DK1695980T3 - Co-krystal af human papillomavirus E2 transaktiveringsdomæne/inhibitor og røntgenkoordinater, der definerer inhibitor-bindingslommen - Google Patents
Co-krystal af human papillomavirus E2 transaktiveringsdomæne/inhibitor og røntgenkoordinater, der definerer inhibitor-bindingslommenInfo
- Publication number
- DK1695980T3 DK1695980T3 DK06012247.0T DK06012247T DK1695980T3 DK 1695980 T3 DK1695980 T3 DK 1695980T3 DK 06012247 T DK06012247 T DK 06012247T DK 1695980 T3 DK1695980 T3 DK 1695980T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitor
- tad
- hpv
- complex
- binding pocket
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 8
- 239000013078 crystal Substances 0.000 title abstract 2
- 101000742658 Human papillomavirus type 1 Regulatory protein E2 Proteins 0.000 title 1
- 230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 title 1
- 239000000872 buffer Substances 0.000 abstract 2
- 239000011548 crystallization buffer Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000002156 mixing Methods 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Laminated Bodies (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30441201P | 2001-07-12 | 2001-07-12 | |
| EP02745024A EP1409525B1 (en) | 2001-07-12 | 2002-07-12 | Human papillomavirus e2 transactivation domain/inhibitor co-crystal and x-ray coordinates defining the inhibitor-binding pocket |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1695980T3 true DK1695980T3 (da) | 2010-08-02 |
Family
ID=23176405
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02745024T DK1409525T3 (da) | 2001-07-12 | 2002-07-12 | Humant papillomavirus-E2-transaktiveringsdomæne/inhibitor-co-krystal og röntgenkoordinater, der definerer den inhibitorbindende lomme |
| DK06012247.0T DK1695980T3 (da) | 2001-07-12 | 2002-07-12 | Co-krystal af human papillomavirus E2 transaktiveringsdomæne/inhibitor og røntgenkoordinater, der definerer inhibitor-bindingslommen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02745024T DK1409525T3 (da) | 2001-07-12 | 2002-07-12 | Humant papillomavirus-E2-transaktiveringsdomæne/inhibitor-co-krystal og röntgenkoordinater, der definerer den inhibitorbindende lomme |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7167801B2 (da) |
| EP (2) | EP1409525B1 (da) |
| JP (1) | JP4602665B2 (da) |
| AT (2) | ATE343588T1 (da) |
| AU (1) | AU2002317122B2 (da) |
| CA (1) | CA2448482C (da) |
| DE (2) | DE60236114D1 (da) |
| DK (2) | DK1409525T3 (da) |
| ES (2) | ES2274051T3 (da) |
| HU (1) | HUP0402069A3 (da) |
| IL (2) | IL159150A0 (da) |
| MX (1) | MXPA04000271A (da) |
| NZ (1) | NZ531068A (da) |
| WO (1) | WO2003006495A2 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1627323A4 (en) * | 2003-05-06 | 2008-04-09 | New Century Pharmaceuticals | ALBUMIN FIXATION SITES FOR EVALUATING DRUG INTERACTIONS OR THE DEVELOPMENT OF MEDICAMENTS BASED ON THEIR ALBUMIN BINDING PROPERTIES |
| CA2526675A1 (en) * | 2003-05-26 | 2004-12-02 | Biotie Therapies Corporation | Crystalline vap-1 and uses thereof |
| CA2585115A1 (en) * | 2003-11-03 | 2005-05-12 | New Century Pharmaceuticals, Inc. | Albumin binding sites for evaluating drug interactions and methods of evaluating or designing drugs based on their albumin binding properties |
| US20090118301A1 (en) * | 2007-11-02 | 2009-05-07 | Arbor Vita Corporation | Compositions and Methods for Treating Cancer |
| CN112891520A (zh) * | 2021-04-13 | 2021-06-04 | 吉林省国大生物工程有限公司 | 一种预防和控制人乳头瘤病毒感染（hpv）的活性生物蛋白的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU671808B2 (en) | 1991-10-11 | 1996-09-12 | Chiron Corporation | Methods and compositions for identifying inhibitors of papilloma virus replication |
| US6306580B1 (en) | 1998-05-01 | 2001-10-23 | Boehringer Ingelheim (Canada) Ltd. | Preparation of human papillomavirus E1 having helicase activity and method therefor |
| ATE235509T1 (de) | 1998-06-30 | 2003-04-15 | Deutsches Krebsforsch | Peptide zur inhibition von hpv e7 proteinen |
| WO2000075182A1 (fr) * | 1999-06-04 | 2000-12-14 | Akira Kaji | Cristal de proteine du facteur de recyclage ribosomique (rrf) et son application sur la base de donnees de structure tridimensionnelles provenant du cristal |
| GB9921938D0 (en) | 1999-09-17 | 1999-11-17 | Univ York | Target for antiviral therapy |
| JP2003515324A (ja) * | 1999-11-16 | 2003-05-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | カスパーゼ−７を含む結晶化可能な組成物 |
| MXPA03005479A (es) | 2000-12-18 | 2004-05-31 | Boehringer Ingelheim Ca Ltd | Inhibidores del virus de papiloma. |
-
2002
- 2002-07-11 US US10/193,460 patent/US7167801B2/en not_active Expired - Lifetime
- 2002-07-12 DE DE60236114T patent/DE60236114D1/de not_active Expired - Lifetime
- 2002-07-12 IL IL15915002A patent/IL159150A0/xx unknown
- 2002-07-12 MX MXPA04000271A patent/MXPA04000271A/es active IP Right Grant
- 2002-07-12 EP EP02745024A patent/EP1409525B1/en not_active Expired - Lifetime
- 2002-07-12 DE DE60215658T patent/DE60215658T2/de not_active Expired - Lifetime
- 2002-07-12 CA CA2448482A patent/CA2448482C/en not_active Expired - Fee Related
- 2002-07-12 NZ NZ531068A patent/NZ531068A/en not_active IP Right Cessation
- 2002-07-12 JP JP2003512265A patent/JP4602665B2/ja not_active Expired - Fee Related
- 2002-07-12 EP EP06012247A patent/EP1695980B1/en not_active Expired - Lifetime
- 2002-07-12 HU HU0402069A patent/HUP0402069A3/hu unknown
- 2002-07-12 DK DK02745024T patent/DK1409525T3/da active
- 2002-07-12 AU AU2002317122A patent/AU2002317122B2/en not_active Ceased
- 2002-07-12 DK DK06012247.0T patent/DK1695980T3/da active
- 2002-07-12 ES ES02745024T patent/ES2274051T3/es not_active Expired - Lifetime
- 2002-07-12 AT AT02745024T patent/ATE343588T1/de active
- 2002-07-12 ES ES06012247T patent/ES2342309T3/es not_active Expired - Lifetime
- 2002-07-12 WO PCT/CA2002/001058 patent/WO2003006495A2/en active IP Right Grant
- 2002-07-12 AT AT06012247T patent/ATE465414T1/de active
-
2003
- 2003-12-02 IL IL159150A patent/IL159150A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002317122B2 (en) | 2007-03-15 |
| ATE465414T1 (de) | 2010-05-15 |
| DE60215658D1 (de) | 2006-12-07 |
| DE60215658T2 (de) | 2007-12-27 |
| EP1695980A2 (en) | 2006-08-30 |
| HUP0402069A3 (en) | 2012-09-28 |
| US20030082769A1 (en) | 2003-05-01 |
| ES2342309T3 (es) | 2010-07-05 |
| MXPA04000271A (es) | 2005-03-07 |
| EP1409525A2 (en) | 2004-04-21 |
| IL159150A (en) | 2009-09-01 |
| WO2003006495A2 (en) | 2003-01-23 |
| DK1409525T3 (da) | 2007-02-05 |
| IL159150A0 (en) | 2004-06-01 |
| HUP0402069A2 (hu) | 2005-01-28 |
| EP1409525B1 (en) | 2006-10-25 |
| CA2448482A1 (en) | 2003-01-23 |
| EP1695980A3 (en) | 2006-09-06 |
| CA2448482C (en) | 2011-12-06 |
| ES2274051T3 (es) | 2007-05-16 |
| WO2003006495A3 (en) | 2003-07-31 |
| JP4602665B2 (ja) | 2010-12-22 |
| EP1695980B1 (en) | 2010-04-21 |
| DE60236114D1 (de) | 2010-06-02 |
| ATE343588T1 (de) | 2006-11-15 |
| US7167801B2 (en) | 2007-01-23 |
| NZ531068A (en) | 2006-06-30 |
| JP2005512954A (ja) | 2005-05-12 |
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