DK1608655T3 - Pyrroloimidazolderivater, fremstillingen deraf, farmaceutiske præparater indeholdende disse og anvendelse deraf som nootrope midler - Google Patents

Pyrroloimidazolderivater, fremstillingen deraf, farmaceutiske præparater indeholdende disse og anvendelse deraf som nootrope midler

Info

Publication number
DK1608655T3
DK1608655T3 DK04741432T DK04741432T DK1608655T3 DK 1608655 T3 DK1608655 T3 DK 1608655T3 DK 04741432 T DK04741432 T DK 04741432T DK 04741432 T DK04741432 T DK 04741432T DK 1608655 T3 DK1608655 T3 DK 1608655T3
Authority
DK
Denmark
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
nootropic agents
action
Prior art date
Application number
DK04741432T
Other languages
Danish (da)
English (en)
Inventor
Carlo Farina
Stefania Gagliardi
Carlo Parini
Marisa Martinelli
Carla Ghelardini
Dipartimento Di O
Original Assignee
Brane Discovery S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brane Discovery S R L filed Critical Brane Discovery S R L
Application granted granted Critical
Publication of DK1608655T3 publication Critical patent/DK1608655T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK04741432T 2003-03-24 2004-03-22 Pyrroloimidazolderivater, fremstillingen deraf, farmaceutiske præparater indeholdende disse og anvendelse deraf som nootrope midler DK1608655T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000573A ITMI20030573A1 (it) 2003-03-24 2003-03-24 Composti ad azione nootropica, loro preparazione,
PCT/EP2004/050339 WO2004085438A2 (en) 2003-03-24 2004-03-22 Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents

Publications (1)

Publication Number Publication Date
DK1608655T3 true DK1608655T3 (da) 2008-11-03

Family

ID=33042696

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04741432T DK1608655T3 (da) 2003-03-24 2004-03-22 Pyrroloimidazolderivater, fremstillingen deraf, farmaceutiske præparater indeholdende disse og anvendelse deraf som nootrope midler

Country Status (24)

Country Link
US (3) US7544705B2 (ja)
EP (1) EP1608655B8 (ja)
JP (1) JP4920408B2 (ja)
CN (1) CN100522963C (ja)
AT (1) ATE401327T1 (ja)
AU (1) AU2004224087B2 (ja)
BR (1) BRPI0408601A (ja)
CA (1) CA2520008C (ja)
CY (1) CY1108401T1 (ja)
DE (1) DE602004015089D1 (ja)
DK (1) DK1608655T3 (ja)
EA (1) EA009558B1 (ja)
ES (1) ES2309534T3 (ja)
HK (1) HK1083837A1 (ja)
HR (1) HRP20050833A2 (ja)
IT (1) ITMI20030573A1 (ja)
NO (1) NO20054898L (ja)
NZ (1) NZ543154A (ja)
PL (2) PL1608655T3 (ja)
PT (1) PT1608655E (ja)
RS (1) RS20050725A (ja)
SI (1) SI1608655T1 (ja)
WO (1) WO2004085438A2 (ja)
ZA (1) ZA200508578B (ja)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20030573A1 (it) * 2003-03-24 2004-09-25 Nikem Research Srl Composti ad azione nootropica, loro preparazione,
EP1925304A1 (en) * 2006-11-15 2008-05-28 Nikem Research S.R.L. Pyrrolo[1,2-a]imidazoledione effective in the treatment of peripheral neurotoxicity induced by chemotherapeutic agents
ITMI20070770A1 (it) * 2007-04-16 2008-10-17 Brane Discovery S R L Impiego di dimiracetam nel trattamento del dolore cronico
AU2012201853B2 (en) * 2007-04-16 2013-06-27 Neurotune Ag Use of dimiracetam in the treatment of chronic pain
BRPI0920342A2 (pt) 2008-10-16 2020-06-23 The Johns Hopkins University Uso de um inibidor da proteína vesicular sináptica 2a (sv2a) ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica para melhora da função cognitiva, uso de levitiracetam ou um sal farmaceuticamente aceitável do mesmo, uso de brivaracetam ou um sal farmaceuticamente aceitável do mesmo, uso do seletracetam ou um sal farmaceuticamente aceitável do mesmo
US9125898B2 (en) 2008-11-14 2015-09-08 Neurotune Ag Acetam derivatives for pain relief
CA2789014C (en) * 2010-02-09 2019-01-15 Michela Gallagher Methods and compositions for improving cognitive function
PL2598504T3 (pl) * 2010-07-26 2014-10-31 Neurotune Ag Sposób otrzymywania dimiracetamu
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
US11160785B2 (en) 2013-03-15 2021-11-02 Agenebio Inc. Methods and compositions for improving cognitive function
EP3827820A1 (en) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam for improving cognitive function
BR112017025031B1 (pt) 2015-05-22 2023-03-21 Agenebio, Inc Composições farmacêuticas de liberação prolongada de levetiracetam
JOP20190251A1 (ar) 2017-05-31 2019-10-21 Metys Pharmaceuticals AG تركيبات تآزرية تشتمل على (r)-ديميراسيتام (1) و(s)-ديميراسيتام (2) بنسبة غير راسيمية
US20220047587A1 (en) 2018-12-04 2022-02-17 Metys Pharmaceuticals AG Synergistic compositions comprising r-2-(substituted-sulfonyl)-hexahydro-pyrrolo[1,2-a]pyrazin-6(2h)-ones and s-2-(substituted-sulfonyl)-hexahydro-pyrrolo[1,2-a]pyrazin-6(2h)-ones in a non-racemic ratio
SG11202105863PA (en) 2018-12-04 2021-07-29 Metys Pharmaceuticals AG Synergistic compositions comprising (r)-2-(2-oxopyrrolidin-1-yl)butanamide and (s)-2-(2-oxopyrrolidin-1-yl)butanamide in a non-racemic ratio

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582838A (en) * 1984-08-24 1986-04-15 Warner-Lambert Company Derivatives of dihydro-1H-pyrrolo[1,2-c]imidazol-3,5-dione as cognition activators
IT1233860B (it) * 1988-02-08 1992-04-21 Isf Spa Derivati del peridroazacicloalca (1,2-a) imidazolo ad attivita' nootropa
US5200406A (en) * 1988-02-08 1993-04-06 I.S.F. Societa Per Azioni Pharmaceutically useful 2,5-dioxo-1H-octahydroimidazo[1,2-A]azepines
JP3400466B2 (ja) * 1991-10-28 2003-04-28 日本水産株式会社 高純度エイコサペンタエン酸またはそのエステルの製造方法
GB9123641D0 (en) 1991-11-07 1992-01-02 Isf Spa Process
ITMI20030573A1 (it) * 2003-03-24 2004-09-25 Nikem Research Srl Composti ad azione nootropica, loro preparazione,
EP1925304A1 (en) * 2006-11-15 2008-05-28 Nikem Research S.R.L. Pyrrolo[1,2-a]imidazoledione effective in the treatment of peripheral neurotoxicity induced by chemotherapeutic agents

Also Published As

Publication number Publication date
US20070027137A1 (en) 2007-02-01
PL378939A1 (pl) 2006-06-12
US20090163565A1 (en) 2009-06-25
CN1756757A (zh) 2006-04-05
ATE401327T1 (de) 2008-08-15
US7544705B2 (en) 2009-06-09
CA2520008C (en) 2011-08-23
PT1608655E (pt) 2008-10-07
JP4920408B2 (ja) 2012-04-18
CN100522963C (zh) 2009-08-05
CY1108401T1 (el) 2014-02-12
PL1608655T3 (pl) 2009-03-31
HK1083837A1 (en) 2006-07-14
WO2004085438A3 (en) 2004-11-25
RS20050725A (en) 2007-11-15
NO20054898L (no) 2005-10-24
ES2309534T3 (es) 2008-12-16
EA200501501A1 (ru) 2006-04-28
WO2004085438A2 (en) 2004-10-07
AU2004224087B2 (en) 2010-04-01
EP1608655A2 (en) 2005-12-28
US7732473B2 (en) 2010-06-08
AU2004224087A1 (en) 2004-10-07
DE602004015089D1 (de) 2008-08-28
EP1608655B8 (en) 2008-10-15
EA009558B1 (ru) 2008-02-28
BRPI0408601A (pt) 2006-03-07
NZ543154A (en) 2008-03-28
ZA200508578B (en) 2007-04-25
CA2520008A1 (en) 2004-10-07
JP2006523198A (ja) 2006-10-12
SI1608655T1 (sl) 2008-12-31
US20100173945A1 (en) 2010-07-08
ITMI20030573A1 (it) 2004-09-25
HRP20050833A2 (en) 2006-02-28
EP1608655B1 (en) 2008-07-16

Similar Documents

Publication Publication Date Title
HK1083837A1 (en) Pyrroloimidazole derivatives, their preperation, pharmaceutical compositions containing them, and their use as nootropic agents
EA200601212A1 (ru) Ингибиторы фосфодиэстеразы, получение и их терапевтическое применение
HK1110651A1 (en) Therapeutic use of farnesyltransferase inhibitors and methods of monitoring the efficacy thereof
DK1611088T3 (da) Hydroxymater som terapeutiske midler
MY142589A (en) Benzimidazole derivatives : preparation and pharmaceutical applications
ATE442142T1 (de) Fredericamycin-derivate als arzneimittel zur tumorbehandlung
MY142329A (en) Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents.
EA200900802A1 (ru) Способы и композиции для лечения амилоидных заболеваний
DK1776349T3 (da) 2-amino-puinazolin derivater anvendelige som inhibitorer af beta-sekretase (BACE)
NO20076447L (no) Bicykliske derivater som modulatorer av ionekanaler
EA200600078A1 (ru) Способы и композиции для лечения амилоидных заболеваний
NO20071742L (no) Kinazoliner som er nyttige som modulatorer av ionekanaler
ATE397930T1 (de) Verwendung von oxazolidinon-chinolin-hybrid- antibiotika zur behandlung von anthrax und anderen infektionen
DK1641803T3 (da) Thienopyrimidinderivater som kaliumkanalinhibitorer
DK1654253T3 (da) Substituerede 3-pyrrolidinindolderivater
TNSN06403A1 (en) 3-B-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF
SG162614A1 (en) Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors
MXPA06007007A (es) Derivados de prolina usados como ingredientes farmaceuticos activos para el tratamiento de tumores.
GB0522908D0 (en) Therapeutic agents
ATE366720T1 (de) Substituierte diarylharnstoffe als stimulatoren der fas-vermittelten apoptose
SG146685A1 (en) Dihydroporphine derivatives, processes for their preparation, and pharmaceutical compositions containing them
ATE423780T1 (de) Makrozyclen zur behandlung von krebserkrankungen
ATE441461T1 (de) Mittel zur behandlung von infektionen
DE602004025001D1 (de) Verbindungen zur behandlung von neuropathischen schmerzen und migräne
DE10390702D2 (de) 2-Methylthiazolidin-2,4-Dicarbonsäure und deren Salze zur Behandlung von neurodegenerativen Erkrankungen