DK1633779T3 - Oxidoreduktase fra Pichia capsulata - Google Patents

Oxidoreduktase fra Pichia capsulata

Info

Publication number
DK1633779T3
DK1633779T3 DK04735228.1T DK04735228T DK1633779T3 DK 1633779 T3 DK1633779 T3 DK 1633779T3 DK 04735228 T DK04735228 T DK 04735228T DK 1633779 T3 DK1633779 T3 DK 1633779T3
Authority
DK
Denmark
Prior art keywords
pichia
pichia capsulata
oxidoreductase
capsulata
hydroxy compounds
Prior art date
Application number
DK04735228.1T
Other languages
English (en)
Inventor
Antje Gupta
Anke Zimmer
Maria Bobkova
Original Assignee
Iep Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iep Gmbh filed Critical Iep Gmbh
Application granted granted Critical
Publication of DK1633779T3 publication Critical patent/DK1633779T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK04735228.1T 2003-06-18 2004-05-28 Oxidoreduktase fra Pichia capsulata DK1633779T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10327454A DE10327454A1 (de) 2003-06-18 2003-06-18 Oxidoreduktase aus Pichia capsulata
PCT/EP2004/005831 WO2004111083A2 (de) 2003-06-18 2004-05-28 Oxidoreduktase aus pichia capsulata

Publications (1)

Publication Number Publication Date
DK1633779T3 true DK1633779T3 (da) 2011-01-31

Family

ID=33520692

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04735228.1T DK1633779T3 (da) 2003-06-18 2004-05-28 Oxidoreduktase fra Pichia capsulata

Country Status (15)

Country Link
US (1) US7575909B2 (da)
EP (1) EP1633779B1 (da)
JP (2) JP4845729B2 (da)
KR (1) KR101085424B1 (da)
CN (1) CN100567321C (da)
AT (1) ATE484518T1 (da)
CA (1) CA2529583C (da)
DE (2) DE10327454A1 (da)
DK (1) DK1633779T3 (da)
ES (1) ES2357113T3 (da)
HK (1) HK1095336A1 (da)
PL (1) PL1633779T3 (da)
PT (1) PT1633779E (da)
SI (1) SI1633779T1 (da)
WO (1) WO2004111083A2 (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10327454A1 (de) * 2003-06-18 2005-01-20 Juelich Enzyme Products Gmbh Oxidoreduktase aus Pichia capsulata
AT413541B (de) * 2004-05-10 2006-03-15 Iep Gmbh Verfahren zur herstellung von 2-butanol
AT501928B1 (de) * 2004-10-27 2010-09-15 Iep Gmbh Verfahren zur herstellung von chiralen alkoholen
DE102004055508A1 (de) * 2004-11-17 2006-06-01 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
AT501496B1 (de) * 2005-02-21 2007-03-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen
DE102005010804A1 (de) * 2005-03-07 2006-09-14 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
AT502395B1 (de) 2005-07-27 2007-03-15 Iep Gmbh Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen
AT502185B1 (de) * 2005-09-23 2007-02-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen
AT503017B1 (de) * 2005-12-19 2007-07-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von hydroxyketoverbindungen
DE102006009744A1 (de) * 2006-03-02 2007-09-06 Wacker Chemie Ag Herstellung von (S)-2-Butanol durch oxidative Racematspaltung
DE102006010994A1 (de) * 2006-03-09 2007-09-13 Wacker Chemie Ag Verfahren zur enzymatischen Herstellung von chiralen Alkoholen
AT503486B1 (de) * 2006-04-11 2008-05-15 Iep Gmbh Verfahren zur enantioselektiven reduktion von steroiden
US7879585B2 (en) 2006-10-02 2011-02-01 Codexis, Inc. Ketoreductase enzymes and uses thereof
AT504542B1 (de) 2006-12-07 2008-09-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von secodionderivaten
TWI601825B (zh) 2007-09-27 2017-10-11 Ｉｅｐ有限公司 對映異構選擇性酶催化還原中間產物之方法
HUE026181T2 (en) 2008-08-27 2016-05-30 Codexis Inc Ketoreductase polypeptide for the preparation of 3-aryl-3-hydroxypropanamine from 3-aryl-3-ketopropanamine
WO2010025287A2 (en) * 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
SG10201404330VA (en) 2008-08-29 2014-10-30 Codexis Inc Ketoreductase Polypeptides For The Stereoselective Production Of (4S)-3[(5S)-5(4-Fluorophenyl)-5-Hydroxypentanoyl]-4-Phenyl-1,3-Oxazolidin-2-One
JP2010104239A (ja) * 2008-10-28 2010-05-13 Kagoshima Univ １，５−ｄ−アンヒドログルシトールの製造法
EP2226386A1 (de) 2009-03-05 2010-09-08 IEP GmbH Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen
MY155662A (en) * 2009-06-22 2015-11-13 Sk Biopharmaceuticals Co Ltd Method for preparation of carbamic acid (r)-1-aryl-2-tetrazolyl-ethyl ester
WO2011016102A1 (ja) 2009-08-03 2011-02-10 トヨタ自動車株式会社 変異型ギ酸脱水素酵素、これをコードする遺伝子及びnadhの製造方法
SG178456A1 (en) 2009-08-19 2012-04-27 Codexis Inc Ketoreductase polypeptides for the preparation of phenylephrine
EA025990B1 (ru) 2009-09-02 2017-02-28 Пюрак Биохем Б.В. Полипептиды с оксидоредуктазной активностью и их применение
US8404461B2 (en) 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
DK2526182T3 (da) 2010-01-20 2017-11-13 Xyleco Inc Dispergering af råmaterialer og forarbejdning af materialer
EP2566497B1 (en) 2010-05-04 2015-07-29 Codexis, Inc. Biocatalysts for ezetimibe synthesis
NZ603816A (en) 2010-05-27 2014-06-27 Pharmazell Gmbh Novel 7alpha-hydroxysteroid dehydrogenase knockout mutants and use thereof
EP2861750B1 (en) * 2012-06-18 2016-11-23 Laboratorio Chimico Internazionale S.p.A. Process for producing chiral 1-substituted 3-piperidinols employing oxidoreductases
DE102012017026A1 (de) 2012-08-28 2014-03-06 Forschungszentrum Jülich GmbH Sensor für NADP(H) und Entwicklung von Alkoholdehydrogenasen
DE102013104418B4 (de) 2013-04-30 2018-09-27 Cambrex Iep Gmbh Biokatalytisches Verfahren für die Herstellung von (R)-3-Chinuclidinol
CN104017780A (zh) * 2014-05-28 2014-09-03 宁波酶赛生物工程有限公司 一种新的氧化还原酶ntro及其应用
CN104560745B (zh) * 2014-12-08 2017-12-01 上海应用技术学院 一种毕赤酵母菌Pichia sp.SIT2014及其培养方法和应用
CN104561136B (zh) * 2014-12-08 2018-07-06 上海应用技术学院 一种将消旋体芳基邻二醇转化为手性芳基邻二醇的方法
CN108220261B (zh) * 2017-12-29 2021-05-14 安徽联创生物医药股份有限公司 酮还原酶、核酸、重组表达载体、重组表达菌株及应用
GB201802383D0 (en) * 2018-02-14 2018-03-28 Givaudan Sa Process

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523223A (en) * 1992-03-13 1996-06-04 Forschungszentrum Julich Gmbh Ketoester reductase for conversion of keto acid esters to optically active hydroxy acid esters
JP3574682B2 (ja) * 1993-09-24 2004-10-06 ダイセル化学工業株式会社 新規な酵素、該酵素を製造する方法、該酵素をコードするｄｎａ、該ｄｎａを含む形質転換体、該酵素による光学活性アルコール等の製造方法
JP2000236883A (ja) * 1998-12-21 2000-09-05 Daicel Chem Ind Ltd 新規なカルボニル還元酵素、該酵素の製造方法、該酵素をコードするｄｎａおよびこれを利用したアルコールの製造方法
US7094565B1 (en) * 1999-12-15 2006-08-22 Millennium Pharmaceuticals, Inc. 21612, novel human dehydrogenases
DE10033902C1 (de) * 2000-07-12 2001-11-22 Vaw Ver Aluminium Werke Ag Verfahren und Vorrichtung zum steigenden Giessen mit einem auf den Giesstisch aufgesetzten Schieberverschluss
JP2002233392A (ja) * 2000-12-07 2002-08-20 Sumitomo Chem Co Ltd 光学活性４−ブロモ−３−ヒドロキシブタン酸エステルの製造法
DE10119274A1 (de) * 2001-04-20 2002-10-31 Juelich Enzyme Products Gmbh Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen
US7232672B2 (en) * 2001-08-03 2007-06-19 Diversa Corporation P450 enzymes, nucleic acids encoding them and methods of making and using them
CN1322129C (zh) * 2002-03-19 2007-06-20 三菱化学株式会社 新型羰基还原酶及其编码基因、以及利用它们制备光学活性醇的方法
ATE416255T1 (de) * 2002-04-30 2008-12-15 Kaneka Corp Carbonylreduktase, deren gen und verwendung
AU2003264502A1 (en) * 2002-09-19 2004-04-08 Kaneka Corporation Novel carbonyl reductase, gene thereof and method of using the same
JP4345425B2 (ja) * 2002-10-07 2009-10-14 ダイソー株式会社 クロロヒドリン及びヒドロキシカルボン酸エステル不斉加水分解酵素遺伝子
DE10327454A1 (de) * 2003-06-18 2005-01-20 Juelich Enzyme Products Gmbh Oxidoreduktase aus Pichia capsulata

Also Published As

Publication number Publication date
JP4845729B2 (ja) 2011-12-28
CN1839153A (zh) 2006-09-27
CA2529583C (en) 2013-07-23
EP1633779B1 (de) 2010-10-13
ES2357113T3 (es) 2011-04-18
JP2007523617A (ja) 2007-08-23
WO2004111083A2 (de) 2004-12-23
EP1633779A2 (de) 2006-03-15
US20070243594A1 (en) 2007-10-18
PL1633779T3 (pl) 2011-04-29
HK1095336A1 (en) 2007-05-04
CN100567321C (zh) 2009-12-09
WO2004111083A3 (de) 2005-03-10
ATE484518T1 (de) 2010-10-15
JP2011244829A (ja) 2011-12-08
DE502004011781D1 (de) 2010-11-25
PT1633779E (pt) 2011-01-18
CA2529583A1 (en) 2004-12-23
KR101085424B1 (ko) 2011-11-21
SI1633779T1 (sl) 2011-03-31
DE10327454A1 (de) 2005-01-20
US7575909B2 (en) 2009-08-18
KR20060030478A (ko) 2006-04-10

Similar Documents

Publication Publication Date Title
DK1633779T3 (da) Oxidoreduktase fra Pichia capsulata
WO2022155530A8 (en) Variant strain-based coronavirus vaccines
BRPI0516323A (pt) construtos de rna
WO2002066667A8 (en) Glucosamine and method of making glucosamine from microbial biomass
WO2004007679A3 (en) Dendritic cell pontentiation
BRPI0512347B8 (pt) preparação da pregabalina e compostos relacionados
WO2002086126A3 (de) Enzymatisches verfahren zur enantioselektiven reduktion von ketoverbindungen
WO2007075976A3 (en) Method of producing biologically active vitamin k dependent proteins by recombinant methods
HK1074059A1 (en) Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
DE60322708D1 (de) Glucosesensor unter verwendung von glucosedehydrogenase
DK1208205T3 (da) Fremgangsmåder til frembringelse af L-aminosyrer ved hjælp af en forögelse af cellulært NADPH
AU2003254344A1 (en) Method for obtaining the pathogenic resistance in plants
PL1851322T3 (pl) Sposób enancjoselektywnej redukcji enzymatycznej związków ketonowych
WO2003013435A3 (en) N-acetyl-d-glucosamine and process for producing n-acetyl-d-glucosamine
BR0317994A (pt) Cepas de levedura recombinante que produzem a fermentação de xilose
DK1685248T3 (da) Oxidoreduktase fra Metschnikowia zobellii
ATE484592T1 (de) Verfahren zur produktion von aminosäuren mit mikroorganismen
WO2008055988A3 (de) Verfahren zur herstellung von (4s)-3, 4-dihydroxy-2,6, 6-trimethyl-cyclohex-2-enon und derivaten davon unter verwendung der azoarcus phenylethanol dehydrogenase
DE602004017867D1 (de) Verbessertes verfahren zur herstellung des coenzyms q-10
WO2008035187A3 (en) Alcohol dehydrogenase from agromyces sp. and a method of producing a chiral secondary alcohol using same
DE602005025225D1 (de) Herstellung von optisch aktiven alkoholen mit ganzzellenkatalysatoren
AU2020268896A8 (en) Methods of reducing the enzymatic hydrolysis activity rate in a composition obtained from a purification platform
WO2005046581A3 (en) P18 in stem cell manipulations
AU2002312816A1 (en) Inactivation of genes of the mep pathway
WO2005072711A3 (de) Verfahren zur herstellung von sorbicillacton a