DK1638594T3 - HIP/PAP polypeptidsammensætning til anvendelse ved leverregenerering og til forebyggelse af leversvigt - Google Patents
HIP/PAP polypeptidsammensætning til anvendelse ved leverregenerering og til forebyggelse af leversvigtInfo
- Publication number
- DK1638594T3 DK1638594T3 DK04740077.5T DK04740077T DK1638594T3 DK 1638594 T3 DK1638594 T3 DK 1638594T3 DK 04740077 T DK04740077 T DK 04740077T DK 1638594 T3 DK1638594 T3 DK 1638594T3
- Authority
- DK
- Denmark
- Prior art keywords
- amino acid
- hip
- liver
- pap
- prevention
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 210000004185 liver Anatomy 0.000 title abstract 2
- 230000008929 regeneration Effects 0.000 title abstract 2
- 238000011069 regeneration method Methods 0.000 title abstract 2
- 206010019663 Hepatic failure Diseases 0.000 title 1
- 208000007903 liver failure Diseases 0.000 title 1
- 231100000835 liver failure Toxicity 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 101000581815 Homo sapiens Regenerating islet-derived protein 3-alpha Proteins 0.000 abstract 2
- 102100027336 Regenerating islet-derived protein 3-alpha Human genes 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 101100063069 Caenorhabditis elegans deg-1 gene Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010067482 No adverse event Diseases 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000002424 anti-apoptotic effect Effects 0.000 abstract 1
- 210000003494 hepatocyte Anatomy 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000002297 mitogenic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Marine Sciences & Fisheries (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03291487A EP1488798A1 (en) | 2003-06-18 | 2003-06-18 | HIP/PAP polypeptide composition for use in liver regeneration and for the prevention of liver failure |
| PCT/EP2004/006633 WO2004112824A1 (en) | 2003-06-18 | 2004-06-18 | Hip/pap polypeptide composition for use in liver regeneration and for the prevention of liver failure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1638594T3 true DK1638594T3 (da) | 2010-12-20 |
Family
ID=33396036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04740077.5T DK1638594T3 (da) | 2003-06-18 | 2004-06-18 | HIP/PAP polypeptidsammensætning til anvendelse ved leverregenerering og til forebyggelse af leversvigt |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20060276388A1 (da) |
| EP (2) | EP1488798A1 (da) |
| JP (1) | JP4709141B2 (da) |
| CN (1) | CN1835764B (da) |
| AT (1) | ATE480254T1 (da) |
| AU (1) | AU2004248914B2 (da) |
| CA (1) | CA2529896C (da) |
| CY (1) | CY1110941T1 (da) |
| DE (1) | DE602004029038D1 (da) |
| DK (1) | DK1638594T3 (da) |
| ES (1) | ES2351893T3 (da) |
| PL (1) | PL1638594T3 (da) |
| PT (1) | PT1638594E (da) |
| SI (1) | SI1638594T1 (da) |
| WO (1) | WO2004112824A1 (da) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1488798A1 (en) * | 2003-06-18 | 2004-12-22 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | HIP/PAP polypeptide composition for use in liver regeneration and for the prevention of liver failure |
| JP5250548B2 (ja) | 2006-06-21 | 2013-07-31 | エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント | 疾患の治療のための補体ｈ因子の標的化 |
| EP1900749A1 (en) | 2006-09-12 | 2008-03-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Nucleic acids for expressing a polynucleotide of interest in mammalian cancer cells |
| US7923014B2 (en) * | 2007-02-12 | 2011-04-12 | The Board Of Regents Of The University Of Texas System | Expression and purification of HIP/PAP and uses therefor |
| EP2260857A1 (en) * | 2009-06-11 | 2010-12-15 | Alfact Innovation | Novel applications of HIP/PAP or derivatives thereof |
| WO2011003098A1 (en) * | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| KR20120130748A (ko) | 2009-11-05 | 2012-12-03 | 알렉시온 캠브리지 코포레이션 | 발작성 야간 혈색소뇨증, 용혈성 빈혈, 및 혈관내 및 혈관외 용혈을 수반한 질환 상태의 치료 |
| SG185483A1 (en) | 2010-05-14 | 2012-12-28 | Univ Colorado Regents | Improved complement receptor 2 (cr2) targeting groups |
| JP2013533243A (ja) | 2010-06-22 | 2013-08-22 | ザ リージェンツ オブ ザ ユニヴァーシティ オブ コロラド，ア ボディ コーポレート | 補体成分３のＣ３ｄ断片に対する抗体 |
| EP2508607A1 (en) | 2011-04-07 | 2012-10-10 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicament for liver regeneration and for treatment of liver failure |
| EP2687225A1 (en) | 2012-07-19 | 2014-01-22 | Alfact Innovation | HIP/PAP protein and derivatives thereof for use in treating cancer |
| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| JP2015535212A (ja) | 2012-08-17 | 2015-12-10 | ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・コロラド、ア・ボデイー・コーポレイト | 補体活性化を検出するための組成物および方法 |
| US8893292B2 (en) | 2012-11-14 | 2014-11-18 | Mitsubishi Electric Research Laboratories, Inc. | Privacy preserving statistical analysis for distributed databases |
| US20160039877A1 (en) | 2013-03-15 | 2016-02-11 | Shenzhen Hightide Biopharmaceutical, Ltd. | Compositions and methods of using islet neogenesis peptides and analogs thereof |
| FR3004354A1 (fr) * | 2013-04-10 | 2014-10-17 | Alfact Innovation | Composition comprenant la proteine hip/pap ou l'un de ses derives pour le traitement de la resistance a l'insuline |
| RU2559935C1 (ru) * | 2014-06-10 | 2015-08-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ стимуляции регенерации резецированной печени l-аргинином |
| RU2590859C1 (ru) * | 2015-06-30 | 2016-07-10 | государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СибГМУ Минздрава России) | Способ дистантной стимуляции регенерации гепатоцитов |
| RU2601160C1 (ru) * | 2015-07-09 | 2016-10-27 | государственное бюджетное образовательное учреждение высшего профессионального образования "Омский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ОмГМУ Минздрава России) | Способ резекции печени у мелких лабораторных животных |
| JP7002727B2 (ja) * | 2016-01-08 | 2022-02-15 | Ｋｍバイオロジクス株式会社 | Ａｄａｍｔｓ１３を主成分とする診断薬および医薬品 |
| RU2636194C1 (ru) * | 2016-11-23 | 2017-11-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ стимуляции репаративной регенерации печени после ее резекции |
| CN107936111B (zh) * | 2017-12-16 | 2021-09-07 | 广州安辰新药研究院有限公司 | 一种hip/pap蛋白的制备方法 |
| CN114621324B (zh) * | 2018-09-18 | 2023-09-12 | 广州领晟医疗科技有限公司 | 促进肝细胞增殖和/或抑制肝细胞凋亡的多肽及其用途 |
| CN110669126B (zh) * | 2019-10-23 | 2022-08-16 | 广州领晟医疗科技有限公司 | 多肽gpr5及其促进肝细胞增殖和抑制肝细胞凋亡的用途 |
| CN110627866B (zh) * | 2019-10-23 | 2022-10-18 | 广州领晟医疗科技有限公司 | 多肽rly4及其促进肝再生和抑制肝细胞凋亡的用途 |
| JP2024500878A (ja) * | 2020-12-21 | 2024-01-10 | フラグシップ パイオニアリング イノベーションズ ブイ，インコーポレーテッド | 組織再生を増加させるための細胞代謝回転因子の使用 |
| EP4085922A1 (en) | 2021-05-07 | 2022-11-09 | The Healthy Aging Company | Hip/pap protein or a derivative thereof for treating peripheral neuropathy |
| CN113528639B (zh) * | 2021-06-04 | 2023-06-13 | 南方医科大学南方医院 | 一组预测慢加急性肝功能衰竭预后的标志物及其应用 |
| EP4252766A1 (en) | 2022-04-01 | 2023-10-04 | The Healthy Aging Company | Hip/pap protein or a derivative thereof for treating and/or preventing a disorder characterized by a high cxcl5 serum level in an individual |
| WO2024095178A1 (en) | 2022-11-01 | 2024-05-10 | Janssen Pharmaceutica Nv | Thrombopoietin mimetic for use in the treatment of acute liver failure |
| CN116004825A (zh) * | 2022-12-08 | 2023-04-25 | 上海交通大学医学院附属上海儿童医学中心 | Reg3a在制备辅助诊断或治疗肝母细胞瘤的试剂或药物中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2661187B1 (fr) * | 1990-04-20 | 1994-08-05 | Inst Nat Sante Rech Med | Proteine associee a la pancreatite aiguue. moyens pour le diagnostic de la pancreatite aiguue. |
| FR2700011B1 (fr) * | 1992-12-24 | 1995-02-24 | Inst Nat Sante Rech Med | Détection de la mucoviscidose ou d'une mutation du gêne CFTR au moyen d'un dosage de la PAP. |
| EP1488798A1 (en) * | 2003-06-18 | 2004-12-22 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | HIP/PAP polypeptide composition for use in liver regeneration and for the prevention of liver failure |
-
2003
- 2003-06-18 EP EP03291487A patent/EP1488798A1/en not_active Withdrawn
-
2004
- 2004-06-18 CA CA2529896A patent/CA2529896C/en not_active Expired - Fee Related
- 2004-06-18 DK DK04740077.5T patent/DK1638594T3/da active
- 2004-06-18 ES ES04740077T patent/ES2351893T3/es not_active Expired - Lifetime
- 2004-06-18 WO PCT/EP2004/006633 patent/WO2004112824A1/en active Application Filing
- 2004-06-18 US US10/561,034 patent/US20060276388A1/en not_active Abandoned
- 2004-06-18 AT AT04740077T patent/ATE480254T1/de active
- 2004-06-18 DE DE602004029038T patent/DE602004029038D1/de not_active Expired - Lifetime
- 2004-06-18 PT PT04740077T patent/PT1638594E/pt unknown
- 2004-06-18 AU AU2004248914A patent/AU2004248914B2/en not_active Ceased
- 2004-06-18 JP JP2006516001A patent/JP4709141B2/ja not_active Expired - Lifetime
- 2004-06-18 EP EP04740077A patent/EP1638594B1/en not_active Expired - Lifetime
- 2004-06-18 PL PL04740077T patent/PL1638594T3/pl unknown
- 2004-06-18 CN CN200480023661.0A patent/CN1835764B/zh not_active Expired - Lifetime
- 2004-06-18 SI SI200431542T patent/SI1638594T1/sl unknown
-
2010
- 2010-11-24 CY CY20101101060T patent/CY1110941T1/el unknown
-
2011
- 2011-02-22 US US13/032,521 patent/US8329661B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PL1638594T3 (pl) | 2011-08-31 |
| US20060276388A1 (en) | 2006-12-07 |
| ATE480254T1 (de) | 2010-09-15 |
| JP4709141B2 (ja) | 2011-06-22 |
| JP2006527733A (ja) | 2006-12-07 |
| WO2004112824A1 (en) | 2004-12-29 |
| US20110144036A1 (en) | 2011-06-16 |
| AU2004248914B2 (en) | 2010-02-25 |
| EP1488798A1 (en) | 2004-12-22 |
| CN1835764B (zh) | 2014-07-09 |
| AU2004248914A1 (en) | 2004-12-29 |
| PT1638594E (pt) | 2010-12-03 |
| CA2529896C (en) | 2014-02-11 |
| EP1638594A1 (en) | 2006-03-29 |
| US8329661B2 (en) | 2012-12-11 |
| CA2529896A1 (en) | 2004-12-29 |
| CN1835764A (zh) | 2006-09-20 |
| CY1110941T1 (el) | 2015-06-10 |
| ES2351893T3 (es) | 2011-02-11 |
| SI1638594T1 (sl) | 2011-03-31 |
| DE602004029038D1 (de) | 2010-10-21 |
| EP1638594B1 (en) | 2010-09-08 |
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