradi v danem primeru v vzorcu prisotnih esterolitskih in/ali proteolitskih encimov, presnovijo z diazonijevo soljo s splosno formulo I v kateri pomenijo R1 C1-C5-alkilno, C1-C5-alkoksi, C1-C5-alkilmerkapto, N-morfolino, N-tio-morfolino, N-jpirolidino, v danem primeru N -alkilirano N-piperazino, N-piperidino skupino, halogen ali vodik, R3 C1-C2-alkilno, C10C5-alkoksi, feniloksi, naftiloksi, C1-C5-alkilmerkapto, alkilamino, dialkilamino, hidroksi, N-morfolino, N-tio-morfolino, N-jpirolidino, v danem primeru N -alkilirano N-piperazino, N-piperidino, fenilamino, v danem primeru s C1-C5-alkilnim ali C1-C5-alkoksi ostankom substituirano fenilno skupino, halogen ali vodik, R2, R4, R5, ki so lahko enaki ali razlicni, vsakokrat C1-C5-alkilno, C1-C5-alkoksi, C1-C5-alkilmerkapto skupino, halogen ali vodik in X stabilizirajoc anion, in nastalo obarvanje merimo. Prijava vsebuje se 1 nezavisni zahtevek in 4 zavisne zahtevke.
YU112483A 1980-05-09 1983-05-19 Sredstvo in postopek za dokaz ekterolitskih in/ali proteolitskih encimov YU45887B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI8311124A SI8311124A8 (sl) 1980-05-09 1983-05-19 Sredstvo in postopek za dokaz ekterolitskih in/ali proteolitskih encimov
HRP-1124/83A HRP940700B1 (en) 1980-05-09 1994-10-19 Agents for the detection of esterolytic and/or proteolytic enzymes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803017721 DE3017721A1 (de) 1980-05-09 1980-05-09 Mittel zum nachweis esterolytischer und/oder proteolytischer enzyme und dafuer geeignete substrate

Publications (2)

Publication Number Publication Date
YU112483A YU112483A (en) 1989-10-31
YU45887B true YU45887B (sh) 1992-09-07

Family

ID=6101946

Family Applications (2)

Application Number Title Priority Date Filing Date
YU01177/81A YU117781A (en) 1980-05-09 1981-05-08 Process for preparing esters of phenoxy-amino acids and phenoxy-peptide esters
YU112483A YU45887B (sh) 1980-05-09 1983-05-19 Sredstvo in postopek za dokaz ekterolitskih in/ali proteolitskih encimov

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU01177/81A YU117781A (en) 1980-05-09 1981-05-08 Process for preparing esters of phenoxy-amino acids and phenoxy-peptide esters

Country Status (24)

Country Link
US (2) US4551428A (sh)
EP (1) EP0039880B2 (sh)
JP (2) JPS578798A (sh)
AR (1) AR228452A1 (sh)
AT (1) ATE3993T1 (sh)
AU (1) AU523744B2 (sh)
BR (1) BR8102876A (sh)
CA (1) CA1186201A (sh)
CS (1) CS223999B2 (sh)
DD (1) DD158559A5 (sh)
DE (2) DE3017721A1 (sh)
DK (1) DK169974B1 (sh)
ES (1) ES502034A0 (sh)
FI (1) FI77692C (sh)
HK (1) HK82586A (sh)
HU (1) HU187334B (sh)
MY (1) MY8600605A (sh)
PL (1) PL131123B1 (sh)
PT (1) PT73005B (sh)
SG (1) SG38786G (sh)
SU (1) SU1466663A3 (sh)
UA (1) UA6035A1 (sh)
YU (2) YU117781A (sh)
ZA (1) ZA812961B (sh)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3017721A1 (de) * 1980-05-09 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim Mittel zum nachweis esterolytischer und/oder proteolytischer enzyme und dafuer geeignete substrate
US4499185A (en) * 1982-05-17 1985-02-12 Miles Laboratories, Inc. Test for esterase activity in a liquid sample
DE3309544A1 (de) * 1983-03-17 1984-09-20 Macherey-Nagel & Co Chemikalienhandel, 5160 Düren Teststreifen zum nachweis von leukozyten im harn
DE3329394A1 (de) * 1983-08-13 1985-02-28 Bayer Ag, 5090 Leverkusen Chromogene und fluorogene carbonsaeureester, verfahren zu deren herstellung sowie verfahren und mittel zum nachweis und zur bestimmung von hydrolasen
DE3484867D1 (de) * 1983-12-14 1991-09-05 Upjohn Co Substituierte naphthalene, indole, benzofurane und benzothiophene als lypoxygenase-inhibitoren.
US4657855A (en) * 1984-04-06 1987-04-14 Miles Laboratories, Inc. Composition and test device for determining the presence of leukocytes, esterase and protease in a test sample
DE3413118A1 (de) * 1984-04-06 1985-10-24 Miles Laboratories, Inc., Elkhart, Ind. Analysenverfahren und mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
US4637979A (en) * 1984-04-06 1987-01-20 Miles Laboratories, Inc. Composition and test device for determining the presence of leukocytes containing a zwitterion coupling agent
DE3413077A1 (de) * 1984-04-06 1985-10-17 Miles Laboratories, Inc., Elkhart, Ind. Chromogene aminosaeure- und peptidester, verfahren zu deren herstellung, verwendung dieser verbindungen in analysenverfahren sowie mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
DE3413120A1 (de) * 1984-04-06 1985-10-24 Miles Laboratories, Inc., Elkhart, Ind. Analysenverfahren und mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
DE3413119A1 (de) * 1984-04-06 1985-10-24 Miles Laboratories, Inc., Elkhart, Ind. Analysenverfahren und mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
DE3413078A1 (de) * 1984-04-06 1985-10-24 Miles Laboratories, Inc., Elkhart, Ind. Chromogene aminosaeure- und peptidester, verfahren zu deren herstellung, verwendung dieser verbindungen in analysenverfahren sowie mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
DE3446714A1 (de) * 1984-12-21 1986-06-26 Boehringer Mannheim Gmbh Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens
US4777267A (en) * 1986-02-07 1988-10-11 Kanebo Ltd. 1,3-dioxol-2-one derivatives
US4677075A (en) * 1986-05-05 1987-06-30 Louderback Allan Lee Urobilinogen control
DE3813503A1 (de) * 1988-04-22 1989-11-02 Boehringer Mannheim Gmbh Traegergebundenes mehrkomponentiges nachweissystem zur kolorimetrischen bestimmung esterolytisch oder/und proteolytisch aktiver inhaltsstoffe von koerperfluessigkeiten
US5084324A (en) * 1989-08-25 1992-01-28 W. R. Grace & Co.-Conn. Micro-bubble laminate with perforated substrate
US4950354A (en) * 1989-08-25 1990-08-21 W. R. Grace & Co.-Conn. Method of making a micro-bubble laminate
JPH0465584U (sh) * 1990-10-12 1992-06-08
EP0661280A1 (en) * 1993-12-29 1995-07-05 Kyoto Daiichi Kagaku Co., Ltd. Novel amino acid ester and reagent composition for detecting leucocytes or elastase in body liquid
CA2161574A1 (en) 1994-11-15 1996-05-16 James Noffsinger Methodology for colorimetrically determining the concentration of white blood cells in a biological fluid
US6348324B1 (en) 1999-01-21 2002-02-19 Hypoguard America Limited Composition and device for detecting leukocytes in urine
US6528652B1 (en) 1999-01-21 2003-03-04 Chronimed Composition and device for detecting leukocytes in urine
US6203496B1 (en) * 1999-08-12 2001-03-20 Michael R. Gael Apparatus with reagents for detection of medical conditions
IL140993A0 (en) 2000-05-15 2002-02-10 Bayer Ag Trypsin substrate and diagnostic device, and method of using same
US6955921B2 (en) 2001-04-30 2005-10-18 Bayer Corporation Trypsin substrate and diagnostic device, and method of using same
US6709868B2 (en) * 2002-05-20 2004-03-23 Portascience Inc. Method and apparatus for measuring white blood cell count
US7727206B2 (en) * 2005-12-27 2010-06-01 Gorres Geoffrey H Device for monitoring a patient for a urinary tract infection
EP3848708A1 (en) * 2020-01-13 2021-07-14 Roche Diagnostics GmbH Reagent formulation for leukocyte test strip

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
GB1128371A (en) * 1965-10-04 1968-09-25 Miles Lab Diagnostic composition
US3585001A (en) * 1969-02-17 1971-06-15 Miles Lab Stabilized test device and process for detecting couplable compounds
US3715325A (en) * 1970-10-02 1973-02-06 Miles Lab Insoluble polymeric diazonium salt chromogen
US3905872A (en) * 1973-12-14 1975-09-16 American Cyanamid Co Alkaline phosphatase test material
DE2531539A1 (de) * 1975-07-15 1977-01-20 Riedel De Haen Ag Indikatorsubstanz zum nachweis von kuppelnden fluessigkeits-inhaltsstoffen, diese enthaltende diagnostische mittel und verfahren zu deren herstellung
DE2836644A1 (de) * 1978-08-22 1980-03-06 Boehringer Mannheim Gmbh Diagnostisches mittel zum nachweis von leukozyten in koerperfluessigkeiten und dafuer geeignete chromogene
DE2854987A1 (de) * 1978-12-20 1980-06-26 Boehringer Mannheim Gmbh Diagnostische mittel zum nachweis proteolytischer enzyme und dafuer geeignete chromogene
DE2905531A1 (de) * 1979-02-14 1981-01-08 Boehringer Mannheim Gmbh Diagnostisches mittel zum nachweis von leukozyten in koerperfluessigkeiten
DE2936543A1 (de) * 1979-09-10 1981-04-09 Behringwerke Ag, 3550 Marburg Chromogene verbindungen
DE3017721A1 (de) * 1980-05-09 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim Mittel zum nachweis esterolytischer und/oder proteolytischer enzyme und dafuer geeignete substrate

Also Published As

Publication number Publication date
JPH0243480B2 (sh) 1990-09-28
US4749648A (en) 1988-06-07
YU112483A (en) 1989-10-31
PT73005A (de) 1981-06-01
DK204881A (da) 1981-11-10
AU7023981A (en) 1981-11-12
HU187334B (en) 1985-12-28
US4551428A (en) 1985-11-05
ATE3993T1 (de) 1983-07-15
BR8102876A (pt) 1982-02-02
FI77692B (fi) 1988-12-30
JPS6145982B2 (sh) 1986-10-11
SU1466663A3 (ru) 1989-03-15
ES8202792A1 (es) 1982-03-01
JPS61199800A (ja) 1986-09-04
JPS578798A (en) 1982-01-18
ZA812961B (en) 1982-05-26
FI77692C (fi) 1989-04-10
MY8600605A (en) 1986-12-31
PT73005B (de) 1982-07-01
AR228452A1 (es) 1983-03-15
EP0039880A1 (de) 1981-11-18
DD158559A5 (de) 1983-01-19
DE3160522D1 (en) 1983-08-04
SG38786G (en) 1989-09-01
ES502034A0 (es) 1982-03-01
EP0039880B1 (de) 1983-06-29
CA1186201A (en) 1985-04-30
YU117781A (en) 1983-12-31
CS223999B2 (en) 1983-11-25
PL131123B1 (en) 1984-10-31
DE3017721A1 (de) 1981-11-26
AU523744B2 (en) 1982-08-12
FI811418L (fi) 1981-11-10
HK82586A (en) 1986-11-07
UA6035A1 (uk) 1994-12-29
EP0039880B2 (de) 1987-06-03
DK169974B1 (da) 1995-04-18
PL231002A1 (sh) 1981-12-23

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