DK169119B1 - Fremgangsmåde til fremstilling af et farmaceutisk præparat i mikrokapselform samt således fremstillet præparat - Google Patents

Fremgangsmåde til fremstilling af et farmaceutisk præparat i mikrokapselform samt således fremstillet præparat Download PDF

Info

Publication number
DK169119B1
DK169119B1 DK285088A DK285088A DK169119B1 DK 169119 B1 DK169119 B1 DK 169119B1 DK 285088 A DK285088 A DK 285088A DK 285088 A DK285088 A DK 285088A DK 169119 B1 DK169119 B1 DK 169119B1
Authority
DK
Denmark
Prior art keywords
core material
solvent
polymer
microcapsules
process according
Prior art date
Application number
DK285088A
Other languages
Danish (da)
English (en)
Other versions
DK285088D0 (da
DK285088A (da
Inventor
James Ronald Lawter
Michael Gerard Lanzilotti
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DK285088D0 publication Critical patent/DK285088D0/da
Publication of DK285088A publication Critical patent/DK285088A/da
Application granted granted Critical
Publication of DK169119B1 publication Critical patent/DK169119B1/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Packages (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Polymerisation Methods In General (AREA)
  • Glass Compositions (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK285088A 1987-05-26 1988-05-25 Fremgangsmåde til fremstilling af et farmaceutisk præparat i mikrokapselform samt således fremstillet præparat DK169119B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/054,372 US5000886A (en) 1987-05-26 1987-05-26 Silicone-hardened pharmaceutical microcapsules and process of making the same
US5437287 1987-05-26

Publications (3)

Publication Number Publication Date
DK285088D0 DK285088D0 (da) 1988-05-25
DK285088A DK285088A (da) 1988-11-27
DK169119B1 true DK169119B1 (da) 1994-08-22

Family

ID=21990585

Family Applications (1)

Application Number Title Priority Date Filing Date
DK285088A DK169119B1 (da) 1987-05-26 1988-05-25 Fremgangsmåde til fremstilling af et farmaceutisk præparat i mikrokapselform samt således fremstillet præparat

Country Status (19)

Country Link
US (1) US5000886A (xx)
EP (1) EP0292710B1 (xx)
JP (1) JP2712101B2 (xx)
KR (1) KR970001209B1 (xx)
AT (1) ATE70992T1 (xx)
AU (1) AU618000B2 (xx)
BR (1) BR1100810A (xx)
CA (1) CA1330533C (xx)
DE (1) DE3867313D1 (xx)
DK (1) DK169119B1 (xx)
ES (1) ES2038236T3 (xx)
GR (1) GR3004186T3 (xx)
HK (1) HK116493A (xx)
IE (1) IE61338B1 (xx)
IL (1) IL86274A (xx)
NO (1) NO177984C (xx)
NZ (1) NZ224722A (xx)
PH (1) PH27019A (xx)
ZA (1) ZA883737B (xx)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030161889A1 (en) * 1984-03-16 2003-08-28 Reid Robert H. Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
US6217911B1 (en) 1995-05-22 2001-04-17 The United States Of America As Represented By The Secretary Of The Army sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
US6410056B1 (en) 1984-03-16 2002-06-25 The United States Of America As Represented By The Secretary Of The Army Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix
US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US5693343A (en) 1984-03-16 1997-12-02 The United States Of America As Represented By The Secretary Of The Army Microparticle carriers of maximal uptake capacity by both M cells and non-M cells
USRE40786E1 (en) 1984-03-16 2009-06-23 The United States Of America As Represented By The Secretary Of The Army Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres
US5811128A (en) * 1986-10-24 1998-09-22 Southern Research Institute Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor
US5985354A (en) 1995-06-07 1999-11-16 Brown University Research Foundation Preparation of multiwall polymeric microcapsules from hydrophilic polymers
US5143661A (en) * 1987-05-26 1992-09-01 American Cyanamid Company Silicone-hardened pharmaceutical microcapsules
ATE105177T1 (de) * 1988-12-22 1994-05-15 American Cyanamid Co Verfahren zur behandlung von periodontitis durch protrahierte wirkstoffabgabe von arzneimitteln in der zahnhoehle, zusammensetzung davon und vorrichtung zur verabreichung.
DE68918419T2 (de) * 1988-12-22 1995-05-04 American Cyanamid Co Durch Phasentrennung microinkapsulierte Arzneimittelzusammensetzung zur Verminderung der Zahnkrankheit.
AU8303691A (en) 1991-04-24 1992-12-21 United States Of America, As Represented By The Secretary Of The Army, The Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
DE4223169C1 (de) * 1992-07-10 1993-11-25 Ferring Arzneimittel Gmbh Verfahren zur Mikroverkapselung wasserlöslicher Wirkstoffe
US5922340A (en) * 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
DE4239244A1 (de) * 1992-11-21 1994-05-26 Basf Ag Retard-Form für pharmazeutische Wirkstoffe
US6939546B2 (en) 1993-05-21 2005-09-06 The United States Of America As Represented By The Secretary Of The Army Model for testing immunogenicity of peptides
US5512278A (en) * 1994-01-11 1996-04-30 Phylomed Corporation Ointment base useful for pharmaceutical preparations
US6855331B2 (en) 1994-05-16 2005-02-15 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US6447796B1 (en) 1994-05-16 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US7033608B1 (en) 1995-05-22 2006-04-25 The United States Of America As Represented By The Secretary Of The Army “Burst-free” sustained release poly-(lactide/glycolide) microspheres
US6902743B1 (en) 1995-05-22 2005-06-07 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
US5942241A (en) 1995-06-09 1999-08-24 Euro-Celtique, S.A. Formulations and methods for providing prolonged local anesthesia
JP2909418B2 (ja) * 1995-09-18 1999-06-23 株式会社資生堂 薬物の遅延放出型マイクロスフイア
US5942253A (en) * 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
AU733867B2 (en) 1996-06-24 2001-05-31 Euro-Celtique S.A. Methods for providing safe local anesthesia
US6046187A (en) 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
WO1999001114A1 (en) * 1997-07-02 1999-01-14 Euro-Celtique, S.A. Prolonged anesthesia in joints and body spaces
SE512663C2 (sv) 1997-10-23 2000-04-17 Biogram Ab Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
AU711760B2 (en) * 1997-12-19 1999-10-21 Agresearch Limited Controlled release vitamin B12 compositions and methods of using them
US20030180368A1 (en) * 1998-03-14 2003-09-25 Cenes Drug Delivery Limited Production of microparticles
US6174873B1 (en) 1998-11-04 2001-01-16 Supergen, Inc. Oral administration of adenosine analogs
US6498153B1 (en) 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
MXPA03003401A (es) * 2000-10-16 2004-06-30 Neopharm Inc Formulacion liposomica de mitoxantrona.
JP2004521111A (ja) * 2001-01-25 2004-07-15 ユーロ−セルティーク，エス．エイ． 局所麻酔薬および使用法
US20040180900A1 (en) * 2001-05-23 2004-09-16 Masaharu Takigawa Therapeutic composition for repairing chondropathy
MXPA03010679A (es) * 2001-05-23 2004-03-02 Tanabe Seiyaku Co Una composicion para acelerar la cicatrizacion de fractura osea.
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US6682348B2 (en) 2002-03-29 2004-01-27 Orapharma, Inc. Dispensing apparatus and cartridge
JP2006514698A (ja) * 2002-10-30 2006-05-11 スフェリックス， インコーポレイテッド ナノ粒子生物活性物質
MXPA05011557A (es) 2003-04-29 2006-03-09 Orexigen Therapeutics Inc Composiciones para afectar perdida de peso.
US20050048115A1 (en) * 2003-08-27 2005-03-03 Murty Mangena Buprenorphine microspheres
CA2630624C (en) 2005-11-22 2013-08-06 Orexigen Therapeutics, Inc. Compositions and methods for increasing insulin sensitivity
WO2007089318A2 (en) * 2005-11-23 2007-08-09 Orexigen Therapeutics, Inc. Compositions and methods for reducing food cravings
US8916195B2 (en) * 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
US9119902B2 (en) * 2006-06-22 2015-09-01 Ethicon, Inc. Semi-crystalline absorbable microspheres
US8580307B2 (en) 2006-06-22 2013-11-12 Ethicon, Inc. High glass transition temperature absorbable microspheres
KR20190042766A (ko) 2006-11-09 2019-04-24 오렉시젠 세러퓨틱스 인크. 신속하게 용해되는 중간층을 포함하는 층상의 약제학적 제형
KR20180066272A (ko) 2006-11-09 2018-06-18 오렉시젠 세러퓨틱스 인크. 단위 용량 팩키지
WO2008097850A1 (en) * 2007-02-02 2008-08-14 Warner Chilcott Company, Inc. Tretracycline compositions for topical administration
US20080188446A1 (en) * 2007-02-02 2008-08-07 Warner Chilcott Company Inc. Tetracycline compositions for topical administration
GB0714223D0 (en) * 2007-07-20 2007-08-29 Fujifilm Mfg Europe Bv Preparation of fine particles
US7976489B2 (en) 2007-12-04 2011-07-12 Orapharma, Inc. Device for delivering medicinal implants
US7976490B2 (en) * 2007-12-04 2011-07-12 Orapharma, Inc. Medicinal implant cartridge
US7976491B2 (en) * 2007-12-04 2011-07-12 Orapharma, Inc. Actuators for device for delivering medicinal implants
CA2725930A1 (en) 2008-05-30 2009-12-30 Orexigen Therapeutics, Inc. Methods for treating visceral fat conditions
US8048021B2 (en) * 2008-12-02 2011-11-01 Orapharma, Inc. Medicinal implant device and cartridge
US8333729B2 (en) * 2009-04-07 2012-12-18 Polybiotics Llc Multi-dose delivery system
MX344303B (es) 2010-01-11 2016-12-13 Orexigen Therapeutics Inc Metodos para proveer terapia de perdida de peso en pacientes con depresion mayor.
US9119793B1 (en) 2011-06-28 2015-09-01 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for doxycycline
RU2514111C2 (ru) * 2012-05-03 2014-04-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Министерства сельского хозяйства Российской Федерации Способ получения микрокапсул лекарственных препаратов группы цефалоспоринов в полудане
RU2508095C2 (ru) * 2012-05-10 2014-02-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Министерства сельского хозяйства Российской Федерации Способ получения микрокапсул лекарственных препаратов группы цефалоспоринов в конжаковой камеди в тетрагидрофуране
RU2514113C2 (ru) * 2012-05-25 2014-04-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Министерства сельского хозяйства Российской Федерации Способ получения микрокапсул лекарственных препаратов группы цефалоспоринов в конжаковой камеди
IL300868A (en) 2012-06-06 2023-04-01 Orexigen Therapeutics Inc Methods for treating overweight and obesity
US10842802B2 (en) 2013-03-15 2020-11-24 Medicis Pharmaceutical Corporation Controlled release pharmaceutical dosage forms
EP3024457A4 (en) 2013-07-26 2017-06-28 Update Pharma Inc. Compositions to improve the therapeutic benefit of bisantrene
US9402701B2 (en) 2013-10-22 2016-08-02 Profounda, Inc Positionable delivery device and method

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS528795B2 (xx) * 1971-12-30 1977-03-11
US4107072A (en) * 1973-05-25 1978-08-15 Merck & Co., Inc. Process of isolating cyclohexane-free ethylcellulose microcapsules
US4107071A (en) * 1977-02-16 1978-08-15 Capsulated Systems, Inc. Method of producing microcapsules and resulting product
US4732763A (en) * 1978-10-17 1988-03-22 Stolle Research And Development Corporation Active/passive immunization of the internal female reproductive organs
CA1143289A (en) * 1978-10-17 1983-03-22 Lee R. Beck Microparticle drug delivery system
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
DE3378250D1 (en) * 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
CH660302A5 (fr) * 1984-10-17 1987-04-15 Debiopharm Sa Procede de micro-encapsulation en phase heterogene de substances medicamenteuses hydrosolubles.
JPH0751496B2 (ja) * 1986-04-02 1995-06-05 武田薬品工業株式会社 リポソ−ムの製造法

Also Published As

Publication number Publication date
NO177984B (no) 1995-09-25
NO177984C (no) 1996-01-03
AU1659288A (en) 1988-12-01
IE61338B1 (en) 1994-11-02
NO882277D0 (no) 1988-05-25
IE881565L (en) 1988-11-26
ES2038236T3 (es) 1993-07-16
IL86274A (en) 1992-03-29
NZ224722A (en) 1990-04-26
DK285088D0 (da) 1988-05-25
PH27019A (en) 1993-02-01
JPS63307813A (ja) 1988-12-15
DE3867313D1 (de) 1992-02-13
BR1100810A (pt) 1999-10-13
DK285088A (da) 1988-11-27
EP0292710A2 (en) 1988-11-30
ATE70992T1 (de) 1992-01-15
EP0292710A3 (en) 1989-03-22
CA1330533C (en) 1994-07-05
GR3004186T3 (xx) 1993-03-31
KR970001209B1 (ko) 1997-02-04
EP0292710B1 (en) 1992-01-02
NO882277L (no) 1988-11-28
JP2712101B2 (ja) 1998-02-10
ZA883737B (en) 1989-02-22
US5000886A (en) 1991-03-19
AU618000B2 (en) 1991-12-12
HK116493A (en) 1993-11-05
KR880013553A (ko) 1988-12-21
IL86274A0 (en) 1988-11-15

Similar Documents

Publication Publication Date Title
DK169119B1 (da) Fremgangsmåde til fremstilling af et farmaceutisk præparat i mikrokapselform samt således fremstillet præparat
US5143661A (en) Silicone-hardened pharmaceutical microcapsules
DK175849B1 (da) Fremgangsmåde til fremstilling af mikropartikler omfattende et lægemiddelstof, formulering med forlænget afgivelse, octreotidpamoat og fremgangsmåde til fremstilling heraf
EP0052510B2 (en) Microencapsulation of water soluble polypeptides
CA2126685C (en) Process for the production of microcapsules
Couvreur et al. Multiple emulsion technology for the design of microspheres containing peptides and oligopeptides
US6844010B1 (en) Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US5500228A (en) Phase separation-microencapsulated pharmaceuticals compositions useful for alleviating dental disease
US5503851A (en) Microencapsulation of water-soluble medicaments
US4675189A (en) Microencapsulation of water soluble active polypeptides
US6902743B1 (en) Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
TW577758B (en) Intra-articular preparation for the treatment of arthropathy
DK175311B1 (da) Vanduoplöselige polypeptider
Dong et al. Stability of poly (D, L-lactide-co-glycolide) and leuprolide acetate in in-situ forming drug delivery systems
CZ2002728A3 (cs) Prostředek ve formě mikročástic obsahující buprenorfin, léková forma a pouľití
Ogawa Injectable microcapsules prepared with biodegradable poly (α-hydroxy) acids for prolonged release of drugs
JP5851518B2 (ja) 生理活性ペプチドを含む微小粒子及びその製造方法、及びそれらを含む薬剤学的組成物
JPH0436233A (ja) 生理活性物質含有生体内分解吸収性の徐放性製剤
CN1257708C (zh) 改进的包埋水溶性药物或疫苗的高分子微球的制备方法
JPH08225454A (ja) マイクロスフェア製剤
JP2002234833A (ja) 徐放型マイクロカプセルの製造法
EP0374532B1 (en) Improved phase separation-microencapsulated pharmaceutical compositions useful for alleviating dental disease
JP6238401B2 (ja) 生理活性ペプチド徐放性微粒子及びその製造方法
CA2271571C (en) Improved phase separation-microencapsulated pharmaceutical compositions useful for alleviating dental disease
KR19980703429A (ko) 신규한 "비파열" 지효성 폴리-(락타이드/글리콜라이드) 미소구

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired