DK1641810T4 - Forudsigelse af sandsynligheden for cancerrecidiv - Google Patents
Forudsigelse af sandsynligheden for cancerrecidiv Download PDFInfo
- Publication number
- DK1641810T4 DK1641810T4 DK04809450.2T DK04809450T DK1641810T4 DK 1641810 T4 DK1641810 T4 DK 1641810T4 DK 04809450 T DK04809450 T DK 04809450T DK 1641810 T4 DK1641810 T4 DK 1641810T4
- Authority
- DK
- Denmark
- Prior art keywords
- dna
- artificial sequence
- probe
- pcr primer
- pcr
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Claims (8)
1. Fremgangsmåde til forudsigelse af sandsynligheden for sygdomsfri overlevelse af en knude-negativ, Er-positiv patient med invasiv duktal brystcancer, hvilken fremgangsmåde omfatter at bestemme ekspressionsniveauet for RNA-transkriptet af STMY3 i en brystcancercelle eller vævsprøve opnået fra patienten, normaliseret mod ekspressionsniveauet for et referencesæt af RNA-transkripter, idet det normaliserede ekspressionsniveau for STMY3 fra patienten sammenlignes med et normaliseret ekspressionsniveau for STMY3 i et brystcancervævsreferencesæt omfattende patienter, som var (a) levende uden lokal, regional eller fjern brystcancertilbagevenden, (b) levende med kontralateral brystcancertilbagevenden, (c) levende med anden primær ikke-bryst-cancer eller (d) døde før brystcancertilbagevenden, hvor et forøget normaliseret ekspressionsniveau for STMY3 fra patienten er tegn på nedsat sandsynlighed for sygdomsfri overlevelse.
2. Fremgangsmåde ifølge krav 1, hvor RNA'et omfatter intron-RNA.
3. Fremgangsmåde ifølge krav 1 eller 2, hvor RNA'et isoleres fra en fikseret, voksind-lejret brystcancervævsprøve fra patienten.
4. Fremgangsmåde ifølge krav 1, 2 eller 3, hvor RNA'et isoleret fra kernebiopsivæv.
5. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor RNA'et isoleres fra finnålsaspiratceller.
6. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor ekspressionsniveauet for RNA-transkriptet bestemmes ved anvendelse af en analyseopstilling omfattende et polynukleotid, der hybridiserer til genet immobiliseret på en fast overflade.
7. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor ekspressionsniveauet for RNA-transkriptet bestemmes ved omvendt transkriptionspolymerasekæde-reaktion (RT-PCR).
8. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor RNA'et er fragmenteret.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48233903P | 2003-06-24 | 2003-06-24 | |
PCT/US2004/019567 WO2005039382A2 (en) | 2003-06-24 | 2004-06-17 | Prediction of likelihood of cancer recurrence |
Publications (2)
Publication Number | Publication Date |
---|---|
DK1641810T3 DK1641810T3 (da) | 2014-08-04 |
DK1641810T4 true DK1641810T4 (da) | 2017-07-03 |
Family
ID=34519967
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK18190058.0T DK3470535T3 (da) | 2003-06-24 | 2004-06-17 | Forudsigelse af sandsynlighed for tilbagevenden af cancer |
DK04809450.2T DK1641810T4 (da) | 2003-06-24 | 2004-06-17 | Forudsigelse af sandsynligheden for cancerrecidiv |
DK14163233.1T DK2775000T3 (da) | 2003-06-24 | 2004-06-17 | Forudsigelse af sandsynligheden for cancerrecidiv |
DK16196459.8T DK3170906T3 (da) | 2003-06-24 | 2004-06-17 | Forudsigelse af sandsynligheden for tilbagefald af kræft |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK18190058.0T DK3470535T3 (da) | 2003-06-24 | 2004-06-17 | Forudsigelse af sandsynlighed for tilbagevenden af cancer |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14163233.1T DK2775000T3 (da) | 2003-06-24 | 2004-06-17 | Forudsigelse af sandsynligheden for cancerrecidiv |
DK16196459.8T DK3170906T3 (da) | 2003-06-24 | 2004-06-17 | Forudsigelse af sandsynligheden for tilbagefald af kræft |
Country Status (11)
Country | Link |
---|---|
US (5) | US7056674B2 (da) |
EP (4) | EP3470535B1 (da) |
JP (1) | JP4680898B2 (da) |
AU (2) | AU2004283068B2 (da) |
CA (2) | CA3061769C (da) |
DK (4) | DK3470535T3 (da) |
ES (4) | ES2690168T3 (da) |
HK (2) | HK1231521A1 (da) |
HU (1) | HUE050365T2 (da) |
PL (1) | PL3470535T3 (da) |
WO (1) | WO2005039382A2 (da) |
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