DK1644351T3 - Imidazolderivater og anvendelsen deraf i behandlingen af mGluR5-receptormedierede lidelser - Google Patents

Imidazolderivater og anvendelsen deraf i behandlingen af mGluR5-receptormedierede lidelser

Info

Publication number
DK1644351T3
DK1644351T3 DK04740542T DK04740542T DK1644351T3 DK 1644351 T3 DK1644351 T3 DK 1644351T3 DK 04740542 T DK04740542 T DK 04740542T DK 04740542 T DK04740542 T DK 04740542T DK 1644351 T3 DK1644351 T3 DK 1644351T3
Authority
DK
Denmark
Prior art keywords
treatment
imidazole derivatives
mediated disorders
mglur5 receptor
mglur5
Prior art date
Application number
DK04740542T
Other languages
English (en)
Inventor
Bernd Buettelmann
Simona Maria Ceccarelli
Georg Jaeschke
Sabine Kolczewski
Richard Hugh Philip Porter
Eric Vieira
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1644351T3 publication Critical patent/DK1644351T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
DK04740542T 2003-07-03 2004-07-01 Imidazolderivater og anvendelsen deraf i behandlingen af mGluR5-receptormedierede lidelser DK1644351T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03014512 2003-07-03
PCT/EP2004/007177 WO2005003117A1 (en) 2003-07-03 2004-07-01 Imidazole derivatives iii

Publications (1)

Publication Number Publication Date
DK1644351T3 true DK1644351T3 (da) 2008-06-23

Family

ID=33560749

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04740542T DK1644351T3 (da) 2003-07-03 2004-07-01 Imidazolderivater og anvendelsen deraf i behandlingen af mGluR5-receptormedierede lidelser

Country Status (27)

Country Link
US (1) US7091222B2 (da)
EP (1) EP1644351B1 (da)
JP (1) JP4571631B2 (da)
KR (1) KR100719653B1 (da)
CN (1) CN100562520C (da)
AR (1) AR044973A1 (da)
AT (1) ATE388145T1 (da)
AU (1) AU2004253657B2 (da)
BR (1) BRPI0412158A (da)
CA (1) CA2531210C (da)
CO (1) CO5660258A2 (da)
DE (1) DE602004012268T2 (da)
DK (1) DK1644351T3 (da)
ES (1) ES2300789T3 (da)
HR (1) HRP20080173T3 (da)
IL (1) IL172821A (da)
MX (1) MXPA06000193A (da)
MY (1) MY142085A (da)
NO (1) NO20060112L (da)
NZ (1) NZ544454A (da)
PL (1) PL1644351T3 (da)
PT (1) PT1644351E (da)
RU (1) RU2360911C2 (da)
SI (1) SI1644351T1 (da)
TW (1) TWI252849B (da)
WO (1) WO2005003117A1 (da)
ZA (1) ZA200600026B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
US7452909B2 (en) * 2003-09-04 2008-11-18 Hoffman-La Roche Inc. Imidazole derivatives
EP1756086B1 (en) * 2004-06-01 2008-06-04 F.Hoffmann-La Roche Ag Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists
JP4690395B2 (ja) 2004-06-01 2011-06-01 エフ.ホフマン−ラ ロシュ アーゲー mGlu5レセプターアンタゴニストとしてのピリジン−4−エチニル−イミダゾール及びピラゾール
US20060173048A1 (en) * 2005-02-03 2006-08-03 Mcarthur Silvia G Imidazole derivatives
DE102005062987A1 (de) * 2005-12-28 2007-07-05 Grünenthal GmbH Substituierte Propiolsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln
AU2007336369B2 (en) 2006-12-21 2013-01-17 F. Hoffmann-La Roche Ag Polymorphs of a mGluR5 receptor antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US304910A (en) * 1884-09-09 Robeet h
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
US7531529B2 (en) * 2003-06-05 2009-05-12 Roche Palo Alto Llc Imidazole derivatives

Also Published As

Publication number Publication date
TWI252849B (en) 2006-04-11
AR044973A1 (es) 2005-10-12
AU2004253657A1 (en) 2005-01-13
DE602004012268T2 (de) 2009-03-12
ATE388145T1 (de) 2008-03-15
CO5660258A2 (es) 2006-07-31
AU2004253657B2 (en) 2009-09-03
TW200514779A (en) 2005-05-01
CA2531210A1 (en) 2005-01-13
ZA200600026B (en) 2007-05-30
PT1644351E (pt) 2008-04-21
NZ544454A (en) 2008-08-29
IL172821A (en) 2011-01-31
EP1644351A1 (en) 2006-04-12
ES2300789T3 (es) 2008-06-16
MY142085A (en) 2010-08-30
HRP20080173T3 (en) 2008-06-30
PL1644351T3 (pl) 2008-08-29
CN100562520C (zh) 2009-11-25
KR100719653B1 (ko) 2007-05-18
IL172821A0 (en) 2006-06-11
RU2006103009A (ru) 2006-08-27
KR20060029677A (ko) 2006-04-06
US20050009878A1 (en) 2005-01-13
JP2009500291A (ja) 2009-01-08
WO2005003117A1 (en) 2005-01-13
SI1644351T1 (sl) 2008-06-30
EP1644351B1 (en) 2008-03-05
RU2360911C2 (ru) 2009-07-10
CN1823054A (zh) 2006-08-23
MXPA06000193A (es) 2006-04-11
JP4571631B2 (ja) 2010-10-27
BRPI0412158A (pt) 2006-08-22
DE602004012268D1 (de) 2008-04-17
CA2531210C (en) 2012-05-29
US7091222B2 (en) 2006-08-15
NO20060112L (no) 2006-01-24

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