DK160985C - Asymmetriske diestere af 1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarboxylsyre, fremgangsmaader til fremstilling heraf samt farmaceutiske praeparater indeholdende disse - Google Patents

Asymmetriske diestere af 1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarboxylsyre, fremgangsmaader til fremstilling heraf samt farmaceutiske praeparater indeholdende disse

Info

Publication number
DK160985C
DK160985C DK063085A DK63085A DK160985C DK 160985 C DK160985 C DK 160985C DK 063085 A DK063085 A DK 063085A DK 63085 A DK63085 A DK 63085A DK 160985 C DK160985 C DK 160985C
Authority
DK
Denmark
Prior art keywords
dihydro
pyridine
dimethyl
procedures
preparing
Prior art date
Application number
DK063085A
Other languages
English (en)
Other versions
DK160985B (da
DK63085D0 (da
DK63085A (da
Inventor
Dante Mardi
Amedo Leonardi
Gabriele Graziani
Giorgio Bianchi
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Publication of DK63085D0 publication Critical patent/DK63085D0/da
Publication of DK63085A publication Critical patent/DK63085A/da
Publication of DK160985B publication Critical patent/DK160985B/da
Application granted granted Critical
Publication of DK160985C publication Critical patent/DK160985C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
DK063085A 1984-02-14 1985-02-12 Asymmetriske diestere af 1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarboxylsyre, fremgangsmaader til fremstilling heraf samt farmaceutiske praeparater indeholdende disse DK160985C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8403866 1984-02-14
GB848403866A GB8403866D0 (en) 1984-02-14 1984-02-14 Diphenylalkylaminoalkyl esters

Publications (4)

Publication Number Publication Date
DK63085D0 DK63085D0 (da) 1985-02-12
DK63085A DK63085A (da) 1985-08-15
DK160985B DK160985B (da) 1991-05-13
DK160985C true DK160985C (da) 1991-11-04

Family

ID=10556581

Family Applications (1)

Application Number Title Priority Date Filing Date
DK063085A DK160985C (da) 1984-02-14 1985-02-12 Asymmetriske diestere af 1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarboxylsyre, fremgangsmaader til fremstilling heraf samt farmaceutiske praeparater indeholdende disse

Country Status (29)

Country Link
US (3) US4705797A (da)
EP (1) EP0153016B1 (da)
JP (1) JPS60199874A (da)
KR (1) KR910005231B1 (da)
AR (1) AR240804A1 (da)
AT (1) ATE52772T1 (da)
AU (1) AU570534B2 (da)
BR (1) BR1101167A (da)
CA (1) CA1277666C (da)
DE (2) DE10199007I2 (da)
DK (1) DK160985C (da)
DZ (1) DZ748A1 (da)
EG (1) EG17772A (da)
ES (1) ES540385A0 (da)
FI (1) FI83954C (da)
GB (1) GB8403866D0 (da)
GR (1) GR850363B (da)
HU (1) HU194171B (da)
IE (1) IE57715B1 (da)
IL (1) IL74238A (da)
LU (1) LU90069I2 (da)
MX (1) MX156874A (da)
NL (1) NL970025I2 (da)
NO (2) NO166123C (da)
NZ (1) NZ210866A (da)
PH (1) PH20725A (da)
PT (1) PT79963B (da)
SG (1) SG48590G (da)
ZA (1) ZA85656B (da)

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EP2111863B1 (en) 2005-10-26 2012-03-28 Asahi Kasei Pharma Corporation Fasudil in combination with bosentan for the treament of pulmonary arterial hypertension
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Also Published As

Publication number Publication date
DZ748A1 (fr) 2004-09-13
DK160985B (da) 1991-05-13
ZA85656B (en) 1985-08-28
FI83954B (fi) 1991-06-14
BR1101167A (pt) 2004-08-17
FI850535L (fi) 1985-08-15
AU3868985A (en) 1985-09-12
HUT37399A (en) 1985-12-28
JPH0517908B2 (da) 1993-03-10
US4772621A (en) 1988-09-20
KR910005231B1 (ko) 1991-07-24
NO166123C (no) 1991-06-05
PT79963A (en) 1985-03-01
EG17772A (en) 1991-08-30
EP0153016A3 (en) 1985-10-02
MX156874A (es) 1988-10-08
CA1277666C (en) 1990-12-11
NO850521L (no) 1985-08-15
DK63085D0 (da) 1985-02-12
NL970025I2 (nl) 1998-01-05
IL74238A (en) 1988-07-31
US4705797A (en) 1987-11-10
AR240804A1 (es) 1991-02-28
DK63085A (da) 1985-08-15
GR850363B (da) 1986-02-06
ES8602664A1 (es) 1985-11-16
IL74238A0 (en) 1985-05-31
JPS60199874A (ja) 1985-10-09
NO166123B (no) 1991-02-25
GB8403866D0 (en) 1984-03-21
KR850005826A (ko) 1985-09-26
US4968832A (en) 1990-11-06
ATE52772T1 (de) 1990-06-15
DE3577703D1 (de) 1990-06-21
NL970025I1 (nl) 1997-09-01
IE57715B1 (en) 1993-03-10
NZ210866A (en) 1988-07-28
LU90069I2 (fr) 1997-07-23
PT79963B (en) 1986-11-10
EP0153016B1 (en) 1990-05-16
PH20725A (en) 1987-03-30
EP0153016A2 (en) 1985-08-28
DE10199007I2 (de) 2003-01-09
ES540385A0 (es) 1985-11-16
FI83954C (fi) 1991-09-25
AU570534B2 (en) 1988-03-17
AR240804A2 (es) 1991-02-28
IE850280L (en) 1985-08-14
SG48590G (en) 1990-08-17
NO2000011I1 (no) 2000-10-17
DE10199007I1 (de) 2001-04-12
HU194171B (en) 1988-01-28
FI850535A0 (fi) 1985-02-08

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