DK166755B1 - Farmaceutisk praeparat indeholdende en angiotensin-omdannende enzym-inhibitor og et sloejfediuretikum og fremgamgsmaade til fremstilling af praeparatet - Google Patents
Farmaceutisk praeparat indeholdende en angiotensin-omdannende enzym-inhibitor og et sloejfediuretikum og fremgamgsmaade til fremstilling af praeparatet Download PDFInfo
- Publication number
- DK166755B1 DK166755B1 DK427886A DK427886A DK166755B1 DK 166755 B1 DK166755 B1 DK 166755B1 DK 427886 A DK427886 A DK 427886A DK 427886 A DK427886 A DK 427886A DK 166755 B1 DK166755 B1 DK 166755B1
- Authority
- DK
- Denmark
- Prior art keywords
- angiotensin
- physiologically acceptable
- formula
- acceptable salt
- converting enzyme
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 238000000034 method Methods 0.000 title claims description 4
- 239000003112 inhibitor Substances 0.000 title description 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 239000005541 ACE inhibitor Substances 0.000 claims abstract description 25
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims abstract description 25
- 239000002171 loop diuretic Substances 0.000 claims abstract description 16
- 101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 claims abstract description 10
- 101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 claims abstract description 10
- 150000003839 salts Chemical class 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 12
- 206010020772 Hypertension Diseases 0.000 claims description 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 239000000654 additive Substances 0.000 claims description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
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- 229960000830 captopril Drugs 0.000 description 2
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- 230000029142 excretion Effects 0.000 description 2
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- 238000002156 mixing Methods 0.000 description 2
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
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- -1 2-furylmethylamino Chemical group 0.000 description 1
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- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
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- 230000002526 effect on cardiovascular system Effects 0.000 description 1
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- 229960000873 enalapril Drugs 0.000 description 1
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 description 1
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- 229960002216 methylparaben Drugs 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
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- 229960003415 propylparaben Drugs 0.000 description 1
- 230000005588 protonation Effects 0.000 description 1
- KEDYTOTWMPBSLG-HILJTLORSA-N ramiprilat Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)C(O)=O)CC1=CC=CC=C1 KEDYTOTWMPBSLG-HILJTLORSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Toys (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3532036 | 1985-09-09 | ||
| DE19853532036 DE3532036A1 (de) | 1985-09-09 | 1985-09-09 | Pharmazeutische zubereitung zur behandlung des bluthochdrucks |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK427886D0 DK427886D0 (da) | 1986-09-08 |
| DK427886A DK427886A (da) | 1987-03-10 |
| DK166755B1 true DK166755B1 (da) | 1993-07-12 |
Family
ID=6280420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK427886A DK166755B1 (da) | 1985-09-09 | 1986-09-08 | Farmaceutisk praeparat indeholdende en angiotensin-omdannende enzym-inhibitor og et sloejfediuretikum og fremgamgsmaade til fremstilling af praeparatet |
Country Status (19)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1337400C (en) * | 1987-06-08 | 1995-10-24 | Norma G. Delaney | Inhibitors of neutral endopeptidase |
| DK9200258U4 (da) * | 1992-03-11 | 1993-07-23 | Merck & Co Inc | Farmaceutisk præparat indeholdende enalapril til brug mod hypertension |
| WO2001080895A2 (en) * | 2000-04-26 | 2001-11-01 | First Horizon Pharmaceutical Corporation | Methods and compositions for the treatment of cardiac indications |
| WO2005067887A2 (en) * | 2004-03-24 | 2005-07-28 | Actavis Group | Formulations of ramipril |
| SI3173075T1 (sl) | 2015-11-27 | 2019-02-28 | Accupharma Spolka Z Ograniczona Odpowiedzialnoscia | Farmacevtski kombinacijski pripravek inhibitorja ACE in diuretika zanke |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4283407A (en) * | 1977-09-28 | 1981-08-11 | Science Union Et Cie | Thiopropionamides, and the pharmaceutical compositions |
| US4217347A (en) * | 1977-12-27 | 1980-08-12 | E. R. Squibb & Sons, Inc. | Method of treating hypertension and medicaments therefor |
| CA1120400A (en) * | 1977-12-27 | 1982-03-23 | Zola P. Horovitz | Method of treating hypertension and medicaments therefor |
| IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| FR2419728A1 (fr) * | 1979-01-05 | 1979-10-12 | Science Union & Cie | Nouvelles compositions pharmaceutiques a action hypotensive et procede pour les preparer |
| US4482725A (en) * | 1980-04-03 | 1984-11-13 | E. R. Squibb & Sons, Inc. | S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics |
| JPS56145220A (en) * | 1980-04-10 | 1981-11-11 | Dainippon Pharmaceut Co Ltd | Antihypertensive agent containing prolylamino acid derivative and diuretic agent as main constituent |
-
1985
- 1985-09-09 DE DE19853532036 patent/DE3532036A1/de not_active Withdrawn
-
1986
- 1986-08-29 EP EP86111973A patent/EP0215357B1/de not_active Expired - Lifetime
- 1986-08-29 DE DE8686111973T patent/DE3685177D1/de not_active Expired - Lifetime
- 1986-08-29 AT AT86111973T patent/ATE75610T1/de not_active IP Right Cessation
- 1986-09-05 ES ES8601665A patent/ES2001940A6/es not_active Expired
- 1986-09-05 FI FI863594A patent/FI863594A7/fi not_active Application Discontinuation
- 1986-09-08 KR KR1019860007498A patent/KR940010032B1/ko not_active Expired - Lifetime
- 1986-09-08 IL IL79965A patent/IL79965A/xx not_active IP Right Cessation
- 1986-09-08 CA CA000517718A patent/CA1340722C/en not_active Expired - Lifetime
- 1986-09-08 NZ NZ217489A patent/NZ217489A/xx unknown
- 1986-09-08 PH PH34228A patent/PH23716A/en unknown
- 1986-09-08 NO NO863583A patent/NO863583L/no unknown
- 1986-09-08 PT PT83322A patent/PT83322B/pt unknown
- 1986-09-08 GR GR862285A patent/GR862285B/el unknown
- 1986-09-08 HU HU863879A patent/HU200685B/hu unknown
- 1986-09-08 JP JP61209772A patent/JPH089549B2/ja not_active Expired - Lifetime
- 1986-09-08 ZA ZA866810A patent/ZA866810B/xx unknown
- 1986-09-08 IE IE239286A patent/IE59308B1/en not_active IP Right Cessation
- 1986-09-08 DK DK427886A patent/DK166755B1/da not_active IP Right Cessation
- 1986-09-08 AU AU62431/86A patent/AU597270B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ZA866810B (en) | 1987-04-29 |
| JPH089549B2 (ja) | 1996-01-31 |
| PT83322B (pt) | 1989-05-12 |
| IL79965A (en) | 1990-08-31 |
| DK427886A (da) | 1987-03-10 |
| HUT41640A (en) | 1987-05-28 |
| ES2001940A6 (es) | 1988-07-01 |
| KR940010032B1 (ko) | 1994-10-21 |
| FI863594L (fi) | 1987-03-10 |
| GR862285B (en) | 1987-01-12 |
| EP0215357A3 (en) | 1989-07-26 |
| IE862392L (en) | 1987-03-09 |
| HU200685B (en) | 1990-08-28 |
| KR870002844A (ko) | 1987-04-13 |
| ATE75610T1 (de) | 1992-05-15 |
| NO863583D0 (no) | 1986-09-08 |
| EP0215357B1 (de) | 1992-05-06 |
| AU597270B2 (en) | 1990-05-31 |
| IL79965A0 (en) | 1986-12-31 |
| EP0215357A2 (de) | 1987-03-25 |
| PT83322A (pt) | 1986-10-01 |
| DE3685177D1 (de) | 1992-06-11 |
| PH23716A (en) | 1989-09-27 |
| IE59308B1 (en) | 1994-02-09 |
| NO863583L (no) | 1987-03-10 |
| DE3532036A1 (de) | 1987-03-26 |
| NZ217489A (en) | 1990-07-26 |
| FI863594A7 (fi) | 1987-03-10 |
| CA1340722C (en) | 1999-09-07 |
| DK427886D0 (da) | 1986-09-08 |
| AU6243186A (en) | 1987-03-12 |
| DE3685177T (enrdf_load_stackoverflow) | 1992-06-11 |
| FI863594A0 (fi) | 1986-09-05 |
| JPS6261928A (ja) | 1987-03-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PUP | Patent expired |