IL68749A - Modified antigens,their preparation and vaccines containing them - Google Patents

Modified antigens,their preparation and vaccines containing them

Info

Publication number
IL68749A
IL68749A IL68749A IL6874983A IL68749A IL 68749 A IL68749 A IL 68749A IL 68749 A IL68749 A IL 68749A IL 6874983 A IL6874983 A IL 6874983A IL 68749 A IL68749 A IL 68749A
Authority
IL
Israel
Prior art keywords
preparation
vaccines containing
modified antigens
antigens
modified
Prior art date
Application number
IL68749A
Original Assignee
Univ Ohio State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ohio State filed Critical Univ Ohio State
Priority to IL7909383A priority Critical patent/IL79093A/en
Priority to IL8202083A priority patent/IL82020A/en
Priority to IL79093A priority patent/IL79093A0/en
Priority to IL82020A priority patent/IL82020A0/en
Publication of IL68749A publication Critical patent/IL68749A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0006—Contraceptive vaccins; Vaccines against sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/5555—Muramyl dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6012—Haptens, e.g. di- or trinitrophenyl (DNP, TNP)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/11—Gonadotropin; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL68749A 1983-03-04 1983-05-20 Modified antigens,their preparation and vaccines containing them IL68749A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IL7909383A IL79093A (en) 1983-03-04 1983-05-20 Antigenic modified polypeptides,their preparation and vaccines containing them
IL8202083A IL82020A (en) 1983-03-04 1983-05-20 Antigenic modified zona pellucida and sperm polypeptides,their preparation and vaccines containing them
IL79093A IL79093A0 (en) 1983-03-04 1986-06-11 Antigenic modified polypeptides,their preparation and vaccines containing them
IL82020A IL82020A0 (en) 1983-03-04 1987-03-26 Antigenic modified polypeptides,their preparation and vaccines containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/472,190 US4526716A (en) 1981-11-20 1983-03-04 Antigenic modification of polypeptides

Publications (1)

Publication Number Publication Date
IL68749A true IL68749A (en) 1988-07-31

Family

ID=23874533

Family Applications (1)

Application Number Title Priority Date Filing Date
IL68749A IL68749A (en) 1983-03-04 1983-05-20 Modified antigens,their preparation and vaccines containing them

Country Status (10)

Country Link
US (1) US4526716A (en)
EP (3) EP0213391A3 (en)
JP (1) JPS60500814A (en)
AU (3) AU570004B2 (en)
DK (1) DK167222B1 (en)
FI (1) FI80603C (en)
GB (3) GB2146646A (en)
GR (1) GR79126B (en)
IL (1) IL68749A (en)
WO (1) WO1984003443A1 (en)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6146633A (en) * 1973-05-07 2000-11-14 The Ohio State University Method for treatment of antigenically modified polypeptides
US6103243A (en) * 1985-05-15 2000-08-15 Biotechnology Australia Pty, Ltd Oral vaccines
CA1239346A (en) * 1985-06-04 1988-07-19 Gursaran P. Talwar Birth control vaccine
US4855285A (en) * 1985-12-04 1989-08-08 The Ohio State University Research Foundation Antigenic modification of polypeptides
US5817753A (en) * 1985-12-04 1998-10-06 The Ohio State University Research Foundation Antigenic modification of polypeptides
US4795634A (en) * 1986-03-14 1989-01-03 Aphton Corporation Method for contraception by immunization against the zona pellucida
US5096706A (en) * 1986-03-25 1992-03-17 National Research Development Corporation Antigen-based treatment for adiposity
NZ221306A (en) * 1986-08-15 1990-02-26 Commw Scient Ind Res Org 2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof
WO1988001176A1 (en) * 1986-08-18 1988-02-25 Bunge (Australia) Pty. Ltd. Regulating animal reproduction
US5110794A (en) * 1987-01-30 1992-05-05 Abbott Laboratories Method of immunization with partially cationized substances and said partially cationized substances
US5346990A (en) * 1987-04-08 1994-09-13 Cytogam, Inc. Sex-associated membrane proteins and methods for increasing the probability that offspring will be of a desired sex
US5021244A (en) * 1988-12-06 1991-06-04 Cytogam, Inc. Sex-associated membrane antibodies and their use for increasing the probability that offspring will be of a desired sex
US4996297A (en) * 1987-10-07 1991-02-26 Zonagen, Inc. Recombinantly expressed rabbit zona pellucida polypeptides
US6610669B1 (en) 1987-09-18 2003-08-26 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
BE1001013A4 (en) * 1987-10-22 1989-06-13 Icp Internat Inst Of Cellular SYNERGIMYCIN DERIVATIVES OF TYPES A AND B, PROCESS FOR THEIR PREPARATION AND USE THEREOF.
US5002883A (en) * 1987-10-30 1991-03-26 Abbott Laboratories Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents
US5023077A (en) * 1989-01-24 1991-06-11 Aphton Corporation Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
ATE114160T1 (en) * 1989-01-24 1994-12-15 Aphton Corp IMMUNOGENIC COMPOSITIONS AGAINST GASTRIN PEPTIDES.
US6861510B1 (en) * 1989-01-24 2005-03-01 Aphton Corporation Immunogenic compositions against gastrin peptides
US5786457A (en) * 1989-02-23 1998-07-28 Colorado State University Research Foundation Hormone-nuclease compounds and method for regulating hormone related diseases
US6326467B1 (en) 1989-02-23 2001-12-04 Colorado State University Research Foundation Hormone-recombinant toxin compounds and methods for using same
AU5186090A (en) * 1989-02-23 1990-09-26 Colorado State University Research Foundation Gnrh analogs for destroying gonadotrophs
US5641487A (en) * 1989-06-12 1997-06-24 The Government Of The United States Of America As Represented By The Secretary Department Of Health And Human Services Contraceptive vaccine based on alloimmunization with zona pellucida polypeptides
FR2656626B1 (en) * 1989-12-29 1994-08-12 Pasteur Institut PEPTIDE FRAGMENT COMPRISING A SEQUENCE FROM THE 28 KDA PROTEIN OF SCHISTOSOMA MANSONI AND VACCINATION AND / OR THERAPEUTIC COMPOSITIONS COMPRISING SAID FRAGMENT.
EP0593572B1 (en) * 1991-07-01 1998-06-17 The Blood Center Of Southeastern Wisconsin PEN POLYMORPHISM OF HUMAN PLATELET MEMBRANE GLYCOPROTEIN IIIa AND DIAGNOSTIC AND THERAPEUTIC APPLICATION THEREOF
WO1993020098A1 (en) 1992-04-07 1993-10-14 The Scripps Research Institute Process for preparing modified proteins
WO1994007530A1 (en) * 1992-09-30 1994-04-14 The Ohio State University Research Foundation Vaccines and antigenic conjugates
US20050277582A1 (en) * 1993-07-20 2005-12-15 Nett Torrance M Method for inactivating gonadotrophs
US5468494A (en) * 1993-11-12 1995-11-21 Aphton Corp. Immunogenic compositions against human gastrin 17
US5688506A (en) * 1994-01-27 1997-11-18 Aphton Corp. Immunogens against gonadotropin releasing hormone
JP2947503B2 (en) * 1994-03-02 1999-09-13 エーザイ株式会社 Method for producing allylquinone derivative and intermediate
US5869057A (en) * 1995-06-07 1999-02-09 Rock; Edwin P. Recombinant vaccines to break self-tolerance
ES2108614B1 (en) * 1995-07-12 1998-07-16 Oncina Fco Javier Martin POLYMERIZED VACCINES.
US5610136A (en) * 1996-01-30 1997-03-11 Milkhaus Laboratory, Inc. Method for treatment of benign prostatic hypertrophy
JP2000504692A (en) * 1996-02-08 2000-04-18 アフトン・コーポレーション Immunological methods for treating gastrointestinal cancer
CA2254082C (en) * 1996-05-03 2012-09-11 Thomas Jefferson University Metastatic colorectal cancer vaccine
DE19622289A1 (en) * 1996-05-23 1997-11-27 Schering Ag Zona Pellucida Proteins for contraception
US6331610B1 (en) 1997-04-25 2001-12-18 Metatron, Inc. Method for treating AIDS and HIV infection using select peptides from the beta subunit of human chorionic gonadotropin
US20040001842A1 (en) * 1997-05-12 2004-01-01 Dov Michaeli Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
NZ511550A (en) * 1997-05-12 2005-03-24 Aphton Corp CCK-B/gastrin receptor inhibitors for the treatment of tumors
ES2260809T3 (en) * 1997-07-01 2006-11-01 Vlp Watertown Limited Partnership METHOD FOR THE DETERMINATION OF THE SEX OF A MAMMARY PROGENIE.
US6120995A (en) * 1997-08-07 2000-09-19 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
US7135333B1 (en) 1997-08-07 2006-11-14 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
BR9907691B1 (en) 1998-02-05 2011-05-31 derived from tumor-associated antigen and mage family antigen, nucleic acid sequence, coding for them, their uses in vaccine preparation, process for vaccine and vaccine production.
ATE361098T1 (en) * 1998-05-15 2007-05-15 Receptor Biologix Inc PREVENTION AND TREATMENT OF HYPERGASTRINEMIA
US20030068326A1 (en) * 1998-05-15 2003-04-10 Aphton Corporation Method for the treatment of gastroesophageal reflux disease
CA2404431C (en) 2000-03-27 2011-06-07 Thomas Jefferson University Guanylyl cyclase c in the detection of stomach and esophageal cancers
EP1303533A2 (en) 2000-05-05 2003-04-23 Aphton Corporation Chimeric peptide immunogens, their preparation and use
US7829276B2 (en) * 2000-09-18 2010-11-09 Thomas Jefferson University Methods of using CRCA-1 as a stomach and esophageal cancer marker
WO2002076499A2 (en) * 2001-03-23 2002-10-03 Aphton Corporation Combination treatment of pancreatic cancer
US20090191232A1 (en) * 2001-05-04 2009-07-30 Gevas Philip C Combination therapy for the treatment of tumors
US20030021786A1 (en) * 2001-07-09 2003-01-30 Gevas Philip C. Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus
US6810583B2 (en) * 2001-08-07 2004-11-02 International Business Machines Corporation Coupling of conductive vias to complex power-signal substructures
AU2003243663A1 (en) 2002-06-20 2004-01-06 The Trustees Of The University Of Pennsylvania Vaccines for suppressing ige-mediated allergic disease and methods for using the same
WO2004088326A2 (en) * 2003-03-28 2004-10-14 Aphton Corporation Gastrin hormone immunoassays
EP1730193A2 (en) * 2004-03-29 2006-12-13 Receptor Biologix, Inc. Monoclonal antibodies to gastrin hormone
WO2006032980A1 (en) * 2004-09-22 2006-03-30 Receptor Biologix, Inc. Monoclonal antibolies to progastrin
WO2010036652A1 (en) * 2008-09-23 2010-04-01 Thomas Jefferson University Cancer vaccines against mucosal antigens and methods of making and using the same
WO2011066048A1 (en) 2009-10-22 2011-06-03 Thomas Jefferson University Cell-based anti-cancer compositions and methods of making and using the same
US9694060B2 (en) 2012-08-02 2017-07-04 The Board Of Trustees Of The Leland Stanford Junior University Peptide vaccines based on the EGFRvIII sequence for the treatment of tumors
CA3066756A1 (en) 2017-06-15 2018-12-20 Cancer Advances Inc. Compositions and methods for inducing humoral and cellular immunities against tumors and cancer

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2301532A (en) * 1938-08-18 1942-11-10 Parke Davis & Co Biological product and process of obtaining same
US2372066A (en) * 1940-12-23 1945-03-20 Parke Davis & Co Biological product and process of obtaining same
US2388260A (en) * 1942-03-11 1945-11-06 Ernst A H Friedheim Therapeutically active aromatic diazo compounds and derivatives thereof
US2744890A (en) * 1952-12-19 1956-05-08 Nat Dairy Res Lab Inc Proteinaceous composition and method of making the same
US3317400A (en) * 1964-11-23 1967-05-02 Upjohn Co Enzymatic modification of bovine growth hormone by proteolytic streptomycete cell extracts
US4384995A (en) * 1980-01-16 1983-05-24 The Ohio State University Antigenic modification of polypeptides
US4201770A (en) * 1973-05-07 1980-05-06 The Ohio State University Antigenic modification of polypeptides
US4302386A (en) * 1978-08-25 1981-11-24 The Ohio State University Antigenic modification of polypeptides
CH622426A5 (en) * 1973-05-07 1981-04-15 Univ Ohio Contraceptive composition
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
IN140168B (en) * 1974-10-14 1976-09-25 All India Inst Med
CA1054937A (en) * 1975-01-28 1979-05-22 Gursaran P. Talwar Antipregnancy vaccine
NZ182272A (en) * 1975-10-14 1985-03-20 Univ Ohio State Modified polypeptides for the immunological control of fertility,and pharmaceutical compositions
FR2334107A1 (en) * 1975-12-05 1977-07-01 Pasteur Institut METHOD OF COUPLING BIOLOGICAL SUBSTANCES BY COVALENT BONDS
US4122166A (en) * 1976-08-17 1978-10-24 Philips Roxane, Inc. Injectable contraceptive and method
US4123519A (en) * 1976-08-17 1978-10-31 Philips Roxane, Inc. Injectable contraceptive vaccine and method
US4256629A (en) * 1978-02-06 1981-03-17 Research Corporation Antigen for early pregnancy test and contraceptive vaccine
US4313871A (en) * 1978-02-06 1982-02-02 Research Corporation Antigen for early pregnancy test and contraceptive vaccine
US4234561A (en) * 1978-02-06 1980-11-18 Research Corporation Antigen for early pregnancy test and contraceptive vaccine
US4268435A (en) * 1979-02-06 1981-05-19 Research Corporation Chorionic gonadotropin derived antigen for early pregnancy test and contraceptive vaccine
US4310455A (en) * 1979-04-17 1982-01-12 Research Corporation Antigen for early pregnancy test and contraceptive vaccine
US4253996A (en) * 1980-02-13 1981-03-03 Scripps Clinic And Research Foundation Immunochemical conjugates: method and composition
US4320386A (en) 1980-07-30 1982-03-16 General Electric Company Selection and power reset circuit
FR2525592B1 (en) * 1982-04-26 1984-09-14 Pasteur Institut

Also Published As

Publication number Publication date
AU570004B2 (en) 1988-03-03
GB8619233D0 (en) 1986-09-17
GB2146646A (en) 1985-04-24
EP0213391A3 (en) 1989-02-01
EP0210628A3 (en) 1989-02-08
DK521584A (en) 1984-11-02
GB2178041A (en) 1987-02-04
FI80603B (en) 1990-03-30
GB2178042A (en) 1987-02-04
US4526716A (en) 1985-07-02
GB8619232D0 (en) 1986-09-17
JPS60500814A (en) 1985-05-30
AU1704083A (en) 1984-09-28
AU7149087A (en) 1987-08-06
GB8425710D0 (en) 1984-12-05
EP0210628A2 (en) 1987-02-04
GR79126B (en) 1984-10-02
AU588448B2 (en) 1989-09-14
EP0117934B1 (en) 1988-07-20
EP0117934A1 (en) 1984-09-12
GB2178041B (en) 1988-01-06
AU7149587A (en) 1987-09-10
WO1984003443A1 (en) 1984-09-13
JPH0557999B2 (en) 1993-08-25
FI844288A0 (en) 1984-11-01
DK167222B1 (en) 1993-09-20
FI844288L (en) 1984-11-01
EP0213391A2 (en) 1987-03-11
FI80603C (en) 1990-07-10
GB2178042B (en) 1988-01-06
DK521584D0 (en) 1984-11-02
AU594453B2 (en) 1990-03-08

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