ATE343588T1 - Zwitterkristall aus humaner papillomavirus-e2- transaktivierungsdomäne und einem inhibitor sowie roentgen-struktur-koordinaten, die die inhibitorbindende tasche definieren - Google Patents
Zwitterkristall aus humaner papillomavirus-e2- transaktivierungsdomäne und einem inhibitor sowie roentgen-struktur-koordinaten, die die inhibitorbindende tasche definierenInfo
- Publication number
- ATE343588T1 ATE343588T1 AT02745024T AT02745024T ATE343588T1 AT E343588 T1 ATE343588 T1 AT E343588T1 AT 02745024 T AT02745024 T AT 02745024T AT 02745024 T AT02745024 T AT 02745024T AT E343588 T1 ATE343588 T1 AT E343588T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitor
- tad
- hpv
- complex
- binding pocket
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 8
- 101000742658 Human papillomavirus type 1 Regulatory protein E2 Proteins 0.000 title 1
- 230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 title 1
- 239000000872 buffer Substances 0.000 abstract 2
- 239000011548 crystallization buffer Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000002156 mixing Methods 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- 239000013078 crystal Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Laminated Bodies (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30441201P | 2001-07-12 | 2001-07-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE343588T1 true ATE343588T1 (de) | 2006-11-15 |
Family
ID=23176405
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02745024T ATE343588T1 (de) | 2001-07-12 | 2002-07-12 | Zwitterkristall aus humaner papillomavirus-e2- transaktivierungsdomäne und einem inhibitor sowie roentgen-struktur-koordinaten, die die inhibitorbindende tasche definieren |
| AT06012247T ATE465414T1 (de) | 2001-07-12 | 2002-07-12 | Zwitterkristall aus menschlicher papillomavirus- e2-transaktivierungsdomäne und einem inhibitor sowie roentgenstrukturkoordinaten, die die inhibitorbindende tasche definieren |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06012247T ATE465414T1 (de) | 2001-07-12 | 2002-07-12 | Zwitterkristall aus menschlicher papillomavirus- e2-transaktivierungsdomäne und einem inhibitor sowie roentgenstrukturkoordinaten, die die inhibitorbindende tasche definieren |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7167801B2 (de) |
| EP (2) | EP1409525B1 (de) |
| JP (1) | JP4602665B2 (de) |
| AT (2) | ATE343588T1 (de) |
| AU (1) | AU2002317122B2 (de) |
| CA (1) | CA2448482C (de) |
| DE (2) | DE60215658T2 (de) |
| DK (2) | DK1409525T3 (de) |
| ES (2) | ES2342309T3 (de) |
| HU (1) | HUP0402069A3 (de) |
| IL (2) | IL159150A0 (de) |
| MX (1) | MXPA04000271A (de) |
| NZ (1) | NZ531068A (de) |
| WO (1) | WO2003006495A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1627323A4 (de) * | 2003-05-06 | 2008-04-09 | New Century Pharmaceuticals | Albumin-bindestellen zur bewertung von medikamentenwechselwirkungen und verfahren zur bewertung oder entwicklung von medikamenten auf der basis ihrer albumin-bindeeigenschaften |
| WO2004104191A1 (en) * | 2003-05-26 | 2004-12-02 | Biotie Therapies Corporation | Crystalline vap-1 and uses thereof |
| US20070043509A1 (en) * | 2003-11-03 | 2007-02-22 | Carter Daniel C | Albumin binding sites for evaluating drug interactions and methods of evaluating or designing drugs based on their albumin binding properties |
| US20090118301A1 (en) * | 2007-11-02 | 2009-05-07 | Arbor Vita Corporation | Compositions and Methods for Treating Cancer |
| CN112891520A (zh) * | 2021-04-13 | 2021-06-04 | 吉林省国大生物工程有限公司 | 一种预防和控制人乳头瘤病毒感染（hpv）的活性生物蛋白的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU671808B2 (en) | 1991-10-11 | 1996-09-12 | Chiron Corporation | Methods and compositions for identifying inhibitors of papilloma virus replication |
| AU767903B2 (en) | 1998-05-01 | 2003-11-27 | Boehringer Ingelheim (Canada) Ltd. | Preparation of human papillomavirus E1 having helicase activity and method therefor |
| ATE235509T1 (de) | 1998-06-30 | 2003-04-15 | Deutsches Krebsforsch | Peptide zur inhibition von hpv e7 proteinen |
| WO2000075182A1 (fr) * | 1999-06-04 | 2000-12-14 | Akira Kaji | Cristal de proteine du facteur de recyclage ribosomique (rrf) et son application sur la base de donnees de structure tridimensionnelles provenant du cristal |
| GB9921938D0 (en) | 1999-09-17 | 1999-11-17 | Univ York | Target for antiviral therapy |
| EP1232253A2 (de) * | 1999-11-16 | 2002-08-21 | Vertex Pharmaceuticals Incorporated | Caspase-7 enthaltende kristallisierbare zusammensetzungen |
| EP1345943B1 (de) | 2000-12-18 | 2007-03-21 | Boehringer Ingelheim (Canada) Ltd. | Inhibitoren des papilloma-virus |
-
2002
- 2002-07-11 US US10/193,460 patent/US7167801B2/en not_active Expired - Lifetime
- 2002-07-12 DE DE60215658T patent/DE60215658T2/de not_active Expired - Lifetime
- 2002-07-12 AT AT02745024T patent/ATE343588T1/de active
- 2002-07-12 DK DK02745024T patent/DK1409525T3/da active
- 2002-07-12 AU AU2002317122A patent/AU2002317122B2/en not_active Ceased
- 2002-07-12 JP JP2003512265A patent/JP4602665B2/ja not_active Expired - Fee Related
- 2002-07-12 MX MXPA04000271A patent/MXPA04000271A/es active IP Right Grant
- 2002-07-12 DK DK06012247.0T patent/DK1695980T3/da active
- 2002-07-12 WO PCT/CA2002/001058 patent/WO2003006495A2/en active IP Right Grant
- 2002-07-12 EP EP02745024A patent/EP1409525B1/de not_active Expired - Lifetime
- 2002-07-12 NZ NZ531068A patent/NZ531068A/en not_active IP Right Cessation
- 2002-07-12 ES ES06012247T patent/ES2342309T3/es not_active Expired - Lifetime
- 2002-07-12 HU HU0402069A patent/HUP0402069A3/hu unknown
- 2002-07-12 IL IL15915002A patent/IL159150A0/xx unknown
- 2002-07-12 EP EP06012247A patent/EP1695980B1/de not_active Expired - Lifetime
- 2002-07-12 ES ES02745024T patent/ES2274051T3/es not_active Expired - Lifetime
- 2002-07-12 AT AT06012247T patent/ATE465414T1/de active
- 2002-07-12 CA CA2448482A patent/CA2448482C/en not_active Expired - Fee Related
- 2002-07-12 DE DE60236114T patent/DE60236114D1/de not_active Expired - Lifetime
-
2003
- 2003-12-02 IL IL159150A patent/IL159150A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK1409525T3 (da) | 2007-02-05 |
| MXPA04000271A (es) | 2005-03-07 |
| JP4602665B2 (ja) | 2010-12-22 |
| EP1409525B1 (de) | 2006-10-25 |
| ATE465414T1 (de) | 2010-05-15 |
| ES2274051T3 (es) | 2007-05-16 |
| IL159150A (en) | 2009-09-01 |
| DK1695980T3 (da) | 2010-08-02 |
| HUP0402069A2 (hu) | 2005-01-28 |
| HUP0402069A3 (en) | 2012-09-28 |
| DE60215658T2 (de) | 2007-12-27 |
| IL159150A0 (en) | 2004-06-01 |
| US7167801B2 (en) | 2007-01-23 |
| EP1409525A2 (de) | 2004-04-21 |
| WO2003006495A2 (en) | 2003-01-23 |
| CA2448482A1 (en) | 2003-01-23 |
| EP1695980A3 (de) | 2006-09-06 |
| DE60236114D1 (de) | 2010-06-02 |
| EP1695980A2 (de) | 2006-08-30 |
| DE60215658D1 (de) | 2006-12-07 |
| ES2342309T3 (es) | 2010-07-05 |
| US20030082769A1 (en) | 2003-05-01 |
| AU2002317122B2 (en) | 2007-03-15 |
| CA2448482C (en) | 2011-12-06 |
| NZ531068A (en) | 2006-06-30 |
| EP1695980B1 (de) | 2010-04-21 |
| JP2005512954A (ja) | 2005-05-12 |
| WO2003006495A3 (en) | 2003-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE452870T1 (de) | (meth)acrylsaeurekristall und verfahren zur herstellung und aufreinigung von waessriger (meth)acrylsaeure | |
| ATE448225T1 (de) | Aza-bicycloalkylether und deren verwendung als alpha7-nachr agonisten | |
| ATE381963T1 (de) | Verfahren zur herstellung von gereinigten partikeln | |
| MXPA04004464A (es) | Compuestos de heteroarilo sustituido con azabiciclo para el tratamiento de enfermedades. | |
| PL373374A1 (en) | Substituted cycloalkyl p1' hepatitis c virus inhibitors | |
| ATE206122T1 (de) | Verbindungen, die als antiproliferative mittel und als garft inhibitoren verwendbar sind | |
| ATE431340T1 (de) | N- (1-benzyl-2-oxo-2- (1-piperazinyl) ethyl) -1- piperidincarboxamid-derivate und verwandte verbindungen als cgrp-antagonisten zur behandlung von kopfschmerzen | |
| RU94038064A (ru) | Производные пиперазина и пиперидина, их применение в качестве противопсихотических средств, способ их получения фармацевтическая композиция | |
| CY1106721T1 (el) | Μεθοδος παρασκευης υψηλης καθαροτητας περινδοπριλης και ενδιαμεσα χρησιμα στη συνθεση | |
| HUP0500034A2 (hu) | N-Aril-N'-(aril-cikloalkil)-karbamid-származékok mint MCH antagonisták és ezeket hatóanyagként tartalmazó gyógyszerkészítmények | |
| DE69934595D1 (de) | Verwendung von verbindungen die alpha2-antiplasmin in vivo reduzieren zur herstellung einer zusammensetzung zur behandlung ischämischer schlaganfälle | |
| ATE343588T1 (de) | Zwitterkristall aus humaner papillomavirus-e2- transaktivierungsdomäne und einem inhibitor sowie roentgen-struktur-koordinaten, die die inhibitorbindende tasche definieren | |
| ATE255124T1 (de) | Verfahren zur gewinnung von phytosterinen durch kristallisation aus verminderten mengen methanols | |
| ATE94757T1 (de) | Lysolecithinderivate zur behandlung von autoimmunerkrankungen. | |
| EA200501593A1 (ru) | Азабициклические производные в качестве антагонистов мускаринового рецептора | |
| DE60316791D1 (de) | Verfahren zur aufreinigung von lanzoprazol | |
| EA200601641A1 (ru) | Кристаллическая композиция, содержащая оксалат эсциталопрама | |
| DE60236853D1 (de) | Pharmazeutische zusammensetzung aus f(ab) 2- fragmenten von antikörpern und verfahren zu ihrer herstellung | |
| GR3021303T3 (en) | Benzimidazoles, pharmaceutical compositions containing them and process for their preparation | |
| RU94000064A (ru) | Новые 2-циано-3-гидроксипропенамиды, метод их получения и содержащие их фармацевтические композиции | |
| DE60005304D1 (de) | Methode zur reinigung und abtrennung von (2s,3s)- oder (2r,3s)-halohydrinderivaten | |
| DE60312953D1 (de) | Stabiles lansoprazol, enthaltend mehr als 500 ppm bis zu 3000 ppm wasser und mehr als 200 ppm bis zu 5000 ppm alkohol | |
| TR200503398T1 (tr) | Trandolapril'in yeni kristal formları. | |
| ATE477267T1 (de) | Methode zur reinigung von proteinen | |
| ATE540974T1 (de) | Reinigung des rekombinanten menschlichen faktors xiii |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1409525 Country of ref document: EP |