EA200501501A1 - Соединения с ноотропным действием, их получение, содержащие их фармацевтические композиции и их применение - Google Patents

Соединения с ноотропным действием, их получение, содержащие их фармацевтические композиции и их применение

Info

Publication number
EA200501501A1
EA200501501A1 EA200501501A EA200501501A EA200501501A1 EA 200501501 A1 EA200501501 A1 EA 200501501A1 EA 200501501 A EA200501501 A EA 200501501A EA 200501501 A EA200501501 A EA 200501501A EA 200501501 A1 EA200501501 A1 EA 200501501A1
Authority
EA
Eurasian Patent Office
Prior art keywords
effect
pharmaceutical compositions
noothropic
compounds
production
Prior art date
Application number
EA200501501A
Other languages
English (en)
Other versions
EA009558B1 (ru
Inventor
Карло Фарина
Стефания Гальярди
Карло Парини
Мариза Мартинелли
Карла Гелардини
Original Assignee
Найкем Рисерч С.Р.Л.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Найкем Рисерч С.Р.Л. filed Critical Найкем Рисерч С.Р.Л.
Publication of EA200501501A1 publication Critical patent/EA200501501A1/ru
Publication of EA009558B1 publication Critical patent/EA009558B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Здесь описаны новые бициклические арилимидазолоны, обладающие ноотропной активностью (т.е. функциями защиты и стимуляции головного мозга), аналгезирующим действием и антигипералгезивным действием; описан также способ их получения и фармацевтические композиции, содержащие их, применимые для лечения дефицитов познавательной функции и различных типов боли.
EA200501501A 2003-03-24 2004-03-22 Соединения с ноотропным действием, их получение, содержащие их фармацевтические композиции и их применение EA009558B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000573A ITMI20030573A1 (it) 2003-03-24 2003-03-24 Composti ad azione nootropica, loro preparazione,
PCT/EP2004/050339 WO2004085438A2 (en) 2003-03-24 2004-03-22 Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents

Publications (2)

Publication Number Publication Date
EA200501501A1 true EA200501501A1 (ru) 2006-04-28
EA009558B1 EA009558B1 (ru) 2008-02-28

Family

ID=33042696

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501501A EA009558B1 (ru) 2003-03-24 2004-03-22 Соединения с ноотропным действием, их получение, содержащие их фармацевтические композиции и их применение

Country Status (24)

Country Link
US (3) US7544705B2 (ru)
EP (1) EP1608655B8 (ru)
JP (1) JP4920408B2 (ru)
CN (1) CN100522963C (ru)
AT (1) ATE401327T1 (ru)
AU (1) AU2004224087B2 (ru)
BR (1) BRPI0408601A (ru)
CA (1) CA2520008C (ru)
CY (1) CY1108401T1 (ru)
DE (1) DE602004015089D1 (ru)
DK (1) DK1608655T3 (ru)
EA (1) EA009558B1 (ru)
ES (1) ES2309534T3 (ru)
HK (1) HK1083837A1 (ru)
HR (1) HRP20050833A2 (ru)
IT (1) ITMI20030573A1 (ru)
NO (1) NO20054898L (ru)
NZ (1) NZ543154A (ru)
PL (2) PL1608655T3 (ru)
PT (1) PT1608655E (ru)
RS (1) RS20050725A (ru)
SI (1) SI1608655T1 (ru)
WO (1) WO2004085438A2 (ru)
ZA (1) ZA200508578B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20030573A1 (it) * 2003-03-24 2004-09-25 Nikem Research Srl Composti ad azione nootropica, loro preparazione,
EP1925304A1 (en) * 2006-11-15 2008-05-28 Nikem Research S.R.L. Pyrrolo[1,2-a]imidazoledione effective in the treatment of peripheral neurotoxicity induced by chemotherapeutic agents
ITMI20070770A1 (it) 2007-04-16 2008-10-17 Brane Discovery S R L Impiego di dimiracetam nel trattamento del dolore cronico
AU2012201853B2 (en) * 2007-04-16 2013-06-27 Neurotune Ag Use of dimiracetam in the treatment of chronic pain
CN107243007A (zh) 2008-10-16 2017-10-13 约翰斯.霍普金斯大学 改善认知功能的方法和组合物
US9125898B2 (en) 2008-11-14 2015-09-08 Neurotune Ag Acetam derivatives for pain relief
BR112012019923A2 (pt) * 2010-02-09 2016-08-09 Univ Johns Hopkins métodos e composições para melhorar a função cognitiva
KR101896349B1 (ko) * 2010-07-26 2018-09-07 노이로툰 아게 디미라세탐의 제조 방법
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
EP2968220B1 (en) 2013-03-15 2021-05-05 Agenebio, Inc. Methods and compositions for improving cognitive function
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
CN107810002B (zh) 2015-05-22 2021-01-05 艾吉因生物股份有限公司 左乙拉西坦的延时释放药物组合物
JOP20190251A1 (ar) 2017-05-31 2019-10-21 Metys Pharmaceuticals AG تركيبات تآزرية تشتمل على (r)-ديميراسيتام (1) و(s)-ديميراسيتام (2) بنسبة غير راسيمية
MX2021006243A (es) 2018-12-04 2021-08-11 Metys Pharmaceuticals AG Composiciones sinergicas que comprenden (r)-2-(2-oxopirrolidin-1-i l)butanamida y (s)-2-(2-oxopirrolidin-1-il)butanamida en una proporcion no racemica.
WO2020115096A1 (en) 2018-12-04 2020-06-11 Metys Pharmaceuticals AG Synergistic compositions comprising r-2-(substituted-sulfonyl)-hexahydro-pyrrolo[1,2-a]pyrazin-6(2h)-ones and s-2-(substituted-sulfonyl)-hexahydro-pyrrolo[1,2-a]pyrazin-6(2h)-ones in a non-racemic ratio

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582838A (en) * 1984-08-24 1986-04-15 Warner-Lambert Company Derivatives of dihydro-1H-pyrrolo[1,2-c]imidazol-3,5-dione as cognition activators
US5200406A (en) * 1988-02-08 1993-04-06 I.S.F. Societa Per Azioni Pharmaceutically useful 2,5-dioxo-1H-octahydroimidazo[1,2-A]azepines
IT1233860B (it) * 1988-02-08 1992-04-21 Isf Spa Derivati del peridroazacicloalca (1,2-a) imidazolo ad attivita' nootropa
JP3400466B2 (ja) * 1991-10-28 2003-04-28 日本水産株式会社 高純度エイコサペンタエン酸またはそのエステルの製造方法
GB9123641D0 (en) * 1991-11-07 1992-01-02 Isf Spa Process
ITMI20030573A1 (it) * 2003-03-24 2004-09-25 Nikem Research Srl Composti ad azione nootropica, loro preparazione,
EP1925304A1 (en) * 2006-11-15 2008-05-28 Nikem Research S.R.L. Pyrrolo[1,2-a]imidazoledione effective in the treatment of peripheral neurotoxicity induced by chemotherapeutic agents

Also Published As

Publication number Publication date
PT1608655E (pt) 2008-10-07
PL1608655T3 (pl) 2009-03-31
DK1608655T3 (da) 2008-11-03
NO20054898L (no) 2005-10-24
JP2006523198A (ja) 2006-10-12
ZA200508578B (en) 2007-04-25
JP4920408B2 (ja) 2012-04-18
PL378939A1 (pl) 2006-06-12
ITMI20030573A1 (it) 2004-09-25
AU2004224087B2 (en) 2010-04-01
US7544705B2 (en) 2009-06-09
NZ543154A (en) 2008-03-28
CA2520008A1 (en) 2004-10-07
CA2520008C (en) 2011-08-23
BRPI0408601A (pt) 2006-03-07
HK1083837A1 (en) 2006-07-14
CN1756757A (zh) 2006-04-05
CY1108401T1 (el) 2014-02-12
SI1608655T1 (sl) 2008-12-31
EP1608655A2 (en) 2005-12-28
US20070027137A1 (en) 2007-02-01
WO2004085438A2 (en) 2004-10-07
US20090163565A1 (en) 2009-06-25
AU2004224087A1 (en) 2004-10-07
RS20050725A (en) 2007-11-15
US20100173945A1 (en) 2010-07-08
EA009558B1 (ru) 2008-02-28
HRP20050833A2 (en) 2006-02-28
EP1608655B1 (en) 2008-07-16
ES2309534T3 (es) 2008-12-16
ATE401327T1 (de) 2008-08-15
EP1608655B8 (en) 2008-10-15
DE602004015089D1 (de) 2008-08-28
US7732473B2 (en) 2010-06-08
WO2004085438A3 (en) 2004-11-25
CN100522963C (zh) 2009-08-05

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Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU