DK1641810T3 - Forudsigelse af sandsynligheden for cancerrecidiv - Google Patents

Forudsigelse af sandsynligheden for cancerrecidiv

Info

Publication number
DK1641810T3
DK1641810T3 DK04809450.2T DK04809450T DK1641810T3 DK 1641810 T3 DK1641810 T3 DK 1641810T3 DK 04809450 T DK04809450 T DK 04809450T DK 1641810 T3 DK1641810 T3 DK 1641810T3
Authority
DK
Denmark
Prior art keywords
likelihood
prediction
cancer recovery
cancer
recovery
Prior art date
Application number
DK04809450.2T
Other languages
English (en)
Other versions
DK1641810T4 (da
Inventor
Joffre Baker
Soonmyung Paik
Steven Shak
John L Bryant
Original Assignee
Genomic Health Inc
Nsabp Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34519967&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1641810(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genomic Health Inc, Nsabp Foundation Inc filed Critical Genomic Health Inc
Application granted granted Critical
Publication of DK1641810T3 publication Critical patent/DK1641810T3/da
Publication of DK1641810T4 publication Critical patent/DK1641810T4/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DK04809450.2T 2003-06-24 2004-06-17 Forudsigelse af sandsynligheden for cancerrecidiv DK1641810T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48233903P 2003-06-24 2003-06-24
PCT/US2004/019567 WO2005039382A2 (en) 2003-06-24 2004-06-17 Prediction of likelihood of cancer recurrence

Publications (2)

Publication Number Publication Date
DK1641810T3 true DK1641810T3 (da) 2014-08-04
DK1641810T4 DK1641810T4 (da) 2017-07-03

Family

ID=34519967

Family Applications (4)

Application Number Title Priority Date Filing Date
DK04809450.2T DK1641810T4 (da) 2003-06-24 2004-06-17 Forudsigelse af sandsynligheden for cancerrecidiv
DK16196459.8T DK3170906T3 (da) 2003-06-24 2004-06-17 Forudsigelse af sandsynligheden for tilbagefald af kræft
DK14163233.1T DK2775000T3 (da) 2003-06-24 2004-06-17 Forudsigelse af sandsynligheden for cancerrecidiv
DK18190058.0T DK3470535T3 (da) 2003-06-24 2004-06-17 Forudsigelse af sandsynlighed for tilbagevenden af cancer

Family Applications After (3)

Application Number Title Priority Date Filing Date
DK16196459.8T DK3170906T3 (da) 2003-06-24 2004-06-17 Forudsigelse af sandsynligheden for tilbagefald af kræft
DK14163233.1T DK2775000T3 (da) 2003-06-24 2004-06-17 Forudsigelse af sandsynligheden for cancerrecidiv
DK18190058.0T DK3470535T3 (da) 2003-06-24 2004-06-17 Forudsigelse af sandsynlighed for tilbagevenden af cancer

Country Status (11)

Country Link
US (5) US7056674B2 (da)
EP (4) EP1641810B2 (da)
JP (1) JP4680898B2 (da)
AU (2) AU2004283068B2 (da)
CA (2) CA3061769C (da)
DK (4) DK1641810T4 (da)
ES (4) ES2609234T3 (da)
HK (2) HK1201569A1 (da)
HU (1) HUE050365T2 (da)
PL (1) PL3470535T3 (da)
WO (1) WO2005039382A2 (da)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030198972A1 (en) 2001-12-21 2003-10-23 Erlander Mark G. Grading of breast cancer
EP2799555B1 (en) * 2002-03-13 2017-02-22 Genomic Health, Inc. Gene expression profiling in biopsied tumor tissues
US7537891B2 (en) * 2002-08-27 2009-05-26 Bristol-Myers Squibb Company Identification of polynucleotides for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in breast cells
JP2006515742A (ja) * 2002-08-27 2006-06-08 ブリストル−マイヤーズ スクイブ カンパニー 乳癌細胞でのプロテインチロシンキナーゼおよび/またはプロテインチロシンキナーゼ経路と相互作用および/またはモデュレートする化合物の活性を予測するためのポリヌクレオチドの同定
US20040231909A1 (en) 2003-01-15 2004-11-25 Tai-Yang Luh Motorized vehicle having forward and backward differential structure
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
ES2609234T3 (es) 2003-06-24 2017-04-19 Genomic Health, Inc. Predicción de la probabilidad de recidiva de cáncer
US9856533B2 (en) 2003-09-19 2018-01-02 Biotheranostics, Inc. Predicting breast cancer treatment outcome
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
WO2005100606A2 (en) 2004-04-09 2005-10-27 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
AU2005267756A1 (en) * 2004-07-30 2006-02-09 Rosetta Inpharmatics Llc Prognosis of breast cancer patients
JP5028601B2 (ja) * 2004-08-10 2012-09-19 オンコセラピー・サイエンス株式会社 乳癌に関連する遺伝子およびポリペプチド
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
EP1815021A2 (en) * 2004-11-03 2007-08-08 Almac Diagnostics Limited Transcriptome microarray technology and methods of using the same
WO2006052862A1 (en) * 2004-11-05 2006-05-18 Genomic Health, Inc. Predicting response to chemotherapy using gene expression markers
ZA200704796B (en) * 2004-12-07 2008-11-26 Genentech Inc Selecting patients for therapy with a HER inhibitor
US7595380B2 (en) * 2005-04-27 2009-09-29 Tripath Imaging, Inc. Monoclonal antibodies and methods for their use in the detection of cervical disease
US20080275652A1 (en) * 2005-05-13 2008-11-06 Universite Libre De Bruxelles Gene-based algorithmic cancer prognosis
ATE400815T1 (de) * 2005-08-01 2008-07-15 Sysmex Corp Verfahren zur beurteilung der beschaffenheit maligner tumore
US20090215054A1 (en) * 2005-12-13 2009-08-27 Carter Scott L Prognosis indicators for solid human tumors
EP1984738A2 (en) 2006-01-11 2008-10-29 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
EP2481815B1 (en) 2006-05-11 2016-01-27 Raindance Technologies, Inc. Microfluidic devices
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
IL282783B2 (en) 2006-05-18 2023-09-01 Caris Mpi Inc A system and method for determining a personalized medical intervention for a disease stage
EP3536396B1 (en) 2006-08-07 2022-03-30 The President and Fellows of Harvard College Fluorocarbon emulsion stabilizing surfactants
WO2008031041A2 (en) * 2006-09-07 2008-03-13 H. Lee Moffitt Cancer Center And Research Institute, Inc. Melanoma gene signature
WO2008073177A2 (en) * 2006-09-21 2008-06-19 Nuclea Biomarkers, Llc Expression profiles associated with irinotecan treatment
SG142186A1 (en) * 2006-10-20 2008-05-28 Agency Science Tech & Res Breast tumour grading
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8030060B2 (en) * 2007-03-22 2011-10-04 West Virginia University Gene signature for diagnosis and prognosis of breast cancer and ovarian cancer
US20090062144A1 (en) * 2007-04-03 2009-03-05 Nancy Lan Guo Gene signature for prognosis and diagnosis of lung cancer
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
JP2008278798A (ja) * 2007-05-10 2008-11-20 Tokyo Medical & Dental Univ 膀胱癌の検出方法
US20090125247A1 (en) * 2007-08-16 2009-05-14 Joffre Baker Gene expression markers of recurrence risk in cancer patients after chemotherapy
CN102395682B (zh) * 2007-09-06 2015-09-30 生物治疗诊断股份有限公司 肿瘤分级和癌症预后
US20100297639A1 (en) * 2007-10-09 2010-11-25 University Of Washington Through Its Center For Commercialization Quantitative/semi-quantitative measurement of epor on cancer cells
EP2201138B1 (en) * 2007-10-16 2015-03-18 Ventana Medical Systems, Inc. Grading, staging, and prognosing cancer using osteopontin-c
KR100980004B1 (ko) 2008-04-21 2010-09-03 한국생명공학연구원 위암 진단 마커로서의 엠이엘케이
WO2009131365A2 (ko) * 2008-04-21 2009-10-29 한국생명공학연구원 위암 진단 마커로서의 cst1, dcc1, ifitm1 또는 melk
EP2641977B1 (en) 2008-05-12 2014-09-03 Genomic Health, Inc. Tests to predict responsiveness of cancer patients to chemotherapy treatment options
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP4047367A1 (en) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Method for detecting target analytes with droplet libraries
TWI466680B (zh) 2008-08-01 2015-01-01 Oncotherapy Science Inc Melk抗原決定位胜肽及含此胜肽的疫苗
US10359425B2 (en) * 2008-09-09 2019-07-23 Somalogic, Inc. Lung cancer biomarkers and uses thereof
US20100221752A2 (en) * 2008-10-06 2010-09-02 Somalogic, Inc. Ovarian Cancer Biomarkers and Uses Thereof
WO2010045463A2 (en) 2008-10-15 2010-04-22 Government Of The United States As Represented By The Secretary Of The Army Clinical decision model
GB2463401B (en) 2008-11-12 2014-01-29 Caris Life Sciences Luxembourg Holdings S A R L Characterizing prostate disorders by analysis of microvesicles
CA2749103A1 (en) * 2009-01-07 2010-07-15 Steve Stone Cancer biomarkers
US20120041274A1 (en) 2010-01-07 2012-02-16 Myriad Genetics, Incorporated Cancer biomarkers
US8597885B2 (en) * 2009-01-28 2013-12-03 University Of Notre Dame Accelerated progression relapse test
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
EP2486154B1 (en) * 2009-10-08 2017-03-01 Wake Forest University Health Sciences Diagnostic and prognostic markers for cancer
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
DE102010043541B4 (de) 2009-12-16 2012-01-26 Technische Universität Dresden Verfahren und Mittel zur Vorhersage der Überlebensdauer beim Pankreaskarzinom durch Analyse von Biomarkern
WO2011079176A2 (en) 2009-12-23 2011-06-30 Raindance Technologies, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
NZ617003A (en) 2010-01-11 2015-04-24 Genomic Health Inc Method to use gene expression to determine likelihood of clinical outcome of renal cancer
TWI485245B (zh) 2010-01-25 2015-05-21 Oncotherapy Science Inc 經修飾之melk胜肽及含此胜肽之疫苗
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
WO2011100604A2 (en) 2010-02-12 2011-08-18 Raindance Technologies, Inc. Digital analyte analysis
KR20130056855A (ko) 2010-03-01 2013-05-30 카리스 라이프 사이언스 룩셈부르크 홀딩스 치료진단용 생물학적 지표들
AU2011237669B2 (en) 2010-04-06 2016-09-08 Caris Life Sciences Switzerland Holdings Gmbh Circulating biomarkers for disease
US20120053253A1 (en) 2010-07-07 2012-03-01 Myriad Genetics, Incorporated Gene signatures for cancer prognosis
MX355020B (es) 2010-07-09 2018-04-02 Somalogic Inc Biomarcadores de cancer de pulmon y usos de los mismos.
EP2913405B1 (en) 2010-07-27 2016-11-09 Genomic Health, Inc. Method for using gene expression to determine prognosis of prostate cancer
BR112013003391B8 (pt) 2010-08-13 2022-10-25 Somalogic Inc Método para diagnosticar câncer pancreático em um indivíduo
WO2012030840A2 (en) 2010-08-30 2012-03-08 Myriad Genetics, Inc. Gene signatures for cancer diagnosis and prognosis
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
WO2012079059A2 (en) 2010-12-09 2012-06-14 Biotheranostics, Inc. Post-treatment breast cancer prognosis
WO2012109600A2 (en) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Methods for forming mixed droplets
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP3709018A1 (en) 2011-06-02 2020-09-16 Bio-Rad Laboratories, Inc. Microfluidic apparatus for identifying components of a chemical reaction
WO2012178128A1 (en) * 2011-06-22 2012-12-27 Oncocyte Corporation Methods and compositions for the treatment and diagnosis of cancer
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
WO2013023132A1 (en) 2011-08-10 2013-02-14 Wake Forest University Health Sciences Diagnostic and prognostic markers for cancer
US20140206574A1 (en) * 2011-08-31 2014-07-24 Karen Chapman Methods and Compositons for the Treatment and Diagnosis of Cancer
WO2013120089A1 (en) 2012-02-10 2013-08-15 Raindance Technologies, Inc. Molecular diagnostic screening assay
EP3524693A1 (en) 2012-04-30 2019-08-14 Raindance Technologies, Inc. Digital analyte analysis
US20130337444A1 (en) 2012-05-22 2013-12-19 Nanostring Technologies, Inc. NANO46 Genes and Methods to Predict Breast Cancer Outcome
EP2920322B1 (en) 2012-11-16 2023-01-11 Myriad Genetics, Inc. Gene signatures for cancer prognosis
WO2014113641A1 (en) 2013-01-18 2014-07-24 Kline Ellis Selective glycosidase regimen for immune programming and treatment of cancer
WO2014124454A1 (en) 2013-02-11 2014-08-14 Katerina Gurova Use of facilitates chromatin transcription complex (fact) in cancer
EP2986762B1 (en) 2013-04-19 2019-11-06 Bio-Rad Laboratories, Inc. Digital analyte analysis
EP3004392B1 (en) 2013-05-30 2020-09-30 Genomic Health, Inc. Gene expression profile algorithm for calculating a recurrence score for a patient with kidney cancer
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
EP3090063B1 (en) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Method for detection of latent retrovirus
CA2947624A1 (en) 2014-05-13 2015-11-19 Myriad Genetics, Inc. Gene signatures for cancer prognosis
NZ730124A (en) * 2014-09-19 2023-05-26 Univ College Dublin Nat Univ Ireland Dublin A method of predicting risk of recurrence of cancer
CN108064380A (zh) 2014-10-24 2018-05-22 皇家飞利浦有限公司 使用多种细胞信号传导途径活性的医学预后和治疗反应的预测
JP7065609B6 (ja) 2014-10-24 2022-06-06 コーニンクレッカ フィリップス エヌ ヴェ 複数の細胞シグナル伝達経路活性を用いる治療応答の医学的予後及び予測
WO2016062891A1 (en) 2014-10-24 2016-04-28 Koninklijke Philips N.V. ASSESSMENT OF TGF-β CELLULAR SIGNALING PATHWAY ACTIVITY USING MATHEMATICAL MODELLING OF TARGET GENE EXPRESSION
EP3334837B1 (en) 2015-08-14 2020-12-16 Koninklijke Philips N.V. Assessment of nfkb cellular signaling pathway activity using mathematical modelling of target gene expression
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US11530448B2 (en) 2015-11-13 2022-12-20 Biotheranostics, Inc. Integration of tumor characteristics with breast cancer index
US10998178B2 (en) 2017-08-28 2021-05-04 Purdue Research Foundation Systems and methods for sample analysis using swabs
EP3461915A1 (en) 2017-10-02 2019-04-03 Koninklijke Philips N.V. Assessment of jak-stat1/2 cellular signaling pathway activity using mathematical modelling of target gene expression
US12027276B1 (en) 2017-10-27 2024-07-02 DecisionQ Corporation Methods, systems and devices for assessing wound healing
EP3502279A1 (en) 2017-12-20 2019-06-26 Koninklijke Philips N.V. Assessment of mapk-ap 1 cellular signaling pathway activity using mathematical modelling of target gene expression

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4699877A (en) 1982-11-04 1987-10-13 The Regents Of The University Of California Methods and compositions for detecting human tumors
CA1252046A (en) 1982-11-04 1989-04-04 Martin J. Cline Methods for oncogenic detection
USRE35491E (en) 1982-11-04 1997-04-08 The Regents Of The University Of California Methods and compositions for detecting human tumors
US7838216B1 (en) 1986-03-05 2010-11-23 The United States Of America, As Represented By The Department Of Health And Human Services Human gene related to but distinct from EGF receptor gene
US5015568A (en) 1986-07-09 1991-05-14 The Wistar Institute Diagnostic methods for detecting lymphomas in humans
US5202429A (en) 1986-07-09 1993-04-13 The Wistar Institute DNA molecules having human BCL-2 gene sequences
US4968603A (en) 1986-12-31 1990-11-06 The Regents Of The University Of California Determination of status in neoplastic disease
US5831066A (en) 1988-12-22 1998-11-03 The Trustees Of The University Of Pennsylvania Regulation of bcl-2 gene expression
US5858678A (en) 1994-08-02 1999-01-12 St. Louis University Apoptosis-regulating proteins
US5830753A (en) 1994-09-30 1998-11-03 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for tumor rejection antigen precursor dage and uses thereof.
DK0868519T3 (da) 1995-12-18 2006-05-08 Sugen Inc Diagnose og behandling af AUR-1- og/eller AUR-2-relaterede lidelser
US6716575B2 (en) 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
US5670325A (en) 1996-08-14 1997-09-23 Exact Laboratories, Inc. Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
US5962313A (en) 1996-01-18 1999-10-05 Avigen, Inc. Adeno-associated virus vectors comprising a gene encoding a lyosomal enzyme
US5741650A (en) 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples
US5821082A (en) 1996-05-23 1998-10-13 St. Louis University Health Sciences Center Anti-proliferation domain of a human Bcl-2 and DNA encoding the same
US5952178A (en) 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
US6143529A (en) 1996-08-14 2000-11-07 Exact Laboratories, Inc. Methods for improving sensitivity and specificity of screening assays
US6146828A (en) 1996-08-14 2000-11-14 Exact Laboratories, Inc. Methods for detecting differences in RNA expression levels and uses therefor
US6203993B1 (en) 1996-08-14 2001-03-20 Exact Science Corp. Methods for the detection of nucleic acids
US6020137A (en) 1996-08-14 2000-02-01 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US5928870A (en) 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6100029A (en) 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
US5861278A (en) 1996-11-01 1999-01-19 Genetics Institute, Inc. HNF3δ compositions
WO1998022589A2 (en) 1996-11-20 1998-05-28 Yale University Survivin, a protein that inhibits cellular apoptosis, and its modulation
US5846723A (en) * 1996-12-20 1998-12-08 Geron Corporation Methods for detecting the RNA component of telomerase
US5830665A (en) 1997-03-03 1998-11-03 Exact Laboratories, Inc. Contiguous genomic sequence scanning
US6033893A (en) 1997-06-26 2000-03-07 Incyte Pharmaceuticals, Inc. Human cathepsin
WO1999002714A1 (en) 1997-07-07 1999-01-21 Abbott Laboratories Reagents and methods useful for detecting diseases of the breast
AUPO938897A0 (en) * 1997-09-23 1997-10-16 Garvan Institute Of Medical Research A potential effector for the grb7 family of signalling proteins
US6358682B1 (en) * 1998-01-26 2002-03-19 Ventana Medical Systems, Inc. Method and kit for the prognostication of breast cancer
US6020135A (en) 1998-03-27 2000-02-01 Affymetrix, Inc. P53-regulated genes
JP2003528564A (ja) 1998-06-06 2003-09-30 ジェノスティック ファーマ リミテッド 遺伝的プロファイリングに使用するプローブ
US6696558B2 (en) 1998-09-09 2004-02-24 The Burnham Institute Bag proteins and nucleic acid molecules encoding them
AU3246200A (en) 1999-02-25 2000-09-14 Boris Bilynsky Nucleic acid molecules associated with melanoma and thyroid tumors
AU3395900A (en) 1999-03-12 2000-10-04 Human Genome Sciences, Inc. Human lung cancer associated gene sequences and polypeptides
US20020039764A1 (en) 1999-03-12 2002-04-04 Rosen Craig A. Nucleic, acids, proteins, and antibodies
US6692916B2 (en) 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US6960439B2 (en) 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
EP1200618A2 (en) * 1999-07-09 2002-05-02 The Burnham Institute A method for determining the prognosis of cancer patients by measuring levels of bag expression
US6326148B1 (en) 1999-07-12 2001-12-04 The Regents Of The University Of California Detection of copy number changes in colon cancer
US6710170B2 (en) 1999-09-10 2004-03-23 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian cancer
US6271002B1 (en) 1999-10-04 2001-08-07 Rosetta Inpharmatics, Inc. RNA amplification method
CA2391805A1 (en) 1999-10-06 2001-04-12 The Regents Of The University Of California Differentially expressed genes associated with her-2/neu overexpression
CA2490909A1 (en) 1999-12-01 2001-06-07 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6750013B2 (en) 1999-12-02 2004-06-15 Protein Design Labs, Inc. Methods for detection and diagnosing of breast cancer
US6248535B1 (en) 1999-12-20 2001-06-19 University Of Southern California Method for isolation of RNA from formalin-fixed paraffin-embedded tissue specimens
WO2001051661A2 (en) 2000-01-13 2001-07-19 Amsterdam Support Diagnostics B.V. A universal nucleic acid amplification system for nucleic acids in a sample
US6322986B1 (en) 2000-01-18 2001-11-27 Albany Medical College Method for colorectal cancer prognosis and treatment selection
US6618679B2 (en) 2000-01-28 2003-09-09 Althea Technologies, Inc. Methods for analysis of gene expression
WO2001055208A1 (en) 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001070979A2 (en) 2000-03-21 2001-09-27 Millennium Pharmaceuticals, Inc. Genes, compositions, kits, and method for identification, assessment, prevention and therapy of ovarian cancer
WO2001075162A2 (en) 2000-03-31 2001-10-11 University Of Louisville Research Foundation, Inc. Microarrays to screen regulatory genes
WO2002000677A1 (en) 2000-06-07 2002-01-03 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
US6974667B2 (en) 2000-06-14 2005-12-13 Gene Logic, Inc. Gene expression profiles in liver cancer
WO2001098359A2 (en) * 2000-06-21 2001-12-27 Wyeth Cyr61 as a target for treatment and diagnosis of breast cancer
ATE445164T1 (de) * 2000-06-22 2009-10-15 Univ Paris Descartes Zusammensetzungen und methoden zum nachweis, behandeln oder vorhersagen der antwort von brust tumorzellen auf eine endocrin-therapie
WO2002008461A2 (en) 2000-07-21 2002-01-31 Global Genomics Ab A METHOD AND AN ALGORITHM FOR mRNA EXPRESSION ANALYSIS
WO2002008282A2 (en) 2000-07-26 2002-01-31 Stanford University Bstp-ras/rerg protein and related reagents and methods of use thereof
WO2002008260A2 (en) 2000-07-26 2002-01-31 Stanford University Bstp-ecg1 protein and related reagents and methods of use thereof
AU2001277172A1 (en) 2000-07-26 2002-02-05 Applied Genomics, Inc. Bstp-trans protein and related reagents and methods of use thereof
WO2002010436A2 (en) * 2000-07-28 2002-02-07 The Brigham And Women's Hospital, Inc. Prognostic classification of breast cancer
US7795232B1 (en) 2000-08-25 2010-09-14 Genta Incorporated Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers
US20020156263A1 (en) * 2000-10-05 2002-10-24 Huei-Mei Chen Genes expressed in breast cancer
FR2815025B1 (fr) 2000-10-06 2003-08-29 Eurodim Sa Systeme de transfert d'un produit fluide, notamment du gaz naturel liquefie a temperature cryogenique, entre un navire de transport et une installation terrestre de traitement et de stockage de ce produit
CA2427858A1 (en) * 2000-11-03 2002-05-10 University Of Vermont And State Agricultural College Compositions for inhibiting grb7
US6602670B2 (en) 2000-12-01 2003-08-05 Response Genetics, Inc. Method of determining a chemotherapeutic regimen based on ERCC1 expression
US6582919B2 (en) 2001-06-11 2003-06-24 Response Genetics, Inc. Method of determining epidermal growth factor receptor and HER2-neu gene expression and correlation of levels thereof with survival rates
AU2002234799A1 (en) * 2000-12-08 2002-06-18 Ipsogen Gene expression profiling of primary breast carcinomas using arrays of candidate genes
AU2002255478A1 (en) 2001-01-10 2002-09-12 Pe Corporation (Ny) Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof
JP4368110B2 (ja) 2001-01-12 2009-11-18 エール ユニヴァーシティ 癌患者の生物学的流体中のサバイビンの検出
US7776518B2 (en) 2001-01-12 2010-08-17 Yale University Detection of survivin in the biological fluids of cancer patients
WO2002059377A2 (en) 2001-01-24 2002-08-01 Protein Design Labs Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer
US20070015148A1 (en) 2001-01-25 2007-01-18 Orr Michael S Gene expression profiles in breast tissue
CN1554025A (zh) 2001-03-12 2004-12-08 Īŵ���ɷ����޹�˾ 患病状态的细胞为基础的检测和鉴别
WO2002072828A1 (fr) * 2001-03-14 2002-09-19 Dna Chip Research Inc. Procede permettant de prevoir un cancer
WO2002084560A1 (en) * 2001-04-06 2002-10-24 Florence Comite System and method for delivering integrated health care
US7514209B2 (en) 2001-06-18 2009-04-07 Rosetta Inpharmatics Llc Diagnosis and prognosis of breast cancer patients
US7125680B2 (en) 2001-07-27 2006-10-24 The Regents Of The University Of California Methods and materials for characterizing and modulating interaction between heregulin and HER3
AU2002343443A1 (en) 2001-09-28 2003-04-14 Whitehead Institute For Biomedical Research Classification of lung carcinomas using gene expression analysis
WO2003040404A1 (en) 2001-11-09 2003-05-15 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
US20030198972A1 (en) 2001-12-21 2003-10-23 Erlander Mark G. Grading of breast cancer
AU2003215460A1 (en) 2002-03-28 2003-10-13 Qlt Inc. Cancer associated protein kinases and their uses
EP1900827A3 (en) 2002-05-21 2008-04-16 Bayer HealthCare AG Methods and compositions for the prediction, diagnosis, prognosis, prevention and treatment of malignant neoplasia
US20040231909A1 (en) * 2003-01-15 2004-11-25 Tai-Yang Luh Motorized vehicle having forward and backward differential structure
ATE412779T1 (de) * 2003-02-20 2008-11-15 Genomic Health Inc Benutzung von intronischen rna sequenzen zur quantifizierung der genexpression
JP2007507222A (ja) 2003-05-28 2007-03-29 ゲノミック ヘルス, インコーポレイテッド 化学療法に対する応答を予測するための遺伝子発現マーカー
ES2609234T3 (es) * 2003-06-24 2017-04-19 Genomic Health, Inc. Predicción de la probabilidad de recidiva de cáncer
CA2531967C (en) * 2003-07-10 2013-07-16 Genomic Health, Inc. Expression profile algorithm and test for cancer prognosis
WO2005100606A2 (en) * 2004-04-09 2005-10-27 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
WO2006052862A1 (en) * 2004-11-05 2006-05-18 Genomic Health, Inc. Predicting response to chemotherapy using gene expression markers
AU2005304878B2 (en) * 2004-11-05 2010-07-08 Genomic Health, Inc. Molecular indicators of breast cancer prognosis and prediction of treatment response
EP1907858A4 (en) * 2005-06-13 2009-04-08 Univ Michigan COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER
US20090125247A1 (en) 2007-08-16 2009-05-14 Joffre Baker Gene expression markers of recurrence risk in cancer patients after chemotherapy
EP2641977B1 (en) * 2008-05-12 2014-09-03 Genomic Health, Inc. Tests to predict responsiveness of cancer patients to chemotherapy treatment options

Also Published As

Publication number Publication date
ES2488845T3 (es) 2014-08-29
CA2530738A1 (en) 2005-05-06
EP1641810A4 (en) 2009-03-25
EP3470535A1 (en) 2019-04-17
US20100267032A1 (en) 2010-10-21
EP3170906B1 (en) 2018-08-22
DK3470535T3 (da) 2020-06-29
DK2775000T3 (da) 2017-02-13
EP2775000A1 (en) 2014-09-10
HUE050365T2 (hu) 2022-09-28
ES2690168T3 (es) 2018-11-19
ES2488845T5 (es) 2017-07-11
US20060286565A1 (en) 2006-12-21
EP3470535B1 (en) 2020-04-01
EP1641810B1 (en) 2014-05-14
EP3170906A1 (en) 2017-05-24
HK1231521A1 (zh) 2017-12-22
CA3061769A1 (en) 2005-05-06
EP1641810B2 (en) 2017-04-19
DK3170906T3 (da) 2018-11-05
ES2609234T3 (es) 2017-04-19
US7056674B2 (en) 2006-06-06
AU2010202424A1 (en) 2010-07-01
DK1641810T4 (da) 2017-07-03
EP2775000B1 (en) 2016-11-09
AU2010202424B2 (en) 2012-12-06
US20200299781A1 (en) 2020-09-24
ES2787475T3 (es) 2020-10-16
AU2004283068A1 (en) 2005-05-06
CA3061769C (en) 2021-10-26
EP1641810A2 (en) 2006-04-05
HK1201569A1 (en) 2015-09-04
WO2005039382A3 (en) 2006-01-12
US7723033B2 (en) 2010-05-25
US20050079518A1 (en) 2005-04-14
WO2005039382A2 (en) 2005-05-06
PL3470535T3 (pl) 2020-08-24
CA2530738C (en) 2020-01-21
US10619215B2 (en) 2020-04-14
AU2004283068B2 (en) 2010-03-18
US20180051348A1 (en) 2018-02-22
JP2007521005A (ja) 2007-08-02
JP4680898B2 (ja) 2011-05-11

Similar Documents

Publication Publication Date Title
DK1641810T3 (da) Forudsigelse af sandsynligheden for cancerrecidiv
MA29069B1 (fr) Vivier submersible perfectionne
DE602004007220D1 (de) Verbinder
DE602004031798D1 (de) Verbinder
ECSP066436A (es) Compuestos heterociclicos fusionados
IS8108A (is) Ný efnasambönd
DK1605897T3 (da) Polyethelen-glycol-link-glp-1-forbindelser
DE602004023161D1 (de) Toner
DE602004002137D1 (de) Toner
IS8228A (is) Ný asetídínefnasambönd
DE602004022898D1 (de) Verbinder
IS8089A (is) Efnasambönd
DE60328378D1 (de) Toner
IS8292A (is) Ný efnasambönd
DE602004026397D1 (de) Verbinder
DE602004023664D1 (de) Toner
DE112004001791D2 (de) Bohrkopf
DE602004003978D1 (de) Verbinder
DE60316553D1 (de) Verbinder
DE602004029309D1 (de) Verbinder
DE602004009500D1 (de) Verbinder
DE602004000496D1 (de) Verbinder
NO20031736D0 (no) Forbindelser
SE0303452D0 (sv) New compounds
DE602004029860D1 (de) Verbinder