ATE540974T1 - Reinigung des rekombinanten menschlichen faktors xiii - Google Patents
Reinigung des rekombinanten menschlichen faktors xiiiInfo
- Publication number
- ATE540974T1 ATE540974T1 AT05815706T AT05815706T ATE540974T1 AT E540974 T1 ATE540974 T1 AT E540974T1 AT 05815706 T AT05815706 T AT 05815706T AT 05815706 T AT05815706 T AT 05815706T AT E540974 T1 ATE540974 T1 AT E540974T1
- Authority
- AT
- Austria
- Prior art keywords
- factor xiii
- less
- methods
- affinity chromatography
- purification
- Prior art date
Links
- 238000000746 purification Methods 0.000 title abstract 2
- 229940005809 human factor xiii Drugs 0.000 title 1
- 238000000034 method Methods 0.000 abstract 8
- 108010071289 Factor XIII Proteins 0.000 abstract 6
- 229940012444 factor xiii Drugs 0.000 abstract 6
- 238000001597 immobilized metal affinity chromatography Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108010000196 Factor XIIIa Proteins 0.000 abstract 1
- 238000001042 affinity chromatography Methods 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000000356 contaminant Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 238000004255 ion exchange chromatography Methods 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63061404P | 2004-11-23 | 2004-11-23 | |
| PCT/EP2005/056169 WO2006056575A1 (en) | 2004-11-23 | 2005-11-23 | Purification of recombinant human factor xiii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE540974T1 true ATE540974T1 (de) | 2012-01-15 |
Family
ID=35717653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05815706T ATE540974T1 (de) | 2004-11-23 | 2005-11-23 | Reinigung des rekombinanten menschlichen faktors xiii |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8461302B2 (de) |
| EP (1) | EP1817339B1 (de) |
| JP (1) | JP5086093B2 (de) |
| AT (1) | ATE540974T1 (de) |
| AU (1) | AU2005308830B2 (de) |
| CA (1) | CA2587139C (de) |
| ES (1) | ES2378777T3 (de) |
| IL (1) | IL182830A (de) |
| WO (1) | WO2006056575A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2743346A1 (de) * | 2012-12-11 | 2014-06-18 | Zedira GmbH | Kristallstruktur des Blutgerinnungsfaktors XIIIa |
| CN110314414B (zh) * | 2019-07-23 | 2021-10-19 | 宝锐生物科技泰州有限公司 | 凝血因子xiii的分离纯化方法及其应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3931399A (en) | 1970-12-22 | 1976-01-06 | Behringwerke Aktiengesellschaft | Process for isolating a fibrin-stabilizing factor |
| US3904751A (en) | 1970-12-22 | 1975-09-09 | Behringwerke Ag | Process for isolating a fibrin stabilizing factor from human placenta |
| US4265233A (en) | 1978-04-12 | 1981-05-05 | Unitika Ltd. | Material for wound healing |
| AT359653B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
| AT359652B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
| DE3105624A1 (de) | 1981-02-16 | 1982-09-02 | Hormon-Chemie München GmbH, 8000 München | Material zum abdichten und heilen von wunden |
| AT369990B (de) | 1981-07-28 | 1983-02-25 | Immuno Ag | Verfahren zur herstellung eines gewebeklebstoffes |
| DE3419581A1 (de) | 1984-05-25 | 1985-11-28 | Behringwerke Ag, 3550 Marburg | Verfahren zur gewinnung einer faktor xiii-praeparation sowie ihre verwendung |
| DE3621371A1 (de) | 1986-03-12 | 1987-09-17 | Behringwerke Ag | Gentechnische herstellung von faktor xiiia |
| ATE121776T1 (de) | 1986-09-19 | 1995-05-15 | Zymogenetics Inc | Expression des biologisch aktiven faktors xiii. |
| JPS63196520A (ja) | 1987-02-09 | 1988-08-15 | Hoechst Japan Kk | 潰瘍性大腸炎治療剤 |
| JPH01216939A (ja) | 1988-02-24 | 1989-08-30 | Hoechst Japan Kk | 末熟児頭蓋内出血阻止剤 |
| US5612456A (en) | 1988-11-14 | 1997-03-18 | Zymogenetics, Inc. | Factor XIII compositions |
| US5204447A (en) | 1988-11-14 | 1993-04-20 | Zymogenetics, Inc. | Purification of factor xiii |
| JPH02247199A (ja) | 1989-03-17 | 1990-10-02 | Green Cross Corp:The | ヒト血液凝固第ｘ３因子の製造法 |
| WO1991014780A1 (en) | 1990-03-21 | 1991-10-03 | Board Of Regents, The University Of Texas System | Yeast expression vectors |
| WO1993003147A1 (en) | 1991-08-07 | 1993-02-18 | Zymogenetics, Inc. | Purification of factor xiii |
| AU3423493A (en) | 1991-12-31 | 1993-07-28 | Zymogenetics Inc. | Methods and compositions for reducing blood loss |
| JP3195439B2 (ja) * | 1992-09-28 | 2001-08-06 | 森永製菓株式会社 | 第ｘｉｉｉ因子の精製方法 |
| CZ20023667A3 (cs) | 2000-05-10 | 2003-04-16 | Novo Nordisk A/S | Farmaceutický prostředek obsahující VIIA a XIII faktory |
| US20040014657A1 (en) | 2001-11-05 | 2004-01-22 | Jan Ohrstrom | Use of blood coagulation factor XIII for treating haemophilia A |
| ATE360437T1 (de) | 2000-11-03 | 2007-05-15 | Zymogenetics Inc | Verwendung des blutgerinnungsfaktors xiii für die behandlung der hämophilie a |
| US20040033947A1 (en) | 2001-11-08 | 2004-02-19 | Jan Ohrstrom | Method for treating hemophilia b |
| AU2002226004A1 (en) | 2000-11-10 | 2002-05-21 | Zymogenetics Inc. | Use of factor xiii for treating hemophilia b |
| US7008926B2 (en) | 2001-02-22 | 2006-03-07 | Zymogenetics Inc. | Blood coagulation factor XIII for treating platelet disorders |
| GB0216001D0 (en) * | 2002-07-10 | 2002-08-21 | Nat Blood Authority | Process and composition |
| JP2004123566A (ja) | 2002-09-30 | 2004-04-22 | Nihon Pharmaceutical Co Ltd | ヒト血漿由来血液凝固第ｘｉｉｉ因子製剤およびその製造方法 |
| CU23475A1 (es) | 2004-07-08 | 2009-12-17 | Ct Ingenieria Genetica Biotech | Composición farmacéutica conteniendo fragmentos polipeptídicos de serralisinas |
| JP2008510476A (ja) * | 2004-08-27 | 2008-04-10 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 生物学的材料からのｘｉｉｉ因子ポリペプチドの精製 |
-
2005
- 2005-11-23 ES ES05815706T patent/ES2378777T3/es not_active Expired - Lifetime
- 2005-11-23 US US11/720,032 patent/US8461302B2/en active Active
- 2005-11-23 EP EP05815706A patent/EP1817339B1/de not_active Expired - Lifetime
- 2005-11-23 CA CA2587139A patent/CA2587139C/en not_active Expired - Lifetime
- 2005-11-23 JP JP2007541983A patent/JP5086093B2/ja not_active Expired - Lifetime
- 2005-11-23 AU AU2005308830A patent/AU2005308830B2/en not_active Expired
- 2005-11-23 WO PCT/EP2005/056169 patent/WO2006056575A1/en not_active Ceased
- 2005-11-23 AT AT05815706T patent/ATE540974T1/de active
-
2007
- 2007-04-26 IL IL182830A patent/IL182830A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005308830B2 (en) | 2012-01-19 |
| ES2378777T3 (es) | 2012-04-17 |
| EP1817339A1 (de) | 2007-08-15 |
| JP2008520220A (ja) | 2008-06-19 |
| US8461302B2 (en) | 2013-06-11 |
| JP5086093B2 (ja) | 2012-11-28 |
| EP1817339B1 (de) | 2012-01-11 |
| US20080281080A1 (en) | 2008-11-13 |
| AU2005308830A1 (en) | 2006-06-01 |
| CA2587139A1 (en) | 2006-06-01 |
| CA2587139C (en) | 2014-05-27 |
| IL182830A0 (en) | 2007-08-19 |
| WO2006056575A1 (en) | 2006-06-01 |
| IL182830A (en) | 2013-12-31 |
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