DK169726B1 - DNA-isolat omfattende en kontinuert sekvens, som koder for humant serumalbumin, og fremgangsmåde til konstruktion deraf samt en replicerbar mikrobiel udtrykkelsesvektor, som er i stand til at udtrykke DNA-sekvensen, en mikroorganisme, som er transformeret med vektoren, en gæringskultur af en sådan mikroorganisme og en fremgangsmåde til fremstilling af humant serumalbumin i moden form ved dyrkning - Google Patents

DNA-isolat omfattende en kontinuert sekvens, som koder for humant serumalbumin, og fremgangsmåde til konstruktion deraf samt en replicerbar mikrobiel udtrykkelsesvektor, som er i stand til at udtrykke DNA-sekvensen, en mikroorganisme, som er transformeret med vektoren, en gæringskultur af en sådan mikroorganisme og en fremgangsmåde til fremstilling af humant serumalbumin i moden form ved dyrkning Download PDF

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Publication number
DK169726B1
DK169726B1 DK384582A DK384582A DK169726B1 DK 169726 B1 DK169726 B1 DK 169726B1 DK 384582 A DK384582 A DK 384582A DK 384582 A DK384582 A DK 384582A DK 169726 B1 DK169726 B1 DK 169726B1
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Denmark
Prior art keywords
serum albumin
human serum
dna
sequence
fragments
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DK384582A
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Danish (da)
English (en)
Other versions
DK384582A (da
Inventor
Richard M Lawn
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK384582A 1981-08-28 1982-08-27 DNA-isolat omfattende en kontinuert sekvens, som koder for humant serumalbumin, og fremgangsmåde til konstruktion deraf samt en replicerbar mikrobiel udtrykkelsesvektor, som er i stand til at udtrykke DNA-sekvensen, en mikroorganisme, som er transformeret med vektoren, en gæringskultur af en sådan mikroorganisme og en fremgangsmåde til fremstilling af humant serumalbumin i moden form ved dyrkning DK169726B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29738081A 1981-08-28 1981-08-28
US29738081 1981-08-28

Publications (2)

Publication Number Publication Date
DK384582A DK384582A (da) 1983-03-01
DK169726B1 true DK169726B1 (da) 1995-01-23

Family

ID=23146077

Family Applications (1)

Application Number Title Priority Date Filing Date
DK384582A DK169726B1 (da) 1981-08-28 1982-08-27 DNA-isolat omfattende en kontinuert sekvens, som koder for humant serumalbumin, og fremgangsmåde til konstruktion deraf samt en replicerbar mikrobiel udtrykkelsesvektor, som er i stand til at udtrykke DNA-sekvensen, en mikroorganisme, som er transformeret med vektoren, en gæringskultur af en sådan mikroorganisme og en fremgangsmåde til fremstilling af humant serumalbumin i moden form ved dyrkning

Country Status (14)

Country Link
EP (1) EP0073646B1 (xx)
JP (4) JPS5856684A (xx)
KR (1) KR840001216A (xx)
AT (1) ATE43138T1 (xx)
AU (2) AU8775582A (xx)
CA (1) CA1221927A (xx)
DE (1) DE3279699D1 (xx)
DK (1) DK169726B1 (xx)
ES (1) ES515259A0 (xx)
GB (2) GB2105343B (xx)
IE (1) IE53892B1 (xx)
IL (1) IL66614A (xx)
NZ (1) NZ201704A (xx)
ZA (1) ZA826250B (xx)

Families Citing this family (44)

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EP0079739A3 (en) * 1981-11-12 1984-08-08 The Upjohn Company Albumin-based nucleotides, their replication and use, and plasmids for use therein
EP0091527A3 (en) * 1981-12-14 1984-07-25 The President And Fellows Of Harvard College Dna sequences, recombinant dna molecules and processes for producing human serum albumin-like polypeptides
FR2579223B1 (fr) * 1985-03-25 1988-12-09 Genetica Procede de preparation microbiologique de la serum-albumine humaine
EP0206733A1 (en) * 1985-06-17 1986-12-30 Genex Corporation Cloned human serum albumin gene
US4956282A (en) * 1985-07-29 1990-09-11 Calgene, Inc. Mammalian peptide expression in plant cells
FR2594846B1 (fr) * 1986-02-21 1989-10-20 Genetica Procede de preparation de la serum albumine humaine mature
CA1323850C (en) * 1987-07-28 1993-11-02 Johannes A. Van Den Berg Kluyveromyces as a host strain
SE459586B (sv) * 1987-09-14 1989-07-17 Mta Szegedi Biolog Koezponti Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning
US5879907A (en) * 1987-09-14 1999-03-09 Skandigen Ab Artificial gene coding for authentic human serum albumin, use thereof and method
GB8725529D0 (en) * 1987-10-30 1987-12-02 Delta Biotechnology Ltd Polypeptides
IL88326A (en) * 1987-11-18 1993-03-15 Gist Brocades Nv Purification of serum albumin
JPH01215289A (ja) * 1988-02-22 1989-08-29 Toa Nenryo Kogyo Kk 遺伝子組換えによる正常ヒト血清アルブミンａの製造方法
US4990447A (en) * 1988-06-24 1991-02-05 Gist-Brocades Nv Process for the purification of serum albumin
GB8820951D0 (en) * 1988-09-07 1988-10-05 Delta Biotechnology Ltd Fermentation method
US5260202A (en) * 1988-09-07 1993-11-09 Delta Biotechnology Limited Fermentation method
US5759802A (en) * 1988-10-26 1998-06-02 Tonen Corporation Production of human serum alubumin A
JPH0671432B2 (ja) * 1991-03-20 1994-09-14 株式会社ミドリ十字 ヒト血清アルブミンの製造方法
CA2058820C (en) * 1991-04-25 2003-07-15 Kotikanyad Sreekrishna Expression cassettes and vectors for the secretion of human serum albumin in pichia pastoris cells
US5330901A (en) * 1991-04-26 1994-07-19 Research Corporation Technologies, Inc. Expression of human serum albumin in Pichia pastoris
DE69230273T2 (de) 1991-07-12 2000-05-31 Dsm N.V., Heerlen Verfahren zur Reinigung von Serumalbumin
US5849874A (en) * 1991-07-12 1998-12-15 Gist-Brocades, N.V. Process for the purification of serum albumin
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
JPH07102148B2 (ja) * 1992-05-20 1995-11-08 株式会社ミドリ十字 遺伝子操作により得られるヒト血清アルブミンの製造方法、およびそれにより得られるヒト血清アルブミン含有組成物
US5728553A (en) 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
JPH07308199A (ja) 1994-05-18 1995-11-28 Green Cross Corp:The ヒト血清アルブミンの製造方法
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
CA2405557C (en) 2000-04-12 2013-09-24 Human Genome Sciences, Inc. Albumin fusion proteins
JP4798832B2 (ja) 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 ヒト血清アルブミン多量体の除去方法
JP4798833B2 (ja) 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 加熱処理工程を含むヒト血清アルブミンの製造方法
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
EP2261250B1 (en) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin fusion proteins
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
ATE428722T1 (de) 2004-01-20 2009-05-15 Chemo Sero Therapeut Res Inst Verfahren zur herstellung von humanserumalbumin durch wärmebehandlung in gegenwart von zweiwertigem kation
JP4651282B2 (ja) 2004-01-21 2011-03-16 田辺三菱製薬株式会社 造血幹細胞及び造血前駆細胞の増幅方法
JP4492156B2 (ja) 2004-03-03 2010-06-30 ニプロ株式会社 血清アルブミンドメインを含む蛋白質
DK2330200T3 (en) 2004-12-23 2017-07-24 Albumedix As GENE EXPRESSION TECHNIQUE
BRPI0912663A2 (pt) 2008-05-15 2016-01-26 R Tech Ueno Ltd composição farmacêutica para o tratamento de olho seco e/ou lesão corneal e conjuntival
EP2396347B1 (en) 2009-02-11 2017-04-12 Albumedix A/S Albumin variants and conjugates
JP5710588B2 (ja) 2009-04-09 2015-04-30 セルカ ゲーエムベーハー 単一細胞クローニングの改良法
BR112014000042A2 (pt) 2011-07-05 2017-02-21 Novozymes Biopharma Dk As composição, meio de cultura celular, uso de uma composição, e, método para cultivar células
EP4442251A1 (en) 2023-04-05 2024-10-09 Albumedix Ltd Formulations and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719177A (en) * 1981-04-20 1988-01-12 Massachusetts Institute Of Technology Production of complementary DNA representing RNA viral sequences by recombinant DNA methods and uses therefor
FR2506326A1 (fr) * 1981-05-19 1982-11-26 Pasteur Institut Fragments d'adn portant des parties de l'information genetique des poliovirus, notamment du type pv1, et procede pour leur obtention
EP0079739A3 (en) * 1981-11-12 1984-08-08 The Upjohn Company Albumin-based nucleotides, their replication and use, and plasmids for use therein
EP0091527A3 (en) * 1981-12-14 1984-07-25 The President And Fellows Of Harvard College Dna sequences, recombinant dna molecules and processes for producing human serum albumin-like polypeptides

Also Published As

Publication number Publication date
AU8775582A (en) 1983-03-03
DE3279699D1 (en) 1989-06-22
JPH0775538B2 (ja) 1995-08-16
EP0073646A2 (en) 1983-03-09
KR840001216A (ko) 1984-03-28
ES8401133A1 (es) 1983-12-01
JPH0460639B2 (xx) 1992-09-28
GB2105343B (en) 1985-12-24
JPH0662841A (ja) 1994-03-08
AU603394B2 (en) 1990-11-15
JPH08228790A (ja) 1996-09-10
IE822085L (en) 1983-02-28
NZ201704A (en) 1986-08-08
JPS5856684A (ja) 1983-04-04
AU8146187A (en) 1988-03-17
EP0073646B1 (en) 1989-05-17
GB2147903A (en) 1985-05-22
EP0073646A3 (en) 1984-08-01
GB2105343A (en) 1983-03-23
ZA826250B (en) 1983-09-28
JP2968052B2 (ja) 1999-10-25
ATE43138T1 (de) 1989-06-15
IL66614A0 (en) 1982-12-31
IE53892B1 (en) 1989-04-12
GB8423932D0 (en) 1984-10-31
CA1221927A (en) 1987-05-19
GB2147903B (en) 1985-12-24
IL66614A (en) 1985-09-29
JPH05292993A (ja) 1993-11-09
ES515259A0 (es) 1983-12-01
DK384582A (da) 1983-03-01

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired