DK1694641T3 - Prostaglandinsyntese - Google Patents
ProstaglandinsynteseInfo
- Publication number
- DK1694641T3 DK1694641T3 DK04801246T DK04801246T DK1694641T3 DK 1694641 T3 DK1694641 T3 DK 1694641T3 DK 04801246 T DK04801246 T DK 04801246T DK 04801246 T DK04801246 T DK 04801246T DK 1694641 T3 DK1694641 T3 DK 1694641T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- group
- prostaglandin synthesis
- halo
- formula
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000003180 prostaglandins Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- -1 prostaglandin compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0329379.2A GB0329379D0 (en) | 2003-12-19 | 2003-12-19 | Prostaglandin synthesis |
| PCT/GB2004/005028 WO2005058812A2 (en) | 2003-12-19 | 2004-12-01 | Prostaglandin synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1694641T3 true DK1694641T3 (da) | 2009-07-20 |
Family
ID=30471335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04801246T DK1694641T3 (da) | 2003-12-19 | 2004-12-01 | Prostaglandinsyntese |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1694641B1 (zh) |
| JP (3) | JP4764828B2 (zh) |
| KR (1) | KR20060118555A (zh) |
| CN (2) | CN101486699B (zh) |
| AT (1) | ATE428693T1 (zh) |
| AU (2) | AU2004299316B2 (zh) |
| CA (2) | CA2549056C (zh) |
| CZ (1) | CZ305964B6 (zh) |
| DE (1) | DE602004020667D1 (zh) |
| DK (1) | DK1694641T3 (zh) |
| ES (1) | ES2325266T3 (zh) |
| GB (1) | GB0329379D0 (zh) |
| IL (2) | IL175940A (zh) |
| WO (1) | WO2005058812A2 (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008037782A (ja) * | 2006-08-04 | 2008-02-21 | Daiichi Fine Chemical Co Ltd | プロスタグランジン誘導体の製造方法 |
| US7642370B2 (en) | 2006-08-07 | 2010-01-05 | Daiichi Fine Chemical Co., Ltd. | Method for preparing prostaglandin derivative |
| AR071312A1 (es) * | 2008-04-09 | 2010-06-09 | Scinopharm Taiwan Ltd | Proceso para la preparacion de analogos de prostaglandina y sus intermediarios |
| EP2135860A1 (en) * | 2008-06-20 | 2009-12-23 | Sandoz AG | Improved process for the production of bimatoprost |
| EP2454227B1 (en) | 2009-07-13 | 2020-08-19 | Patheon API Services Inc. | Synthesis of prostanoids |
| WO2011050638A1 (zh) | 2009-11-02 | 2011-05-05 | 上海天伟生物制药有限公司 | 一种比马前列素晶体及其制备方法和用途 |
| CN106349138A (zh) | 2011-06-02 | 2017-01-25 | 奇诺因私人有限公司 | 用于制备前列腺素酰胺的新的方法 |
| HU231203B1 (hu) * | 2011-12-21 | 2021-10-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Új eljárás travoprost előállítására |
| EP2822927A1 (en) * | 2012-03-09 | 2015-01-14 | Instytut Farmaceutyczny | PROCESS FOR PREPARATION OF PROSTAGLANDIN F2alpha ANALOGUES |
| CN104884006B (zh) | 2012-10-26 | 2017-12-15 | 弗赛特影像5股份有限公司 | 用于持续释放药物到眼睛的眼科系统 |
| CA2925927C (en) | 2013-09-30 | 2022-09-06 | George Petros Yiannikouros | Novel synthesis routes for prostaglandins and prostaglandin intermediates using metathesis |
| EP3283004A4 (en) | 2015-04-13 | 2018-12-05 | Forsight Vision5, Inc. | Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent |
| EP3235810A1 (en) * | 2016-04-19 | 2017-10-25 | Gentec, S.A. | Process for the preparation of bimatoprost |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1582853A (en) * | 1977-06-16 | 1981-01-14 | Ici Ltd | Prostane derivatives |
| JPS562979A (en) * | 1979-06-19 | 1981-01-13 | Ono Pharmaceut Co Ltd | Prostaglandin i2 analog compound, its preparation, and pharmaceutical composition containing the same |
| JPS57171965A (en) * | 1981-04-15 | 1982-10-22 | Teijin Ltd | Novel prostaglandin intermediate and its preparation |
| US4708966A (en) * | 1986-06-27 | 1987-11-24 | The Procter & Gamble Company | Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation |
| JPS63188687A (ja) * | 1987-01-30 | 1988-08-04 | Sagami Chem Res Center | 有機ケイ素化合物の製造方法 |
| JP2536026B2 (ja) * | 1988-03-10 | 1996-09-18 | 史衛 佐藤 | α，β―置換シクロペンタノン誘導体の製造法 |
| US5698733A (en) * | 1994-09-30 | 1997-12-16 | Alcon Laboratories, Inc. | Use of 9-deoxy prostaglandin derivatives to treat glaucoma |
| US6015922A (en) * | 1997-12-19 | 2000-01-18 | Alcon Laboratories, Inc. | N-alkyl-N-alkoxycarboxamides and methods of use in prostaglandin synthesis |
| GB9908327D0 (en) * | 1999-04-12 | 1999-06-09 | Chirotech Technology Ltd | Process for the preparation of prostaglandin precursors |
| AU770343B2 (en) * | 1999-09-06 | 2004-02-19 | Fumie Sato | Prostaglandin E analogues |
| KR100581647B1 (ko) * | 2001-07-17 | 2006-05-22 | 파마시아 앤드 업존 캄파니 엘엘씨 | 라타노프로스트 제조를 위한 방법 및 중간체 |
| US20030187071A1 (en) * | 2001-07-17 | 2003-10-02 | Henegar Kevin E. | Process and intermediates to prepare latanoprost |
-
2003
- 2003-12-19 GB GBGB0329379.2A patent/GB0329379D0/en not_active Ceased
-
2004
- 2004-12-01 KR KR1020067012014A patent/KR20060118555A/ko not_active Application Discontinuation
- 2004-12-01 CA CA2549056A patent/CA2549056C/en active Active
- 2004-12-01 WO PCT/GB2004/005028 patent/WO2005058812A2/en active Application Filing
- 2004-12-01 AU AU2004299316A patent/AU2004299316B2/en active Active
- 2004-12-01 AT AT04801246T patent/ATE428693T1/de active
- 2004-12-01 ES ES04801246T patent/ES2325266T3/es active Active
- 2004-12-01 DK DK04801246T patent/DK1694641T3/da active
- 2004-12-01 CN CN2009100028542A patent/CN101486699B/zh active Active
- 2004-12-01 CA CA2854783A patent/CA2854783C/en active Active
- 2004-12-01 DE DE602004020667T patent/DE602004020667D1/de active Active
- 2004-12-01 CN CN2004800379243A patent/CN1894209B/zh active Active
- 2004-12-01 EP EP04801246A patent/EP1694641B1/en active Active
- 2004-12-01 CZ CZ2006-386A patent/CZ305964B6/cs unknown
- 2004-12-01 JP JP2006544532A patent/JP4764828B2/ja active Active
-
2006
- 2006-05-25 IL IL175940A patent/IL175940A/en active IP Right Grant
-
2011
- 2011-02-23 AU AU2011200763A patent/AU2011200763B2/en active Active
- 2011-04-15 JP JP2011091348A patent/JP5653827B2/ja active Active
-
2012
- 2012-01-22 IL IL217670A patent/IL217670A/en active IP Right Grant
-
2013
- 2013-07-03 JP JP2013140108A patent/JP5795354B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007517780A (ja) | 2007-07-05 |
| KR20060118555A (ko) | 2006-11-23 |
| JP2011201883A (ja) | 2011-10-13 |
| IL175940A (en) | 2012-05-31 |
| CN101486699B (zh) | 2012-06-27 |
| ATE428693T1 (de) | 2009-05-15 |
| IL175940A0 (en) | 2006-10-05 |
| GB0329379D0 (en) | 2004-01-21 |
| WO2005058812A2 (en) | 2005-06-30 |
| EP1694641B1 (en) | 2009-04-15 |
| JP4764828B2 (ja) | 2011-09-07 |
| CA2549056C (en) | 2014-09-02 |
| CN1894209B (zh) | 2010-12-22 |
| CZ305964B6 (cs) | 2016-05-25 |
| CA2854783C (en) | 2017-01-10 |
| AU2004299316A1 (en) | 2005-06-30 |
| EP1694641A2 (en) | 2006-08-30 |
| AU2011200763B2 (en) | 2013-05-30 |
| AU2004299316B2 (en) | 2011-01-06 |
| AU2011200763A1 (en) | 2011-03-17 |
| DE602004020667D1 (en) | 2009-05-28 |
| JP5795354B2 (ja) | 2015-10-14 |
| WO2005058812A3 (en) | 2005-10-13 |
| JP2013231053A (ja) | 2013-11-14 |
| CZ2006386A3 (cs) | 2006-11-15 |
| ES2325266T3 (es) | 2009-08-31 |
| CA2854783A1 (en) | 2005-06-30 |
| JP5653827B2 (ja) | 2015-01-14 |
| CA2549056A1 (en) | 2005-06-30 |
| CN101486699A (zh) | 2009-07-22 |
| CN1894209A (zh) | 2007-01-10 |
| IL217670A (en) | 2013-02-28 |
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