DK169119B1 - Fremgangsmåde til fremstilling af et farmaceutisk præparat i mikrokapselform samt således fremstillet præparat - Google Patents

Fremgangsmåde til fremstilling af et farmaceutisk præparat i mikrokapselform samt således fremstillet præparat Download PDF

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Publication number
DK169119B1
DK169119B1 DK285088A DK285088A DK169119B1 DK 169119 B1 DK169119 B1 DK 169119B1 DK 285088 A DK285088 A DK 285088A DK 285088 A DK285088 A DK 285088A DK 169119 B1 DK169119 B1 DK 169119B1
Authority
DK
Denmark
Prior art keywords
core material
solvent
polymer
microcapsules
process according
Prior art date
Application number
DK285088A
Other languages
Danish (da)
English (en)
Other versions
DK285088A (da
DK285088D0 (da
Inventor
James Ronald Lawter
Michael Gerard Lanzilotti
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DK285088D0 publication Critical patent/DK285088D0/da
Publication of DK285088A publication Critical patent/DK285088A/da
Application granted granted Critical
Publication of DK169119B1 publication Critical patent/DK169119B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Packages (AREA)
  • Materials For Medical Uses (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Polymerisation Methods In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Glass Compositions (AREA)
DK285088A 1987-05-26 1988-05-25 Fremgangsmåde til fremstilling af et farmaceutisk præparat i mikrokapselform samt således fremstillet præparat DK169119B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/054,372 US5000886A (en) 1987-05-26 1987-05-26 Silicone-hardened pharmaceutical microcapsules and process of making the same
US5437287 1987-05-26

Publications (3)

Publication Number Publication Date
DK285088D0 DK285088D0 (da) 1988-05-25
DK285088A DK285088A (da) 1988-11-27
DK169119B1 true DK169119B1 (da) 1994-08-22

Family

ID=21990585

Family Applications (1)

Application Number Title Priority Date Filing Date
DK285088A DK169119B1 (da) 1987-05-26 1988-05-25 Fremgangsmåde til fremstilling af et farmaceutisk præparat i mikrokapselform samt således fremstillet præparat

Country Status (19)

Country Link
US (1) US5000886A (xx)
EP (1) EP0292710B1 (xx)
JP (1) JP2712101B2 (xx)
KR (1) KR970001209B1 (xx)
AT (1) ATE70992T1 (xx)
AU (1) AU618000B2 (xx)
BR (1) BR1100810A (xx)
CA (1) CA1330533C (xx)
DE (1) DE3867313D1 (xx)
DK (1) DK169119B1 (xx)
ES (1) ES2038236T3 (xx)
GR (1) GR3004186T3 (xx)
HK (1) HK116493A (xx)
IE (1) IE61338B1 (xx)
IL (1) IL86274A (xx)
NO (1) NO177984C (xx)
NZ (1) NZ224722A (xx)
PH (1) PH27019A (xx)
ZA (1) ZA883737B (xx)

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US20030161889A1 (en) * 1984-03-16 2003-08-28 Reid Robert H. Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
US6217911B1 (en) 1995-05-22 2001-04-17 The United States Of America As Represented By The Secretary Of The Army sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
US5693343A (en) 1984-03-16 1997-12-02 The United States Of America As Represented By The Secretary Of The Army Microparticle carriers of maximal uptake capacity by both M cells and non-M cells
US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US5811128A (en) * 1986-10-24 1998-09-22 Southern Research Institute Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor
US5985354A (en) * 1995-06-07 1999-11-16 Brown University Research Foundation Preparation of multiwall polymeric microcapsules from hydrophilic polymers
US5143661A (en) * 1987-05-26 1992-09-01 American Cyanamid Company Silicone-hardened pharmaceutical microcapsules
ATE111729T1 (de) * 1988-12-22 1994-10-15 American Cyanamid Co Durch phasentrennung microinkapsulierte arzneimittelzusammensetzung zur verminderung der zahnkrankheit.
DE68915132T2 (de) * 1988-12-22 1994-12-08 American Cyanamid Co., Wayne, N.J. Verfahren zur Behandlung von Periodontitis durch protrahierte Wirkstoffabgabe von Arzneimitteln in der Zahnhöhle, Zusammensetzung davon und Vorrichtung zur Verabreichung.
WO1992019263A1 (en) 1991-04-24 1992-11-12 The United States Of America, As Represented By The Secretary Of The Army Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
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US7033608B1 (en) 1995-05-22 2006-04-25 The United States Of America As Represented By The Secretary Of The Army “Burst-free” sustained release poly-(lactide/glycolide) microspheres
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Also Published As

Publication number Publication date
DK285088A (da) 1988-11-27
JPS63307813A (ja) 1988-12-15
CA1330533C (en) 1994-07-05
KR880013553A (ko) 1988-12-21
PH27019A (en) 1993-02-01
EP0292710A3 (en) 1989-03-22
GR3004186T3 (xx) 1993-03-31
KR970001209B1 (ko) 1997-02-04
NO882277L (no) 1988-11-28
IE61338B1 (en) 1994-11-02
AU618000B2 (en) 1991-12-12
AU1659288A (en) 1988-12-01
ZA883737B (en) 1989-02-22
ES2038236T3 (es) 1993-07-16
IL86274A (en) 1992-03-29
IL86274A0 (en) 1988-11-15
IE881565L (en) 1988-11-26
DE3867313D1 (de) 1992-02-13
US5000886A (en) 1991-03-19
HK116493A (en) 1993-11-05
JP2712101B2 (ja) 1998-02-10
BR1100810A (pt) 1999-10-13
EP0292710B1 (en) 1992-01-02
NO177984B (no) 1995-09-25
NO177984C (no) 1996-01-03
NO882277D0 (no) 1988-05-25
DK285088D0 (da) 1988-05-25
ATE70992T1 (de) 1992-01-15
EP0292710A2 (en) 1988-11-30
NZ224722A (en) 1990-04-26

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B1 Patent granted (law 1993)
PUP Patent expired