DK167222B1 - Antigen, fremgangsmaade til fremstilling heraf og vaccine indeholdende dette - Google Patents
Antigen, fremgangsmaade til fremstilling heraf og vaccine indeholdende dette Download PDFInfo
- Publication number
- DK167222B1 DK167222B1 DK521584A DK521584A DK167222B1 DK 167222 B1 DK167222 B1 DK 167222B1 DK 521584 A DK521584 A DK 521584A DK 521584 A DK521584 A DK 521584A DK 167222 B1 DK167222 B1 DK 167222B1
- Authority
- DK
- Denmark
- Prior art keywords
- pro
- animal
- ser
- protein
- hcg
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title claims description 44
- 102000036639 antigens Human genes 0.000 title claims description 44
- 108091007433 antigens Proteins 0.000 title claims description 44
- 229960005486 vaccine Drugs 0.000 title claims description 21
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 119
- 239000012634 fragment Substances 0.000 claims description 105
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 82
- 108090000623 proteins and genes Proteins 0.000 claims description 82
- 102000004169 proteins and genes Human genes 0.000 claims description 81
- 235000018102 proteins Nutrition 0.000 claims description 79
- 229920001184 polypeptide Polymers 0.000 claims description 66
- 241001465754 Metazoa Species 0.000 claims description 56
- 229920000642 polymer Polymers 0.000 claims description 38
- 230000002163 immunogen Effects 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 239000007822 coupling agent Substances 0.000 claims description 21
- 230000001588 bifunctional effect Effects 0.000 claims description 17
- 230000015572 biosynthetic process Effects 0.000 claims description 15
- 125000003277 amino group Chemical group 0.000 claims description 14
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 14
- 235000018417 cysteine Nutrition 0.000 claims description 13
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 13
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 12
- 238000002523 gelfiltration Methods 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 3
- 230000001939 inductive effect Effects 0.000 claims description 2
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 238000004821 distillation Methods 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 description 23
- 239000005556 hormone Substances 0.000 description 23
- 239000000463 material Substances 0.000 description 23
- 239000003153 chemical reaction reagent Substances 0.000 description 18
- 210000000987 immune system Anatomy 0.000 description 16
- 238000006116 polymerization reaction Methods 0.000 description 16
- 150000001413 amino acids Chemical group 0.000 description 15
- 238000005859 coupling reaction Methods 0.000 description 15
- 241000700605 Viruses Species 0.000 description 14
- 230000008878 coupling Effects 0.000 description 14
- 238000010168 coupling process Methods 0.000 description 14
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 12
- 230000003213 activating effect Effects 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 8
- 239000000539 dimer Substances 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 7
- 230000009260 cross reactivity Effects 0.000 description 7
- 201000009030 Carcinoma Diseases 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- 210000004899 c-terminal region Anatomy 0.000 description 6
- 238000007385 chemical modification Methods 0.000 description 6
- 238000004132 cross linking Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000000746 purification Methods 0.000 description 6
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 5
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 5
- 241000282412 Homo Species 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 5
- 230000035558 fertility Effects 0.000 description 5
- 230000001900 immune effect Effects 0.000 description 5
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 4
- 208000009889 Herpes Simplex Diseases 0.000 description 4
- 241000282414 Homo sapiens Species 0.000 description 4
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 4
- 108010067390 Viral Proteins Proteins 0.000 description 4
- 229940015047 chorionic gonadotropin Drugs 0.000 description 4
- 230000028993 immune response Effects 0.000 description 4
- 238000002649 immunization Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 4
- 229940032094 squalane Drugs 0.000 description 4
- 229940031439 squalene Drugs 0.000 description 4
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 4
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 3
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 3
- 108010051696 Growth Hormone Proteins 0.000 description 3
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 102000013275 Somatomedins Human genes 0.000 description 3
- 102100038803 Somatotropin Human genes 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 230000037029 cross reaction Effects 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 238000006471 dimerization reaction Methods 0.000 description 3
- 229960003983 diphtheria toxoid Drugs 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 229940028334 follicle stimulating hormone Drugs 0.000 description 3
- 125000000524 functional group Chemical group 0.000 description 3
- 239000000122 growth hormone Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 210000000582 semen Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 208000030507 AIDS Diseases 0.000 description 2
- 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 description 2
- 101000687438 Homo sapiens Prolactin Proteins 0.000 description 2
- 102000004576 Placental Lactogen Human genes 0.000 description 2
- 108010003044 Placental Lactogen Proteins 0.000 description 2
- 239000000381 Placental Lactogen Substances 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000002939 deleterious effect Effects 0.000 description 2
- -1 dimethyl adipimidate Chemical class 0.000 description 2
- 150000002148 esters Chemical group 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000000379 polymerizing effect Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229960000814 tetanus toxoid Drugs 0.000 description 2
- 150000003573 thiols Chemical class 0.000 description 2
- 210000004340 zona pellucida Anatomy 0.000 description 2
- CUKWUWBLQQDQAC-VEQWQPCFSA-N (3s)-3-amino-4-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2s,3s)-1-[[(2s)-1-[(2s)-2-[[(1s)-1-carboxyethyl]carbamoyl]pyrrolidin-1-yl]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-ox Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 CUKWUWBLQQDQAC-VEQWQPCFSA-N 0.000 description 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 description 1
- LORRLQMLLQLPSJ-UHFFFAOYSA-N 1,3,5-trithiane Chemical compound C1SCSCS1 LORRLQMLLQLPSJ-UHFFFAOYSA-N 0.000 description 1
- 101150066838 12 gene Proteins 0.000 description 1
- QWCKQJZIFLGMSD-UHFFFAOYSA-N 2-Aminobutanoic acid Natural products CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 description 1
- WOJKKJKETHYEAC-UHFFFAOYSA-N 6-Maleimidocaproic acid Chemical compound OC(=O)CCCCCN1C(=O)C=CC1=O WOJKKJKETHYEAC-UHFFFAOYSA-N 0.000 description 1
- 206010000599 Acromegaly Diseases 0.000 description 1
- 102400000345 Angiotensin-2 Human genes 0.000 description 1
- 101800000733 Angiotensin-2 Proteins 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- QWCKQJZIFLGMSD-GSVOUGTGSA-N D-alpha-aminobutyric acid Chemical compound CC[C@@H](N)C(O)=O QWCKQJZIFLGMSD-GSVOUGTGSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010053155 Epigastric discomfort Diseases 0.000 description 1
- 102400000921 Gastrin Human genes 0.000 description 1
- 108010052343 Gastrins Proteins 0.000 description 1
- 102400000321 Glucagon Human genes 0.000 description 1
- 108060003199 Glucagon Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010020850 Hyperthyroidism Diseases 0.000 description 1
- PMMMQRVUMVURGJ-XUXIUFHCSA-N Ile-Leu-Pro Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(O)=O PMMMQRVUMVURGJ-XUXIUFHCSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 208000000913 Kidney Calculi Diseases 0.000 description 1
- IXHKPDJKKCUKHS-GARJFASQSA-N Lys-Ala-Pro Chemical compound C[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CCCCN)N IXHKPDJKKCUKHS-GARJFASQSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010029148 Nephrolithiasis Diseases 0.000 description 1
- 102000003982 Parathyroid hormone Human genes 0.000 description 1
- 108090000445 Parathyroid hormone Proteins 0.000 description 1
- 102000007079 Peptide Fragments Human genes 0.000 description 1
- 108010033276 Peptide Fragments Proteins 0.000 description 1
- SHAQGFGGJSLLHE-BQBZGAKWSA-N Pro-Gln Chemical compound NC(=O)CC[C@@H](C([O-])=O)NC(=O)[C@@H]1CCC[NH2+]1 SHAQGFGGJSLLHE-BQBZGAKWSA-N 0.000 description 1
- HWLKHNDRXWTFTN-GUBZILKMSA-N Pro-Pro-Cys Chemical compound C1C[C@H](NC1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CS)C(=O)O HWLKHNDRXWTFTN-GUBZILKMSA-N 0.000 description 1
- 108010086019 Secretin Proteins 0.000 description 1
- 102100037505 Secretin Human genes 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 102000011923 Thyrotropin Human genes 0.000 description 1
- 108010061174 Thyrotropin Proteins 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 201000008629 Zollinger-Ellison syndrome Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229950006323 angiotensin ii Drugs 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 229940124462 contraceptive vaccine Drugs 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- RZVGUUMNWCDIBV-UHFFFAOYSA-N diethyl propanediimidate Chemical compound CCOC(=N)CC(=N)OCC RZVGUUMNWCDIBV-UHFFFAOYSA-N 0.000 description 1
- 239000007862 dimeric product Substances 0.000 description 1
- 230000000447 dimerizing effect Effects 0.000 description 1
- ZLFRJHOBQVVTOJ-UHFFFAOYSA-N dimethyl hexanediimidate Chemical compound COC(=N)CCCCC(=N)OC ZLFRJHOBQVVTOJ-UHFFFAOYSA-N 0.000 description 1
- FRTGEIHSCHXMTI-UHFFFAOYSA-N dimethyl octanediimidate Chemical compound COC(=N)CCCCCCC(=N)OC FRTGEIHSCHXMTI-UHFFFAOYSA-N 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 201000000052 gastrinoma Diseases 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 1
- 229960004666 glucagon Drugs 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 229940084986 human chorionic gonadotropin Drugs 0.000 description 1
- 150000002463 imidates Chemical class 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 239000000568 immunological adjuvant Substances 0.000 description 1
- 230000002134 immunopathologic effect Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002715 modification method Methods 0.000 description 1
- 230000002969 morbid Effects 0.000 description 1
- BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000000199 parathyroid hormone Substances 0.000 description 1
- 229960001319 parathyroid hormone Drugs 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 229920005990 polystyrene resin Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 229960002101 secretin Drugs 0.000 description 1
- OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 125000004149 thio group Chemical group *S* 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000006257 total synthesis reaction Methods 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0006—Contraceptive vaccins; Vaccines against sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/5555—Muramyl dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6012—Haptens, e.g. di- or trinitrophenyl (DNP, TNP)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/11—Gonadotropin; related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47219083 | 1983-03-04 | ||
| US06/472,190 US4526716A (en) | 1981-11-20 | 1983-03-04 | Antigenic modification of polypeptides |
| PCT/US1983/000777 WO1984003443A1 (en) | 1983-03-04 | 1983-05-18 | Antigenic modification of polypeptides |
| US8300777 | 1983-05-18 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK521584D0 DK521584D0 (da) | 1984-11-02 |
| DK521584A DK521584A (da) | 1984-11-02 |
| DK167222B1 true DK167222B1 (da) | 1993-09-20 |
Family
ID=23874533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK521584A DK167222B1 (da) | 1983-03-04 | 1984-11-02 | Antigen, fremgangsmaade til fremstilling heraf og vaccine indeholdende dette |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4526716A (de) |
| EP (3) | EP0210628A3 (de) |
| JP (1) | JPS60500814A (de) |
| AU (3) | AU570004B2 (de) |
| DK (1) | DK167222B1 (de) |
| FI (1) | FI80603C (de) |
| GB (3) | GB2146646A (de) |
| GR (1) | GR79126B (de) |
| IL (1) | IL68749A (de) |
| WO (1) | WO1984003443A1 (de) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6039948A (en) * | 1973-05-07 | 2000-03-21 | The Ohio State University | Method for treatment of antigenically modified polypeptides |
| US6103243A (en) * | 1985-05-15 | 2000-08-15 | Biotechnology Australia Pty, Ltd | Oral vaccines |
| CA1239346A (en) * | 1985-06-04 | 1988-07-19 | Gursaran P. Talwar | Birth control vaccine |
| US4855285A (en) * | 1985-12-04 | 1989-08-08 | The Ohio State University Research Foundation | Antigenic modification of polypeptides |
| US5817753A (en) * | 1985-12-04 | 1998-10-06 | The Ohio State University Research Foundation | Antigenic modification of polypeptides |
| US4795634A (en) * | 1986-03-14 | 1989-01-03 | Aphton Corporation | Method for contraception by immunization against the zona pellucida |
| US5096706A (en) * | 1986-03-25 | 1992-03-17 | National Research Development Corporation | Antigen-based treatment for adiposity |
| NZ221306A (en) * | 1986-08-15 | 1990-02-26 | Commw Scient Ind Res Org | 2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof |
| JPH01500663A (ja) * | 1986-08-18 | 1989-03-09 | バンジ・（オーストラリア）・プロプライアタリー・リミテッド | 動物の生殖機能の調節 |
| US5110794A (en) * | 1987-01-30 | 1992-05-05 | Abbott Laboratories | Method of immunization with partially cationized substances and said partially cationized substances |
| US5021244A (en) * | 1988-12-06 | 1991-06-04 | Cytogam, Inc. | Sex-associated membrane antibodies and their use for increasing the probability that offspring will be of a desired sex |
| US5346990A (en) * | 1987-04-08 | 1994-09-13 | Cytogam, Inc. | Sex-associated membrane proteins and methods for increasing the probability that offspring will be of a desired sex |
| US4996297A (en) * | 1987-10-07 | 1991-02-26 | Zonagen, Inc. | Recombinantly expressed rabbit zona pellucida polypeptides |
| US6610669B1 (en) | 1987-09-18 | 2003-08-26 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
| BE1001013A4 (fr) * | 1987-10-22 | 1989-06-13 | Icp Internat Inst Of Cellular | Derives de synergimycines de types a et b, procede pour leur preparation et utilisation de ceux-ci. |
| US5002883A (en) * | 1987-10-30 | 1991-03-26 | Abbott Laboratories | Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents |
| US6861510B1 (en) * | 1989-01-24 | 2005-03-01 | Aphton Corporation | Immunogenic compositions against gastrin peptides |
| US5023077A (en) * | 1989-01-24 | 1991-06-11 | Aphton Corporation | Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease |
| ATE114160T1 (de) * | 1989-01-24 | 1994-12-15 | Aphton Corp | Immunogenische zusammensetzungen gegen gastrin- peptide. |
| WO1990009799A1 (en) * | 1989-02-23 | 1990-09-07 | Colorado State University Research Foundation | GnRH ANALOGS FOR DESTROYING GONADOTROPHS |
| US5786457A (en) * | 1989-02-23 | 1998-07-28 | Colorado State University Research Foundation | Hormone-nuclease compounds and method for regulating hormone related diseases |
| US6326467B1 (en) | 1989-02-23 | 2001-12-04 | Colorado State University Research Foundation | Hormone-recombinant toxin compounds and methods for using same |
| US5641487A (en) * | 1989-06-12 | 1997-06-24 | The Government Of The United States Of America As Represented By The Secretary Department Of Health And Human Services | Contraceptive vaccine based on alloimmunization with zona pellucida polypeptides |
| FR2656626B1 (fr) * | 1989-12-29 | 1994-08-12 | Pasteur Institut | Fragment peptidique comprenant une sequence issue de la proteine 28 kda de schistosoma mansoni et compositions vaccinantes et/ou therapeutiques comprenant ledit fragment. |
| AU2254792A (en) * | 1991-07-01 | 1993-02-11 | Blood Center Of Southeastern Wisconsin, The | Pen polymorphism of human platelet membrane glycoprotein iiia and diagnostic and therapeutic application thereof |
| ATE227307T1 (de) | 1992-04-07 | 2002-11-15 | Scripps Research Inst | Verfahren zur herstellung modifizierten proteine |
| EP1129724B1 (de) * | 1992-09-30 | 2007-09-19 | The Ohio State University Research Foundation | Impfstoffe zur Behandlung von Kolonkrebs |
| US20050277582A1 (en) * | 1993-07-20 | 2005-12-15 | Nett Torrance M | Method for inactivating gonadotrophs |
| US5468494A (en) * | 1993-11-12 | 1995-11-21 | Aphton Corp. | Immunogenic compositions against human gastrin 17 |
| US5688506A (en) | 1994-01-27 | 1997-11-18 | Aphton Corp. | Immunogens against gonadotropin releasing hormone |
| JP2947503B2 (ja) * | 1994-03-02 | 1999-09-13 | エーザイ株式会社 | アリルキノン誘導体の製造方法および中間体 |
| US5869057A (en) * | 1995-06-07 | 1999-02-09 | Rock; Edwin P. | Recombinant vaccines to break self-tolerance |
| ES2108614B1 (es) * | 1995-07-12 | 1998-07-16 | Oncina Fco Javier Martin | Vacunas polimerizadas. |
| US5610136A (en) * | 1996-01-30 | 1997-03-11 | Milkhaus Laboratory, Inc. | Method for treatment of benign prostatic hypertrophy |
| EP0889735B1 (de) * | 1996-02-08 | 2011-04-13 | Cancer Advances, Inc., | Immunologische methoden zur behandlung von gastrointestinalem krebs |
| WO1997042220A1 (en) * | 1996-05-03 | 1997-11-13 | Thomas Jefferson University | Metastatic colorectal cancer vaccine |
| DE19622289A1 (de) * | 1996-05-23 | 1997-11-27 | Schering Ag | Zona Pellucida Proteine zur Kontrazeption |
| US6331610B1 (en) | 1997-04-25 | 2001-12-18 | Metatron, Inc. | Method for treating AIDS and HIV infection using select peptides from the beta subunit of human chorionic gonadotropin |
| EP0981369B1 (de) * | 1997-05-12 | 2004-11-17 | Aphton Corporation | Immunogene zusammensetzungen gegen den cck-b-gastrin-rezeptor und verfahren zur behandlung von tumoren |
| US20040001842A1 (en) * | 1997-05-12 | 2004-01-01 | Dov Michaeli | Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors |
| ES2260809T3 (es) * | 1997-07-01 | 2006-11-01 | Vlp Watertown Limited Partnership | Metodo para la determinacion del sexo de una progenie mamifera. |
| US6120995A (en) * | 1997-08-07 | 2000-09-19 | Thomas Jefferson University | Compositions that specifically bind to colorectal cancer cells and methods of using the same |
| US7135333B1 (en) | 1997-08-07 | 2006-11-14 | Thomas Jefferson University | Compositions that specifically bind to colorectal cancer cells and methods of using the same |
| HU228467B1 (en) * | 1998-02-05 | 2013-03-28 | Smithkline Beecham Biolog | Tumor-associated antigen derivatives from the mage family, and nucleic acid sequences encoding them, used for the preparation of fusion proteins and of compositions for vaccination |
| DK1077721T3 (da) * | 1998-05-15 | 2007-09-03 | Receptor Biologix Inc | Forebyggelse og behandling af hypergastrinæmi |
| US20030068326A1 (en) * | 1998-05-15 | 2003-04-10 | Aphton Corporation | Method for the treatment of gastroesophageal reflux disease |
| CA2404432A1 (en) | 2000-03-27 | 2001-10-04 | Thomas Jefferson University | Compositions and methods for identifying and targeting cancer cells |
| US6783761B2 (en) | 2000-05-05 | 2004-08-31 | Aphton Corporation | Chimeric peptide immunogens |
| WO2002022885A1 (en) * | 2000-09-18 | 2002-03-21 | Thomas Jefferson University | Compositions and methods for identifying and targeting stomach and esophageal cancer cells |
| EP1372717A2 (de) * | 2001-03-23 | 2004-01-02 | Aphton Corporation | Kombinationsbehandlung von pankreaskrebs |
| US20090191232A1 (en) * | 2001-05-04 | 2009-07-30 | Gevas Philip C | Combination therapy for the treatment of tumors |
| US20030021786A1 (en) * | 2001-07-09 | 2003-01-30 | Gevas Philip C. | Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus |
| US6810583B2 (en) * | 2001-08-07 | 2004-11-02 | International Business Machines Corporation | Coupling of conductive vias to complex power-signal substructures |
| US20060052592A1 (en) | 2002-06-20 | 2006-03-09 | Levinson Arnold I | Vaccines for suppressing ige-mediated allergic disease and methods for using the same |
| AU2004225437B2 (en) * | 2003-03-28 | 2010-05-13 | Cancer Advances, Inc. | Gastrin hormone immunoassays |
| EP1730193A2 (de) * | 2004-03-29 | 2006-12-13 | Receptor Biologix, Inc. | Monoklonale antikörper gegen gastrinhormon |
| EP2567974A3 (de) | 2004-09-22 | 2013-05-22 | Cancer Advances, Inc., | Monoklonale Antikörper gegen Progastrin |
| WO2010036652A1 (en) * | 2008-09-23 | 2010-04-01 | Thomas Jefferson University | Cancer vaccines against mucosal antigens and methods of making and using the same |
| WO2011066048A1 (en) | 2009-10-22 | 2011-06-03 | Thomas Jefferson University | Cell-based anti-cancer compositions and methods of making and using the same |
| WO2014022835A2 (en) | 2012-08-02 | 2014-02-06 | The Board Of Trustees Of The Leland Stanford Junior University | PEPTIDE VACCINES BASED ON THE EGFRvIII SEQUENCE FOR THE TREATMENT OF TUMORS |
| EP3624841A4 (de) | 2017-06-15 | 2021-01-27 | Cancer Advances, Inc., | Zusammensetzungen und verfahren zur induzierung humoraler und zellulärer immunitäten gegen tumore und krebs |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2301532A (en) * | 1938-08-18 | 1942-11-10 | Parke Davis & Co | Biological product and process of obtaining same |
| US2372066A (en) * | 1940-12-23 | 1945-03-20 | Parke Davis & Co | Biological product and process of obtaining same |
| US2388260A (en) * | 1942-03-11 | 1945-11-06 | Ernst A H Friedheim | Therapeutically active aromatic diazo compounds and derivatives thereof |
| US2744890A (en) * | 1952-12-19 | 1956-05-08 | Nat Dairy Res Lab Inc | Proteinaceous composition and method of making the same |
| US3317400A (en) * | 1964-11-23 | 1967-05-02 | Upjohn Co | Enzymatic modification of bovine growth hormone by proteolytic streptomycete cell extracts |
| US4302386A (en) * | 1978-08-25 | 1981-11-24 | The Ohio State University | Antigenic modification of polypeptides |
| CH622426A5 (en) * | 1973-05-07 | 1981-04-15 | Univ Ohio | Contraceptive composition |
| US4201770A (en) * | 1973-05-07 | 1980-05-06 | The Ohio State University | Antigenic modification of polypeptides |
| US4384995A (en) * | 1980-01-16 | 1983-05-24 | The Ohio State University | Antigenic modification of polypeptides |
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| IN140168B (de) * | 1974-10-14 | 1976-09-25 | All India Inst Med | |
| CA1054937A (en) * | 1975-01-28 | 1979-05-22 | Gursaran P. Talwar | Antipregnancy vaccine |
| NZ182272A (en) | 1975-10-14 | 1985-03-20 | Univ Ohio State | Modified polypeptides for the immunological control of fertility,and pharmaceutical compositions |
| FR2334107A1 (fr) * | 1975-12-05 | 1977-07-01 | Pasteur Institut | Procede de couplage de substances biologiques par des liaisons covalentes |
| US4123519A (en) * | 1976-08-17 | 1978-10-31 | Philips Roxane, Inc. | Injectable contraceptive vaccine and method |
| US4122166A (en) * | 1976-08-17 | 1978-10-24 | Philips Roxane, Inc. | Injectable contraceptive and method |
| US4256629A (en) * | 1978-02-06 | 1981-03-17 | Research Corporation | Antigen for early pregnancy test and contraceptive vaccine |
| US4234561A (en) * | 1978-02-06 | 1980-11-18 | Research Corporation | Antigen for early pregnancy test and contraceptive vaccine |
| US4313871A (en) * | 1978-02-06 | 1982-02-02 | Research Corporation | Antigen for early pregnancy test and contraceptive vaccine |
| US4268435A (en) * | 1979-02-06 | 1981-05-19 | Research Corporation | Chorionic gonadotropin derived antigen for early pregnancy test and contraceptive vaccine |
| US4310455A (en) * | 1979-04-17 | 1982-01-12 | Research Corporation | Antigen for early pregnancy test and contraceptive vaccine |
| US4253996A (en) * | 1980-02-13 | 1981-03-03 | Scripps Clinic And Research Foundation | Immunochemical conjugates: method and composition |
| US4320386A (en) | 1980-07-30 | 1982-03-16 | General Electric Company | Selection and power reset circuit |
| FR2525592B1 (de) * | 1982-04-26 | 1984-09-14 | Pasteur Institut |
-
1983
- 1983-03-04 US US06/472,190 patent/US4526716A/en not_active Expired - Lifetime
- 1983-05-18 WO PCT/US1983/000777 patent/WO1984003443A1/en active IP Right Grant
- 1983-05-18 GB GB08425710A patent/GB2146646A/en not_active Withdrawn
- 1983-05-18 JP JP58502046A patent/JPS60500814A/ja active Granted
- 1983-05-18 AU AU17040/83A patent/AU570004B2/en not_active Ceased
- 1983-05-20 IL IL68749A patent/IL68749A/xx unknown
- 1983-05-20 EP EP86110377A patent/EP0210628A3/de not_active Withdrawn
- 1983-05-20 EP EP86110378A patent/EP0213391A3/de not_active Withdrawn
- 1983-05-20 EP EP83302888A patent/EP0117934B1/de not_active Expired
- 1983-05-24 GR GR71441A patent/GR79126B/el unknown
-
1984
- 1984-11-01 FI FI844288A patent/FI80603C/fi not_active IP Right Cessation
- 1984-11-02 DK DK521584A patent/DK167222B1/da not_active IP Right Cessation
-
1986
- 1986-08-06 GB GB08619232A patent/GB2178041B/en not_active Expired
- 1986-08-06 GB GB08619233A patent/GB2178042B/en not_active Expired
-
1987
- 1987-04-13 AU AU71495/87A patent/AU594453B2/en not_active Ceased
- 1987-04-13 AU AU71490/87A patent/AU588448B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DK521584D0 (da) | 1984-11-02 |
| EP0117934A1 (de) | 1984-09-12 |
| JPS60500814A (ja) | 1985-05-30 |
| EP0210628A3 (de) | 1989-02-08 |
| JPH0557999B2 (de) | 1993-08-25 |
| DK521584A (da) | 1984-11-02 |
| AU594453B2 (en) | 1990-03-08 |
| GB2178042B (en) | 1988-01-06 |
| GB2178041A (en) | 1987-02-04 |
| WO1984003443A1 (en) | 1984-09-13 |
| AU570004B2 (en) | 1988-03-03 |
| GB2146646A (en) | 1985-04-24 |
| EP0117934B1 (de) | 1988-07-20 |
| FI80603B (fi) | 1990-03-30 |
| GB8619232D0 (en) | 1986-09-17 |
| US4526716A (en) | 1985-07-02 |
| GB2178041B (en) | 1988-01-06 |
| AU7149087A (en) | 1987-08-06 |
| EP0210628A2 (de) | 1987-02-04 |
| FI844288A0 (fi) | 1984-11-01 |
| AU1704083A (en) | 1984-09-28 |
| AU7149587A (en) | 1987-09-10 |
| EP0213391A3 (de) | 1989-02-01 |
| AU588448B2 (en) | 1989-09-14 |
| FI844288L (fi) | 1984-11-01 |
| GB8425710D0 (en) | 1984-12-05 |
| GB8619233D0 (en) | 1986-09-17 |
| GR79126B (de) | 1984-10-02 |
| GB2178042A (en) | 1987-02-04 |
| IL68749A (en) | 1988-07-31 |
| EP0213391A2 (de) | 1987-03-11 |
| FI80603C (fi) | 1990-07-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK167222B1 (da) | Antigen, fremgangsmaade til fremstilling heraf og vaccine indeholdende dette | |
| AU2018203170B2 (en) | Multimeric Fusion Protein Vaccine And Immunotherapeutic | |
| US5019387A (en) | Production of antibodies to HIV | |
| Reynolds et al. | T and B epitope determination and analysis of multiple antigenic peptides for the Schistosoma mansoni experimental vaccine triose-phosphate isomerase. | |
| US5013548A (en) | Production of antibodies to HIV | |
| JPH09501933A (ja) | 植物、動物、およびヒトのワクチンとして並びに免疫療法に有用な抗体の免疫優性エピトープの弱化 | |
| NO313917B1 (no) | Antigen-presenterende kapsid med fusert MS2-kappeprotein | |
| CA2342289A1 (en) | Treatment of cervical cancer | |
| EP1129724B1 (de) | Impfstoffe zur Behandlung von Kolonkrebs | |
| WO2022011021A1 (en) | Use of conserved peptide epitopes from sars-cov-2 for the development of a broad covid-19 vaccine | |
| JPH03503539A (ja) | 抗マラリヤワクチンとして有用な多重抗原ペプチドの樹木状ポリマー | |
| WO2018052854A1 (en) | Hepatitis b therapeutic vaccines | |
| US20030219452A1 (en) | HIV envelope V3-CCR5 binding site immunogen | |
| Frenchick et al. | Biochemical and immunological characterization of a novel peptide carrier system using rotavirus VP6 particles | |
| CN100409900C (zh) | 葡萄球菌肠毒素a基因及其编码蛋白的新用途 | |
| CN111032681B (zh) | 修饰型HSV gB蛋白及包含其的HSV疫苗 | |
| NO174183B (no) | Fremgangsm}te for fremstilling av et modifisert antigen | |
| NO163778B (no) | Fremgangsmaate for fremstilling av et linaert, polymert polypeptid. | |
| WO1992003553A1 (en) | Footrot vaccine | |
| JP7513303B2 (ja) | 腫瘍免疫増強剤、その調製方法および適用 | |
| WO1992000098A1 (en) | Methods of inducing immune response to aids virus | |
| JPH08198774A (ja) | Ｄｎａワクチン | |
| CN113527441A (zh) | 腺病毒抗原多肽及其应用 | |
| CN101362794A (zh) | 卵泡刺激素受体b细胞表位及包含此表位的抗原肽 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |